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Articles by Yingying Su
Lateral septum GABAergic neurons mediate the effects of dexmedetomidine on allodynia and sleep in a male mouse model of neuropathic pain
Abstract Chronic pain and sleep disorders frequently co-occur and exacerbate each other, yet the neural mechanisms underlying this comorbidity remain poorly understood. Here, we found that hyperactivity of GABAergic neurons in the dorsal division of the lateral septum (LSGABA) drives both pain-like behavior and sleep disruption induced by spared nerve injury (SNI) in male mice.
Adipocyte-specific ablation of Gadd45b exacerbates obesity-associated cellular senescence and metabolic disorders via Fgf1b promoter hypermethylation
Abstract Cellular senescence contributes to obesity-associated adipose dysfunction, yet the upstream regulators of this process remain poorly understood. Here, we identified growth arrest and DNA damage-inducible protein 45 beta (Gadd45b) as an adaptive regulator of adipocyte senescence and systemic metabolic homeostasis. GADD45B expression was elevated in adipose tissue from obese human subjects and positively correlated with senescence-related markers.
Apple ZAT11, a C2H2-type zinc finger protein, enhances resistance to Penicillium expansum by affecting jasmonic acid biosynthesis in apple
Data availability The data supporting this study are available in Supporting Information Tables . All relevant data can be found within the manuscript and its supporting materials.
Comprehensive artificial intelligence-assisted mental health program for university students in China (CAMPUS): study protocol for a multi-center prospective cohort with planned embedded randomized intervention trials
Abstract University students face a rising prevalence of depression, anxiety, insomnia, and suicidal ideation that exceeds the capacity of conventional, resource-constrained campus support services. Although artificial intelligence (AI)-assisted screening tools have emerged, many have evaluated selected modalities or isolated prediction tasks, and their integration with prospectively evaluated intervention pathways remains limited.
Understanding depression through an intersectional framework: the joint impact of childhood adversities and social determinants using Canadian longitudinal study on aging (CLSA) data
Abstract While previous research has focused on individual risk factors, few studies have utilized an intersectionality-informed framework to examine how multiple social factors collectively impact depression risk, particularly in the context of childhood adversities.
Design of a Solvation-Based Chemiluminescence Sensing Platform for Water in Organic Solvents Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Chemiluminescence (CL) sensing has emerged as a promising paradigm due to its advantages of high sensitivity, simple operation, low cost, and low background. However, the availability of effective chemiluminophores remains limited, which substantially impedes their practical applications.
Identificación de factores asociados a la cronicidad de la depresión
Me Gusta 1 1 Comentar 2 2 Autor/autores: Gabriella Spiegler , Yingying Su , Muzi Li ...(et.al) Fecha de publicación: 18/09/2025 Artículo | Artículo revisado por nuestra redacción Objetivo La identificación de factores de riesgo para la cronicidad de la depresión es esencial para reducir la carga de la enfermedad, ya que puede orientar tanto la prevención como las estrategias de tratamiento.
Intensive lipid-lowering therapy-related regression of a vulnerable plaque confirmed by serial optical coherence tomography: a case report
Abstract Introduction: Acute coronary syndrome (ACS) remains a leading cause of mortality and disability worldwide. Vulnerable plaques constitute a key pathological substrate underlying ACS. Although lipid-lowering therapy (LLT) is central to plaque stabilization and secondary prevention in ACS, a substantial proportion of patients fail to achieve recommended lipid targets, underscoring a persistent gap between guideline recommendations and real-world outcomes.
Potential for nano-enhanced molten salts in solar energy storage
The depletion of fossil fuels in the near future has necessitated the search for alternative sources of energy generation. The escalating worldwide energy trouble and environmental issues have led to a growing interest in the exploitation of energy extracted via renewable sources and the recuperation of waste heat energy from industry in the past few years. Solar thermal energy is widely recognized as an economically viable alternative within many different renewable energy resources.
Simultaneous Detection of Eight Dairy-Derived Components Using Double-Tube Multiplex qPCR Based TaqMan Probe
1. Introduction The issue of identifying the animal species origin of milk and dairy products has garnered growing interest, particularly in relation to traceability, allergic reactions, and the provision of precise consumer information. Milk is an excellent and highly nutritious dietary component that is abundant in protein, essential fatty acids, vitamins, calcium, and potassium, among other minerals [1].
Characterization of a ferroptosis-related gene signature predicting survival and immunotherapeutic response in lung adenocarcinoma
Research Paper Volume 16, Issue 18 pp 12608—12622 1 Department of Pediatric Surgery, The First Hospital of Jilin University, Changchun, China 2 Department of Anatomy, College of Basic Medical Sciences, Jilin University, Jilin, China 3 Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China 4 Department of Neonatology, The First Hospital of Jilin University, Changchun, China 5 Department of Microbiology and Immunology, Changchun University of...
Characterization of a ferroptosis-related gene signature predicting survival and immunotherapeutic response in lung adenocarcinoma
Research Paper Volume 16, Issue 18 pp 12608—12622 1 Department of Pediatric Surgery, The First Hospital of Jilin University, Changchun, China 2 Department of Anatomy, College of Basic Medical Sciences, Jilin University, Jilin, China 3 Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, China 4 Department of Neonatology, The First Hospital of Jilin University, Changchun, China 5 Department of Microbiology and Immunology, Changchun University of...
The longitudinal patterns of depression subtypes and stressors in depression severity in the Canadian longitudinal study on aging (CLSA)
Depression in late life is a growing public health challenge as the population aged 65 and older rapidly increases domestically and worldwide.1 Compared to younger patients, older adults with depression more commonly have a poorer disease course, a high disease burden,2, 3 reduced life satisfaction,4 higher healthcare service use, and poor functional status.5, 6 However, research on late-life depression has been hindered by the heterogeneity of depression.7, 8 The diagnosis of depression...
The association of diabetes with progression of sleep‐disordered breathing based on a prospective cohort
Aim Prospective studies suggest that sleep-disordered breathing enhances the risk of diabetes. However, it remains unclear whether diabetes could worsen sleep-disordered breathing. Methods The participants from Sleep Heart Health Study underwent two polysomnograms at a 5-year interval.
Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance
Introduction The 21st century is facing unprecedented challenges in the agricultural sector. World population growth and recent climate change are of particular concern. With over 8 billion inhabitants, a critical phase has been reached, with populations increasingly faced with the problem of access to natural resources such as food crops (Vollset et al., 2020).
Long-term efficacy of a recombinant hepatitis E vaccine in adults: 10-year results from a randomised, double-blind, placebo-controlled, phase 3 trial
Footnotes † Joint senior authors who contributed equally Affiliations State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health and National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Innovation Platform for Industry-Education Integration in Vaccine Research, NMPA Key Laboratory for Research and Evaluation of Infectious...
Adipocyte-specific Hnrnpa1 knockout aggravates obesity-induced metabolic dysfunction via upregulating of CCL2
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) is involved in lipid and glucose metabolism via mRNA processing. However, whether and how HNRNPA1 alters adipocyte function in obesity remain obscure. Here, we found that obese state downregulated HNRNPA1 expression in white adipose tissue (WAT).
Near-Infrared Catalytic Chemiluminescence System based on Zinc Gallate Nanoprobe for Hydrazine Sensing
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
The Opening of High-Speed Rail and Economic Growth: The Moderating Role of Government Efficiency and Innovation Environment
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Multisignals Sensing Platform for Highly Sensitive, Accurate, and Rapid Detection of p-Aminophenol Based on Adsorption and Oxidation Effects Induced by Defective NH2-Ag-nMOFs
Labile toxic pollutants detection remains a challenge due to the problem that a single method is prone to producing false-negative/-positive signals. The construction of a multisignal sensing platform with the advantages of different strategies is an effective way to solve this problem.
Multisignals Sensing Platform for Highly Sensitive, Accurate, and Rapid Detection of p-Aminophenol Based on Adsorption and Oxidation Effects Induced by Defective NH2-Ag-nMOFs
Labile toxic pollutants detection remains a challenge due to the problem that a single method is prone to producing false-negative/-positive signals. The construction of a multisignal sensing platform with the advantages of different strategies is an effective way to solve this problem.
Revealing the thermal damage mechanism of an Al‐Zr‐Er alloy wire by quantitative calculation: the contribution of dislocations and nano‐precipitates
The thermal damage mechanism of Al wires for long-distance overhead transmission under extreme service condition is an important scientific issue that restricts the design and development of high-performance Al wires. In this study, the thermal damage mechanism of the Al-Zr-Er alloy wires with a good combination of ultimate tensile strength in 170.0 MPa and electrical conductivity in 61.42 %IACS was investigated by a simulated high-temperature service experiment.
Controllable Synthesis of Defective UiO-66 for Efficient Degradation and Detection of Ozone
Metal–organic framework (MOF) structures have gained significant attention for their exceptional catalytic performance in ozone degradation, even under high humidity conditions, which is attributed to the presence of unsaturated metal sites (MOF defects). However, the correlation between MOF defects and catalytic ozone remains ambiguous, and a general approach for the controllable synthesis of high-performance MOF structures is currently lacking.
Neonatal Meningitis-Causing Escherichia coli Induces Microglia Activation which Acts as a Double-Edged Sword in Bacterial Meningitis
Abstract : Bacterial meningitis is a devastating disease occurring worldwide, with up to half of survivors left with permanent neurological sequelae. Neonatal meningitis-causing Escherichia coli (NMEC) is the most common Gram-negative bacillary organism that causes meningitis, particularly during the neonatal period. Here, RNA-seq transcriptional profiles of microglia in response to NMEC infection show that microglia are activated to produce inflammatory factors.
Effect of Vacuum Heat Treatment on Larch Earlywood and Latewood Cell Wall Properties
Abstract : The aim of this study was to evaluate the hygroscopicity and nanomechanics of earlywood (EW) and latewood (LW) larch after thermal modification under vacuum conditions. Wood samples were heat-treated in a vacuum atmosphere at 180–220 °C for 6 h, then their cell wall properties were observed using dynamic water vapor sorption (DVS), imaging Fourier-transform infrared (FTIR) microscopy, and nanoindentation.
Dielectric Barrier Discharge Plasma Coupled with Catalysis for Organic Wastewater Treatment: A Review
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Enhancing Cell Membrane Phase Separation for Inhibiting Cancer Metastasis with a Stimuli-responsive DNA Nanodevice
Enhancing Cell Membrane Phase Separation for Inhibiting Cancer Metastasis with a Stimuli-responsive DNA Nanodevice Di Li, Yingying Su, Xiaoqing Chen, Hui Wang, Lele Sun and YIng Xu Abstract Phase separation at cell membranes promotes the assembly of transmembrane receptors to initiate signal transduction in response to environmental cues. Many cellular behaviors are manipulated by promoting membrane phase separation through binding to multivalent extracellular ligands.
Effect of introducing human papillomavirus genotyping into real-world screening on cervical cancer screening in China: a retrospective population-based cohort study - Binhua Dong, Huachun Zou, Xiaodan Mao, Yingying Su, Hangjing Gao, Fang Xie, Yuchun Lv, Y
Introduction Cervical cancer is the third most common cancer among women in the world,1 and 85% of cases occur in low- and middle-income countries (LMICs).2 The number of cervical cancer cases was largest in China, with 98,900 new cases and 30,500 deaths each year3 due to inadequate screening, low coverage of human papillomavirus (HPV) vaccine and increased HPV infection rates.4 A recent study found that the age-standardized incidence rate and the age-standardized mortality rate of...
A novel method to synthesize luminescent silicon carbide nanoparticles based on dielectric barrier discharge plasma
A novel method to synthesize luminescent silicon carbide nanoparticles based on dielectric barrier discharge plasma† Wenxi Yang,a Mingxia Sun, b Hongjie Song, a Yingying Sub and Yi Lv *ab Author affiliations * Corresponding authors a Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China E-mail: lvy@scu.edu.cn b Analytical & Testing Center, Sichuan University, Chengdu, Sichuan 610064, China Abstract...
Research Review: Developmental origins of depression - a systematic review and meta‐analysis
Abstract Background Many observational studies have found a direct association between adverse in utero, perinatal and postnatal exposures and offspring’s depression. These findings are consistent with the ‘developmental origins of disease hypothesis’. But no review has comprehensively summarized the roles of these exposures.
Efficient generation of sulfate radicals in Fe (II)/S (IV) system induced by WS2 nanosheets and examined by its intrinsic chemiluminescence
Efficient generation of sulfate radicals in Fe (II)/S (IV) system induced by WS2 nanosheets and examined by its intrinsic chemiluminescence You have access to this article Please wait while we load your content... Something went wrong. Try again?
Serology characteristics of SARS-CoV-2 infection since the exposure and post symptoms onset
Abstract Background Timely diagnosis of SARS-CoV-2 infection is the prerequisite for treatment and preventive quarantine. The serology characteristics and complement diagnosis value of antibody test to RNA test needs to be demonstrated. Method A patient cohort study was conducted at the first affiliated hospital of Zhejiang University, China. Serial sera of COVID-19 patients were collected and total antibody (Ab), IgM and IgG antibody against SARS-CoV-2 were detected.
Synergistic chemiluminescence nanoprobe: Au clusters-Cu2+-induced chemiexcitation of cyclic peroxides and resonance energy transfer
Synergistic chemiluminescence nanoprobe: Au clusters-Cu2+-induced chemiexcitation of cyclic peroxides and resonance energy transfer An interesting chemiluminescence (CL) phenomenon of cyclic peroxides originated from Tetrahydrofuran hydrogen peroxide (THF-HPO) in the presence of BSA-stabilized Au NCs (Au@BSA NCs) was found for the first time.
DNA nanotweezers for stabilizing and dynamically lighting up a lipid raft on living cell membranes and the activation of T cells
DNA nanotweezers for stabilizing and dynamically lighting up a lipid raft on living cell membranes and the activation of T cells† Lele Sun,‡ab Yingying Su,‡a Jun-Gang Wang,a Fei Xia, a Ying Xuc and Di Li *a Author affiliations * Corresponding authors a School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China E-mail: dli@chem.ecnu.edu.cn b Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and...
Engineer the Energy Gap of Black Phosphorene Quantum Dots by Surface Modification for Efficient Chemiluminescence
Engineer the Energy Gap of Black Phosphorene Quantum Dots by Surface Modification for Efficient Chemiluminescence In this work, NH2-functionalized BPQDs (N-BPQDs) were purposely synthesized by using an ultrasound exfoliation technique combined with solvothermal treatment.
Chemiluminescence of black phosphorus quantum dots induced by hypochlorite and peroxide
H. Liu, M. Sun, Y. Su, D. Deng, J. Hu and Y. Lv, Chem. Commun., 2018, Accepted Manuscript , DOI: 10.1039/C8CC04513E If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
Short-term efficacy and tolerability of venlafaxine extended release in adults with generalized anxiety disorder without depression: A meta-analysis
Although efficacy of venlafaxine extended release (XR) for generalized anxiety disorder (GAD) has been reported in previous analyses in 2002 and 2004, the sample size was rather small and estimate of safety or tolerability was not clear. The present analysis had the advantage of large sample size and provided evidence for tolerability. Literature databases were searched, including Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of science and clinical trials.
Cataluminescence gas sensor based on mesoporous Mg-doped SnO2 structures for detection of gaseous acetone
In this work, the fabrication of mesoporous magnesium doped tin oxide (Mg-doped SnO2) materials with various doping levels have been achieved through a facile one pot and low cost hydrothermal method without the use of surfactant. The structure, morphology, chemical states and specific surface area were analyzed in detail.
Persistent Luminescence Microspheres-based Probe for Convenient Imaging Analysis of Dopamine
The probe based on persistent luminescence nanoparticles (PLNPs) is one of promising methodologies for direct imaging analysis of bio-molecules. In the present work, SrMgSi2O6:Eu0.01,Dy0.02 persistent luminescence microspheres have been synthesized via a simple template method and sunlight could successfully excite its luminescence. Further, a new probe was established based on turn-off of the persistent luminescence emission for detecting and optical imaging of dopamine (DA).
Improved Neurological Outcome With Mild Hypothermia in Surviving Patients With Massive Cerebral Hemispheric Infarction
Background and Purpose—We conducted this randomized controlled trial to investigate the effects of therapeutic hypothermia on mortality and neurological outcome in patients with massive cerebral hemispheric infarction. Methods—Patients within 48 hours of symptom onset were randomized to either a hypothermia group or a control group. Patients in the hypothermia group were given standard medical treatment plus endovascular hypothermia with a target temperature of 33 or 34°C.
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