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Articles by Zhen Jin
Highly potent, brain-penetrant EP 2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice
COX-2 cyclooxygenase-2 FJB Fluoro-Jade B GFAP glial fibrillary acidic protein Iba1 ionised calcium-binding adaptor molecule 1 LVO large-vessel occlusion MAP 2 microtubule-associated protein 2 OGD oxygen–glucose deprivation PGE2 prostaglandin E2 pMCAO permanent middle cerebral artery occlusion PSD95 postsynaptic density protein 95 TTC 2,3,5-triphenyltetrazolium chloride What is already known? PGE2 signalling via the EP2 receptor is a mediator of neuroinflammation and secondary brain injury.
Integrated air-coupled ultrasonic transducer with front-end preamplification for structural health monitoring
Abstract Air-coupled ultrasonic testing provides non-contact structural evaluation for scenarios in which liquid or gel couplants are impractical. However, its field deployment is limited by severe acoustic impedance mismatch, microvolt-scale received signals, electromagnetic interference, and cable-induced signal degradation.
Head Loss Prediction Model for a Pontoon Mesh Rotary Filter Based on Dimensional Analysis
Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement All data, models, and code generated or used during the study appear in the published article.
Precision prediction of venetoclax-azacitidine treatment efficacy in acute myeloid leukemia via integrative drug screening and machine learning
ArticleOnline now102461Open access 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 2Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China 3Department of Geriatrics...
Lmo3-expressing peri-isthmus progenitor cells sustain renewal and repair of the mammalian intestinal telocyte niche
Keywords intestinal telocyte telocyte progenitor cell villus formation LMO3 FOXL1 mesenchymal cell niche irradiation damage BMP stem cell self-renewal cell differentiation Get full text access Log in, subscribe or purchase for full access. References 1. Barker, N. ∙ van Es, J.H. ∙ Kuipers, J. ... Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature. 2007; 449:1003-1007 2. Sato, T. ∙ van Es, J.H. ∙ Snippert, H.J. ...
Finite Gröbner-Shirshov bases and faithful representations for Catalan monoids
Advanced search Communications in Algebra Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/00927872.2025.2522155?needAccess=true Abstract It is shown that every Catalan algebra of finite rank admits a finite Gröbner-Shirshov basis, which is proved by constructing a finite complete rewriting system for the corresponding Catalan monoid.
Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor
Abstract Bacteria, the smallest and most abundant life forms on Earth, have been a source of insights that have had a considerable impact on human health. Helicobacter pylori has captured substantial attention due to its role in provoking an array of gastrointestinal ailments and other human diseases. Here, we report that H.
Propagation Dynamic for a Physiological Age-Structured SIR Epidemic Model with Diffusion
Ayuda Buscar en la ayuda Buscar en la ayuda Propagation Dynamic for a Physiological Age-Structured SIR Epidemic Model with Diffusion Xiaoxia Li [1] ; Yang Wang [1] ; Juping Zhang [1] ; Zhen Jin [1] [1] Shanxi University Localización: Qualitative theory of dynamical systems, ISSN 1575-5460, Vol. 24, Nº 1, 2025 Idioma: inglés Enlaces Texto completo Resumen Age structure is one of the key characteristics of modeling population dynamics and infectious diseases.
Multi-region infectious disease prediction modeling based on spatio-temporal graph neural network and the dynamic model
Loading metrics Open Access Peer-reviewed Research Article Citation: Wang X, Jin Z (2025) Multi-region infectious disease prediction modeling based on spatio-temporal graph neural network and the dynamic model. PLoS Comput Biol 21(1): e1012738. https://doi.org/10.1371/journal.pcbi.1012738 Editor: Jessica M. Conway, Pennsylvania State University, UNITED STATES OF AMERICA Received: July 10, 2024; Accepted: December 18, 2024; Published: January 9, 2025 Copyright: © 2025 Wang, Jin.
Clearing Amyloid-Beta by Astrocytes: The Role of Rho GTPases Signaling Pathways as Potential Therapeutic Targets
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dynamic analysis and optimal control of HIV/AIDS model considering the first 95% target
Wenhui Hao Complex Systems Research Center, Shanxi University, Taiyuan, China Key Laboratory of Complex Systems and Data Science of Ministry of Education, Shanxi University, Taiyuan, China Shanxi Key Laboratory for Mathematical Technology in Complex Systems, Shanxi University, Taiyuan, China Contribution: Conceptualization, Data curation, Formal analysis, Methodology, Software, Validation, Writing - original draft Search for more papers by this author
Dual trigger or hCG alone: A retrospective analysis on patients with diminished ovarian reserve under in vitro fertilization and embryo transfer (IVF-ET) treatment
Keywords Dual trigger Diminished ovarian reserve IVF-ET Abbreviations GEE (generalized estimating equation) MPA (medroxyprogesterone acetate) OPU (oocyte pick-up) WGGE (weighted generalized estimating equation) Get full text access Log in, subscribe or purchase for full access. References 1. Ubaldi, F. ∙ Vaiarelli, A. ∙ D’Anna, R. ... Management of poor responders in IVF: Is there anything new? Biomed Res Int. 2014; 2014, 352098 2. Kessler, M. ∙ Reddy, M. ∙ Shah, R. ...
Studying the impacts of variant evolution for a generalized age-group transmission model
Loading metrics Open Access Peer-reviewed Research Article Citation: Wei F, Zhou R, Jin Z, Sun Y, Peng Z, Cai S, et al. (2024) Studying the impacts of variant evolution for a generalized age-group transmission model. PLoS ONE 19(7): e0306554. https://doi.org/10.1371/journal.pone.0306554 Editor: Yury E. Khudyakov, Centers for Disease Control and Prevention, UNITED STATES Received: December 11, 2023; Accepted: June 18, 2024; Published: July 5, 2024 Copyright: © 2024 Wei et al.
Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is associated with bone metabolism in human and mouse
Research Article MUSCULOSKELETAL DISEASE Yan Mao https://orcid.org/0000-0003-0782-4611, Zhen Jin https://orcid.org/0000-0003-3647-9845, [...] , Jing Yang, Dengqiu Xu https://orcid.org/0000-0002-9502-0543, [...] , Lei Zhao https://orcid.org/0000-0003-0364-893X, Abdukahar Kiram, Yujing Yin https://orcid.org/0000-0002-0253-989X, Danxia Zhou, Zongchao Sun https://orcid.org/0000-0002-3773-6391, [...] , Liwei Xiao https://orcid.org/0000-0001-6971-9222, Zheng Zhou...
Prognosis and therapy in thyroid cancer by gene signatures related to natural killer cells
Natural killer (NK) cells are crucial to cancer development and prognosis. However, the role of NK cell-related genes in immunotherapy and the tumor immune microenvironment (TIME) is not well understood. This study aimed to develop reliable risk signatures associated with NK cell-related genes for predicting thyroid cancer (THCA). The single-cell RNA sequencing (scRNA-seq) data from seven THCA samples (GSE184362) and bulk-RNA-seq data of 502 THCA patients (TCGA-THCA) were included.
Acid-Sensing Ion Channel 1a Contributes to the Prefrontal Cortex Ischemia-Enhanced Neuronal Activities in the Amygdala
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Agronomy | Free Full-Text | Effects of the Combined Application of Nitrogen and Selenium on Tea Quality and the Expression of Genes Involved in Nitrogen Uptake and Utilization in Tea Cultivar ‘Chuancha No.2’
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Planar Bistable Structures Detection via the Conley Index and Applications to Biological Systems
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Neuronal acid-sensing ion channel 1a regulates neuron-to-glioma synapses
Abstract Neuronal activity promotes high-grade glioma progression via secreted proteins and neuron-to-glioma synapses, and glioma cells boost neuronal activity to further reinforce the malignant cycle. Whereas strong evidence supports that the activity of neuron-to-glioma synapses accelerates tumor progression, the molecular mechanisms that modulate the formation and function of neuron-to-glioma synapses remain largely unknown.
Acid-sensing ion channel 1a contributes to the prefrontal cortex ischemia-enhanced neuronal activities in the amygdala
Abstract Following a stroke, the emergence of amygdala-related disorders poses a significant challenge, with severe implications for post-stroke mental health, including conditions such as anxiety and depression. These disorders not only hinder post-stroke recovery but also elevate mortality rates. Despite their profound impact, the precise origins of aberrant amygdala function after stroke remain elusive.
Processes | Free Full-Text | Highly Sensitive Ethylene Sensors Based on Ultrafine Pd Nanoparticles-Decorated Porous ZnO Nanosheets and Their Application in Fruit Ripeness Detection
3. Results and Discussion 3.1. Characterization of the UPNP ZnO Nanosheets and ZnO Nanosheets The crystal structures of the porous ZnO nanosheets and as-prepared UPNP ZnO nanosheets were determined using XRD (Figure 2). All peaks of the porous ZnO nanosheets could be indexed to wurtzite ZnO (JCPDS 36-1451). Three main peaks corresponding to the (100), (002) and (101) crystallographic planes can be clearly observed.
Synthesis and Characterization of Porous MgO Nanosheet-Modified Activated Carbon Fiber Felt for Fluoride Adsorption
3.1. Characterization of Materials displays the XRD patterns of the pure ACFF, precursor-modified ACFF ([email protected]), and [email protected] Obviously, only two broad amorphous packages can be seen from the XRD pattern of the ACFF. After modification, the peaks of the magnesium carbonate hydroxide hydrate (Mg5(CO3)4OH•4H2O, JCPDS No. 70-1177) appear in the diffraction patterns, indicating that the precursor has been successfully modified on the ACFF.
Synthesis of Graphene-Oxide-Decorated Porous ZnO Nanosheet Composites and Their Gas Sensing Properties
1. Introduction The demand for accurate detection for volatile organic compounds (VOCs) is increasing alongside the development of industrialization [1,2]. Therefore, many methods have been developed for the efficient detection of VOCs. Among various techniques, metal oxide semiconductor (MOS) gas sensors with benefits including fast response, low energy consumption and compact size are widely used [3,4,5].
An α type gluco-oligosaccharide from brown algae Laminaria japonica stimulated the growth of Lactic Acid Bacteria encoding specific ABC transport system components
An α type gluco-oligosaccharide from brown algae Laminaria japonica stimulated the growth of Lactic Acid Bacteria encoding specific ABC transport system components Zhen Jin, Qingqing Ma, Xuemei Chen, Hongchao Wang, Jinlin Zhu, Yuan Lee, Hao Zhang, Jianxin Zhao, Wenwei Lu and Wei Chen Abstract We determined a novel neutral α type gluco-oligosaccharide from the brown alga Laminaria japonica with a degree of polymerization (DP) of 2-8 and a structure that mainly consists of α-(1→4)-linked...
A low molecular weight brown algae Laminaria japonica glycan modulates gut microbiota and body weight in mice
A low molecular weight brown algae Laminaria japonica glycan modulates gut microbiota and body weight in mice Brown algae glycan from Laminaria japonica (LJNP) is a heterogeneous glycan with two apparent molecular weight of 1.1 and 37.3 kDa, mainly composed of α β-glucan and few fucosyl residues. To explore the regulation to gut microbiota and host, LJNP and 2’-fucosyllactose (2’FL) were compared to investigate the effect upon mice via oral administration.
Data‐driven dynamical modeling of the transmission of African swine fever in a few places in China
ORIGINAL ARTICLE Juan Li, Complex Systems Research Center, Shanxi University, Taiyuan, Shanxi, China China Animal Health and Epidemiology Center, Qingdao, 266032 China Laboratory of Mathematical Parallel Systems (LAMPS) and Canadian Centre for Diseases Modeling (CCDM), Department of Mathematics and Statistics, York University, Toronto, Canada Search for more papers by this author Zhen Jin, Complex Systems Research Center, Shanxi University, Taiyuan, Shanxi, China Shanxi Key Laboratory of...
A Progressive Somatic Cell Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary
Highlights • The escort cells in the fly ovary constitute two spatial domains: aEC and pEC • Ecdysone is produced in the aEC to regulate synchronous germline cyst division • The pEC regulates soma-germline adhesion to promote cyst-to-egg chamber transition • The patterning of aEC/pEC domains requires JAK signaling emanated from posterior Summary In the germarium of the Drosophila ovary, developing germline cysts are surrounded by a population of somatic escort cells that are known to function...
Efficiency comparison of apigenin‐7‐O‐glucoside and trolox in antioxidative stress and anti‐inflammatory properties
Research Paper Wei Wang Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China Search for more papers by this author Zhen Jin Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation,...
The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level
Highlights • dSox9/Sox100B promotes ISC proliferation only at an appropriate level • Sox100B is directly induced by both JAK/STAT and EGFR/Ras signaling pathways • Sox100B overexpression inhibits MAPK signaling by suppressing EGFR expression • Sox100B promotes cell differentiation via a Sox100B-Sox21a-Pdm1 regulatory circuitry Summary Balanced stem cell self-renewal and differentiation is essential for maintaining tissue homeostasis, but the underlying mechanisms are poorly understood.
Caloric restriction reverses left ventricular hypertrophy through the regulation of cardiac iron homeostasis in impaired leptin signaling mice
Abstract Leptin-deficient and leptin-resistant mice manifest obesity, insulin resistance, and left ventricular hypertrophy (LVH); however, LVH’s mechanisms are not fully understood. Cardiac iron dysregulation has been recently implicated in cardiomyopathy. Here we investigated the protective effects of caloric restriction on cardiac remodeling in impaired leptin signaling obese mice. RNA-seq analysis was performed to assess the differential gene expressions in the heart of wild-type and ob/ob mice.
Protective Effect of Hydroxytyrosol Acetate against Inflammation of Vascular Endothelial Cells partly through SIRT6-mediated PKM2 Signaling Pathway
Protective Effect of Hydroxytyrosol Acetate against Inflammation of Vascular Endothelial Cells partly through SIRT6-mediated PKM2 Signaling Pathway Hydroxytyrosol acetate (HT-AC), a polyphenolic compound in olive oil, exerts an anti-inflammatory effect in murine collagen-induced arthritis. However, the effect of HT-AC on inflammatory response in cardiovascular diseases remains unclear.
TanCAR T cells targeting CD19 and CD133 efficiently eliminate MLL leukemic cells
Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371:1507–17. Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA, et al. T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial. Lancet. 2015;385:517–28. Majzner RG, Heitzeneder S, Mackall CL.
Effects of lobeglitazone on insulin resistance and hepatic steatosis in high-fat diet-fed mice
Lobeglitazone (Lobe) is a novel thiazolidinedione antidiabetic drug that reduces insulin resistance by activating peroxisome proliferator-activated receptor-gamma (PPARγ). However, the exact mechanisms of antidiabetic effects of Lobe have not been established in an animal model. The aim of this study was to evaluate the hypoglycemic effects of Lobe and investigate possible factors involved in Lobe-enhanced hepatic steatosis in high-fat diet (HFD)-fed mice. Mice were fed an HFD for 15 weeks.
Consensus guidelines on the optimal management in interventional EUS procedures: results from the Asian EUS group RAND/UCLA expert panel
Objectives Interventional endoscopic ultrasonography (EUS) procedures are gaining popularity and the most commonly performed procedures include EUS-guided drainage of pancreatic pseudocyst, EUS-guided biliary drainage, EUS-guided pancreatic duct drainage and EUS-guided celiac plexus ablation. The aim of this paper is to formulate a set of practice guidelines addressing various aspects of the above procedures.
Consensus guidelines on the optimal management in interventional EUS procedures: results from the Asian EUS group RAND/UCLA expert panel
Objectives Interventional endoscopic ultrasonography (EUS) procedures are gaining popularity and the most commonly performed procedures include EUS-guided drainage of pancreatic pseudocyst, EUS-guided biliary drainage, EUS-guided pancreatic duct drainage and EUS-guided celiac plexus ablation. The aim of this paper is to formulate a set of practice guidelines addressing various aspects of the above procedures.
Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-hydroxyflavone and 7,8-dihydroxyflavone
Flavonoids are a class of compounds that having the benzo-?-pyrone skeleton, which possess anti-inflammatory properties in vitro and in vivo. The aim of this study was to investigate the inhibition of two flavonoids 7-hydroxyflavone (HF) and 7,8-dihydroxyflavone (DHF) on the production of pro-inflammatory mediators in RAW264.7 cells activated by lipopolysaccharides (LPS).
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