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Articles by Concetta Castilletti
Oropouche virus causes severe congenital disease in embryonic mice
Abstract The recent outbreak of Oropouche virus (OROV) in Latin-America with unprecedented reports of vertical transmission resulting in congenital malformations and fetal death, redefines the threat posed by this arbovirus. We discover that injection of a low inoculum of the epidemic OROVIRCCS-SCDC_1/2024 strain into the placenta of Swiss mice results in viral replication across embryonic organs, in particular the brain.
Epidemiological and genomic features of chikungunya virus disease in travellers returning from Cuba, September 2025 to January 2026: a GeoSentinel analysis
Article metrics loading... /content/10.2807/1560-7917.ES.2026.31.16.2600286 Click here for cited by /content/10.2807/1560-7917.ES.2026.31.16.2600286 Download as PowerPoint /deliver/fulltext/eurosurveillance/31/16/eurosurv-31-16-2.html?itemId=/content/10.2807/1560-7917.ES.2026.31.16.2600286&mimeType=html&fmt=ahah References European Centre for Disease Prevention and Control (ECDC). Factsheet for health professionals about chikungunya virus disease. Stockholm: ECDC. [Accessed 13 Jan 2026].
Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery
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Keywords Oropouche emergence liver organoids therapeutic discovery Introduction Oropouche virus (OROV) is a neglected vector-borne pathogen that causes Oropouche fever, first identified in Latin America and the Caribbean in 1955.1 In late 2023, it re-emerged in the Brazilian Amazon and quickly spread eastward, establishing transmission across all regions of Brazil by 2024.2,3,4 Endemic circulation has also been reported in Barbados, Bolivia, Colombia, Cuba, the Dominican Republic, Ecuador,...
By Jiajing Li, Xin Wang, Yibo Ding, Fang Qin, Lito Papamichail, Rick Schraauwen, Julia Forato, Ingra M Claro, Xinyi Hua, Monique M.A. Verstegen, Marjan Boter, Maikel P. Peppelenbosch, Anna Barbiero, Elisabetta Pagani Verified, Harry Janssen, Jose Silva, José Silva, Eder C. Pincinato, José Luiz Proenca-Modena, Pengfei Li, Adam A. Anas, Concetta Castilletti, William de Souza, Wenshi Wang, Qiuwei Pan, Shirlene T.S. de Lima, Leda M. Simões Mello, Luc J.W. van der Laan, Bas B. Oude Munnink
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Cell Reports Medicine
Verified
Impairment of Innate Immunity and Depletion of Vaccine‐Induced Memory B and T Cells in the Absence of the Spleen
1 Introduction The spleen is not indispensable for survival, but splenectomy is associated with an increased risk of bacteriemia and fulminant sepsis by encapsulated bacteria, such as Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenza [1]. Antibiotic prophylaxis and vaccination represent the main preventive tools. Guidelines recommend vaccination either before or 2 weeks after splenectomy [2-4].
Replication-Competent Oropouche Virus in Semen of Traveler Returning to Italy from Cuba, 2024
Concetta Castilletti1, Ralph Huits1 , Rebeca Passarelli Mantovani, Silvia Accordini, Francesca Alladio, and Federico Gobbi Author affiliations: IRCCS Sacro Cuore Don Calabria Hospital, Negrar di Valpolicella, Italy (C. Castilletti, R. Huits, R. Passarelli Mantovani, S. Accordini, F. Alladio, F. Gobbi); University of Brescia, Brescia, Italy (F.
Author’s response: Oropouche virus risk for European travellers to Cuba: an emerging public health concern
Article metrics loading... /content/10.2807/1560-7917.ES.2024.29.38.2400607 Click here for cited by http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.38.2400607 Download as PowerPoint /deliver/fulltext/eurosurveillance/29/38/eurosurv-29-38-7.html?itemId=/content/10.2807/1560-7917.ES.2024.29.38.2400607&mimeType=html&fmt=ahah References Castilletti C, Mori A, Pomari E, Matucci A, Martelli G, Curiale S, et al.
First diagnoses of Oropouche virus in Europe: how can we strengthen communication and preparedness globally?
Preparedness and communication are key to preventing and tackling existing and future epidemics, whether caused by known, lesser-known, or unknown pathogens. We need to strengthen and speed up cooperation among health authorities at regional, national, and international levels and, more importantly, we should remain alert and open minded. In the past few months, there has been increased detection of infections with Oropouche virus in some areas of the Americas.
Oropouche fever cases diagnosed in Italy in two epidemiologically non-related travellers from Cuba, late May to early June 2024
Article metrics loading... /content/10.2807/1560-7917.ES.2024.29.26.2400362 Click here for cited by http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.26.2400362 Download as PowerPoint /deliver/fulltext/eurosurveillance/29/26/eurosurv-29-26-1.html?itemId=/content/10.2807/1560-7917.ES.2024.29.26.2400362&mimeType=html&fmt=ahah References Anderson CR, Spence L, Downs WG, Aitken TH. Oropouche virus: a new human disease agent from Trinidad, West Indies. Am J Trop Med Hyg.
Immunogenicity to COVID-19 mRNA vaccine third dose in people living with HIV - Nature Communications
Abstract In order to investigate safety and immunogenicity of SARS-CoV-2 vaccine third dose in people living with HIV (PLWH), we analyze anti-RBD, microneutralization assay and IFN-γ production in 216 PLWH on ART with advanced disease (CD4 count <200 cell/mm3 and/or previous AIDS) receiving the third dose of a mRNA vaccine (BNT162b2 or mRNA-1273) after a median of 142 days from the second dose. Median age is 54 years, median CD4 nadir 45 cell/mm3 (20–122), 93% HIV-RNA < 50 c/mL.
Live and Replication-Competent SARS-CoV-2 in Ocular Fluids
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Cosa cambia con le varianti del virus?
26 gennaio 2021 26 gennaio 2021 09:54 Durante i mille anni che separano la caduta dell’impero romano d’occidente dall’invenzione della stampa, nei monasteri benedettini sparsi per l’Europa legioni di monaci amanuensi copiavano su robusti fogli di pergamena ricavati dalla pelle di agnello o di vitello i testi antichi, tramandati su fragili rotoli di papiro e sopravvissuti al trascorrere del tempo e alle vicissitudini politiche e militari dell’alto medioevo.
Lack of Zika virus antibody response in confirmed patients in non-endemic countries
Publication HistoryPublished online: December 21, 2017Received: October 19, 2017;
Travel-Associated Zika Virus Disease
Hamer and colleagues ( 1 ) provide informative data on the clinical manifestations and epidemiology of Zika virus infection in travelers returning from countries with ongoing viral transmission. Ninety-three cases of Zika virus infection were reported from 63 travel clinics in 30 countries in the GeoSentinel network. Among the reported cases, 4 pregnant women were infected and 3 developed severe fetal complications.
Zika Virus Infection in the Central Nervous System and Female Genital Tract
To the Editor: On April 9, 2016, a 32-year-old woman from Italy traveled to Santo Domingo in the Dominican Republic. She worked as a volunteer nurse in the outpatient clinic of a primary school of a nongovernmental organization based in Italy. She returned to Italy on April 17. She did not have sexual intercourse during her stay abroad.
Diagnosis of Zika virus infection in pregnant women travelling to or residing in endemic areas
Guilherme Calvet and colleagues1x1Calvet, G, Aguiar, RS, Melo, AS et al. Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study. Lancet Infect Dis. ; 16: 653–660 Summary | Full Text | Full Text PDFSee all References1 reported the detection and sequencing of Zika virus from amniotic fluid. The two pregnant women from the state of Paraíba in Brazil experienced a Zika-like febrile illness at weeks 18 and 10 of gestation.
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