Xiaolin Wei
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Articles by Xiaolin Wei
TRIM27-Cas9–loaded EVs suppress HCC proliferation and enhance responsiveness to anti–PD-1 therapy by promoting ACSL4-mediated ferroptosis
Abstract Inducing ferroptosis in hepatocellular carcinoma (HCC) cells represents an important therapeutic strategy, but intrinsic resistance mechanisms often limit efficacy. Therefore, elucidating the mechanisms underlying ferroptosis resistance in HCC cells can facilitate the development of effective therapeutic strategies. Here, we performed genome-wide CRISPR/Cas9 library screens to identify TRIM27 as a key determinant of ferroptosis resistance.
Single-cell trimodal profiling with scHiCAR
All cells in an organism share the same genome but adopt remarkably different identities and functions because the genes they express differ. These differences are shaped by multiple layers of genomic regulation, including chromatin accessibility and three-dimensional (3D) genome organization. Bulk chromosome conformation capture (3C) methods such as Hi-C have revealed a key role for the 3D genome in gene regulation but cannot resolve cellular heterogeneity within complex tissues.
Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - Nature Biotechnology
Abstract The three-dimensional (3D) organization of cis-regulatory elements (CREs) is critical in transcription control. However, capturing transcriptome, epigenome and 3D genome from the same single cells remains challenging. Here we present scHiCAR (single-cell Hi-C with assay for transposase-accessible chromatin and RNA sequencing), a plate-based combinatorial barcoding method that simultaneously profiles mRNA, open chromatin and chromosome conformation capture from the same cells.
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial | Nature Medicine
Abstract Antimicrobial resistance is driven by inappropriate use of antibiotics for acute respiratory infections (ARIs), which is a major challenge in primary care in low- and middle-income countries. Here we conducted a pragmatic, cluster randomized controlled trial in 34 township hospitals in two rural counties of Guangdong, China, to evaluate whether a digitally enabled stewardship program could reduce antibiotic prescribing.
JMIR Research Protocols - Effectiveness of an Education Toolkit Delivered by Soap Operas Among Communities Living in Extreme Poverty in Improving Vaccination Confidence in the Philippines: Protocol for a Cluster Randomized Controlled Trial
Background Objectives Study Design Setting Soap Opera Trial Vaccine Confidence Trial Intervention aims To evaluate the impact of a variation of their standard Transform Program, which uses aspirational videos to deliver education about food security, livelihood, and health. To improve the knowledge of and confidence in measles and polio vaccines in communities living in extreme poverty in the Philippines.
In situ holistic optimization method for a collinear reflection Mueller matrix imaging polarimeter
In this paper, we propose an in situ holistic optimization method for a collinear reflection Mueller matrix imaging polarimeter (CRMMIP). Traditional instrument matrix optimization approaches for CRMMIP have often neglected the polarization characteristics of non-polarization modulation elements, such as objectives, tube lenses, and beam splitters, leading to reduced instrument stability.
Active case finding using mobile vans with artificial intelligence aided radiology tests and sputum collection for rapid diagnostic tests to reduce tuberculosis prevalence among high-risk population in rural China: Protocol for a pragmatic trial
Citation: Wei X, Liang D, Zhang Z, Thorpe KE, Zhou L, Zhao J, et al. (2025) Active case finding using mobile vans with artificial intelligence aided radiology tests and sputum collection for rapid diagnostic tests to reduce tuberculosis prevalence among high-risk population in rural China: Protocol for a pragmatic trial. PLoS ONE 20(4): e0316073.
Association between Vitamin D Deficiency and Prediabetes Phenotypes: A Population-Based Study in Henan, China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
List prices and clinical value of anticancer drugs in China, Japan, and South Korea: a retrospective comparative study
Research in context High prices and the mismatch between prices and the clinical value of anticancer drugs are critical global issues. Previous studies primarily focused on investigating prices and their correlation with clinical value of anticancer drugs within the US and European countries, including the UK, France, Germany, and Italy. Although attention has been directed towards China and Japan, evidence from East Asia regarding this issue remains insufficient.
Evaluating population-level interventions to reduce inappropriate antibiotic use in healthcare and community settings: A systematic review protocol
Citation: Wu S, Magwood O, Dong Q, Wei X (2024) Evaluating population-level interventions to reduce inappropriate antibiotic use in healthcare and community settings: A systematic review protocol. PLoS ONE 19(3): e0300780. https://doi.org/10.1371/journal.pone.0300780 Editor: Tariku Shimels, SPHMMC: St Paul’s Hospital Millennium Medical College, ETHIOPIA Received: November 7, 2023; Accepted: March 5, 2024; Published: March 18, 2024 Copyright: © 2024 Wu et al.
The hidden threat of subclinical tuberculosis
Despite the UN's resolution of ending tuberculosis infection by 2035, it remains a major public health challenge. Tuberculosis used to be the leading cause of death in infectious diseases and became the second after COVID-19 during the pandemic.
Effectiveness of a comprehensive package based on electronic medication monitors at improving treatment outcomes among tuberculosis patients in Tibet: a multicentre randomised controlled trial
Background WHO recommends that electronic medication monitors, a form of digital adherence technology, be used as a complement to directly observed treatment (DOT) for tuberculosis, as DOT is inconvenient and costly. However, existing evidence about the effectiveness of these monitors is inconclusive. Therefore, we evaluated the effectiveness of a comprehensive package based on electronic medication monitors among patients with tuberculosis in Tibet Autonomous Region (hereafter Tibet), China.
Nutrients | Free Full-Text | Barriers to and Facilitators of the Implementation of a Micronutrient Powder Program for Children: A Systematic Review Based on the Consolidated Framework for Implementation Research
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Burden of tuberculosis among vulnerable populations worldwide: an overview of systematic reviews
Introduction Tuberculosis is a communicable disease that is a major cause of morbidity and mortality worldwide. In 2021, an estimated 10·6 million people developed active tuberculosis disease and 1·6 million deaths were caused by tuberculosis.1 The COVID-19 pandemic has interrupted the delivery of essential screening and tuberculosis treatment services globally, serving to only further exacerbate underlying inequalities in care.
Defining tuberculosis vulnerability based on an adapted social determinants of health framework: a narrative review.
The World Health Organization’s new End TB Strategy emphasises socioeconomic interventions to reduce access barriers to TB care and address the social determinants of TB. To facilitate developing interventions that align with this strategy, we examined how TB vulnerability and vulnerable populations were defined in literature, with the aim to propose a definition and operational criteria for TB vulnerable populations through social determinants of health and equity perspectives.
Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cells
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Design and management considerations for control groups in hybrid effectiveness-implementation trials: Narrative review & case studies
1. Introduction In the last decade, there has been a gradual shift in the field of implementation science towards combining the study of clinical effectiveness and implementation. This shift has the potential to reduce the translational gap between evidence and practice (1).
Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort
http://orcid.org/0000-0002-3622-3287Erjia Ge1, Jianhui Gao1, Xiaolin Wei1, Zhoupeng Ren2, http://orcid.org/0000-0002-8803-7056Jing Wei3, Xin Liu4, Xiaomeng Wang5, Jieming Zhong5, Jingru Lu6, Xiaomei Tian6, Fangrong Fei5, Bin Chen5, Xiaolin Wang6, Ying Peng5, Ming Luo7, Juan Lei6 1 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada 2 State Key Laboratory of Resources and Environmental Information System (LREIS), Institute of Geographic Sciences and Natural...
HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization
Abdennur N. Mirny L.A. Cooler: scalable storage for Hi-C data and other genomically labeled arrays. Bioinformatics. 2020; 36: 311-316 Bonev B. Mendelson Cohen N. Szabo Q. Fritsch L. Papadopoulos G.L. Lubling Y. Xu X. Lv X. Hugnot J.P. Tanay A. Cavalli G. Multiscale 3D genome rewiring during mouse neural development. Cell. 2017; 171 (): 557 Boyle A.P. Davis S. Shulha H.P. Meltzer P. Margulies E.H. Weng Z. Furey T.S. Crawford G.E. High-resolution mapping and characterization of open chromatin across the genome.
Download Hi-Res ImageDownload to MS-PowerPointCite This:Energy Fuels 2022, XXXX, XXX RETURN TO ARTICLES ASAPPREVBatteries and Energy...Batteries and Energy StorageNEXT Heqin Wang Heqin Wang Hunan Institute of Advanced Sensing and Information Technology, Xiangtan University, Xiang Tan, Hunan 411105, China School of Physics and Electronic Engineering, Heng Yang Normal University, Heng Yang, Hunan 421008, China , Lujun Lei Lujun Lei Hunan Institute of Advanced Sensing and Information Technology,...
Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort
Effect modification of greenness on PM2.5 associated all-cause mortality in a multidrug-resistant tuberculosis cohort http://orcid.org/0000-0002-3622-3287Erjia Ge1, Jianhui Gao1, Xiaolin Wei1, Zhoupeng Ren2, http://orcid.org/0000-0002-8803-7056Jing Wei3, Xin Liu4, Xiaomeng Wang5, Jieming Zhong5, Jingru Lu6, Xiaomei Tian6, Fangrong Fei5, Bin Chen5, Xiaolin Wang6, Ying Peng5, Ming Luo7, Juan Lei6 1Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada 2State Key...
Migration and Diabetes Incidence Among Chinese Adults in Canada, China, Hong Kong, and Taiwan: An International Population-Based Comparative Study from 2000 to 2017
Highlights • Diabetes incidence is heterogeneous across Chinese immigrant and source populations. • Immigrant selection, source territory, age, and sex affect diabetes in immigrants. • The “healthy immigrant” hypothesis does not apply to many Chinese immigrants. • Young-onset diabetes is sharply increasing in immigrants from China and Hong Kong. • Earlier diabetes screening is justified for some, but not all, Chinese populations.
Evaluation of a package of risk-based pharmaceutical and lifestyle interventions in patients with hypertension and/or diabetes in rural China: A pragmatic cluster randomised controlled trial
Loading metrics Open Access Peer-reviewed Research Article Xiaolin Wei, Zhitong Zhang, Marc K. C. Chong, Joseph P. Hicks, Weiwei Gong, Guanyang Zou, Jieming Zhong, John D. Walley, Ross E. G. Upshur, Min Yu Xiaolin Wei, Zhitong Zhang, Marc K. C. Chong, Joseph P. Hicks, Weiwei Gong, Guanyang Zou, Jieming Zhong, John D. Walley, Ross E. G.
Antibiotic overuse in China: call for consolidated efforts to develop antibiotic stewardship programmes
John D Walley Zhitong Zhang Xiaolin Wei On the basis of large-scale prescription data, Houyu Zhao and colleagues reported the first nationally representative investigation of antibiotic prescribing in China. We note the high rate of antibiotic prescription (40% for outpatient visits) for viral upper respiratory tract infections, which is inappropriate. The authors recommended a hospital antibiotic stewardship programme.
HiCAR: a robust and sensitive multi-omic co-assay for simultaneous measurement of transcriptome, chromatin accessibility, and cis-regulatory chromatin contacts
New Results Xiaolin Wei, Yu Xiang, Armen Abnousi, Tongyu Sun, Xin Lin, Wei Li, Ming Hu, Yarui Diao doi: https://doi.org/10.1101/2020.11.02.366062 Abstract High-order chromatin organization plays a central role in regulating spatial-temporal gene expression by facilitating or constraining the interactions between cis-regulatory elements (cREs). cREs are often the accessible DNA sequences and can be identified at genome-wide scale with assays such as ATAC-seq, DHS-seq, and FAIRE-seq.
Numerical Simulation of Oxy-Fuel Combustion with Different O2/CO2 Fractions in a Large Cement Precalciner
Download Hi-Res ImageDownload to MS-PowerPointCite This:Energy Fuels 2020, XXXX, XXX RETURN TO ARTICLES ASAPPREVArticleNEXT Leyu Zhang Leyu Zhang State Key Laboratory of High-Temperature Gas Kinetics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China Xiaolin Wei* Xiaolin Wei State Key Laboratory of High-Temperature Gas Kinetics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, China School of Engineering Science, University of Chinese Academy of...
Understanding factors influencing antibiotic prescribing behaviour in rural China: a qualitative process evaluation of a cluster randomized controlled trial - Xiaolin Wei, Simin Deng, Victoria Haldane, Claire Blacklock, Wei Zhang, Zhitong Zhang, John D Wa
1. Butler, CC, Hood, K, Verheij, Tet al. Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ 2009; 338: b2242. Google Scholar | Crossref | Medline 2. Mao, W, Vu, H, Xie, Zet al. Systematic review on irrational use of medicines in China and Vietnam. PLoS One 2015; 10: e0117710. Google Scholar | Crossref | Medline 3. Ding, L, Sun, Q, Sun, Wet al.
Effects of Alkali Metals on the Formation of Particulate Matter and Adsorption of Floating Beads during Zhundong Coal Combustion
RETURN TO ARTICLES ASAPPREVArticleNEXT Yufeng Zhang Yufeng Zhang State Key Laboratory of High Temperature Gas Dynamics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China School of Engineering and Science, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Jing Zhao Jing Zhao State Key Laboratory of High Temperature Gas Dynamics, Institute of Mechanics, Chinese Academy of Sciences, Beijing 100190, People’s...
Long-term outcomes of an educational intervention to reduce antibiotic prescribing for childhood upper respiratory tract infections in rural China: Follow-up of a cluster-randomised controlled trial
Loading metrics Open Access Peer-reviewed Research Article Xiaolin Wei, Zhitong Zhang, Joseph P. Hicks, John D. Walley, Rebecca King, James N. Newell, Jia Yin, Jun Zeng, Yan Guo, Mei Lin, Ross E. G. Upshur, Qiang Sun Xiaolin Wei, Zhitong Zhang, Joseph P. Hicks, John D. Walley, Rebecca King, James N.
Ultra-low thermal conductivity of two-dimensional phononic crystals in the incoherent regime
The termination of lattice periodicity in the surface normal direction of nanostructures will reduce the atomic coordination number (CN). Because of larger surface-to-volume ratio (SVR), a nanostructure has a high portion of under-coordinated atoms in the surface skin. Interatomic interaction and the changing fraction of the under-coordinated atoms are important factors for the different phonon transport behaviors of a nanomaterial from that of its bulk counterpart.
Effect of a training and educational intervention for physicians and caregivers on antibiotic prescribing for upper respiratory tract infections in children at primary care facilities in rural China: a cluster-randomised controlled trial - The Lancet Glob
Our trial is one of the first rigorously designed trials on antimicrobial stewardship strategies in LMICs. The results show that the intervention package was highly effective, with a 29% absolute reduction in the prescribing of antibiotics for childhood upper respiratory tract infections in primary care facilities in rural China.
Implementation of a comprehensive intervention for patients at high risk of cardiovascular disease in rural China: A pragmatic cluster randomized controlled trial
A total of 28,130 participants, in 33 intervention and 34 control township hospitals, were recruited. Compared with the control arm, participants in the intervention arm had substantially improved prescribing rates of anti-hypertensives, statins and aspirin (P<0.001), and had higher medication taking rates of aspirin and statins (P0.05).
Protocol for a pragmatic cluster randomised controlled trial for reducing irrational antibiotic prescribing among children with upper respiratory infections in rural China -- Zou et al. 6 (5) -- BMJ Open
Methods and analysis This is a pragmatic, parallel-group, controlled, cluster-randomised superiority trial, with blinded evaluation of outcomes and data analysis, and un-blinded treatment. From two counties in Guangxi Province, 12 township hospitals will be randomised to the intervention arm and 13 to the control arm. In the control arm, the management of antibiotics prescriptions will continue through usual care via clinical consultations.
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