Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Yanni Ma
Microglial NUS1 deficiency drives dopaminergic neurodegeneration through intercellular iron dysregulation in Parkinson’s disease models
Abstract The selective loss of dopaminergic neurons in the substantia nigra pars compacta is a defining feature of Parkinson’s disease (PD), yet its underlying mechanisms remain unclear. NUS1, which encodes neurite outgrowth inhibitor-B receptor (NgBR), was recently identified as a PD risk gene. Here we show that NgBR is highly expressed in microglia, where its deficiency drives progressive PD-like motor deficits and dopaminergic neurodegeneration via the LCN2–SLC22A17 iron-transport axis in mice.
Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation
|
Abstract Mutations in splicing factors are recurrent across human cancers and drive widespread RNA splicing dysregulation. Among these, SF3B1 is the most frequently mutated, yet its hotspot mutations exhibit lineage specificity, with SF3B1R625 mutations predominantly found in melanoma and SF3B1K700E in hematologic malignancies. However, the mechanistic basis for this cancer-type specificity remains unclear.
By Dennis Wylie, Masahiro Yoshida, Wouter J. Holman, Ruixin Jiang, Peiqi Xing, Jindou Xie, Gang Bai, Yuzhu Zhang, Pengcong Hou, Hao Luo, Yanni Ma, Ruixin Liu, Yang Zheng, Xiangyu Chen, Bin Jiang, Jing Huang, Yanjie Zhang, A. Hunter Shain, Ming Lei, Robert L. Judson-Torres, Jing Ye, Zhaoqi Liu, Hanlin Zeng
|
Science Magazine
Verified
Publisher Correction: Peptide-centric local stability assay (PELSA) for sensitive identification of ligand-targeting proteins and binding sites at proteome scale
Correction to: Nature Protocols https://doi.org/10.1038/s41596-026-01354-w, published online 22 April 2026. In the version of this article initially published, there was an error in Fig. 3a, in the untreated control / native trypsinization diagram, where ligand molecules appeared incorrectly; the figure is now amended in the HTML and PDF versions of the article. About this article Wang, K., Li, K., Yan, J. et al.
Peptide-centric local stability assay (PELSA) for sensitive identification of ligand-targeting proteins and binding sites at proteome scale
Abstract The peptide-centric local stability assay (PELSA) was developed to identify the protein targets and binding regions of diverse ligands at a proteome-wide scale. In this approach, the ligand is added to a cell lysate, and the proteins are digested for a short, defined time period using 0.5 mg ml−1 trypsin. Protein regions involved in ligand binding show less digestion, making it possible to identify binding sites and even quantify binding activity by dose-dependent analysis.
Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles
Flow cytometry The cells were collected at the indicated time points, washed twice with ice-cold PBS containing 0.5% BSA to block Fc receptors. The transduced CD34+ HSPCs were assessed for CD235a expression after staining with PE-conjugated anti-CD235a and APC-conjugated anti-CD71 antibodies (BD Biosciences PharMingen). Flow cytometry was performed using Accuri™ C6 Plus Flow Cytometer (BD Biosciences) and Attune® NxT Flow Cytometer (Thermo Fisher Scientific).
SRSF10 promotes cisplatin resistance in bladder cancer via BIN1 Exon 12 retention and ANXA1 activation
Abstract RNA alternative splicing is a fundamental post-transcriptional mechanism that plays a key role in generating protein diversity. Previous studies from our group have shown that overexpression SRSF10 could promote liver cancer cell proliferation and invasion. However, its involvement in bladder cancer remains poorly understood. In the present study, we investigated SRSF10 expression using data from TCGA and GEO databases, immunohistochemistry, and proteomics.
Tissue-specific inflammation induces cell state plasticity with oncogenic addiction in mucosal melanoma
Abstract Mucosal melanoma (MM), an aggressive melanoma subtype arising in mucosal tissues, displays resistance to therapies effective in cutaneous melanoma.
Decoding Arginine Dimethylation Isomers via pH-Tuned Reactivity with Methylglyoxal: A Chemical Approach for Functional Proteomics
Abstract Click to copy section linkSection link copied! Arginine dimethylation, encompassing asymmetric and symmetric configurations, represents a fundamental post-translational modification. Despite sharing identical chemical formulas, the two arginine dimethylation isomers exhibit different or even opposite biological effects. Therefore, it is necessary to determine their specific structure before conducting a further biological investigation.
Combined MEK and PARP inhibition enhances radiation response in rectal cancer
|
Keywords rectal cancer radiation therapy organoids drug combination screen RAS signaling DNA repair radiosensitizer MEK inhibitor PARP inhibitor RAD51 Introduction Colorectal cancer (CRC) stands as a leading cause of cancer-related mortality.1 Over one-third of CRC originates in the rectum, often presenting at a locally advanced stage, which is defined as Union for International Cancer Control (UICC) classification T3/T4 (invasion beyond muscular layers) and/or node-positive disease.
By Qiyun Xiao, Julian E. Riedesser, Theresa Mulholland, Zhenchong Li, Philipp Albrecht, Anna Klupsch, Li Wang, Sebastian Belle, Nadine Schulte, Daniel Schmitz, Matthias F. Froelich, Kyrhatii Trikhirhisthit, Erica Valentini, Kim E. Boonekamp, Elke Burgermeister, Christoph Brochhausen, Jeroen Krijgsveld, Ina Kurth, Yuxing Zhu, Yanni Ma, Ke Cao, Michael Boutros, Matthias Ebert, Tianzuo Zhan, Johannes Betge, Jonas Buchloh, Xinchen Yang, Nachiyappan Venkatachalam, Olga Skabkina, Ella Eichhorn, Yvonne Petersen, Thilo Miersch, Carsten Herskind, Marlon R. Veldwijk, Robert Ihnatko
|
Cell Reports Medicine
Verified
Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia
|
Main text (Developmental Cell 56, 478–493.e1–e11; February 22, 2021) In the originally published version of this paper, due to the similar electrophoretic patterns between the TAL1 and HBBP1 PCR products, the gel image of TAL1 PCR product in Figure 5A was erroneously replaced with that of HBBP1 PCR product from Figure 4F, resulting in duplicated images in Figures 5A and 4F. The authors sincerely apologize for the error, and the corrected version of the image can be found below.
By Yanni Ma, Siqi Liu, Jie Gao, Chunyan Chen, Xin Zhang, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Yi Shao, Qian Liu, Jiayue Xu, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Haipeng Li, Graham L. Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi, Yong Zhang, Jia Yu, Fanqi Zhou, Yanmin Si, Hualu Zhao
|
Cell Press
Verified
Analysis, isolation and anti-tumour activity of the alkaloids from Ceratocarpus arenarius L
Advanced search Natural Product Research Formerly Natural Product Letters Latest Articles Submit an article Journal homepage Full Article Figures & data References Supplemental Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/14786419.2025.2509149?needAccess=true Abstract Ceratocarpus arenarius L.
Exploring the Impact of Coconut Peat and Vermiculite on the Rhizosphere Microbiome of Pre-Basic Seed Potatoes under Soilless Cultivation Conditions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
High Breakthrough Pressure in Hydrogels Enabled Ultrastable Treatment of Hypersaline Wastewaters
Download Hi-Res ImageDownload to MS-PowerPointCite This:Nano Lett. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Molecules | Free Full-Text | Quality Evaluation of Peony Petals Based on the Chromatographic Fingerprints and Simultaneous Determination of Sixteen Bioactive Constituents Using UPLC-DAD-MS/MS
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Hydrogel‐assisted electrokinetics for high‐resolution and non‐invasive flow monitoring in microfluidic chips
Supporting Information Filename Description cjoc202300582-sup-0001-supinfo.docxWord 2007 document , 366.3 KB Supporting Information
Next‐generation of melanoma researchers: Trainee perspectives from around the world
The Society for Melanoma Research (SMR) was created 20 years ago and has unequivocally contributed to the vast progress of the field, particularly for the treatment of melanoma patients with metastatic disease by facilitating synergistic collaborations between clinicians, researchers at the bench, and industry.
Aerobic Benzylic C(sp3)-H Bond Oxygenations Catalyzed by NBS under Visible Light Irradiation
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Org. Chem.
Aerobic Benzylic C(sp3)-H Bond Oxygenations Catalyzed by NBS under Visible Light Irradiation
Friday, December 22, 2023 Please be aware that pubs.acs.org is undergoing maintenance that may have an impact on your experience. During this time, you may not be able to access certain features like purchasing single articles, saving searches, modifying your e-Alert preferences, or accessing Librarian administrative functions. We appreciate your patience as we continue to improve the ACS Publications platform.
The Introduction of Detergents in Thermal Proteome Profiling Requires Lowering the Applied Temperatures for Efficient Target Protein Identification
Abstract : Although the use of detergents in thermal proteome profiling (TPP) has become a common practice to identify membrane protein targets in complex biological samples, surprisingly, there is no proteome-wide investigation into the impacts of detergent introduction on the target identification performance of TPP.
Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia
Highlights • Pseudogenic HBBP1 confers human-specific essentiality in erythropoiesis • HBBP1 competitively binds the RNA-binding protein HNRNPA1 to stabilize TAL1 mRNA • HBBP1/TAL1 interaction contributes to milder symptoms of β-thalassemia patients • Compared with retropseudogene, duplicated pseudogene often binds RBP but not miRNA Summary The human genome harbors 14,000 duplicated or retroposed pseudogenes.
More Evidence of Psychological Reactance to Consensus Messaging: A Response to van der Linden, Maibach, and Leiserowitz (2019)
In a recent article, van der Linden, Maibach, and Leiserowitz ([2019]. Exposure to Scientific Consensus Does Not Cause Psychological Reactance. Environmental Communication, 1–8) claim that exposure to a consensus message on climate change does not cause psychological reactance. In doing so, they provide a critique and “replication” of our recently published study which found evidence to the contrary (Ma, Dixon, & Hmielowski, 2019.
Early β-hCG Trajectories After Single-Dose Methotrexate Treatment and Their Predictive Value for Treatment Failure in Tubal Ectopic Pregnancy: A Retrospective Cohort Study
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The de-identified data that support the findings of this study are available from the corresponding author upon reasonable request and subject to institutional and ethical approval. The data are not publicly available because of patient privacy and ethical restrictions.
Improving Climate Change Acceptance Among U.S. Conservatives Through Value-Based Message Targeting
Although prior research has identified communication strategies for reducing climate change skepticism, recent research suggests such approaches can backfire. To explore this issue, we report on a preliminary study investigating two prominent messaging styles: consensus and targeted messages. While consensus messaging did not produce significant effects, targeted messages emphasizing free market solutions to climate change were effective at improving conservatives’ climate change acceptance.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Yanni
Contact Yanni, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack