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Byrd D.R

As seen in: Cell Press, Cell Reports, Cell Reports Medicine, The Lancet, The Journal of Allergy & Clinical Immunology, Gastrointestinal Endoscopy Clinics of North America, Clinical Gastroenterology and Hepatology, European Journal of Cancer, Lung Cancer, EJSO - European Journal of Surgical Oncology and
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Articles

Ethno-racial inequalities on adverse birth and neonatal outcomes: a nationwide, retrospective cohort study of 21 million Brazilian newborns

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By Byrd D.R, Julia M Pescarini, Maria Yury Ichihara, Elzo Pereira Pinto-Junior
| The Lancet Verified
Research in context We searched PubMed from January 1, 2000 to January 1, 2023 for Brazilian studies using the following search terms ((“ethnicity” OR “ethno-racial disparit∗” OR “ethno-racial inequalit∗”) AND (“early neonatal deaths” OR “prematur∗” OR “small for gestational age” OR “low birth weight” OR “SGA” OR “LBW” OR “birth outcomes”)) AND (Brasil OR Brazil). As a result, we identified eight articles that investigated ethnic-racial inequalities on adverse birth outcomes.
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Single-cell spatial multiomics reveals tumor microenvironment vulnerabilities in cancer resistance to immunotherapy

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By Byrd D.R, Camelia Quek, Aditya Pratapa
| Cell Reports Verified
Highlights • Resistant tumors evolve into immune-striving phenotype following immunotherapy • MITF+SPARCL1+ and CENPF+ melanocytes emerge in tumors after combination therapy • B cell signature from lymphoid aggregates differentiates immunotherapy outcomes • Loss of memory state in T cells instigate the development of acquired resistance Summary Heterogeneous resistance to immunotherapy remains a major challenge in cancer treatment, often leading to disease progression and death.
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Cell-free multi-omics analysis reveals potential biomarkers in gastrointestinal cancer patients’ blood

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By Byrd D.R, Changping District, Zhi Lu, Litang Road
| Cell Reports Medicine Verified
Highlights • 15 types of variation events are derived from 4 categories of cell-free multi-omics data • cfRNAs are more sensitive than cfDNAs in terms of detecting cancer-related genes • Certain immune signatures are suppressed in gastrointestinal cancer patients’ plasma • cfRNA biomarkers in blood predict clinical statuses like cancer stage and survival Summary During cancer progression, tumorigenic and immune signals are spread through circulating molecules, such as cell-free DNA (cfDNA)...
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