Eric Lai
California
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Articles by Eric Lai
Large-scale RNA-binding protein tethering screen discovers modulators of circular RNA metabolism
Abstract Circular RNAs (circRNAs) are emerging as important regulators in mammalian cells and promising substrates for RNA therapeutics, yet the trans-acting factors governing their metabolism remain poorly defined. Here we systematically evaluate 730 RNA-binding proteins (RBPs) using a tethered reporter assay and identify 281 RBPs that significantly modulate circRNA activity.
香港寵物醫療需求上升 黎昌生獸醫診所梳理接診至術後隨訪鏈路
從前線接診到術後跟進，整理各環節溝通與照護安排 HONGKONG, HONGKONG, HONG KONG, October 9, 2026 / EINPresswire.com / -- 第三方數據顯示，香港寵物護理行業規模於2024年約為14.4億美元，全港約有200間獸醫診所、約1,100名註冊獸醫。黎昌生獸醫診所以將軍澳及跑馬地兩間分店運作，團隊由4名專業獸醫及約10名員工組成。 香港，2026年9月29日 —— 黎昌生獸醫診所有限公司（Dr. Eric's Animal Clinic，下稱「黎昌生獸醫診所」）現時在香港設有兩間獸醫診所，分別位於將軍澳至善街3號G09舖，以及跑馬地山光道1A意盧小築地下B舖。該公司成立於2000年，在香港提供寵物醫療服務超過二十年，服務涵蓋常規門診、24小時急診、疫苗接種、健康檢查、影像檢查、手術治療、住院觀察及術後護理。根據公司資料，其醫療團隊由4名專業獸醫組成，並僱用約10名員工，以細團隊模式運作。 行業背景：寵物醫療開支上升，獸醫供應同步擴張 第三方市場研究機構 EverBright Actuarial...
Weekend effect in emergency hospitalizations of older adults in Hong Kong
Abstract The impact of the weekend effect on hospitalization outcomes remains debated. This study evaluated the “weekend effect” by defining two distinct patterns based on admission–discharge timing: “weekend-admission/discharge” (either admission or discharge occurring on weekends) and “weekday-admission-discharge” (both admission and discharge occurring on weekdays).
Building level heat-health risk assessment in a three-dimensional and deprived built environment in Hong Kong
Abstract Extreme heat events are becoming more frequent, intense, and prolonged under global climate change, with urban areas particularly affected by the urban heat island effect. Rapid urbanisation has transformed city environments through three interrelated features—high-rise morphology, dense building clusters with overcrowded housing, and socioeconomic disparities—compounding heat-health risks.
2026 年香港三大優質獸醫服務機構：推動動物醫療服務的創新與卓越
回應寵物家庭需求升級，為寵物提供更安全、高效的診療體驗 HONG KONG, HONG KONG, CHINA, March 18, 2026 / EINPresswire.com/ -- 香港，2026年3月17日——隨著寵物在家庭中的地位日益提升，香港社會對於專業、可靠且全面的獸醫服務需求持續增長。寵物主人不僅尋求基礎的疫苗接種與健康檢查，更期望獲得包括專科診斷、複雜手術及持續護理在內的高階醫療支持。在眾多提供獸醫服務的機構中，有三家憑藉其專業團隊、先進設備、服務模式及合規性，在2026年的市場中脫穎而出，為香港的動物醫療服務樹立了新的標杆。 香港獸醫服務市場的專業化趨勢 根據行業觀察，香港的獸醫服務正朝著高度專業化與精細化的方向發展。成功的機構不僅依賴於持有由香港獸醫管理局根據《獸醫註冊條例》頒發的有效執業牌照（例如牌照編號 R000163），更在於其整合臨床經驗、診斷技術與客戶關懷的綜合能力。服務範圍已從傳統的貓狗診治，擴展至兔子、龍貓、倉鼠等小動物，並涵蓋從常規體檢、疫苗接種到骨科手術、化療及冷凍手術等複雜治療。 三大優質獸醫服務機構深度剖析...
2026 年香港三大優質獸醫服務機構：推動動物醫療服務的創新與卓越
回應寵物家庭需求升級，為寵物提供更安全、高效的診療體驗 HONG KONG, HONG KONG, CHINA, March 18, 2026 /EINPresswire.com/ -- 香港，2026年3月17日——隨著寵物在家庭中的地位日益提升，香港社會對於專業、可靠且全面的獸醫服務需求持續增長。寵物主人不僅尋求基礎的疫苗接種與健康檢查，更期望獲得包括專科診斷、複雜手術及持續護理在內的高階醫療支持。在眾多提供獸醫服務的機構中，有三家憑藉其專業團隊、先進設備、服務模式及合規性，在2026年的市場中脫穎而出，為香港的動物醫療服務樹立了新的標杆。 香港獸醫服務市場的專業化趨勢 根據行業觀察，香港的獸醫服務正朝著高度專業化與精細化的方向發展。成功的機構不僅依賴於持有由香港獸醫管理局根據《獸醫註冊條例》頒發的有效執業牌照（例如牌照編號 R000163），更在於其整合臨床經驗、診斷技術與客戶關懷的綜合能力。服務範圍已從傳統的貓狗診治，擴展至兔子、龍貓、倉鼠等小動物，並涵蓋從常規體檢、疫苗接種到骨科手術、化療及冷凍手術等複雜治療。 三大優質獸醫服務機構深度剖析...
OCTA in the Retina Clinic
Optical coherence tomography (OCT) represents a significant advancement in ophthalmic imaging, enabling in vivo imaging of the retina, optic nerve, anterior segment, and other structures within the eye. Essentially, OCT uses low-coherence interferometry to establish differences in depth of tissue being imaged.
Jimmy Lai’s Criminal Conviction Epitomizes China’s Cognitive Warfare
The ruling is a capstone in the ongoing effort to rewrite the history of Hong Kong and its pro-democracy movement – using the once-respected courts. Jimmy Lai reports to the court for detention on Dec. 31, 2020.
Systematic Review and Meta‐Analysis of Mortality in Patients With Anorexia Nervosa
Patients with anorexia nervosa (AN) have a standardized mortality ratio (SMR) of 5.06. Suicide and cardiac deaths accounted for 21% and 19% of deaths, respectively. Studies on patients with lower body mass index (BMI) have shown higher mortality. Male and female patients with AN have similar SMR. 1 Background Anorexia nervosa (AN) is recognized as a mental disorder with one of the highest mortality rates (Chesney et al. 2014). A previous widely cited meta-analysis by Arcelus et al.
Clinical Integration of Genetic Testing in the Management of Inherited Retinal Diseases
Information Copyright 2025, SLACK Incorporated Address correspondence to Eric W. Lai, MD, Yale School of Medicine, 40 Temple Street, Suite 3A, New Haven, CT 06510; email: eric.lai@yale.edu. From Yale School of Medicine, Department of Ophthalmology and Visual Science, New Haven, Connecticut (EWL); Walter Reed National Military Medical Center, Department of Ophthalmology, Bethesda, Maryland (TL); and Elman Retina Group, Baltimore, Maryland (SAS).
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Salesforce Under Fire: The Salesloft Drift Supply-Chain Breach | | API vulnerability, customer support, Cyber Security, cyber threat, Cyber-attack, Cybersecurity, Data breach, Data Privacy, data retention, Digital Privacy, drift, Episodes, google, Incident Response, Information Security, Infosec, integration, notification, Palo Alto Networks, Podcast, Podcasts, Privacy, SaaS, Salesforce, Salesloft, security, Security Recommendations, social engineering, supply chain, technology, Tenable,...
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Survey: Enterprise IT Teams Spend 11 Hours Investigating Identity Incidents | | , Cybersecurity, enterprise IT, identity management, zero trust A survey of 370 IT and cybersecurity decision makers in organizations with at least 100 employees published today finds, on average, enterprise IT organizations are spending 11 person-hours investigating and remediating each ...
Hong Kong’s Prison Rule Amendments Create a New Chilling Zone
Unsatisfied with the extent of the crackdown, local authorities are moving to expand their control inside the prison system. Subscribe for ads-free reading Five years after China imposed the National Security Law (NSL) in Hong Kong, most of the pillars that once upheld a free and open society – namely independent media, human rights organizations, political opposition, and liberal as well as critical voices – have been dismantled one by one.
Hong Kong’s Prison Rule Amendments Create a New Chilling Zone - Tribune Content Agency
Five years after China imposed the National Security Law (NSL) in Hong Kong, most of the pillars that once upheld a free and open society – namely independent media, human rights organizations, political opposition, and liberal as well as critical voices – have been dismantled one by one. Hundreds of individuals have been arrested and charged with national security offenses, many receiving long prison sentences. Yet the local authorities remain unsatisfied with the extent of the crackdown.
Hong Kong’s Prison Rule Amendments Create a New Chilling Zone
Unsatisfied with the extent of the crackdown, local authorities are moving to expand their control inside the prison system. Subscribe for ads-free reading Five years after China imposed the National Security Law (NSL) in Hong Kong, most of the pillars that once upheld a free and open society – namely independent media, human rights organizations, political opposition, and liberal as well as critical voices – have been dismantled one by one.
Author Correction: Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision - Nature Methods
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Correction to: Nature Methods https://doi.org/10.1038/s41592-023-01944-6, published online 13 July 2023. In the version of the article initially published, 55,238 of 1,137,055 (~ 5%) circRNAs were accidentally shifted one nucleotide in both the start (–1) and end position (+1) and therefore were wrongly annotated. For example, a circRNA with position chr18:8718424–8720495 in the original data became chr18:8718423–8720496. This set of circRNAs comes from 3 tools: KNIFE/NCLscan/NCLcomparator.
By Marieke Vromman, Jasper Anckaert, Trees-Juen Chuang, Roozbeh Dehghannasiri, Christoph Dieterich, Paul Flicek, Enrico Gaffo, Chunjiang He, Osagie Izuogu, Tobias Jakobi, Eric Lai, Justine Nuytens, Peter F. Stadler, Olivier Thas, Eveline Vanden Eynde, Jakub O. Westholm, Chu-Yu Ye, Nurten Yigit, Guo-Hua Yuan, Jinyang Zhang, Fangqing Zhao, Jo Vandesompele
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Nature
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Double trouble: two retrotransposons triggered a cascade of invasions in Drosophila species within the last 50 years - Nature Communications
Abstract Horizontal transfer of genetic material in eukaryotes has rarely been documented over short evolutionary timescales. Here, we show that two retrotransposons, Shellder and Spoink, invaded the genomes of multiple species of the melanogaster subgroup within the last 50 years. Through horizontal transfer, Spoink spread in D. melanogaster during the 1980s, while both Shellder and Spoink invaded D. simulans in the 1990s. Possibly following hybridization, D.
Clinical Advances of Intraoperative OCT in Vitreoretinal Surgery
The idea of integrating optical coherence tomography (OCT) into surgery arose during the late 2000s, when surgeons recognized the potential to visualize real-time tissue and surgical interfaces.1 Intraoperative optical coherence tomography (iOCT) thus emerged as a significant innovation in vitreoretinal surgery, transforming how retina specialists visualize and address retinal conditions.
Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing
Published In Science Volume 386 | Issue 6728 20 December 2024 Article versions Submission history Received: 18 April 2024 Accepted: 18 October 2024 Published in print: 20 December 2024 Permissions Request permissions for this article. Acknowledgments We thank B. Cullen for DICER-KO HEK293T cells and Alnylam Pharmaceuticals for providing the GalNAc-siRNAs. Funding: This study was supported by NYSTEM training award no.
Mapping the microRNA landscape in the older adult brain and its genetic contribution to neuropsychiatric conditions - Nature Aging
Abstract MicroRNAs (miRNAs) play a crucial role in regulating gene expression and influence many biological processes. Despite their importance, understanding of how genetic variation affects miRNA expression in the brain and how this relates to brain disorders remains limited.
Technology Mergers & Acquisitions in Singapore
All questions Year in review The year 2024 has been one of significant geopolitical events and uncertainty. Singapore, being an open economy, is not insulated from the crosswinds caused by the challenging geopolitical events. Despite that, the Singapore market has shown resilience. For the first three quarters of 2024, Singapore saw an aggregate S$66 billion of M&A deals involving Singapore companies, almost 30 per cent higher than the same period in 2023.
A general introduction to Technology Mergers & Acquisitions in Singapore
All questions Introduction The technology sector has been a significant driver in merger and acquisition (M&A) activities globally and this is no different in Singapore. Singapore is a leading tech hub in Southeast Asia, attracting tech giants, startups, and venture capital investment. Its strategic location and strong infrastructure make it a preferred base for companies expanding across the Asia-Pacific region.
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs
Keywords RNAi miRNA biogenesis Microprocessor cryo-EM protein-RNA let-7 miRNA Introduction MicroRNAs (miRNAs) are ∼22 nucleotides (nt) non-coding RNAs that generally repress mRNA expression post-transcriptionally.1 miRNAs are processed from hairpin-containing transcripts called primary miRNAs (pri-miRNAs), typically transcribed by RNA polymerase II.
Water-energy efficiencies: Catalyst to semiconductor sustainability
By Eric Lai FUELED by the explosive growth of emerging markets like AI and electric vehicles, the semiconductor industry — which manufactures the essential materials that power these technologies — is poised to grow into a massive trillion-dollar industry by 20301. At the very heart of this growth lies Southeast Asia, as markets in the region actively pursue opportunities to capture higher value-add positions within the burgeoning global industry.
Water-energy efficiencies: The catalyst to semiconductor sustainability
Fuelled by the explosive growth of emerging markets like AI and electric vehicles, the semiconductor industry—which manufactures the essential materials that power these technologies—is poised to grow into a massive trillion-dollar industry by 2030. At the very heart of this growth lies Southeast Asia, as markets in the region actively pursue opportunities to capture higher value-add positions within the burgeoning global industry.
Water-energy efficiencies: Catalyst to semiconductor sustainability
Published Fri, Aug 23, 2024 · 05:00 AM FUELLED by the explosive growth of emerging markets such as artificial intelligence and electric vehicles, the semiconductor industry – which produces the vital components that power these technologies – is poised to grow into a massive trillion-dollar industry by 2030. At the very heart of this growth lies South-east Asia, as markets in the region actively pursue opportunities to capture higher value-add positions within the burgeoning global industry.
The structural landscape of Microprocessor Mediated pri-let-7 miRNA processing
Abstract miRNA biogenesis is initiated upon cleavage of a primary miRNA (pri-miRNA) hairpin by the Microprocessor (MP), composed of the Drosha RNase III enzyme and its partner DGCR8. Multiple pri-miRNA sequence motifs affect MP recognition, fidelity, and efficiency. Here, we performed cryo-EM and biochemical studies of several let-7 family pri-miRNAs in complex with human MP.
‘Glory to Hong Kong’ ban sets a chilling precedent
In May 2024, the Hong Kong Court of Appeal ruled in favour of the government by reversing the lower court’s rejection of a civil injunction that would, in effect, heavily restrict the dissemination of a famous Hong Kong protest song, Glory to Hong Kong. The song was recorded by local artists in August 2019, when the Anti-Extradition Bill Movement was flourishing.
The structural landscape of Microprocessor Mediated pri-let-7 miRNAs processing
Abstract miRNA biogenesis is initiated upon cleavage of a primary miRNA (pri-miRNA) hairpin by the Microprocessor (MP), composed of the Drosha RNase III enzyme and its partner DGCR8. Multiple pri-miRNA sequence motifs affect MP recognition, fidelity, and efficiency. Here, we performed cryo-EM and biochemical studies of several let-7 family pri-miRNAs in complex with human MP.
Article 23: Implications for Hong Kong
When Hong Kong was handed over to China by the United Kingdom 1997, the city was given a mini-Constitution called the “Basic Law.” Article 23 of the Basic Law states that Hong Kong shall enact laws of its own to prohibit various national security offenses. The law did not pass, however, and was scrapped after mass protests in 2003.
Implications of Article 23 Legislation on the Future of Hong Kong
Executive Summary: Hong Kong’s Article 23 legislation will integrate the PRC’s national security framework into Hong Kong’s legal system, impacting the city’s rule of law and foreign business interests. Broad and vague definitions of national security will create challenges for Hong Kong’s common law system. It will likely contribute to the erosion of legal certainty and judicial independence.
Will Hong Kong’s National Security Law safeguard or harm its citizens?
Author: Eric Lai, Georgetown University In October 2023, Hong Kong Chief Executive John Lee Ka-chiu announced that the government would table its own local national security legislation, with the China-imposed National Security Law (NSL) remaining in effect during the process.
What Agnes Chow’s Case Tells Us About the Rule of Law in Hong Kong - Tribune Content Agency
In the past three years since Beijing imposed a National Security Law (NSL) on Hong Kong, many analysts and observers worried that the authorities would continue to legislate new bills to weaponize laws and courts to suppress the free and open society of Hong Kong. These concerns were not invalid; the chief executive of Hong Kong made it clear that they would complete the legislation of the local security bill by next year.
What Agnes Chow’s Case Tells Us About the Rule of Law in Hong Kong
The Hong Kong government’s arbitrary use of powers against Chow, who has not yet faced trial, further confirms that politics is above the law. In the past three years since Beijing imposed a National Security Law (NSL) on Hong Kong, many analysts and observers worried that the authorities would continue to legislate new bills to weaponize laws and courts to suppress the free and open society of Hong Kong.
Hong Kong’s Legal War on a Protest Anthem
China Power | Politics | East Asia The attempt fits into a longer tradition of using injunction orders to check free speech – and pressuring the courts to follow political directives. Last week, Hong Kong’s high court dismissed a government request for an injunction order against the protest song “Glory to Hong Kong.” The government accused the piece of desiring and promoting Hong Kong’s independence, and previously attempted to bar the dissemination and circulation of the song on the internet.
Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precision - Nature Methods
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Author notes These authors jointly supervised this work: Jo Vandesompele, Pieter-Jan Volders.
By Marieke Vromman, Jasper Anckaert, Trees-Juen Chuang, Roozbeh Dehghannasiri, Christoph Dieterich, Paul Flicek, Enrico Gaffo, Chunjiang He, Osagie Izuogu, Tobias Jakobi, Eric Lai, Justine Nuytens, Peter F. Stadler, Olivier Thas, Eveline Vanden Eynde, Jakub O. Westholm, Chu-Yu Ye, Nurten Yigit, Guo-Hua Yuan, Jinyang Zhang, Fangqing Zhao, Jo Vandesompele
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Nature
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The Association between Autoimmune Thyroid Disease and Ocular Surface Damage: A Retrospective Population-Based Cohort Study
Altmetric share Share announcement Help format_quote Cite thumb_up ... Endorse textsms ... Comment Need Help? Support Find support for a specific problem in the support section of our website. Get Support Feedback Please let us know what you think of our products and services. Give Feedback Information Visit our dedicated information section to learn more about MDPI.
Prior Knowledge of Diagnostic Results Does Not Bias A Subject’s Interpretation of At-Home COVID-19 Antigen Tests
Abstract : In developing in vitro diagnostic (IVD) tests, in particular at-home/over-the-counter (OTC) tests, one of the generally accepted exclusion criteria in IVD clinical trial protocols has been that of subjects with prior knowledge of their positive status, due to potential bias. With COVID-19 antigen tests now widely available, it is common for individuals to test themselves at home with an antigen test if they have symptoms associated with COVID-19, flu, or the common cold.
Hong Kong intenta salvar su imagen. ¿A quién engaña?
Tras el revuelo causado por la pandemia de COVID-19 y la imposición por China de la ley de seguridad nacional (NSL), el gobierno de Hong Kong está preocupado por el atractivo de la ciudad para la inversión extranjera. Organizaron una serie de foros y cumbres para promover la vuelta de Hong Kong a la "normalidad". También organizaron numerosas campañas de propaganda y giras para contar "una buena historia de Hong Kong".
Hong Kong Is Trying to Salvage Its Image. Who Is It Fooling?
China Power | Politics | East Asia The government is eager to tell “a good Hong Kong story” – but actions speak louder than words. After the turmoil of the COVID-19 pandemic and China’s imposition of the national security law (NSL), the Hong Kong government is anxious about the city’s attractiveness to foreign investment.
Hong Kong Is Trying to Salvage Its Image. Who Is It Fooling?
China Power | Politics | East Asia The government is eager to tell “a good Hong Kong story” – but actions speak louder than words. After the turmoil of the COVID-19 pandemic and China’s imposition of the national security law (NSL), the Hong Kong government is anxious about the city’s attractiveness to foreign investment.
„Die führenden demokratischen Köpfe werden als Kriminelle verfolgt“: Ist Hongkong noch zu retten?
Es ist der bislang größte Prozess seit der Einführung des „Nationalen Sicherheitsgesetzes“ vor zweieinhalb Jahren. Seit dem 6. Februar stehen 47 Mitglieder der Hongkonger Demokratiebewegung vor Gericht, darunter bekannte Gesichter wie der Aktivist Joshua Wong, die Journalistin und Politikerin Claudia Mo und der Juraprofessor Benny Tai. In dem Verfahren, das drei Monate dauern soll, droht ihnen lebenslange Haft.
Hong Kong’s Democratic Primary Trials Show a Dark Truth
China Power | Society | East Asia Hong Kong’s legal prosecution of opposition figures puts it in the company of authoritarian regimes worldwide. Weaponizing laws and courts to imprison opposition leaders is a common strategy for authoritarian and hybrid regimes around the world, such as Russia, Belarus, Myanmar, Singapore, and China. The legal system is used as a tool to eliminate forces of political opposition, prevent mass mobilization against the rulers, and create a chilling effect in society.
Judicial Repression Becomes the Norm in Hong Kong
What you need to know As of 2022, more than 100 civil society organizations and trade unions have been dissolved or closed in Hong Kong under the threat of the National Security Law. By Eric Lai On September 26, 2022, a university professor, two former lawmakers, a Cantopop singer, and a Catholic cardinal were charged by the Hong Kong government for failing to register a humanitarian aid fund with the police.
Judicial repression new norm for Hong Kong
On September 26, 2022, a university professor, two former lawmakers, a Cantopop singer and a Catholic cardinal were charged by the Hong Kong government for failing to register a humanitarian aid fund with the police. The five defendants — 90-year-old Cardinal Joseph Zen, singer Denise Ho, cultural studies professor Po-Keung Hui and former lawmakers Margaret Ng and Cyd Ho — are well-known supporters of the pro-democracy movement in Hong Kong.
Judicial repression becomes the norm in Hong Kong
Author: Eric Lai, Georgetown University On 26 September 2022, a university professor, two former lawmakers, a Cantopop singer and a Catholic cardinal were charged by the Hong Kong government for failing to register a humanitarian aid fund with the police. The five defendants — 90-year-old Cardinal Joseph Zen, singer Denise Ho, cultural studies professor Po-Keung Hui and former lawmakers Margaret Ng and Cyd Ho — are well-known supporters of the pro-democracy movement in Hong Kong.
Pneumatic Retinopexy in Dialysis-Associated Rhegmatogenous Retinal Detachments
Pneumatic retinopexy (PR) is a promising treatment option for rhegmatogenous retinal detachment (RRD) because of its minimally invasive nature, ability to be performed without delay in a clinic, and favorable success rates in appropriately selected patients. 1 Pneumatic retinopexy: the evolution of case selection and surgical technique. A twelve-year study of 302 eyes.
Disadvantage in early-life and persistent asthma in adolescents: a UK cohort study
Strengths and limitations The significant strengths of our study include the use of data from a large, representative UK cohort, longitudinal follow-up from birth to adolescence and the inclusion of a range of socially patterned risk factors for asthma operating in the early years. A key strength of our analysis is the application of a modern approach to mediation analysis applied to high resolution cohort data to better understand mediating pathways to address health inequalities in asthma.
UN Human Rights Committee Criticizes Rulings of Hong Kong’s Top Court
China Power | Society | East Asia The Committee’s call to repeal the National Security Law got the most press, but its criticism of the Court of Final Appeal is also important. The United Nations Human Rights Committee, the official watchdog of the implementation of the International Covenant on Civil and Political Rights (ICCPR), issued strong-worded concluding observations in light of Hong Kong’s human rights violations after the National Security Law (NSL) was enacted.
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