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Connor Gillis

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Articles

Development of a tissue-specific bioscaffold for intestinal stem cell culture

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By Mathieu Derouet, Liyue Zhang, Connor Gillis, Sachin Kakar
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Citation: Kakar S, Derouet MF, Zhang L, Gillis CJ, Larsen F, Paul A, et al. (2025) Development of a tissue-specific bioscaffold for intestinal stem cell culture. PLoS One 20(8): e0328898. https://doi.org/10.1371/journal.pone.0328898 Editor: Gianpaolo Papaccio, Università degli Studi della Campania, ITALY Received: January 18, 2025; Accepted: July 8, 2025; Published: August 6, 2025 Copyright: © 2025 Kakar et al.
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A Simple, Cost‐Effective Microfluidic Device Using a 3D Cross‐Flow T‐Junction for Producing Decellularized Extracellular Matrix‐Derived Microcarriers

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By Farah Kamar, Connor Gillis, Anorin Ali, Grace Bischof
| Wiley Online Library Verified
1 Introduction Cell therapies using human mesenchymal stromal cells (MSCs) have shown promise for a wide range of clinical applications. However, a limitation for broad-scale clinical translation is that conventional culture methods for MSC expansion within 2D tissue-culture flasks can lead to cell senescence, reflected through changes in cell shape, diminished proliferative and differentiation capacities, and an altered secretome [1].
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A simple, cost-effective microfluidic device using a 3D cross-flow T-junction for producing decellularized extracellular matrix-derived microcarriers

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By Farah Kamar, Connor Gillis, Grace Bischoff, Anorin Ali
| BioRxiv
Abstract Cell therapies using human mesenchymal stromal cells (MSCs) are promising for a wide variety of clinical applications. However, broad-scale clinical translation is limited by conventional culture methods for MSC expansion within 2D tissue-culture flasks. MSC expansion on ECM-derived microcarriers within stirred bioreactor systems offers a promising approach to support MSC growth.
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