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Articles by Christopher Lyon
A rapid CRISPR-based nanodroplet assay enables direct clinical identification of mycobacteria species
Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Abstract The global incidence and mortality of nontuberculous mycobacterial infections have risen sharply with population aging. In some regions, they are now surpassing Mycobacterium tuberculosis complex infections, imposing a substantial clinical and economic burden.
Lessons from Canada on assisted dying Original
Prime Minister Andy Burnham has argued that parliament should wait before returning to assisted dying until palliative and social care are properly funded. His intervention comes before MPs are due to debate a new assisted-dying bill for England and Wales on September 11. Public debate often centres on people with terminal illnesses who are experiencing unbearable suffering and want greater control over how they die.
Quand la peste a décimé la population mondiale, la diversité des plantes a, paradoxalement, elle aussi chuté
Par Christopher Lyon, chercheur invité, Centre sur la mort et la société à l'Université de Bath et Jonathan D. Gordon, chercheur postdoctoral en paléoécologie à l'Université de York On imagine souvent qu'une nature débarrassée des humains se porterait mieux. Mais une nouvelle étude sur la peste noire montre l'inverse : lorsque la population européenne s'est effondrée au XIVᵉ siècle, la diversité des plantes a, elle aussi, chuté.
When Nature Didn’t Heal: The Black Death Wiped Out Millions And Surprisingly Destroyed Europe’s Plant Diversity Too
Miniature from the Toggenburg Bible (Switzerland), 1411. The disease is widely believed to be the plague, although the location of bumps and blisters is more consistent with smallpox. Between 1347 and 1353, Europe was gripped by the most catastrophic pandemic in its history: the Black Death. Killing many millions, the plague wiped out between one-third and a half of Europe’s population. In some cities, mortality rates were as high as 80%.
Christopher Lyon
Christopher Lyon Christopher Lyon is a Visiting Research Fellow at Centre for Death and Society, University of Bath, and a Fellow at the Leverhulme Centre for Anthropocene Biodiversity and a member of the Department of Environment and Geography, University of York.
Quand la peste a décimé la population mondiale, la biodiversité a, paradoxalement, elle aussi chuté
On imagine souvent qu’une nature débarrassée des humains se porterait mieux. Mais une nouvelle étude sur la peste noire montre l’inverse : lorsque la population européenne s’est effondrée au XIVᵉ siècle, la diversité des plantes a elle aussi chuté. [Un article de The Conversation écrit par Christopher Lyon - Visiting Research Fellow, Centre for Death and Society, University of Bath & Jonathan D.
Quand la peste a décimé la population mondiale, la biodiversité a, paradoxalement, elle aussi chuté
On imagine souvent qu’une nature débarrassée des humains se porterait mieux. Mais une nouvelle étude sur la peste noire montre l’inverse : lorsque la population européenne s’est effondrée au XIVᵉ siècle, la diversité des plantes a elle aussi chuté. Entre 1347 et 1353, l’Europe a été frappée par la pandémie la plus catastrophique de son histoire : la peste noire. En faisant des dizaines de millions de morts, l’épidémie a anéanti entre un tiers et la moitié de la population européenne.
The Black Death’s counterintuitive effect: as human numbers fell, so did plant diversity Original
Between 1347 and 1353, Europe was gripped by the most catastrophic pandemic in its history: the Black Death. Killing many millions, the plague wiped out between one-third and a half of Europe’s population. In some cities, mortality rates were as high as 80%. In rural areas, Black Death mortality caused intense labour shortages. Entire villages were left empty as rural economies collapsed. In many places, cultivated fields were abandoned and reclaimed by woodland, scrub and deer.
How vulnerable is the UK’s food system?
Food systems around the world face a variety of risks. It is in this context that the UK government launched its much anticipated food strategy in July 2025, with a vision of ensuring ‘improved resilience of the supply chain, with reduced impact of shocks and chronic risks on access to healthy and sustainable food’. But what risks does the food system face and how vulnerable is the UK?
Medical sects, euthanasia and assisted suicide
Dear Editor Owen et al.[1], in a contribution to the discourse around the Terminally Ill Adults (End of Life) (TIAB) and the Assisted Dying for Terminally Ill Adults (Scotland) Bills in the UK’s parliaments, follows other recent work arguing that euthanasia or assisted suicide (EAS) are not medicine [2,3]. Owen et al argue that ‘outside of life there is no health’ and thus no knowable risk or benefit to the patient from death.
Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay
Blood-based diagnosis of pediatric tuberculosis: a prospective cohort study in South Africa and Dominican Republic
Keywords Pediatric tuberculosis Extrapulmonary tuberculosis Paucibacillary tuberculosis Mycobacterium tuberculosis antigen-derived peptide Non-sputum diagnostics Immuno-affinity liquid chromatography-tandem mass spectrometry Introduction The number of children <15 years of age estimated to develop TB annually increased from 1 to 1·3 million between 2019 and 2022.1 Most of these children, especially those <5 years of age, are never diagnosed with TB and are thus excluded from global TB control...
Re: Palliative medicine doctors in the UK have a plurality of views on assisted dying, but you wouldn’t know it
Dear Editor In Canada in 2022, only 8% of deaths in Medical Assistance in Dying (MAID) involved palliative care specialists [1]. Psychiatry, the specialism mostly likely to address suicidality, accounted for just 0.8% of deaths. However, the majority, 67.7%, of deaths involved family practitioners. Accordingly, it seems unlikely that there is any significant silent plurality of palliative care physicians’ views, as these authors imply.
CRISPR for companion diagnostics in low-resource settings
CRISPR for companion diagnostics in low-resource settings† New point-of-care tests (POCTs), which are especially useful in low-resource settings, are needed to expand screening capacity for diseases that cause significant mortality: tuberculosis, multiple cancers, and emerging infectious diseases.
Client Wins Dismissal after Legal Malpractice Claims Proven Insufficient | JD Supra
Stellar defense work by Goldberg Segalla partner Christopher F. Lyon secured in New York County Supreme Court the dismissal of a claim brought against our client in a legal malpractice action. The case was filed by a plaintiff who sued her former attorneys for failing to add in a timely manner a volunteer ambulance company to a lawsuit she initiated following a car accident.
Dad’s death in Canada a warning to NY against Medical Aid in Dying (Guest Opinion by Christopher Lyon)
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Dad’s death in Canada a warning to NY against Medical Aid in Dying (Guest Opinion by Christopher Lyon)
Christopher Lyon, Ph.D., is a Canadian social scientist at the University of York in the United Kingdom. He witnessed his father’s death under Canada’s Medical Aid in Dying program andrecently discussed some of his concerns with MAID in the Journal of Medical Ethics.
THE CRITIC REFLECTS
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Words matter: ‘enduring intolerable suffering’ and the provider-side peril of Medical Assistance in Dying in Canada
Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. View Full Text Read the full text or download the PDF:
Words matter: ‘enduring intolerable suffering’ and the provider-side peril of Medical Assistance in Dying in Canada
Words matter: ‘enduring intolerable suffering’ and the provider-side peril of Medical Assistance in Dying in Canada Correspondence to Dr Christopher Lyon, Leverhulme Centre for Anthropocene Biodiversity, University of York, York YO10 5DD, UK; christopher.lyon{at}york.ac.uk View Full Text Citation Words matter: ‘enduring intolerable suffering’ and the provider-side peril of Medical Assistance in Dying in Canada Journal of Medical Ethics doi: 10.1136/jme-2023-109555 Publication history Received...
A Panorama of Extracellular Vesicle Applications: From Biomarker Detection to Therapeutics
Extracellular vesicles (EVs) play essential roles in cell communication and regulation, including several processes associated with disease pathology since these nanoscale particles are abundantly secreted by all cell types to induce local and systemic effects, particularly during cell injury responses.
Managing Offshore Operations from an Offshore Command Center
There are many benefits for transferring control of offshore ROV operations to shore to carry out subsea tasks from survey to inspection and commissioning. Working from a remote onshore-based location eliminates offshore and transportation safety exposure for the shore-based team and allows for the transition from 12-hour operations to 24-hour without the need for additional personnel mobilization.
CRISPR Assays for Disease Diagnosis: Progress to and Barriers Remaining for Clinical Applications
Shared Barriers to Clinical Translation: Key Milestones and Open Questions Rigorous clinical validation studies required for clinical adoption have not been performed for most of the CRISPR-Dx assays described to date.
How to smooth the road for electric work trucks
February 13, 2023 – There are good reasons for many fleets to switch to electric power, but converting a fleet of work trucks to run on electricity is no easy flip of a switch. To start with, producing just a regular work truck is far from simple, as these vehicles are often constructed in multiple stages by multiple manufacturers. Converting them from internal combustion engines to electric drive systems adds to the complexity.
How to smooth the road to electric work trucks
There are good reasons for many fleets to switch to electric power. But converting a fleet of work trucks to run on electricity is no flip of a switch. To start with, producing a work truck is far from simple. These vehicles are often constructed in multiple stages and by multiple manufacturers. Converting from powering them with internal combustion engines to electric drive systems piles on the complexity.
Smoothing the Road to Electric Work Trucks
Electric power is beneficial, but converting a fleet of work trucks to run on electricity is not as simple as flipping a switch. Producing a work truck is far from simple. These vehicles are often constructed in multiple stages and by multiple manufacturers. Converting from internal combustion engines to electric drive systems piles on the complexity.
Dying Indignity
I share my account of my father’s euthanasia as a reference case study for those watching, studying, campaigning, safeguarding, and legislating around Medical Assistance in Dying (MAiD) in Canada and its equivalents elsewhere. We hear many uncritical claims that there are no problems with MAiD and that suicide, or not-suicide as MAiD is sometimes promoted, is somehow always dignified, a noble “choice”.
Taking the Measure of David Smith
Michael Brenson’s David Smith: The Art and Life of a Transformational Sculptor, the first biography of the celebrated twentieth century artist, was published by Farrar, Straus and Giroux this week. Brenson contributed the lead essay to David Smith Sculpture: A Catalogue Raisonné, 1932–1965, published last year by The Estate of David Smith and Yale University Press. Christopher Lyon, its editor and a contributing essayist, spoke with Brenson recently about his Smith biography.
Thunderstorms in the vicinity
Dad believed the best way to become an old pilot is by hanging out with other pilots, listening to their tales of close calls, near misses, and unique experiences, while learning lessons embedded in their stories. He would say, “You won’t live long enough to learn all those lessons from your own mistakes.” Well, here’s a story where no obvious mistakes were made, but the lessons learned will shape my future aeronautical decision making.
Toward a Taxonomy of Climate Emotions
Introduction The Significance of Climate Emotions The climate crisis is rapidly growing more intense globally. In the 2000s, scholars have started to pay more attention to the complex ways in which emotions are related to the climate crisis.
Climate Projections Suggest Earth Could Become Alien to Humans by 2500
Photo: Ishan @seefromthesky/Unsplash There are many reports based on scientific research that talk about the long-term impacts of climate change by the year 2100. While some climate projections do look past 2100, these longer-term projections aren’t being factored into mainstream climate adaptation and environmental decision-making today. In 2100, will the climate stop warming? If not, what does this mean for humans now and in the future?
Look: 3 images reveal the year when Earth becomes inhospitable to humans
Christopher Lyon, Alex Dunhill, Andrew P. Beckerman, Ariane Burke, Bethany Allen, Chris Smith, Daniel J. Hill, Erin Saupe, James McKay and Julien Riel-Salvatore There are many reports based on scientific research that talks about the long-term impacts of climate change — such as rising levels of greenhouse gases, temperatures, and sea levels — by the year 2100.
Earth Could Be Alien to Humans by 2500
Unless greenhouse gas emissions drop significantly, warming by 2500 will make the Amazon barren, Iowa tropical and India too hot to live in Credit: Getty Images The following essay is reprinted with permission from The Conversation, an online publication covering the latest research. There are many reports based on scientific research that talk about the long-term impacts of climate change—such as rising levels of greenhouse gases, temperatures and sea levels—by the year 2100.
Our climate projections for 2500 show an Earth that is alien to humans
Disclosure statement Christopher Lyon received funding from the White Rose University Consortium (UK) to support this research while at the University of Leeds in the UK. Andrew P Beckerman received funding from the White Rose University Consortium (UK) to support this research while at the University of Sheffield in the UK. He is also supported by grants NE/T003502/1 and NERC:NE/S001395/1 from the Natural Environment Research Council, UK.
Climate change research and action must look beyond 2100
Abstract Anthropogenic activity is changing Earth's climate and ecosystems in ways that are potentially dangerous and disruptive to humans. Greenhouse gas concentrations in the atmosphere continue to rise, ensuring that these changes will be felt for centuries beyond 2100, the current benchmark for projection. Estimating the effects of past, current, and potential future emissions to only 2100 is therefore short-sighted.
Phosphorus: the Hidden Bedrock of the UK Food System
There is a growing threat to the UK’s food system, and most of us aren’t even aware of it. Christopher Lyon Phosphorus is an element that is essential to all living things; it forms a key component of DNA and is important for energy transfers in cells. We take in about 1 gram of phosphorus a day, and store approximately 750g in our bodies (primarily in the form of calcium-phosphate in our bones and teeth).
Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscope
Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscope Nanoparticles exhibit properties that could prove useful in certain quantitative assay approaches, but in practice exhibit trade-offs between sensitivity and utility, due to the need to use time-intensive and analysis methods subject to selection bias to quantitate nanoparticle signal.
Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
Bioengineering Unable to load video. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. An unexpected error occurred. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. Summary Clinical translation of exosome-derived biomarkers for diseased and malignant cells is hindered by the lack of rapid and accurate quantification methods.
Understanding Sulfur Content in Alkylate from Sulfuric Acid-Catalyzed C3/C4 Alkylations
David L. Minnick†, Rajkumar R. Kore , Christopher J. Lyon, Bala Subramaniam , Mark B. Shiflett , and Aaron M. Scurto* Department of Chemical & Petroleum Engineering and Center for Environmentally Beneficial Catalysis, University of Kansas, Lawrence, Kansas 66045 , United States Energy Fuels, Article ASAP DOI: 10.1021/acs.energyfuels.8b04364 Publication Date (Web): April 9, 2019 Copyright © 2019 American Chemical Society *Email: ascurto@ku.edu. Phone: +1 (785) 864-4947.
System and Sensibility: Dorothea Rockburne at Dia:Beacon
Dorothea Rockburne, “Egyptian Painting: Stele” (1980) (© Dorothea Rockburne/Artist Rights Society (ARS), New York, photo by Bill Jacobson Studio, New York, all images courtesy Dia Art Foundation, New York) At the end of January, Dia:Beacon opened an exhibition of works made by Dorothea Rockburne between 1967 and 1980, much of it ephemeral installation art re-created for this show, presented in five galleries of different sizes.
Understanding the Consequences of Driving Overloaded Vehicles - Fleet Management Weekly
By Christopher Lyon, Director of Fleet Relations, NTEA – The Association for the Work Truck Industry Fleet professionals are tasked with providing safe, reliable and compliant vehicles for their organization. In many cases, fleet professionals that design these work trucks only have indirect control and/or input on how these vehicles are used after being placed in service. One of the biggest concerns is understanding the consequences of operating overloaded vehicles.
Extracellular Vesicles as Cancer Liquid Biopsies: from discovery, validation, to clinical application
Extracellular Vesicles as Cancer Liquid Biopsies: from discovery, validation, to clinical application Substantial research has been devoted to elucidate the roles that extracellular vesicles (EVs) play in the regulation of both normal and pathological processes, and multiple studies have demonstrated their potential as a source of cancer biomarkers.
Hydraulic Pump Drives-Underhood or PTO?
Vocational vehicles are designed to handle many different tasks and come with a multitude of auxiliary equipment and support. The key question becomes, what works best for operations? Many variables need to be considered before a fleet professional can offer a recommendation or even think about starting the work truck design process. Historically, in Classes 2–5, auxiliary power export options have been mainly limited to a belt-driven provision off the engine and under the hood.
Underhood versus PTO solutions
Vocational vehicles are designed to handle many unique tasks and come with a multitude of auxiliary equipment and support. The key question becomes what works best for operations. Many variables need to be considered before a fleet professional can offer a recommendation or even think about starting the work truck design process. Historically, in Classes 2–5, auxiliary power export options have been mainly limited to a belt-driven provision off the engine and under the hood.
Danh Vo's Elegy for Democracy
History and art collide in the complex and provocative exhibition Danh Vo: Take My Breath Away at the Guggenheim Museum. A visual poem that enmeshes the viewer, it presents of a decade of Vo’s installations, which have propelled him to a prominent position in the contemporary art world. The exhibition is less a straightforward survey than a reconfiguration of elements from past installations deployed to new ends.
European Tires – Understanding the Basics - Fleet Management Weekly
As truck manufacturers continue to bring Euro-style vans into the North American market, it is important to understand subtle differences in components that can have significant influence on operations. As safety is an important mission within your organization, it’s your job as fleet manager to provide employees and customers with safe, compliant vehicles and equipment. This includes understanding many aspects of vehicle design and OEM specification replacement parts.
Preparing efficient vocational truck specifications
Vocational vehicle specifications serve as building blocks for a fleet and provide financial responsibility for the end product. As work trucks become more complex, mistakes are inevitable. However, a well-written spec can be invaluable when determining who is responsible for correcting errors and, ultimately, monetarily accountable. Efficient specs can lower an organization’s overall acquisition and life cycle costs.
Work Trucks
Vocational vehicle specifications serve as building blocks for a fleet and provide financial responsibility for the end product. As work trucks become more complex, mistakes are inevitable. However, a well-written spec can be invaluable when determining who is responsible for correcting errors and, ultimately, monetarily accountable. Efficient specs can lower an organization’s overall acquisition and life cycle costs.
Artist Interviews and the Literature of Self-Endorsement
The insights-per-acre yield of an artist interview collection may be discouragingly low compared with a book of focused criticism. Still, the presumed authority of the creator—“the horse’s mouth” of Joyce Cary’s great novel narrated by a painter—lends considerable rhetorical heft when artists are asked to describe their work, their influences, or their creative aims.
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