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Yingzi Zhang

As seen in: Color Research & Application, Nature, Wiley Online Library, MDPI, Taylor & Francis Online, Royal Society of Chemistry, Cell Stem Cell, RAND Corporation, Dove Medical Press, Oxford Nanopore Technologies and
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Articles

Spatial distribution patterns and influencing factors of rural settlements in Lhasa, Tibet

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By Yibing Xie, Xuan Lei, Yumeng Song, Luyang Zhong, Yingzi Zhang
| Nature Verified
Abstract As a central hub on the Qinghai–Tibet Plateau, Lhasa exhibits unique rural settlement patterns shaped by harsh high-altitude environments, economic disparities, and profound socio-cultural influences. To elucidate the underlying formation mechanisms, this study constructs a “Nature-Economy-Culture” tripartite framework. Using data from 226 villages, we established an integrated workflow encompassing pattern identification, driver detection, and mechanism modeling.
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Bclaf1 drives heart failure by recruiting Srsf2 to enhance Hand2 pre-mRNA splicing and pathological hypertrophy

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By Yang Zhang, Haiyu Gao, Ying Lu, Yingzi Zhang, Xiaofang Zhang, Yinfeng Zhao, Liying Yu, Shuang Wang, Lexin Zhao, Guohui Yang, Jialiang Li, Jiaxin Yu, Chenhong Li, Changzhu Li, Yifan Wang Verified, Ying Yang, YUE LI, Luyang Yu, Deli Zhao, Lida Yang, Lei Jiao, Baofeng Yang, Yanjie Lu, Zhenwei Pan, Yinghe Zhai
| Nature Verified
Abstract Heart failure with reduced ejection fraction (HFrEF) remains a major therapeutic challenge. B-cell lymphoma 2-associated transcription factor 1 (Bclaf1) is implicated in RNA splicing and cardiac disease, but its role in HFrEF pathogenesis is unknown. Here, we demonstrate that Bclaf1 expression is elevated in human HFrEF myocardium and in male murine pressure-overload models.
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ZNF512B safeguards genome integrity at regulatory regions to repress the SASP and inflammation

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By Sanjeeb Kumar Sahu, Sebastian Memczak, Sudhir Thakurela, Jinlong Y. Lu, Priya Gupta, Yingzi Zhang, Tomoaki Hishida, Masakazu Kurita, Chao Wang, Yanjiao Shao, April Williams, Vijay K Tiwari, Concepcion Rodriguez Esteban, Pradeep Reddy, Alexander Meissner, Mo Li, Naresh Mutukula, Alex Hirano, Max Shokhirev
| Cell Stem Cell Verified
Keywords genome integrity DNA repair senescence senescence-associated secretory phenotype SASP inflammation CRISPR-Cas9 screening ZNF512B chromatin remodeling amyotrophic lateral sclerosis neuromuscular organoids Get full text access Log in, subscribe or purchase for full access. References 1. Di Micco, R. ∙ Krizhanovsky, V. ∙ Baker, D. ... Cellular senescence in ageing: from mechanisms to therapeutic opportunities Nat. Rev. Mol. Cell Biol. 2021; 22:75-95 2. Eggert, T. ∙ Wolter, K. ∙ Ji, J. ...
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