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Yinghe Zhai on Muck Rack

Yinghe Zhai

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Articles

Bclaf1 drives heart failure by recruiting Srsf2 to enhance Hand2 pre-mRNA splicing and pathological hypertrophy

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By Yang Zhang, Haiyu Gao, Ying Lu, Yingzi Zhang, Xiaofang Zhang, Yinfeng Zhao, Liying Yu, Shuang Wang, Lexin Zhao, Guohui Yang, Jialiang Li, Jiaxin Yu, Chenhong Li, Changzhu Li, Yifan Wang Verified, Ying Yang, YUE LI, Luyang Yu, Deli Zhao, Lida Yang, Lei Jiao, Baofeng Yang, Yanjie Lu, Zhenwei Pan, Yinghe Zhai
| Nature Verified
Abstract Heart failure with reduced ejection fraction (HFrEF) remains a major therapeutic challenge. B-cell lymphoma 2-associated transcription factor 1 (Bclaf1) is implicated in RNA splicing and cardiac disease, but its role in HFrEF pathogenesis is unknown. Here, we demonstrate that Bclaf1 expression is elevated in human HFrEF myocardium and in male murine pressure-overload models.
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