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Articles by Xiaoting Huang
FoxL2 exhibits two-stage expression and maintains the ovarian niche in a lophotrochozoan
Abstract The genetic pathways governing sex determination remain a key enigma in lophotrochozoans, a major branch of bilaterian animals, hindering a comprehensive understanding of their evolution. Here, we enable genetic analysis in the gonochoristic scallop Chlamys farreri by developing robust female-specific DNA markers for accurate molecular sex identification. Leveraging this, we perform a systematic dissection of a female sex-determination pathway in this major bilaterian clade.
Multidimensional mechanisms shape participation intention in digital cultural heritage through experience attitude
Abstract As digital technologies increasingly reshape how cultural heritage is preserved, interpreted and experienced, understanding participation intention in digital cultural heritage has become theoretically important and practically urgent.
Construction and validation of an interpretable machine learning model for predicting diabetes risk in COPD patients
Abstract To construct and validate a machine learning (ML) model for predicting diabetes risk in COPD patients, enabling early and personalized intervention. Using data from the MIMIC-IV database, 49 variables were screened by LASSO and logistic regression. Six ML algorithms were constructed and internally validated on a 70%/30% split dataset. Model performance was assessed using multiple metrics, followed by external validation. Interpretability was achieved through SHAP analysis.
Conversion cascades for sensory and oral capability in primary care and community settings
Introduction Across ageing societies, ministries of health1 and primary care networks2,3 are increasingly adopting WHO’s integrated care for older people (ICOPE)4 approach to functional checks delivered through primary care and community services. This shift has substantial conceptual value, as it moves attention from single-disease detection to preserving functional ability and gives clinical teams a shared language across medical and social care.
Cost-effectiveness analysis of encorafenib in untreated BRAF V600E -mutant metastatic colorectal cancer in China
Abstract This study assessed the cost-effectiveness of encorafenib plus cetuximab (EC) and EC combined with mFOLFOX6 versus standard of care (SOC) as first-line treatment for BRAF V600E-mutant metastatic colorectal cancer from a Chinese healthcare perspective.
Glycometabolic profiles and pregnancy outcomes across pathophysiological subtypes of gestational diabetes mellitus
Abstract Background: Gestational diabetes mellitus (GDM) exhibits profound pathophysiological heterogeneity, but current management fails to account for subtype-specific differences in clinical features and pregnancy prognoses. This study aimed to characterize the glycometabolic profiles and pregnancy outcomes of GDM subtypes defined by insulin resistance and β-cell function, and provide a foundation for precision medicine in GDM.
Latent Profiles of Oral Health Self-Management and Associated Factors Among Adolescents Undergoing Fixed Orthodontic Treatment
Back to Journals » Patient Preference and Adherence » Volume 20 Authors Huang X , Yu J, Yang Y, Yao L Received 27 April 2026 Accepted for publication 29 June 2026 Published 11 July 2026 Volume 2026:20 620367 DOI https://doi.org/10.2147/PPA.S620367 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Johnny Chen Xiaoting Huang,1,2 Jiawen Yu,2 Yuane Yang,2 Lan Yao2 1School of Nursing, Kunming Medical University, Kunming,...
Multi-omics identifies a T2DM-associated immune-regulatory network modulated by electroacupuncture
Abstract Background: Recent studies suggest a link between immune-related processes and type 2 diabetes (T2DM), yet the specific genes and mechanisms remain unclear. This study aimed to explore the mechanistic relationship by integrating multi-omics data. Methods: We identified T2DM-associated candidate genes through summary data-based Mendelian Randomization (SMR) and colocalization analyses using immune-related QTL data and large-scale GWAS data.
Toward Optimized Platinum Therapy: A Risk Prediction Model for Toxicity Based on Platinum Accumulation and Its Impact on Treatment Outcomes
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Huang X , Chen C, Zheng J, Lai Y, Yang Y, Zhang Y, Fang L Received 25 February 2026 Accepted for publication 5 June 2026 Published 10 June 2026 Volume 2026:20 600037 DOI https://doi.org/10.2147/DDDT.S600037 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Anastasios Lymperopoulos Xiaoting Huang,1,* Chen Chen,1,* Jieting...
Global daily CO2 emissions from 1970 to 2024 - Scientific Data
Abstract As extreme temperature events become increasingly frequent, there is a growing need for daily CO2 emissions data to quantify their impacts. However, such data are available only from 2019 onward.
Rapid and reagent-free screening of occult hepatitis B virus infection based on plasma Vis-NIR spectral pattern recognition
Abstract Introduction: Occult hepatitis B virus infection (OBI) is a specific form of hepatitis B virus (HBV) infection characterized by testing negative for Hepatitis B surface antigen (HBsAg) with the presence of HBV DNA in the blood. Due to the complexity and high cost of HBV DNA testing, which is rarely included in routine physical examinations, leading to underdiagnosis of OBI.
Inavolisib-based Therapy for PIK3CA-mutated Advanced Male Breast Cance
Back to Journals » Breast Cancer: Targets and Therapy » Volume 17 Authors Huang X, Lin S, Lin R, Luo S, Huang P, Zeng D Received 25 September 2025 Accepted for publication 17 December 2025 Published 26 December 2025 Volume 2025:17 Pages 1385—1396 DOI https://doi.org/10.2147/BCTT.S566088 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Pranela Rameshwar Xiaoting Huang,1,2,* Shen Lin,1,2,* Rongfang...
Monthly methane emissions in Chinese mainland provinces from 2013–2022 - Scientific Data
Abstract As the world’s largest source of methane emissions, accurately measuring and tracking China’s emissions across various sectors is essential for global climate change efforts. Methane, a potent greenhouse gas, is emitted from diverse anthropogenic and natural sources, many of which exhibit pronounced temporal variability.
Risk assessment of heavy metal toxicity induced by platinum accumulation in tumor patients
1Research Institute of Clinical Pharmacy, Shantou University Medical College, Shantou, Guangdong, China 2Department of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong, China 3Pharmacy Intravenous Admixture Service, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China 4Department of Clinical Laboratory Medicine, Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China 5Pharmacy Department, Cancer Hospital of...
Fintech, financial constraints, and corporate performance: evidence from China
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Investigating serum and placental levels of IGF-1 and IGF-1R in preecl
Junyou Su,1,* Xiaoting Huang,1,* Shengping Meng,2 Sumei Wang2 1Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, People’s Republic of China; 2Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China *These authors contributed equally to this work Correspondence: Sumei Wang, Email [email protected] Objective: To investigate the levels of...
Health co-benefits of post-COVID-19 low-carbon recovery in Chinese cities - Nature Cities
Abstract Post-pandemic green recovery is pivotal in achieving global sustainable development goals by simultaneously revitalizing economies and reducing greenhouse gas emissions, air pollution and improving public welfare. However, subnational and city-level understanding of green recovery, its efficacy and its alignment with public health is poorly understood.
An Equivalent Modeling Method for Wideband Magnetic Radiation Interference of Power-Electronic Equipment
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Antioxidants | Free Full-Text | Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Preoperative structural-functional coupling at the default mode network predicts surgical outcomes of temporal lobe epilepsy
Corresponding Author Li Feng Department of Neurology, Xiangya Hospital, Central South University, Changsha, China National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China Department of Neurology, Xiangya Hospital, Central South University (Jiangxi Branch), Nanchang, China Correspondence Zhiquan Yang, Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, China.
Sirtuin1 Mediates the Protective Effects of Echinacoside against Sepsis-Induced Acute Lung Injury via Regulating the NOX4-Nrf2 Axis
1. Introduction Sepsis was listed as a global health priority by the World Health Organization and the World Health Assembly in 2017 [1]. It has a high clinical mortality rate and affects organs throughout the body [2]. As the most susceptible organ to sepsis, the lungs suffer from acute lung injury (ALI), a common clinical emergency with clinical symptoms ranging in severity from acute dyspnea to end-stage respiratory failure or acute respiratory distress syndrome (ARDS) [3].
Frontiers | Single-cell transcriptomics reveals heterogeneity in esophageal squamous epithelial cells and constructs models for predicting patient prognosis and immunotherapy
1 Introduction Esophageal cancer(EC), a prevalent malignant neoplasm affecting populations worldwide, exhibits alarmingly high incidence and mortality rates. The year 2020 alone witnessed a staggering 604,000 newly diagnosed cases of EC, tragically resulting in 544,000 fatalities (1).
System analysis based on the lysosome-related genes identifies HPS4 as a novel therapy target for liver hepatocellular carcinoma
1 Introduction Globally, LIHC ranks sixth among the most common cancers (1, 2). There are projected to be more than one million cases of liver cancer by 2030 (3). The number of patients who die from LIHC each year exceeds half a million (4). In the early stages, LIHC has no symptoms but rapidly progresses (5). At present, LIHC is mainly treated with liver transplantation, hepatic resection, and medication (6). LIHC can be surgically excised in only 10%–20% of patients, but recurrences are common (7).
Surgical management of broad‐based sessile vocal cord polyps: Transnasal vocal fold polypectomy versus microlaryngoscopic surgery: Our experience in 159 cases
ORIGINAL ARTICLE Shuchun Lin and Qin Lin contributed equally to this study. Abstract Objectives In this study, we retrospectively reviewed and compared the treatment outcomes and complications of office transnasal vocal fold polypectomy (TVFP) with those of microplarygoscopic surgery (MLS) for different clinical and histopathological features of broad-based sessile vocal fold polyps.
Multiple exposures to sevoflurane during the neonatal period impair hippocampus development and cognitive function in young mice
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Bivalves and microbes: a mini-review of their relationship and potential implications for human health in a rapidly warming ocean
1 Introduction Marine heatwaves have been widely recognized as one of the most significant drivers of change in the marine environment in recent years (Oliver et al., 2018). These heatwaves, defined as prolonged and intense periods of elevated water temperature, have become more frequent and intense with global warming, leading to severe impacts on the marine ecosystem (Frölicher et al., 2018; He et al., 2022a; Xu et al., 2022).
Prophylaxis for Pneumocystis carinii pneumonia in non-Hodgkin’s lymphoma undergoing R-CHOP21 in China: a meta-analysis and cost-effectiveness analysis
Methods Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research. Meta-analysis Literature search Following the recommendations of the Cochrane Handbook and other published meta-analyses, databases including PubMed, Embase, Web of Science and the Cochrane Library were queried for relevant studies published from inception to December 2022.
Ecological Civilization and High-Quality Development: Do Tourism Industry and Technological Progress Affect Ecological Economy Development?
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Wei Yang 1, Qiuxia Chen 1, Yanyue Dao 1, Xiaoting Huang 1,2,* and Weifang Shao 1 1 School of Management, Shandong University, Jinan 250100, China 2 Yellow River National Strategic Research Institute, Shandong University, Jinan 250100, China * Author to whom correspondence should be addressed. Int. J. Environ. Res.
Frontiers | Developmental Expression Pattern of the Piwi1 Gene, Timing of Sex Differentiation and Maturation in Artificially Produced Juvenile Boring Giant Clam, Tridacna crocea | Marine Science
Impact Factor 4.912 | CiteScore 5.0 More on impact › TABLE OF CONTENTS Yinyin Zhou1,2,3,4, Yunqing Li1,2,3,4, Qingliang Liao1,2,3, Gongpengyang Shi1,2,3, Yanpin Qin1,3,4, Yuehuan Zhang1,3,4, Haitao Ma1,3,4, Jun Li1,3,4* and Ziniu Yu1,2,3,4* 1Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Provincial Key Laboratory of Applied Marine Biology, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese...
Frontiers | AquaGWAS: A Genome-Wide Association Study Pipeline for Aquatic Animals and Its Application to Reference-Required and Reference-Free Genome-Wide Association Study for Abalone | Marine Science
Introduction Genome-wide association study (GWAS) effectively identifies genotypic variants associated with particular phenotypic traits. Lots of related tools have been developed to improve the efficiency of GWAS analysis. However, many tools were designed using a specific model or for a certain processing step, which led to fussy file format conversions between various interfaces and frequent switches among different running environments (C/C++, Python, R, etc.).
Designing Lanthanide Coordination Nanoframeworks as X-ray Responsive Radiosensitizers for Efficient Cancer Therapy
Designing Lanthanide Coordination Nanoframeworks as X-ray Responsive Radiosensitizers for Efficient Cancer Therapy You have access to this article Please wait while we load your content... Something went wrong. Try again?
Activity Coefficients of RbF in the RbF + RbBr + H2O and RbF + RbNO3 + H2O Ternary Systems Using the Potentiometric Method at 298.2 K
Thermodynamic properties of the RbF + RbBr + H O and RbF + RbNO + H O systems were determined by the potentiometric method at the total ionic strengths ranging from 0.0017 to 0.7005 mol·kg–1 for different ionic strength fractions y of RbBr/RbNO with y = 0.00, 0.30, 0.60, and 0.90, at 298.2 K. Combining the Nernst equation and Pitzer equation, the mean ionic activity coefficients of RbF and RbBr/RbNO , the osmotic coefficients, and the excess Gibbs energies of the studied systems were calculated.
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