Yao Lu on Muck Rack

Yao Lu

Verified
China
As seen in: Cell Reports Medicine, Cell Press
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Articles

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain

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By Li Zhang, Minhui Yu, Guoqing Chen, Siyuan Ge, Mengdi Wang, Xianying Zhang, Miao Zhao, Huating Gu, Meizhu Huang, Aixue Liu, Gengxin Ran, Zeyuan Liu, Tiepeng Liao, Qi Chen, Chenjian Miao, Yao Lu Verified, Yibing Wang, Fengchao Wang, Zhihui Liu, Hongying Zhu, Qian Wu, Zhuan Zhou, Wei Xiong, Xiaoqun Wang, Peng Cao
| Cell Press Verified
To determine whether α-Syn-6H-EGFP could be used to explore the pathological effects of α-Syn inclusions on transcription, we performed scRNA-seq on SNc dopaminergic neurons. Single neurons were collected using the patch-seq approach74 (Figure 5A). Neurons with α-Syn-6H-EGFP inclusions were identified by their filamentous structures and enhanced fluorescence (Figure S5A).
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