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Articles by Xiaolin Sun
Static-dynamic-thermal characteristic analysis and experimental study of motorized spindle
Abstract Prolonged uninterrupted running triggers obvious thermal displacement in high-speed motorized spindles. Taking the A01 turning spindle as the research object, this work develops a split double-spiral cooling sleeve with independent flow channels for the stator and front bearing. A fluid–solid multi-field coupling model covering static, dynamic and thermal characteristics is established and partially validated via steady-state temperature tests of stator windings.
Low dose IL-2 therapy restores regulatory T cells in patients with systemic lupus erythematosus in a dose-dependent manner: a phase IIb trial
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Abstract Low-dose interleukin 2 (Ld-IL2) has shown therapeutic effects in autoimmune diseases, particularly systemic lupus erythematosus (SLE), yet optimal dosage has not been established in clinical trials. In this multicentre, double-blind, phase IIb trial, 152 patients with active SLE were randomised (1:1:1:1) to receive subcutaneous IL2 (0.2, 0.5, or 1.0 million IU) or placebo every other day for 12 weeks, then weekly for another 12 weeks.
By Xia Zhang, Ruiling Feng, Yifan Wang Verified, Wenqiang Fan, Xiao Gao, Miaomiao Ma, Dongbin Jiang, Ting Li, Huifang Guo, Lingyan Lei, Ke Xu, Wei Wei, Na Zhang, Wenping Pan, Qingwen Wang, Juan He, Ruijun Zhang, Rong Mu, Yongfu Wang, Hui Wang, Yuan Jia, Xiaolin Sun, Zhanguo Li, Jing He, Guanmin Gao, Yucui Li, Kuanting Wang, Yueming Cai, Tongjun Mao
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Nature
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Knowledge, attitudes, and practices of nurses in preventing unplanned extubation of orotracheal intubation in the adult intensive care unit: a multicenter questionnaire survey
Abstract Background: Endotracheal intubation is a common procedure performed in the intensive care unit (ICU), which can lead to life-threatening outcomes. Aim: To understand the knowledge, attitudes, and practices, as well as influence factors, on nurses for unplanned extubation prevention in patients with orotracheal intubation in intensive care unit. Study design: A total of 698 ICU nurses from 26 tertiary hospitals were enrolled in January 2022.
Beyond GWR: A Spatial Clustering and Partitioned Stacking Framework for Capturing Nonlinear Locational Premiums and Submarket Specificity in Real Estate Valuation
You are already at the latest version Based on a spatial clustering and partitioned stacking ensemble model, this study addresses the limitations of traditional geoweighting regression in capturing nonlinear location premiums and submarket heterogeneity within urban real estate markets.
Efficacy and safety of low-dose interleukin 2 for Behçet’s syndrome: a randomized, placebo-controlled, double-blind, phase 2 clinical trial - Nature Communications
Abstract Behçet’s syndrome (BS), a chronic vasculitis, leads to recurrent oral ulcers, severely impacting quality of life. Here we report the results of a randomized, double-blind, placebo-controlled trial (NCT04065672) to evaluate the efficacy and safety of low-dose interleukin-2 (LD-IL-2) in BS patients. 60 participants with active oral ulcers are randomly assigned to receive LD-IL-2 or placebo. The primary endpoint is the oral ulcer count at week 12.
The Impact of Artificial Intelligence on Corporate Green Value Co-creation-Empirical Evidence from China's Manufacturing Industry
This version is not peer-reviewed. Submitted: 25 November 2025 You are already at the latest version Against the dual demands of green transformation and digital integration in the man-ufacturing industry, green value co-creation has become a core pathway for enterpris-es to integrate stakeholder resources and synergize ecological and economic values, with the widespread application of artificial intelligence (AI) providing critical ena-bling support.
Molecular Assembly Unlocks Dual‐Defect Synergy in Carbon Nitride for Efficient H2O2 Photosynthesis
1 Introduction In the context of the global energy structure transition and “carbon neutrality” strategies, the development of green and sustainable energy carriers and chemical synthesis pathways is paramount.
Vericiguat reduces atrial fibrillation recurrence by alleviating myocardial fibrosis via the TGF-β1/Smad2/3 pathway
Loading metrics Open Access Peer-reviewed Research Article Citation: Sun X, Sheng Y, Xu P, Peng Q, Ruan Z (2025) Vericiguat reduces atrial fibrillation recurrence by alleviating myocardial fibrosis via the TGF-β1/Smad2/3 pathway. PLoS One 20(7): e0328272. https://doi.org/10.1371/journal.pone.0328272 Editor: Li-Da Wu, Nanjing First Hospital, Nanjing Medical University, CHINA Received: October 19, 2024; Accepted: June 28, 2025; Published: July 18, 2025 Copyright: © 2025 Sun et al.
Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging
Keywords chimeric antigen receptor: CAR circular mRNA T cells uPAR senolytic aging-inflamed disorders Introduction Over the past several decades, chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of previously incurable hematological malignancies, including lymphoma, leukemia, and multiple myeloma.1 The remarkable specificity and potent cytotoxicity of CAR-T cells have sparked interest in exploring non-cancer applications, though their clinical utility remains...
A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study - Scientific Data
Abstract Alterations in intestinal microbiota have been identified as a key risk factor in rheumatoid arthritis (RA). This study presents a multidimensional gut microbiota profile from a large cohort of RA patients, stratified by disease stage and treatment regimens, and compared to healthy controls. Our dataset comprises gut microbiota profiles from 2,238 individuals, including 1,034 RA patients (Ascia Pacific RA cohort, APRAC) and 1,204 healthy controls.
Stabilizing the Interphase in an Ultra-High-Nickel Cathode Enabling High-Performance Lithium-Ion Batteries
Energy, Environmental, and Catalysis ApplicationsSeptember 5, 2024 Qing Zhao Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Zhibin Zhang Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China Depeng Song Qingdao Institute of Bioenergy and Bioprocess...
Spatial-temporal assessment of future population exposure to compound extreme precipitation-high temperature events across China
Citation: Jin K, Wu Y, Sun X, Sun Y, Gao C (2024) Spatial-temporal assessment of future population exposure to compound extreme precipitation-high temperature events across China. PLoS ONE 19(8): e0307494. https://doi.org/10.1371/journal.pone.0307494 Editor: Mohammed Magdy Hamed, Arab Academy for Science Technology and Maritime Transport, EGYPT Received: February 16, 2024; Accepted: July 7, 2024; Published: August 14, 2024 Copyright: © 2024 Jin et al.
Single‐cell mitochondrial sequencing reveals low‐frequency mitochondrial mutations in naturally aging mice
3T-3-L1 Mouse Adipocyte-Like Cell Line1 ATAC Assay for Transposase-Accessible Chromatin Bcl11b B-Cell CLL/Lymphoma 11B CD4+ CD4 antigen positive CD8+ CD8 antigen negative EGR3 Early Growth Response 3 HEK-293 Human Embryonic Kidney 293 Cells KLF15 Kidney-Enriched Krueppel-Like Factor 15 NRF1 Nuclear Respiratory Factor 1 Pax5 Paired Box 5 S1008a S100 calcium binding protein A8 SP3 Sp9 Transcription Factor 3 SP9 Sp9 Transcription Factor 9 1 INTRODUCTION The advent of microfluidic systems has...
Spatial-temporal assessment of future extreme precipitation and extreme high‐temperature exposure across China
Supporting Information Filename Description joc8452-sup-0001-Figures.docxWord 2007 document , 8.8 MB Figure S1. Precipitation and temperature Taylor diagram of simulated under 5 climate models and MME in eight climatic sub-regions of China from 1970 to 2000. Figure S2. Spatial distribution of observed and simulated precipitation in the China at MME models from 1970 to 2000. Figure S3. Spatial distribution of observed and simulated precipitation in the China at MIR-ESM2-0 from 1970 to 2000. Figure S4.
Deficiency of peripheral CLA+ Tregs and clinical relevance in Behcet’s syndrome - Arthritis Research & Therapy
References Bettiol A, Prisco D, Emmi G. Behçet: the syndrome[J]. Rheumatology (Oxford). 2020;59(Suppl 3):iii101–7. https://doi.org/10.1093/rheumatology/kez626. Yazici Y, Hatemi G, Bodaghi B, et al. Behçet syndrome[J]. Nat Rev Dis Primers. 2021;7(1):67. https://doi.org/10.1038/s41572-021-00301-1. Yazici H, Seyahi E, Hatemi G, et al. Behçet syndrome: a contemporary view[J]. Nat Rev Rheumatol. 2018;14(2):107–19. https://doi.org/10.1038/nrrheum.2017.208. Tong B, Liu X, Xiao J, et al.
Effects of Ti and N Contents on the Characteristic Evolution and Thermal Stability of MC Carbonitrides Holding at 1250 °C in H13 Die Steel
1. Introduction AISI H13, a hot-work die steel, is widely used in die casting, extrusion, and hot forging, where H13 inevitably suffers from mechanical stress and thermal shock [1]. Large primary carbonitrides are precipitated for interdendritic segregation during the solidification process [2,3].
Long‐term function of a novel autologous transcatheter pulmonary heart valve implant in an adult animal model
cMRI cardiac magnetic resonance imaging CT computer tomography GA glutaraldehyde ICE intracardiac echocardiography ISO International Organization for Standardization IU/kg international units per kilogram body weight α-SMA α-smooth muscle actin 1 INTRODUCTION Since Charles A.
H2O2-triggered controllable carbon monoxide delivery for photothermal augmented gas therapy
H2O2-triggered controllable carbon monoxide delivery for photothermal augmented gas therapy Carbon monoxide (CO) gas therapy has shown great potential as a very promising approach in the ongoing fight against tumors. However, delivering unstable CO in the tumor site and being safely released for maximum efficacy still have unsatisfactory outcomes.
MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation - Nature Communications
Abstract Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed in activated B cells, it is not clear how MCT1-governed monocarboxylates transportation is functionally coupled to antibody production during the glucose metabolism.
Machine Learning Deciphered Molecular Mechanistics with Accurate Kinetic and Thermodynamic Prediction
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Chem. Theory Comput. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Flood Risk Assessment Based on Hydrodynamic Model-A Case of the China-Pakistan Economic Corridor
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Stability of high internal‐phase emulsions prepared from phycocyanin and small‐molecule sugars
Supporting Information Filename Description jsfa13184-sup-0001-Supinfo.docxWord 2007 document , 16.5 MB Appendix S1. Supporting Information. REFERENCES 1, , , , and , Stability, rheology, and β-carotene bioaccessibility of high internal phase emulsion gels. Food Hydrocoll 88: 210–217 (2019). 2, , , , and , Stability, oxidizability, and topical delivery of resveratrol encapsulated in octenyl succinic anhydride starch/chitosan complex-stabilized high internal phase Pickering emulsions.
Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization
We elucidated the molecular mechanism of Cancer-associated fibroblasts (CAF)-associated gene IGFBP2-induced M2 macrophage polarization in the tumor microenvironment involved in glioma progression. TCGA and CGGA provided bulk RNA-seq datasets, ESTIMATE scores for glioma stromal cells, and OS-clinicopathological correlation analyses.
Global Proteome-Wide Analysis of Cysteine S-Nitrosylation in Toxoplasma gondii
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by *, , and College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China * Author to whom correspondence should be addressed.
LINC00922 decoys SIRT3 to facilitate the metastasis of colorectal cancer through up-regulation the H3K27 crotonylation of ETS1 promoter - Molecular Cancer
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Human CRC cell lines, including HCT116 (TCHu 99), LoVo (TCHu 82), DLD-1 (TCHu134), SW620 (TCHu101), and SW480 (SCSP-5033), were purchased from the cell bank of the Chinese academy of science (Shanghai, China). Human normal colorectal epithelial cell line FHC (CRL-1831) was purchased from American type culture collection (Manassas, VA, USA). HCT116, LoVo, DLD-1, SW480, and FHC were cultured in Dulbecco’s modified eagle medium (DMEM) (Bio-Channel, Cat.
By Meijian Liao, Xiaolin Sun, Mengdi Wu, Yifan Wang Verified, Jia Yao, Yu Ma, Dongsheng Pei, Wendan Zheng, Shoucui Gao
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Molecular Cancer
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DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells (pdf) | Paperity
PLOS ONE, Aug 2023 Sick sinus syndrome (SSS) is a a life-threatening disease, and biological pacemakers derived from bone marrow mesenchymal stem cells (BMSCs) have practical clinical applications. Previous studies demonstrated that epigenetics plays an important role in the differentiation of BMSCs into pacemaker-like cells. However, the underlying mechanisms remain unclear.
DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells
Loading metrics Open Access Peer-reviewed Research Article Citation: Sun X, Jin K, Ding X, Ruan Z, Xu P (2023) DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells. PLoS ONE 18(8): e0289510.
Development and testing of a questionnaire assessing knowledge, attitudes, and practices to prevent unplanned oral extubation
CONFLICT OF INTEREST STATEMENT All authors declare no competing interests. REFERENCES 1. Unplanned extubations in the adult intensive care unit: a prospective multicenter study. Am J Respir Crit Care Med. 1998; 157(4): 1131-1137. 2, , , , . Estubazioni non pianificate nei pazienti adulti in terapia intensiva: un aggiornamento. Assist Inferm Ric. 2015; 34: 21-29. 3. Accidental extubation in intensive care units: what implications for nursing care? Assistenza Infermieristica e Ricerca. 2004; 23(1): 36-47. 4, .
NIR-II Absorbing Conjugated Polymer Nanotheranostics for Thermal Initiated NO Enhanced Photothermal Therapy
Open AccessArticle by 1, 1, 1, 1, 1, 1, 1, 1, 2, 1,* and 1,* 1 Key Laboratory of Medical Molecular Probes, Department of Medical Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, China 2 Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Medicine, Linyi University, Linyi 276005, China * Authors to whom correspondence should be addressed.
Joint Maritime Bunker Hedging and Operational Consumption Based on CVaR Optimization
Abstract : Maritime shipping is an important driver of global economic growth. Efficient green maritime technologies are critical for both the profitability and sustainability of shipping carriers due to the fact that fuel consumption has already made up 45–55% of the total operational cost of a ship. Moreover, the application of green maritime technologies also challenges the input/output of the maritime industry.
Applied Sciences | Free Full-Text | Straightened Segmentation in 4D Cardiac CT: A Practical Method for Multiparametric Characterization of the Landing Zone for Transcatheter Pulmonary Valve Replacement
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Machine learning for predicting preoperative red blood cell demand
ORIGINAL ARTICLE Yannan Feng, orcid.org/0000-0002-0596-4007 Department of Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing, China Search for more papers by this author Zhenhua Xu, Beijing Hexing Chuanglian Health Technology Co., Ltd, Beijing, China Search for more papers by this author Xiaolin Sun, Department of Transfusion Medicine, The First Medical Center of Chinese PLA General Hospital, Beijing, China Search for more papers by this author Deqing...
JUN promotes chicken female differentiation by inhibiting Smad2
Abstract The sex determination and control of poultry is a key problem in production and scientific research despite few studies on regulatory factors, especially transcription factors in sex determination. In the early stage of this study, high-throughput sequencing was used to screen the differentially expressed gene JUN in male and female embryonic stem cells (ESCs) and primordial germ cells (PGCs).
An autoimmune disease variant of IgG1 modulates B cell activation and differentiation
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A Lightweight and Binder-free Electrode Enabled by Lignin Fibers@Carbon-Nanotubes and Graphene for Ultrastable Lithium-Sulfur Batteries
Realizing high sulfur loading while ensuring high sulfur utilization holds the key to enhancing practical energy density of Li−S batteries. Inspired by the reinforced concrete structure in buildings, a facile route for the synthesis of a lightweight and binder-free electrode, composed of lignin fibers@carbon nanotubes as sulfur host and graphene as current collector, was reported.
An autoimmune disease variant of IgG1 modulates B cell activation and differentiation
Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Profiling the origin, dynamics, and function of traction force in B cell activation
B cells recognize antigens through membrane-bound antibodies that are part of the B cell receptor (BCR). Antigen recognition stimulates BCR-dependent intracellular signaling that is required for B cell activation. Noting that B cells first spread over antigen-presenting surfaces before contracting, Wang et al. used traction force microscopy to measure the displacing forces exerted by B cells on fluorescent beads coated onto antigen-containing gel surfaces of different stiffness values.
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