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Articles by Andy Xiang
Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia
Abstract Patients who survive stroke usually experience rapid muscle wasting and an increased risk of physical disability. Although multifactorial interactions, including malnutrition, disuse, systemic catabolic imbalance, and neurohormonal dysregulation, are thought to contribute to the progression of stroke-related sarcopenia, the underlying mechanisms of this brain–muscle crosstalk remain elusive.
An extracellular vesicle-mediated mitochondrial transfer network critical for testosterone synthesis - Nature Cell Biology
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Abstract Testosterone production by testicular Leydig cells (LCs) in male mammals is energetically demanding and prone to mitochondrial damage. Despite these challenges, LCs exhibit remarkable longevity and minimal turnover, suggesting the existence of specialized mechanisms that maintain LC mitochondrial homeostasis under such constrains. Here we identify a mitochondrial transfer network between LCs and different testicular macrophage (tMac) subpopulations.
By Kai Xia, Suyuan Zhang, Hao Peng, Hainan Chen, Jiajie Yu, Peng Luo, Hong Chang Chen, Li Huang, Yifei Xiong, Lei Jia, Lu Li, Yuan Qiu, Yan Guo, Hang Fan, Guihua Liu, Qiong Ke, TAO WANG, Weiqiang Li, Lili Chen, Chunhua Deng, Haipeng Xiao, Andy Xiang, Cuifeng Yang, Qiying Lu, Lerong Zhao, Congyuan Liu, Ziran Dai
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Nature
Verified
Mesenchymal stromal cells induce neutrophil aggregation and extracellular vesicle storms for systemic lupus erythematosus - Signal Transduction and Targeted Therapy
Abstract Mesenchymal stromal cell (MSC) transplantation has achieved significant clinical benefits for many diseases, such as systemic lupus erythematosus (SLE) and inflammatory diseases. However, the detailed therapeutic mechanism of MSCs is not fully understood. Here, in the SLE treatment, we show that MSC transplantation triggers recipient bone marrow neutrophil aggregation to generate an endogenous extracellular vesicle (EV) storm in the circulation via the TNFα/ICAM-1/Rab11b axis.
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
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Keywords aging senescence biomarker stem cell intervention rejuvenation gene editing FOXO3 brain reproductive system Introduction Aging, an unavoidable trajectory, precipitates tissue and physiological deterioration, leading to conditions such as neurodegenerative diseases, reduced fertility, and cardiovascular problems.1,2,3,4,5,6,7,8,9,10,11 Emerging research implicates the decline of stem cell populations and a diminishing regenerative potential as pivotal to the aging...
By Jinghui Lei, Zijuan Xin, Ning Liu, Taixin Ning, Ying Jing, Zan He, Mengmeng Jiang, Yuanhan Yang, Zhiyi Zhang, Liyun Zhao, Jingyi Li, Yupeng Yan, Lingling Xiao, Baohu Zhang, Haoyan Huang, Shuhui Sun, Fangshuo Zheng, Xiaoyu Jiang, Huifen Lu, Feifei Liu, Yanxia Ye, Kaowen Yan, Qinchao Hu, Gang Xu, Qian Zhao, Ruochen Wu, Yusheng Cai, Yanling Fan, Yaobin Jing, Qiaoran Wang, Pradeep Reddy, Xiaoyong Lu, Zikai Zheng, Beibei Liu, Amin Haghani, Shuai Ma, Keiichiro Suzuki, Concepcion Rodriguez Esteban, Jiayin Yang, Moshi Song, Steve Horvath, Weiqi Zhang, Wei Li, Andy Xiang, Lan Zhu, Xiaobing Fu, Guoguang Zhao, Jing Qu, Si Qi Wang, Guang-Hui Liu, Yicheng Qiao, Dongliang Lv, Xueda Dong, Shasha Yue, Chencan Ma, Jichen Shuai, Zhejun Ji
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Cell Press
Verified
Impaired ketogenesis in Leydig Cells drives testicular aging - Nature Communications
Abstract Testicular aging commonly leads to testosterone deficiency and impaired spermatogenesis, yet the underlying mechanisms remain elusive. Here, we show that Leydig cells are particularly vulnerable to aging processes in testis. Single-cell RNA sequencing identifies the expression of Hmgcs2, the gene encoding rate-limiting enzyme of ketogenesis, decreases significantly in Leydig cells from aged mice.
Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans - Nature Communications
Abstract Chromatin topology can impact gene regulation, but how evolutionary divergence in chromatin topology has shaped gene regulatory landscapes for distinctive human traits remains poorly understood. CTCF sites determine chromatin topology by forming domains and loops. Here, we show evolutionary divergence in CTCF-mediated chromatin topology at the domain and loop scales during primate evolution, elucidating distinct mechanisms for shaping regulatory landscapes.
Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs
Keywords U1 snRNP telescripting PCPA splicing U6 snRNP U2 snRNP Research topic(s) CP: Molecular biology Introduction The continuous transcription of numerous eukaryotic genes necessitates the inhibitory utilization of cryptic polyadenylation sites (PASs) situated within introns.
Dynamic forecasting module for chronic graft-versus-host disease progression based on a disease-associated subpopulation of B cells: a multicenter prospective study
ArticlesVolume 113105587Open access aDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China bCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, Guangdong, 510080, China cNational-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-Sen University,...
Human skeletal muscle aging atlas - Nature Aging
Abstract Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes.
Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Aging Biomarker Consortium represents a new era for aging research in China - Nature Medicine
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‘Aging biomarkers’ refers to scientifically measurable parameters of the aging process; these are age-related changes at cellular, organ and organismal levels that can be applied to predict the transition into a pathological state1. Biomarkers can be classified into six categories: physiological characteristics; imaging traits; histological features; cellular alterations; molecular changes; and secretory factors.
By Moshi Song, Weiqi Zhang, Guobing Chen, Weimin Ci, Qiurong Ding, Feng Gao, Shaorong Gao, Jing-Dong J. Han, Zhenyu Ju, Qing-Peng Kong, Ji Li, Jingyi Li, Baohua Liu, Feng Liu, Jun-Ping Liu, Qiang Liu, Xingguo Liu, Yong Liu, Zhiyong Mao, Jing Qu, Zhou Songyang, Liang Sun, Shusen Wang, Xia Wang, Andy Xiang, Yichuan Xiao, Zhi-Xiong Xiao, Wei Xiong, Daichao Xu, Wei Yu, Rui Yue, Hongbo Zhang, Liang Zhang, Yong Zhang, Yun-wu Zhang, Tongbiao Zhao, Yuzheng Zhao, Zhongjun Zhou, DaHai Zhu, Weiguo Zou, Wengong Wang, Zhuohua Zhang
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Nature
Verified
Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-β receptor I
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that is characterised by aberrant proliferation of activated myofibroblasts and pathological remodelling of the extracellular matrix. Previous studies have revealed that the intermediate filament protein nestin plays key roles in tissue regeneration and wound healing in different organs. Whether nestin plays a critical role in the pathogenesis of IPF needs to be clarified.
Nestin promotes pulmonary fibrosis via facilitating recycling of TGF-β receptor I
Jiancheng Wang, Xiaofan Lai, Senyu Yao, Hainan Chen, Jianye Cai, Yulong Luo, Yi Wang, Yuan Qiu, Yinong Huang, Xiaoyue Wei, Boyan Wang, Qiying Lu, Yuanjun Guan, Tao Wang, Shiyue Li, Andy Peng Xiang European Respiratory Journal 2021; DOI: 10.1183/13993003.03721-2020 Abstract Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that is characterised by aberrant proliferation of activated myofibroblasts and pathological remodelling of the extracellular matrix.
Review criteria of jurisdictional dispute involving joint infringement issues | Lexology
In the latest issue of the Intellectual Property Cases Annual Report (2018) by Supreme People's Court (“SPC”), the case between Qualcomm and Apple, represented by the author, was selected as one of the representative cases. SPC used this case to give guidance to the review criteria for jurisdictional dispute involving joint infringement.
涉及共同侵权问题的管辖权异议审查标准 - Lexology
Asia-Pacific, China August 12 2019 在2019年最新发布的《最高人民法院知识产权案件年度报告（2018）》中，笔者代理的针对高通公司与苹果公司之间诉讼的（2018)最高法民辖终77号裁定（77、78和79号三份裁定涉及完全相同的问题，报告中仅列举了77号裁定）被选为典型案例。最高院借此案件对涉及共同侵权的管辖权异议案件的审查标准，作出了具有指导意义的裁判指引。 简言之，最高院认为，在管辖权异议阶段，原则上只需审理与建立案件管辖连接点相关的事实。如果与建立管辖连接点相关的事实同时涉及案件实体争议内容的，只需审查案件初步证据是否能够证成一个可争辩的管辖连接点事实即可，一般不对案件实体争议内容作出明确认定。 所涉案件的具体事实和裁判要点如下：...
Introduction to the protection of new plant varieties in China | Lexology
In addition to industrial intellectual property rights in the traditional sense of patents, trademarks, copyrights, etc., there is also a unique intellectual property right in the field of agricultural forestry, which is the new plant variety right (also known as Plant Breeder's Rights (PBR) or Plant Variety Rights (PVR)). This relatively small form of intellectual property protection, with the rapid development of modern agriculture, is gradually being valued by all sectors of society.
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