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Articles by Brian Lam
Genome-wide mapping of common and rare variant effects on adiposity across childhood
Abstract Our understanding of the genetic architecture of obesity is primarily based on studies of adults, with sparser data from childhood. Here, we conducted age-stratified genetic association studies against objectively measured (n = 62,276) or recalled childhood adiposity-related traits (neff = 599,924), identifying 624 common variants associated with childhood adiposity, with one-third having no concordant association with adult body mass index.
Optical diagnosis, not endoscopic submucosal dissection, is the rate-limiting step in organ preservation for suspected T1 colorectal cancers
To the Editor: We congratulate van Eijck van Heslinga et al1 on their important multicenter evaluation of endoscopic submucosal dissection outcomes in 1202 cases of suspected T1 colorectal cancers across 5 European centers (2011-2022). Optical diagnosis accuracy is the principal limitation. All 139 suspected deep submucosal invasive cancer (SMIC) cases originated from Dutch centers where zoom endoscopes are unavailable, and 28% were reclassified histologically as high-grade dysplasia or pT1Sm1.
NodoMap: A single-cell and spatial transcriptomic atlas of the mouse nodose ganglion
Introduction The vagus nerve is a major component of the parasympathetic nervous system and transmits information crucial to an array of physiological functions between the brain and peripheral organs.
Immune-Mediated Necrotising Myopathy Following Semaglutide Treatment: A Contributing Factor?
Faculty, Staff and Student Publications Publication Date 3-5-2026 DOI 10.1136/bcr-2025-269690 PubMedCentral® Posted Date 3-5-2026 PubMedCentral® Full Text Version Post-print Abstract This report describes a female patient in her 60s with an immune-mediated necrotising myopathy (IMNM) occurring after semaglutide use. She was found to have progressive dysphagia, dysphonia, proximal muscle weakness and creatine kinase elevation over a 4-month course.
Cav3.1 is a neuronal leucine sensor that mediates satiety and weight loss in response to dietary protein
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ArticleVolume 38, Issue 5p876-890.e13Open access Affiliations & Notes 1Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Cambridge, UK 2Department of Internal Medicine, Center for Hypothalamic Research, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA 3Department of Pharmacology, University of Cambridge, Cambridge, UK Article Info Publication History: Received June 24, 2025; Revised October 3, 2025; Accepted March 27, 2026;...
By Anthony H Tsang, Nicholas Heeley, Constanza Alcaino, Eunsang Hwang, Brian Lam, Taufiq Rahman, Tamana Darwish, Danaé Nuzzaci, Richard Kay, Amar Sarkar, Ruiyan Wang, Nihal Basha, Austin Punnoose, Peter Kirwan, Marcella Ma, Giles Yeo, Florian T. Merkle, Fiona M. Gribble, Kevin Williams, Clemence Blouet, Frank Reinmann
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Cell Metabolism
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Su2034 WAIST-HEIGHT RATIO, POSSIBLY A SURROGATE FOR SARCOPENIA IN PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD), CORRELATES WITH COGNITIVE PERFORMANCE, ACTIVITY AND FUNCTION
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Su1422 PREVALENCE OF ENDOSCOPICALLY CURABLE CANCER IN LARGE NON-PEDUNCULATED LEFT COLONIC POLYPS
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285 RETHINKING THE INDETERMINATE GASTRIC SUBEPITHELIAL LESION: INFLAMMATORY FIBROID POLYPS AS A MODEL FOR DEFINITIVE ENDOSCOPIC DIAGNOSIS AND CURE
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Su1950 IMPROVING HISTOLOGICAL ASSESSMENT OF INTRADUCTAL EXTENSION IN PAPILLARY ADENOMAS BY GUIDEWIRE CANNULATION OF THE EX VIVO SPECIMEN
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Sa1414 THE CLINICOPATHOLOGICAL CHARACTERISTICS OF LARGE TRADITIONAL SERRATED ADENOMAS: AN UNDERRECOGNIZED ENTITY
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1170 A SELECTIVE RESECTION ALGORITHM FOR BARRETT’S NEOPLASIA FAVORS ENDOSCOPIC SUBMUCOSAL DISSECTION FOR CANCER
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Su1229 CLINICAL OUTCOMES OF A STANDARDISED DECOMPRESSION AND CLOSURE PROTOCOL FOR SIGNIFICANT CAPNOPERITONEUM DURING GASTRIC ENDOSCOPIC SUBMUCOSAL DISSECTION AND EXPOSING ENDOSCOPIC FULL THICKNESS RESECTION
Cookie Preference Center We use cookies which are necessary to make our site work. We may also use additional cookies to analyse, improve and personalise our content and your digital experience. For more information, see our Cookie Policy and the list of Google Ad-Tech Vendors. You may choose not to allow some types of cookies. However, blocking some types may impact your experience of our site and the services we are able to offer.
Best cases for iPhone 13 and iPhone 13 Pro Max
Below are some steps that help you choose out the best iphone 13 case in 2025 for your needs. Have a look at some important points we are going to mention. Determining your needs and budget It is essential to know what you are looking for. You should first know well about your own usage needs so that your choice will not be wasted. You may have more expectations of what a product can bring to you, or someone just wants to buy it because of a certain feature.
Endurance training increases a ubiquitylated form of histone H3 in the skeletal muscle, supporting Notch1 upregulation in an MDM2‐dependent manner
Introduction The skeletal muscle represents about 40% of the whole-body mass. This tissue supports movement as well as cardiovascular and metabolic health. To properly function, the skeletal muscle is equipped with an impressive network of vascular capillaries (Wagenmakers et al., 2016).
Comparison of Direct Endoscopic Necrosectomy With Endoscopic Step‐Up Approach After Endoscopic Drainage of Pancreatic Walled‐Off Necrosis: Systematic Review and Meta‐Analysis - Yuen - Digestive Endoscopy - Wiley Online Library
Background and Study Aims Direct endoscopic necrosectomy (DEN) is a safe and effective option in the treatment of pancreatic walled-off necrosis (WOPN). Whether DEN should be performed immediately after drainage (DEN) or as a step-up approach (SUA) is unknown. The aim of this meta-analysis was to compare SUA with DEN in the treatment of WOPN.
An Apprenticeship at Somakosha
For reasons I cannot fully understand, I was invited to work at Somakosha as a carpentry apprentice. As I am not a young man and have a life with some complications, accepting the job wasn't straightforward. The personal backstory is that when I received the offer, I was going through a separation. And as my family life unraveled, so did this idea that I could continue to travel to Japan together as I studied craft.
Consumer Trends Report by Homeer
The customers will always be willing to pay for a product that can meet their needs regardless of its high price. There are some things you should carefully consider once you want to buy something. In this article, to make it easy for you to choose best toothpaste for repairing tooth enamel, our experts pick out some of the most important factors that help you figure out the best toothpaste for repairing tooth enamel suiting your requirements most.
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FIVE-YEAR CLINICAL OUTCOMES AFTER PERORAL ENDOSCOPY MYOTOMY FOR ACHALASIA
Eckardt scores over the follow-up period, spanning from pre-POEM to 5 years post-procedure with median and interquartile range (IQR)
Background Removal API - remove.bg
Remove Background automatically with 1 API call Explore our API documentation and examples to integrate remove.bg into your application or workflow. Not a developer? There are plenty ready to use Tools & Apps by remove.bg and our community. Was this section helpful? Yes No Thanks for your feedback.
How to be an American carpenter in Japan? Do not take ‘no’ for an answer
JAPAN – Mr Jon Stollenmeyer, 42, grew up in Ohio and studied architecture at the University of Cincinnati. In 2005, he visited a classmate in Japan with the idea of seeing the work of modern architects such as Tadao Ando and Kengo Kuma. He soon revised his itinerary when he encountered the country’s antique temples, farmhouses and teahouses, and became infatuated with Japanese wood architecture.
An American Carpenter Finds Success in Japan Original
Jon Stollenmeyer, 42, grew up in Ohio and studied architecture at the University of Cincinnati. In 2005, he visited a classmate in Japan with the idea of seeing the work of modern architects like Tadao Ando and Kengo Kuma. He soon revised his itinerary when he encountered the country's antique temples, farmhouses and teahouses and became infatuated with Japanese wood architecture.
The impact of the COVID‐19 pandemic on patients with chronic liver disease: Results from the Global Liver Registry
Hand planing a walkway (over a koi pond)
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False Positive Anti-Topoisomerase I (Scl-70) Antibody Results in Clinical Practice: A Case Series From a Scleroderma Referral Center
PURPOSE: To determine if some patients who tested positive for anti-Scl-70 antibody in clinical practice, but did not have classifiable systemic sclerosis, were negative for anti-Scl-70 antibody by the more specific immunodiffusion method of testing.
Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health
New Results Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health Sam M Lockhart, Milan Muso, Ilona Zvetkova, Brian Lam, Alessandra Ferrari, Erik Schoenmakers, Katie Duckett, Jack Leslie, Beatriz Romartinez-Alonso, John Tadross, Raina Jia, Eugene Gardner, Katherine Kentistou, Yajie Zhao, Felix Day, Alexander Morseburg, Kara Rainbow, Deb Rimmington, Matteo Mastantuoni, James Harrison, Meritxell Nus, Khalid Guma'a,...
Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation
Approximately 1 in 4 people worldwide have non-alcoholic fatty liver disease (NAFLD); however, there are currently no medications to treat this condition. This study investigated the role of adiposity-associated orphan G protein-coupled receptor 75 (GPR75) in liver lipid accumulation. We profiled Gpr75 expression and report that it is most abundant in the brain.
A Nomogram to Predict Pneumothorax Requiring Chest Tube Placement following Percutaneous CT-guided Lung Biopsy
The authors have declared no competing interest. This study did not receive any funding. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: IRB of University of California San Francisco (UCSF) gave ethical approval for this work.
Clinical Significance of Tumour-Infiltrating B Lymphocytes (TIL-Bs) in Breast Cancer: A Systematic Literature Review
Abstract : Simple Summary Breast cancer is the most frequently diagnosed cancer among women worldwide. Although there have been significant advances in the past decade in our understanding of breast cancer biology and the choice of treatment, mortality remains high, especially among certain subgroups of patients.
A program of successive gene expression in mouse one-cell embryos
Highlights • A gene expression program, iEGA, initiates within 4 h of mouse fertilization • Upregulated genes are normatively spliced, protein coded, and soon downregulated • iEGA genes predict cancer-associated pathways and transcription regulators • Inhibiting predicted transcription regulators acutely disrupts iEGA and development Summary At the moment of union in fertilization, sperm and oocyte are transcriptionally silent.
The Magical (and Sometimes Ridiculous) Gadgets of Tomorrow
Hello! I just found a handful of wonderful technology in Las Vegas at CES, the country's biggest electronics show. There are over 100,000 people here to see roughly 20,000 gadgets brought to the light of day in less time than it takes for a rattlesnake to shed its skin. Without hype, these are the gadgets that will be worth knowing about in 2012. I found about 9, with the help of my friends.
The initiation of mammalian embryonic transcription: to begin at the beginning
A model of EGA initiation emerges from recent work in which cues during fertilization activate maternal TFs such as MYC (Figure 1). Activated TFs initiate an embryonic program of transcription by Pol II, enabled by permissive chromatin at expressed gene promoters, either because the chromatin was already present in gametes, or due to modification in response to meiotic exit, by remodeling factors from the oocyte.
Human embryonic genome activation initiates at the one-cell stage
Highlights • Gene expression initiates at the one-cell stage in human embryos • Expression is of low magnitude but remains elevated until the eight-cell stage • Upregulated transcripts are spliced and correspond to embryonic processes • Upregulation is disrupted in morphologically abnormal one-cell embryos Summary In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs by the eight-cell stage, but its exact timing and profile are unclear.
The “Bill & Ted” Guide To Successful Theatrical Launches
Lessons Learned About PVOD From One of the Most Successful Movie Releases of 2020 With cameras ready to roll on the long-awaited sequel in the “Bill & Ted” franchise, no one knew a global pandemic would force Orion pictures to “Face the Music” in more ways than one. In addition, no one could predict that “Bill and Ted Face the Music” would become a playbook for the future of not just Premium Video on Demand (PVOD), but launches across the board, from PVOD to theatrical.
Beware Dark Patterns – What are They and What Should Your Business Do About Them? | JD Supra
While the term “dark patterns” is not new, it has recently been getting a more attention, not least because the newly passed California Privacy Rights Act (“CPRA”) will regulate dark patterns. In this article, we will focus on what dark patterns are, how your business should be thinking about them, and how CPRA is approaching this issue. What are Dark Patterns?
Beware Dark Patterns – What Are They And What Should Your Business Do About Them? - Privacy - United States
United States: Beware Dark Patterns – What Are They And What Should Your Business Do About Them? 06 April 2021 Mintz Your LinkedIn Connections with the authors To print this article, all you need is to be registered or login on Mondaq.com. While the term "dark patterns" is not new, it has recently been getting a more attention, not least because the newly passed California Privacy Rights Act ("CPRA") will regulate dark patterns.
Beware Dark Patterns – What are They and What Should Your Business Do About Them?
Friday, April 2, 2021 While the term “dark patterns” is not new, it has recently been getting a more attention, not least because the newly passed California Privacy Rights Act (“CPRA”) will regulate dark patterns. In this article, we will focus on what dark patterns are, how your business should be thinking about them, and how CPRA is approaching this issue. What are Dark Patterns?
A survey of the mouse hindbrain in the fed and fasted state using single-nucleus RNA sequencing
New Results Georgina K.C. Dowsett, View ORCID ProfileBrian Y.H. Lam, View ORCID ProfileJohn Tadross, Irene Cimino, Debra Rimmington, View ORCID ProfileAnthony P.
Students welcome the opening of athletic facilities, but hope changes will come – The Bowdoin Orient
Mindy LederRERACK YOUR WEIGHTS: Laila McCain '21 puts back her weights after using one of Bowdoin's many squat racks. To mitigate the risk of community spread, after McCain got a full, 45-minute workout in, her station was sterilized and sat unused for 15-minutes. While the COVID-19 pandemic has brought intercollegiate athletics to a grinding stop, the College’s move to “Yellow” status has allow students to use athletic facilities starting last Monday.
Equestrian team faces budget cuts and distanced community in wake of COVID-19 – The Bowdoin Orient
Once bustling with life from eager riders and half a dozen horses, an unfamiliar silence overtook Underwood Farm, the local, family-owned equestrian facility that the club uses. For a team once racing toward the finish line at a breakneck pace, the Bowdoin Equestrian Club found itself grinding to a halt as a result of the novel coronavirus (COVID-19) pandemic.
California Privacy Rights Act Passes
Mondaq Ltd requires you to register and provide information that personally identifies you, including your content preferences, for three primary purposes (full details of Mondaq’s use of your personal data can be found in our Privacy and Cookies Notice): Mondaq hopes that our registered users will support us in maintaining our free to view business model by consenting to our use of your personal data as described below. Mondaq has a "free to view" business model.
California Privacy Rights Act Passes - Dramatically Altering the CCPA | JD Supra
Voters in California have passed Proposition 24, commonly referred to as the California Privacy Rights Act of 2020 (“CPRA”). Less than a year after the CCPA became effective, the voters’ approval of the CPRA will provide significant new rights to California consumers, create new compliance obligations for covered businesses, establish a new enforcement agency, and provide for data minimization and retention obligations, among other aspects.
California Privacy Rights Act Passes - Dramatically Altering the CCPA
Friday, November 6, 2020 Voters in California have passed Proposition 24, commonly referred to as the California Privacy Rights Act of 2020 (“CPRA”). Less than a year after the CCPA became effective, the voters’ approval of the CPRA will provide significant new rights to California consumers, create new compliance obligations for covered businesses, establish a new enforcement agency, and provide for data minimization and retention obligations, among other aspects.
NIST Provides Important Guidance For IOT Industry
Mondaq Ltd requires you to register and provide information that personally identifies you, including your content preferences, for three primary purposes (full details of Mondaq’s use of your personal data can be found in our Privacy and Cookies Notice): Mondaq hopes that our registered users will support us in maintaining our free to view business model by consenting to our use of your personal data as described below. Mondaq has a "free to view" business model.
Apple Tablet To Redefine Newspapers, Textbooks and Magazines
Steve Jobs said people don't read any more. But Apple is in talks with several media companies rooted in print, negotiating content for a "new device." And they're not just going for e-books and mags. They're aiming to redefine print. Several years ago, a modified version of OS X was presented to Steve Jobs, running on a multitouch tablet. When the question "what would people do with this?" couldn't be answered, they shelved it.
NIST Provides Important Guidance For IOT Industry | JD Supra
More prevalent than ever before, Internet of Things (“IOT”) devices, a term that includes connected “smart” devices, such as internet connected TVs, wearables, smart speakers, such as the Amazon Echo and Google Home, are fast becoming a staple of how we interact with each other, and obtain and consume entertainment and information.
Alleged Privacy Law Violations Create Potential $5 Billion Issue For Google | JD Supra
In a proposed class action lawsuit filed in the U.S. District Court for the Northern District of California, Google is facing a potential $5 billion dollar class action for alleged privacy law violations. The complaint alleges that millions of Google users have been impacted and asks for damages of at least $5,000 per harmed individual.
NIST Provides Important Guidance For IOT Industry
Monday, June 22, 2020 More prevalent than ever before, Internet of Things (“IOT”) devices, a term that includes connected “smart” devices, such as internet connected TVs, wearables, smart speakers, such as the Amazon Echo and Google Home, are fast becoming a staple of how we interact with each other, and obtain and consume entertainment and information.
Alleged Privacy Law Violations Create Potential $5 Billion Issue For Google
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