Bin Lin
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Articles by Bin Lin
Computer Science > Multiagent Systems
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The Genome Atlas of 1,020 Probands and 409 Unaffected Parents Decodes the Clinical Heterogeneity in β-thalassemia
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Abstract β-thalassemia is an extensively studied monogenic disorder, yet the basis of its striking phenotypic diversity remains unresolved. Here we present the 1000 β-Thalassemia Genomes Project (KbTGP), providing the first comprehensive atlas of 1,429 Chinese genomes (1,020 probands and 409 unaffected parents, 61.63× coverage) linked to 77 clinical traits.
By Yuhua Ye, Yushan Huang, Lian Deng, Xinyue Liu, Xiang Guo, Qianqian Zhang, Yongzhong Zhao, Dan Xie, Yong Long, Songyang Li, Mingyan Fang, Chao Niu, Peng Zhang, Lang Qin, Jingyu Zeng, Yang Gao Verified, Yanyan Li, Liuhua Liao, Riyang Liu, Xinhua Zhang, Lihong Zeng, Bin Lin, Kui Li, Binbin Huang, Yueyan Huang, Zhijing Huang, Xiang Qu, Juanjuan Chen, Xiaoqin Feng, Qiujun Liu, Xianming Chen, Weijie Chen, Wanying Lin, Xiaoman Zhou, Zhanping Lu, Xuemei Song, Yan Chen, Yidan Liang, Lixiang Yan, Weijian Zhu, Lian Yu, Chengwu Fan, Tianyu Zhong, Huanhuan Zhu, Yumeng Sun, Linxuan Li, Xia Tang, Xinjiang Tan, Ziyi Yang, Yirong Shi, Xiaoyu Yan, Duonan Yu, Li Jin, Narla Mohandas, Shuquan Rao, Shunmin He, Xin Jin, Shuhua Xu, Xiangmin Xu, Junqin Cai, Yaoyun Li, Xiaoyun Hua, Honggui Qin, Jinquan Lao, Qinlong Zeng, Xingjiang Long, Jiaofeng Qin, Deguo Tang, Jufang Tan
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Nature
Verified
The NEK8/ALYREF axis promotes cisplatin resistance in bladder cancer by stabilizing CDK18 mRNA to facilitate DNA damage repair
Abstract Cisplatin-based chemotherapy remains a standard treatment for advanced bladder cancer (BCa), however, the development of chemoresistance substantially compromises its clinical efficacy and patient prognosis. In this study, we investigated the functional role of NEK8 in cisplatin resistance in BCa and elucidated its underlying molecular mechanisms. We found that NEK8 was significantly upregulated in cisplatin-resistant BCa and was associated with unfavorable prognosis.
Sex-related refractive disparities in school-aged children: a population-based cross-sectional study of 4.47 million screening records
Abstract Purpose: To delineate cross-sectional group-level sex-specific patterns of refractive development in school-aged children and to determine whether sex-related myopic disparities widen across age strata, addressing limitations in current large-scale epidemiological evidence. Methods: This population-based cross-sectional study analyzed 4.47 million valid vision screening records from 1,623,070 unique students (ages 3–18 years) across Southern Fujian, China (2021–2024).
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Regional disparities and factors associated with third-child fertility intentions among reproductive-age population in Eastern China post the three-child policy: a systematic review and meta-analysis
Abstract Background and purpose: Fertility decline and population aging have become major demographic challenges in China. This systematic review and meta-analysis aimed to estimate the prevalence of third-child fertility intention (TCFI) among reproductive-age populations and further childbearing intention (FCI) among participants with two children in Eastern China, and to examine associated factors.
Multidimensional factors associated with childhood obesity severity in southern China: a cross-sectional study
Abstract Background: Childhood obesity poses a major public health challenge, yet evidence on its graded associations with modifiable factors across dietary, behavioral, familial, and socioeconomic dimensions remains limited, particularly in Southeast China. This study aimed to comprehensively examine the multidimensional factors associated with childhood obesity. Methods: This cross-sectional study included 680 school-aged children from Fujian Province, China.
Real-world evidence on childhood refractive errors in a developed coastal region of China: a multi-center analysis of 4.47 million school-based screening encounters in Southern Fujian
Abstract Background: Despite rapid economic development in coastal China, the alignment between socioeconomic growth and pediatric eye health remains poorly understood. School-based screening may provide an opportunity to bridge this knowledge gap, yet large-scale, real-world evidence from diverse urban-rural gradients is scarce. Methods: This cross-sectional study analyzed 4.47 million valid screening encounters from Xiamen, Quanzhou, and Zhangzhou (2021–2024).
Water-Mediated Hydrogen Bonding Enables Precise Pore-Size Engineering in Hydrogen-Bonded Organic Frameworks for Ultrafast Thorium(IV) Adsorption
Bin Lin and Shu-Yuan Zhang contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The X-ray crystallographic data for the structure reported in this article has been deposited at the Cambridge Crystallographic Data Centre (CCDC) with the number of CCDC 2426831 and 2426646. Supporting Information Filename Description smll74954-sup-0001-SuppMat.docx15.4 MB Supporting File: smll74954-sup-0001-SuppMat.docx.
Farm Size, Technical Efficiency, and Environmental Performance: Evidence From Rice Production in China
Bin Lin and Xiaoxi Wang contributed equally to this work. Conflicts of Interest The authors declare no conflicts of interest. References , and . 2011. “Pollution Shadow Prices in Conventional and Organic Farming: An Application in a Mediterranean Context.” Spanish Journal of Agricultural Research 9: 363–376. https://doi.org/10.5424/sjar/20110902-541-10. , , , et al. 2014. “Importance of Food-Demand Management for Climate Mitigation.” Nature Climate Change 4: 924–929. https://doi.org/10.1038/nclimate2353.
Petrogenesis and Geodynamic Setting of the Mamupu Lamprophyres in Eastern Tibet: Constraints From Geochronology, Geochemistry, and Sr-Nd-Pb Isotopes
Data Availability Statement The data that supports the findings of this study are available in the of this article. Peer Review For transparency, the peer review documents associated with this article are available at https://doi.org/10.1002/gj.70416.
Neuroprotective effect of intraperitoneal Humanin-G in retinal degeneration of Royal College of Surgeons rats
Abstract This study aimed to examine whether Humanin-G (HNG), a mitochondrial derived peptide with cytoprotective properties, could improve the retinal function and gene expression in Royal College of Surgeons (RCS) rats with retinal pigment epithelium (RPE) dysfunction and retinal degeneration. Starting at postnatal day 21, RCS rats received twice a week intraperitoneal injection of either Low Dose HNG (0.4 mg/kg), High Dose HNG (4 mg/kg), or sham-saline for 1 or 4 weeks.
Thoracic ratio and diaphragmatic excursion predict lung function impairment in COPD patients
Abstract To investigate the correlation between the thoracic transverse diameter/anteroposterior diameter (TTD/ATD) ratio and diaphragmatic excursion during deep breathing (DE-DB) in patients with chronic obstructive pulmonary disease (COPD), to evaluate their predictive value for lung function impairment, and to elucidate the underlying mechanism and clinical utility using mediation and decision curve analysis (DCA).
Full-thickness macular penetration by welding laser injury
Fig. 1: Imaging of full-thickness macular penetration from welding laser. A Slit-lamp images of a 40-year-old male who presented with immediate left eye pain and vision loss after occupational welding laser exposure shows focal iris charring with obscured iris texture and deposition of carbonized material in the inferior anterior chamber angle. B Color fundus examination shows a well-defined full-thickness laser-induced macular burn.
Phenothiazine-based photosensitizers for free radical polymerization under visible light in an air atmosphere
Supporting Information Filename Description pi70165-sup-0001-Supinfo.docxWord 2007 document , 2.9 MB Figure S1. 1H NMR spectrum of BPT (DMSO-d6) (DMSO-d6, deuterated dimethyl sulfoxide). Figure S2. 1H NMR spectrum of BPT-F (DMSO-d6). Figure S3. 19F NMR spectrum of BPT-F (DMSO-d6). Figure S4. 1H NMR spectrum of BPT-O (DMSO-d6). Figure S5. 1H NMR spectrum of BPT-Ph (DMSO-d6). Figure S6. 1H NMR spectrum of BPTF-Ph (DMSO-d6). Figure S7. 19F NMR spectrum of BPTF-Ph (DMSO-d6).
TPM1 drives cytoskeleton-immunometabolism coupling and LGALS9/CD45-mediated neuroinflammatory propagation in retinitis pigmentosa
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Retinitis pigmentosa (RP), the most prevalent inherited retinal degeneration, features progressive photoreceptor loss with no approved disease-modifying therapies. While microglia-driven neuroinflammation accelerates RP progression, its sustaining mechanisms remain elusive.
A negative survival pressure selection system enables GPCR antagonist screening
Dear Editor, G protein-coupled receptors (GPCRs) play pivotal roles in regulating physiological processes, and comprehensive statistical analyses indicate that ~36% of approved drugs exert their therapeutic effects by acting on GPCRs, collectively contributing to over 27% of the global pharmaceutical market revenue1,2.
Enhanced Antibiotic Dissipation in Swine Wastewater Facilitated by Heavy Metals through a Transcriptionally Upregulated Microalgal Metallohydrolase Click to copy article link Article link copied!
Cite Jump to ExpandCollapse Occurrence, Fate, and Transport of Aquatic and Terrestrial ContaminantsMay 8, 2026 Enhanced Antibiotic Dissipation in Swine Wastewater Facilitated by Heavy Metals through a Transcriptionally Upregulated Microalgal Metallohydrolase Click to copy article linkArticle link copied! Si-Fen Liu Si-Fen Liu Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou...
Case Report: Novel FOXC1 variant c.311T>G (p.Ile104Ser) in a Chinese family with Axenfeld-Rieger syndrome
Abstract Background: Juvenile-onset open-angle glaucoma (JOAG) is a heterogeneous early-onset glaucoma subtype. Axenfeld-Rieger syndrome (ARS) is an autosomal dominant disorder caused by FOXC1 variants, which may present with severe early-onset glaucoma and can be clinically mistaken for JOAG. This study aimed to determine the genetic cause and clarify the clinical diagnosis in a Chinese family initially diagnosed with JOAG.
Disrupting SRSF10-dependent BCAT2 exon skipping reprograms tumor-associated macrophages and enhances anti-PD-1 efficacy in gastric cancer
Abstract Aberrant alternative splicing (AS) in cancer generates oncogenic proteomic diversity that drives tumor progression. Given the suboptimal efficacy of immune checkpoint inhibitors (ICIs) in gastric cancer (GC), the therapeutic potential of modulating RNA splicing to augment immunotherapy remains unclear. Here, we demonstrate that the splicing factor SRSF10 is progressively upregulated during gastric tumorigenesis and exhibits elevated expression in ICIs-resistant GC.
The utilization, characteristics, and influencing factors of non-therapeutic traditional Chinese medicine services among middle-aged and older population in Guangzhou, China: a cross-sectional study
Abstract Background: As an integral part of the “Healthy China” strategy, healthy aging emphasizes meeting the non-therapeutic health needs of middle-aged and older populations, which is highly consistent with Traditional Chinese Medicine (TCM) concepts. However, empirical studies focusing on the utilization patterns and determinants of such services among the middle-aged and older population remain limited.
A feedback mechanism from prostate cancer cells to macrophages, reinforced by STAT1, regulates tumor progression and resistance to radiotherapy
Abstract The resistance to radiotherapy of prostate cancer is driven by interactions within the tumor microenvironment, particularly between prostate cancer cells and tumor-associated macrophages, however the underlying mechanisms remain poorly understood. In this study, we found that STAT1 enhanced the transcription of critical glycolytic enzymes, leading to an increase in lactate secretion from prostate cancer cells.
A GPCR-G protein-β-arrestin megacomplex enabled by a versatile allosteric modulator
Keywords G protein-coupled receptors GPCRs cryo-EM drug discovery GPCR signaling transduction GPCR structures megacomplex positive allosteric modulator sustained signaling Get full text access Log in, subscribe or purchase for full access. References 1. Sriram, K. ∙ Insel, P.A. G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? Mol. Pharmacol. 2018; 93:251-258 2. Benovic, J.L. ∙ Strasser, R.H. ∙ Caron, M.G. ...
The outcomes of valve-in-valve TMVR for patients with mitral bioprosthetic valve dysfunction: a single-center retrospective study
Abstract Objective: To explore the clinical efficacy and follow-up results of the valve-in-valve transcatheter mitral valve replacement (TMVR) technique in patients with mitral bioprosthetic valve dysfunction. Methods: The medical data of patients with biological valve dysfunction after mitral valve replacement who underwent TMVR in our hospital from January 2019 to January 2024 were retrospectively collected.
Rapid Discovery of Quassinoids with Antifeedant Activity from Picrasma chinensis Employing Molecular Networking Integrated with Mzmine and DeepMass
Bioactive Constituents, Metabolites, and FunctionsNovember 3, 2025 Bensong Xin Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province; Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province; Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China...
[2511.00844] Minimizing Maximum Latency of Task Offloading for Multi-UAV-assisted Maritime Search and Rescue
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Understanding Self-Admitted Technical Debt in Test Code: An Empirical Study
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
[2510.20443] Joint Computation Offloading and Resource Management for Cooperative Satellite-Aerial-Marine Internet of Things Networks
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Cardiac Myosin Activators in Heart Failure: Experimental Advances Amid
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Hou L, Lin B, Ji X, Huang A Received 18 September 2025 Accepted for publication 8 January 2026 Published 12 January 2026 Volume 2026:20 Pages 1—13 DOI https://doi.org/10.2147/DDDT.S568587 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Prof.
Short-Wave Infrared Spectral Characteristics of the Mamupu Cu-Au Skarn Deposit in Eastern Tibet: Insights Into Exploration and Evaluation
1 Introduction In recent years, short-wave infrared (SWIR) spectroscopy has emerged as an essential tool for mineral exploration, capitalising on its rapid, non-destructive and efficient analytical capabilities.
Cardiac Myosin Inhibitors in Hypertrophic Cardiomyopathy: Clinical Adv
Introduction Heart failure encompasses a spectrum of cardiac disorders, among which hypertrophic cardiomyopathy (HCM) represents a distinct and common inherited disease.
Bacterial colonization contributes to pathological scar formation via the regulation of inflammatory response - Journal of Translational Medicine
Inclusion criteria: scars that are raised above the skin surface; accompanied by pain/itching; recent volume growth with a surface that is red, flushed or purple. Exclusion criteria: presence of chronic underlying diseases; chronic wounds at the scar site; history of scar-related treatment; immunodeficiency diseases; mental illness cannot cooperate with treatment or other conditions that are not suitable for participation in this study.
Investigation of wear mechanisms in multi‐scale short carbon fiber reinforced PTFE composites for blade rotor volumetric pumps in variable lubrications
REFERENCES 1, , . Tribological behaviors of some polymeric materials in sea water. Chin Sci Bull. 2009; 54: 4541-4548. doi:10.1007/s11434-009-0578-4 2, , , . Mechanisms behind the environmental sensitivity of carbon fiber reinforced polytetrafluoroethylene (PTFE). Friction. 2023; 12(5): 997-1015. doi:10.1007/s40544-023-0824-9 3, , , . Effect of oxygen and moisture on the friction and Wear of carbon fiber-reinforced polymers. Lubricants. 2023; 11(9):412. doi:10.3390/lubricants11090412 4, , , , .
Bundled measures for China’s food system transformation reveal social and environmental co-benefits - Nature Food
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Abstract Food systems are essential for the achievement of the United Nations Sustainable Development Goals in China. Here, using an integrated assessment modelling framework that considers country-specific pathways and covers 18 indicators, we find that most social and environmental targets for the Chinese food system under current trends are not aligned with the United Nations Agenda 2030.
By Xiaoxi Wang, Hao Cai, Jiaqi Xuan, Bin Lin, Benjamin Leon Bodirsky, Miodrag Stevanović, Quitterie Collignon, Changzheng Yuan, Lu Yu, Michael Crawford, Felicitas Beier, Hui Chen, Marco Springmann, David Chen Verified, Florian Humpenöder, Patrick von Jeetze, Bjoern Soergel, Jan Dietrich, Christoph Müller, Alexander Popp
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Nature
Verified
High-speed rail and outward foreign direct investment: evidence from China
ABSTRACT China has made significant advancements in both outward foreign direct investment (OFDI) and high-speed rail (HSR) construction. However, the causal relationship between these two developments remains unclear. This study examines this causality, which is crucial for designing effective policies to promote OFDI. We hypothesize that HSR can promote OFDI by facilitating innovation.
Finite Element Research of Cup Wheel Grinding Heat Based on Trochoid Scratch Model
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Radiomics of Periprostatic Fat and Tumor Lesion Based on MRI Predicts the Pathological Upgrading of Prostate Cancer from Biopsy to Radical Prostatectomy
Endothelial Dysfunction and Impaired Wound Healing Following Radiation Combined Skin Wound Injury
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Collision Avoidance for Unmanned Surface Vehicles in Multi-Ship Encounters Based on Analytic Hierarchy Process-Adaptive Differential Evolution Algorithm
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Endothelial Dysfunction and Impaired Wound Healing Following Radiation Combined Skin Wound Injury
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 30 October 2024 / Approved: 31 October 2024 / Online: 2 November 2024 (03:50:52 CET) Wang, L.; Lin, B.; Zhai, M.; Hull, L.; Cui, W.; Xiao, M. Endothelial Dysfunction and Impaired Wound Healing Following Radiation Combined Skin Wound Injury. Preprints 2024, 2024102603. https://doi.org/10.20944/preprints202410.2603.v1 Wang, L.; Lin, B.; Zhai, M.; Hull, L.; Cui, W.; Xiao, M.
Effect of Surface Roughness on Corrosion Resistance of Mooring Chains for Offshore Floating Photovoltaics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Energy Efficiency Maximization for Multi-UAV-IRS-Assisted Marine Vehicle Systems
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Influences of Weizmannia coagulans PR06 Fermentation on Texture, Cooking Quality and Starch Digestibility of Oolong Tea-Fortified Rice Noodles
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Exploring the Impact of Alcohol Consumption and Smoking on Primary Open Angle Glaucoma A Mendelian Randomization Study
Objective: Utilizing Mendelian Randomization, this study employs Single Nucleotide Polymorphisms (SNPs) as instrumental variables to explore the causal relationships between bibulosity, smoking, and Primary Open Angle Glaucoma (POAG). Methods: GWAS data for bibulosity, smoking, and POAG were obtained from the Social Science Genetic Association Consortium website and the IEU OpenGWAS Project website, respectively.
A series‐fed high‐quality linear array antenna for 5G maritime communications
REFERENCES 1, , , , , . Unmanned surface vessel assisted maritime wireless communication toward 6G: opportunities and challenges. IEEE Wirel Commun. 2022; 29(6): 72-79. 2, , , , . A compact channel patch antenna with reconfigurable circularly polarized pattern for mobile satellite communications. AEU Int J Electrom Commun. 2023; 164. 3, . Research on 5G wireless signal propagation and coverage capability for marine environment.
Split‐level folding, step‐type tension‐relieving suture technique, and the evaluation on scar minimization
1 INTRODUCTION Among species, the human skin structure stands out as exceptionally intricate, boasting a resting tension unparalleled by any other. This is particularly evident during the wound healing process.1 While persistent tension can endure for up to a year, the recovery of injured skin tissue to approximately 70%–80% of its normal tensile strength necessitates a minimum of 3 months.2-5 This range aligns closely with the tensile strength typical of most scars.
Effect of Age, Comedications, and CYP3A4/5 Polymorphisms on Perampanel Exposure in Chinese Pediatric Patients With Epilepsy
Conflicts of Interest The authors declare no conflict of interest. References 1Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 18(4): 357-375. 2, , , , , . Epilepsy in China: major progress in the past two decades. Lancet Neurol. 2021 20(4): 316-326. 3, , , .
Decoupled Unipolar Hysteresis Current Control for Single-Phase Grid-Tied Inverter Without Current Zero-Crossing Distortion
Photovoltaic power generation is one of the most rapidly developing renewable energy power generation technologies in recent years [1], [2]. As the core component of photovoltaic power generation, the control performance of grid-connected inverters is related to the stability and the power quality of the entire grid-connected system [3].
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