James Harding
VerifiedArticles by James Harding
Managing Multifocal BCLC-C HCC With Portal Vein Invasion and Variceal History
Opinion|Videos|August 28, 2026 Author(s)Rachna T. Shroff, MD, MS, FASCO, James J. Harding, MD, Lipika Goyal, MD In the first clinical scenario of this Cancer Network Face Off on advanced hepatocellular carcinoma (HCC), Team Deep-Dish Pizza manages a 67-year-old woman with hepatitis B cirrhosis and BCLC stage C disease, multifocal bilobar tumors with branch portal vein invasion (Vp3), Child-Pugh A6, ALBI grade 2, and an elevated alpha-fetoprotein level.
3D Visualization With da Vinci Single Port Boosts Breast Surgery Precision
Kay Yoon-Flannery, DO, MPH, FACS, chief of Women’s Oncology at AtlantiCare in Egg Harbor Township, NJ, was the first breast surgeon in the US invited to train on the da Vinci Single Port (SP) robotic surgical system in South Korea. Following recent FDA clearance of the platform, she now performs robotic nipple-sparing mastectomy at AtlantiCare Regional Medical Center’s Atlantic City campus, making AtlantiCare the first health system in the tri-state region to offer the procedure.
How to Speak With Patients About Potential Changes to Care During Biopsy Needle Delays
Kathryn Eckert, DO, a breast surgeon at Hackensack Meridian Jersey Shore University Medical Center, discussed how her practice communicates with patients about the ongoing breast biopsy needle shortage and whether referral guidelines have changed.
Real-World Outcomes With Atezolizumab Plus Bevacizumab vs Durvalumab-Based Therapy
Opinion|Videos|July 17, 2026 Author(s)Rachna T. Shroff, MD, MS, FASCO, James J. Harding, MD, Lipika Goyal, MD Midhun Malla, MD, presents real-world data for Team Deep-Dish Pizza, reviewing a multicenter retrospective study comparing frontline atezolizumab plus bevacizumab with durvalumab-based therapy in advanced hepatocellular carcinoma (HCC).
Overcoming PD-1 Resistance in Relapsed/Refractory Hodgkin Lymphoma
At the 2026 European Hematology Association (EHA) Congress, long-term data from the phase 2 KEYFORM-008 trial (NCT05508867) were presented by Guilherme Perini, MD, PhD, first author of the study and investigator at Instituto Américas and Einstein Hospital Israelita in São Paulo, Brazil, who shed light on a novel approach for managing classic Hodgkin lymphoma that has grown resistant to standard PD-1 blockade.
Opening Remarks and the Frontline Treatment Landscape in Advanced HCC
9th Annual School of Nursing Oncology™ Beth Faiman, PhD, MSN, APN-BC, BMTCN, AOCN, FAAN, FAPO; Beth Sandy, MSN, CRNP, FAPO; Lindsay Adkins, MSN, FNP-BC, BMTCN; Jeneth Aquino, DNP, FNP-BC; Casey Gormley, MSN, FNP-C, AOCNP; Heather J. Jackson, PhD, FNP-BC; Kelsey Martin, AG-ACNP-BC, AOCNP; Nerina T. McDonald, PA-C; Lauren Verity Moore, DNP, MSN, AGACNP-BC; Faith A.
Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial
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Abstract Homologous recombination deficiency (HRD) arising from BRCA1or BRCA2 or PALB2 mutations confers sensitivity to platinum chemotherapy and PARP inhibition in pancreatic cancer (PC) and may enable prolonged disease control with immune checkpoint blockade (ICB). The phase 2 POLAR trial evaluated maintenance pembrolizumab plus olaparib following platinum-based chemotherapy in biomarker-stratified metastatic PC.
By Wungki Park, Catherine A. O’Connor, Joanne F. Chou, Marc Hilmi, Zeynep Tarcan, Carly Schwartz, Mary Larsen Verified, Karthigayini Sivaprakasam, Shigeaki Umeda, Maria Perry, Anna Varghese, Fiyinfolu Balogun, Alice Zervoudakis, Seth Katz, Tae-Hyung Kim, Ken Zhao, Allison Richards, Nicolas Lecomte, Daniel Muldoon, Walid K. Chatila, Jessica Yang, Devika Rao Verified, Smita Joshi, Michael Foote, James Harding Verified, Andrew Epstein, David P. Kelsen, Fergus Keane, Joshua D. Schoenfeld, Anupriya Singhal, Erin DiGuglielmo, Chaitanya Bandlamudi, Junmin Song, Haochen Zhang, Maria Teresa Lao, Jerry P Melchor, Ronak Shah, Wenfei Kang, Francesca Mazzoni, Kevin C. Soares, Ernesto Santos, Vineet S. Rolston, Marsha Reyngold, Alice Wei, Murray J. Tipping, Olca Basturk, Michael Berger, Mark Schattner, William R. Jarnagin, Nadeem Riaz, Vinod P. Balachandran, Dana Pe’er, Marinela Capanu, Eileen M. O’Reilly, Ramzi Homsi, Elias Karnoub, Imane El-Dika, Ryan Sugarman, Sree Chalassani, Hulya Sahin Ozkan, Junguei Hong, Agustin III Cardenas, Mark TA Donoghue, Richard Kihn Do, Christine Iacobuzio-Donahue
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Michelin CrossClimate 3 Sport
The Michelin CrossClimate 3 Sport (CC3 S) is a modern performance road tyre developed for drivers who want confident handling, strong wet-weather grip, and dependable everyday performance. Designed for fast road driving rather than track-only conditions, it delivers a well-balanced driving experience. Suited to the realities of UK roads. This tyre is part of the wider CrossClimate 3 range, combining all-weather confidence with performance-focused tuning.
Immune checkpoint blockade and transarterial chemoembolization in liver-limited hepatocellular carcinoma: new questions at the dawn of a new era
Abstract Anti-programed cell death protein-1 (PD-1) and anti-programmed cell death 1 ligand 1 (PD-L1) antibodies combined with anti-vascular endothelial growth factor (VEGF) or anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies are now standard therapeutic options for patients with treatment-naïve, advanced stage, hepatocellular carcinoma.
Why Are My Brakes Squeaking?
Squeaky brakes might seem like a minor annoyance, but they could be a warning sign that your braking system needs attention. Learn what causes the squeal when to call in the pros. Squeaky Brakes: Diagnostics Table To get straight to the point, here are some of the most common causes of squeaky brakes, with a note on the severity of the issue and recommended actions.
Speed Limits in Germany
Whether you're planning a business trip, a holiday, or are driving across Europe - understanding Germany’s speed limits is very important. While parts of the German motorway network are famous for having no upper speed limit, there are still clear rules in place that drivers must follow. Standard Speed Limits in Germany Germany uses kilometres per hour (km/h) rather than miles per hour (mph), so speed readings will look different to UK drivers.
Companies are increasingly leveraging digital marketing strategies to gain a competitive edge. From SEO to social media, digital channels are becoming essential tools for attracting and retaining clients. Working with a specialized link building agency can further strengthen your online presence by improving search engine rankings and increasing website authority.
Knife-edge of the Western world
The historic town hall of Lithuania’s capital Vilnius lies at the heart of an implausibly photogenic old town, a UNESCO World Heritage Site. This seat of the city administration is a modestly imposing late eighteenth-century building, gleaming in an impeccably refreshed coat of cream paint, exuding civic prosperity and continuity. Close up, on the right hand side of its colonnaded portico, a plaque from the 1990s commemorates a new and unbreakable alliance between the United States and Lithuania.
Understanding Ford Focus Tyre Pressure
When it comes time to check your tyres for their pressure, it can be hard to work out what the correct tyre pressure is for a Ford Fiesta. As there are a few different recommendations depending on the trim and year. Even though Ford retired the Fiesta a couple of years ago, there are still plenty of Ford Fiestas on the road. Which will remain on the road for a good time yet to come.
A Step-by-Step Guide to Creating Video Content That Converts
Video has exploded onto the scene, capturing attention spans and driving conversions like never before. It’s no longer a nice-to-have; it’s a must-have for businesses looking to stay competitive. But creating video content that truly resonates with your audience and drives them to take action is more than just pointing a camera and pressing record. It’s a strategic process that requires careful planning and execution. Let’s break it down step by step.
Bridgestone Tyres vs Goodyear Tyres
When it comes to choosing tyres, Bridgestone and Goodyear are two brands that often stand out. Both have built strong reputations for innovation, reliability, and offering a wide range of products. In this comparison, we'll look at what makes each brand special, their product ranges, pricing, and overall performance. Whether you want tyres that save fuel, handle high speeds, or last a long time, knowing more about Bridgestone and Goodyear can help you choose the best car tyres.
Protecting Brick-and-Mortar Stores: 4 Crucial Tips for Physical Business Owners
With most of the world going digital and taking their business online, running a successful physical store is becoming more challenging by the day. Brick-and-mortar shops are slowly but surely dying out, as the unique challenges of running such a shop in the modern day and age are becoming too much to bear for some owners.
Goodyear Tyres vs Pirelli Tyres
When choosing the right tyres for your vehicle, two popular brands are Goodyear and Pirelli. Both are well-known for their quality, performance, and innovation. In this article, we'll look at what each brand offers, including their range of products, prices, and overall performance, to help you decide which is best for you. Goodyear Tyres: Reliable Performance Goodyear has been a leading tyre manufacturer since 1898.
Michelin CrossClimate 2 vs Hankook Kinergy 4S2
Choosing the right all season tyre can significantly impact your driving experience. The Michelin CrossClimate 2 and Hankook Kinergy 4S2 are two top contenders in this category. Both tyres perform well across various weather conditions, but which one is the best tyre for your car? This article compares these tyres in key areas to help you make an informed decision.
Transarterial Chemoembolization Plus Immune Checkpoint Blockade for Patients With Hepatocellular Carcinoma
At Great Debates and Updates in Gastrointestinal Malignancies in New York, New York, James Harding, MD, Memorial Sloan Kettering Cancer Center, New York, New York, discussed results from the EMERALD-1 study which demonstrated that transarterial chemoembolization plus immune checkpoint blockade improved progression-free survival among patients with hepatocellular carcinoma. Transcript: Thank you so much for having me, I'm James Harding.
20mph Speed Limit Across the UK
Over the past few years, you will have no doubt noticed the increasing number of 20mph speed limits are becoming common across many cities in England, Scotland, and Wales. The introduction of these 20mph limits have been put in place in a bid to improve road safety, reduce accidents, and encourage more walking and cycling. In this article we’re going to have a closer look at where and why these speed limits are being introduced.
23 April 2024 - The future of news: impartiality, trust and technology - Oral evidence
Andrew Neil and other media executives give evidence on future of news The Communications and Digital Committee takes evidence from Andrew Neil, Chairman of the Spectator, and other media executives as it continues its inquiry into the future of news.
James Harding | The Critic Magazine
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Chasing votes on foreign soil
This article is taken from the April 2024 issue of The Critic. To get the full magazine why not subscribe? Right now we’re offering five issues for just £10. It’s a sunny, warm day in late summer. A brand-new, purpose-built kindergarten and nursery school is awaiting its official opening. Smiling small children line up, gently marshalled by quietly-spoken female teachers.
Man City and Arsenal both draw quarter-final first legs
UEFA Champions League holders Manchester City and Premier League leaders Arsenal both drew their quarter-final first legs against Real Madrid and Bayern Munich respectively on a sensational night of European football. City led twice in Spain, but a late wonder strike from Federico Valverde ensured it finished 3-3, while Arsenal substitute Leandro Trossard salvaged a 2-2 draw against Bayern in Arsenal's first appearance at this stage of the competition since 2010.
Navigating the new UK IoT legislation
The Product Security and Telecommunications Act 2022 (PSTI) marks a pivotal advancement in UK Internet of Things (IoT) legislation. As you read on, we’ll focus on enhancing the security of connectable consumer products, commonly called IoT or smart devices. The PSTI Act received royal assent in December 2022, following which the government published a complete draft in April 2023. The regulations were signed into UK law on the 14th of September 2023.
Boris Johnson meeting in Venezuela and should we change the way we fund the police?
Boris Johnson meeting in Venezuela and should we change the way we fund the police? – Tortoise Good morning. It appears that you are using an ad blocker that may be preventing our website from functioning properly. To get the best Tortoise experience possible, make sure all blockers are turned off and refresh the page. If you have any questions or need help, let us know at [email protected] Boris Johnson meeting in Venezuela and should we change the way we fund the police?
Raya the hero as Arsenal advance to quarter-finals
David Raya made two stunning penalty shootout saves as Arsenal advanced to the quarter-finals of the UEFA Champions League for the first time since 2010 by eliminating Porto. The Gunners trailed 1-0 from the first leg in Portugal, but Leandro Trossard levelled the tie in the first half with a cool finish. But chances were at a premium in the second half and during a tense extra-time period as the tie went to a penalty shootout.
Outsourcing vs. In-House Web Development: Making the Right Decision for Your Company
A good website isn’t just a place to show off online; it’s also highly important for marketing, talking with customers, and making your brand stronger. But, when businesses need to build a web application, they have to choose whether to outsource this task to external agencies or handle it in-house. This article looks at the good and bad sides of both options so you can pick the best one for you. Outsourcing means getting someone outside your company to do a job instead of doing it yourself.
Mobile Businesses: How Shipping Containers Enable On-The-Go Ventures
Shipping containers entice entrepreneurs with their versatility and customization options for mobile solutions, allowing businesses to transcend fixed locations and adapt to shifting consumer behaviors and market fluctuations. The use of shipping containers in mobile ventures is driven by their flexibility, eco-friendly features, and customization options, showcasing the significant impact of creative thinking and resourcefulness in the ever-evolving business landscape.
The Horizon Post Office scandal and Lionel Rishi on Apple Podcasts
Why did it take a TV drama to wake politicians up to what’s been described as the most widespread miscarriage of justice in British legal history? More than 700 sub-postmasters were convicted of theft, due to accounting discrepancies caused by the Post Office’s faulty computer system. ITV’s Mr Bates vs The Post Office caused public outrage and has forced the Government into taking unprecedented action.
How to Jump Start a Car
If your car will not start and you hear a slow crank or just a clicking sound, a flat car battery is the most likely cause. Knowing how to jump start a car safely can get you moving again without waiting for recovery. However, modern vehicles contain sensitive electronics. Incorrect use of jump leads or a battery booster pack can cause damage or even injury. If at any point you feel unsure, it is always safer to contact a breakdown professional. How Do You Know If The Battery Is Flat?
President of ECIPS Criticizes Belgium Deputy PM’s Call for Sanctions on Israel
In a recent statement, the President of the European Centre for Information Policy and Security (ECIPS), Ricardo Baretzky, has strongly criticized Belgium’s Deputy Prime Minister, Petra De Sutter, for advocating sanctions against Israel in the aftermath of the Gaza war. Baretzky contends that De Sutter is overlooking the crucial detail that it was Palestine’s Hamas, not Israel, that initiated the hostilities by launching an terrorist attack.
President of ECIPS Criticizes Belgium Deputy PM’s Call for Sanctions on Israel
In a recent statement, the President of the European Centre for Information Policy and Security (ECIPS), Ricardo Baretzky, has strongly criticized Belgium’s Deputy Prime Minister, Petra De Sutter, for advocating sanctions against Israel in the aftermath of the Gaza war. Baretzky contends that De Sutter is overlooking the crucial detail that it was Palestine’s Hamas, not Israel, that initiated the hostilities by launching an terrorist attack.
President of ECIPS Criticizes Belgium Deputy PM’s Call for Sanctions on Israel
"In una recente dichiarazione, il presidente del Centro europeo per la politica e la sicurezza dell'informazione (ECIPS), Ricardo Baretzky, ha fortemente criticato il vice primo ministro belga, Petra De Sutter, per aver sostenuto sanzioni contro Israele all'indomani della guerra di Gaza.
King's Speech: What is the Automated Vehicles Bill?
This week, in what was his first King's Speech, King Charles introduced an Automated Vehicles Bill (AV). One of 21 priority bills set out by the Government. But what is the Automated Vehicles Bill? Put simply, the Government hopes to launch a "transport revolution". Their aim is to achieve this by facilitating the use of self-driving vehicles. With the main priority to establish a comprehensive legal framework for such vehicles.
Goodyear’s UltraGrip Performance 3: A New Era in Winter Tyres
This year Goodyear launched the UltraGrip Performance 3, and with it new winter tyre technology. This new winter tyre from Goodyear looks to be a significant step forward in performance and innovation – with a meticulously designed overall product to meet the everchanging needs of drivers. Market Demand Shifts Over the last 5-10 years, larger, heavier and more powerful vehicles, such as SUVs and electric cars, have cemented their popularity amongst motorists.
DriverReviews Customer Choice Tyre Awards 2023: Genuine Reviews for Your Driving Needs!
The market for tyres can be like the ocean. Deep, vast and – when it comes time to choose a new set - somewhat daunting. DriverReviews aims to help with this process. Acting like a lighthouse, ushering you safely into the port of... making the right tyre choice... right ok, this metaphor is gaining water and sinking fast. What I’m trying to say is that they have just launched the 2023 DriverReviews Customer Choice Awards! These annual awards are driven by genuine customer feedback.
🎵Jorja Smith is Soaring High with Her New Album 'Falling or Flying'🎵
When it comes to the ever-changing landscape of pop music, consistent artists who constantly innovate and push genre boundaries are a rarity, and few are as unique as Jorja Smith. Since she began her career in 2016, the Midlands raised songstress has been releasing a steady stream of bangers, and her latest album 'Falling or flying' is no different. Following the five year wait since her debut 'Lost & Found', Smith has truly delivered on the hype she's been building.
Israel-Hamas War on Apple Podcasts
Since Hamas attacked Israel on Saturday, killing at least 1,200 people and kidnapping about 150, including Americans, the atrocities continue to grow. At least 1,400 Palestinians have been killed in the violence, and Israel has massed troops on the border with Gaza, placing the territory under siege.
Numbers and Words? Why Marketing Writers Need Data
Content marketing can be an extremely successful tool to optimize brand awareness, website traffic, and conversion rates. 97 percent of brands generate positive results from content marketing, and 69 percent will increase their content spend in 2023. But with all the online content, your business needs a strategic, relevant approach to stand out. One effective way to do that is by incorporating data into articles, blogs, and other written content.
New: Firestone Firehawk Sport
If you love driving and crave the thrill of the open road, the Firestone Firehawk Sport is here to empower your journey. A Legacy of Excellence and Innovation With a heritage spanning over 100 years, Firestone is a name associated with strength and reliability. You don't earn a century-old legacy, without becoming synonymous with driving excellence and reliability. Firestone's philosophy and pioneering spirit have traversed countless roads and racetracks.
Funded Trading Plus Review: Is This Proprietary Trading Firm Legit?
In trading, deciding on the right platform can make or break your journey to success. You’ve likely heard about Funded Trading Plus, a rising star in the field, and you’re probably wondering if it’s worth your investment. In this Funded Trading Plus review, we’ll deeply dive into the pros and cons, features, and user experience of Funded Trading Plus to help you make an informed decision. What is Funded Trading Plus?
New: Goodyear EfficientGrip Compact 2
Recently Goodyear announced the launch of their latest tyre - the Goodyear EfficientGrip Compact 2. A tyre that is specifically designed to enhance performance in compact cars, catering to the needs of the small passenger vehicle segment and helping to boost Goodyear’s goal of being the leading brand in the field.
Zanidatamab for HER2-amplified, unresectable, locally advanced or metastatic biliary tract cancer (HERIZON-BTC-01): a multicentre, single-arm, phase 2b study
Background HER2 is overexpressed or amplified in a subset of biliary tract cancer. Zanidatamab, a bispecific antibody targeting two distinct HER2 epitopes, exhibited tolerability and preliminary anti-tumour activity in HER2-expressing or HER2 (also known as ERBB2)-amplified treatment-refractory biliary tract cancer.
Cardiff Riots, Rape Trials And Tina Turner
Pet News 2Day is an online platform for the latest news, expert guides, and heart warming stories about pets from around the world. Our mission is to educate, entertain, and inspire pet owners and enthusiasts alike, providing them with up-to-date information and valuable insights about their beloved furry, feathery, and scaly companions.
Musical Theatre West Announces FIORELLO Reading For 3/11
FIORELLO!, the next staged reading of MUSICAL Theatre West'S REINER READING SERIES will take place on March 11, 2012 at 7:00 p.m. at the University Theater on the CSU Long Beach campus at the 7th Street entrance. About the show: "FIORELLO! is the story of the rise of Fiorello LaGuardia (1882-1947) before he became a three term mayor of New York.
Non-Surgical Locoregional Therapies Alone or in Combination with Systemic Therapy in Patients with Hepatocellular Carcinoma
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Spotlight on the new Bridgestone Turanza 6
When it comes to driving, safety is king. That's why Bridgestone has been working tirelessly to develop premium tyres that can keep you safe on the road while also providing superior mileage and energy efficiency. Enter their latest flagship summer tyre - the Bridgestone Turanza 6. Tyre Tests: Bridgestone Turanza 6 Designed with cutting-edge technologies, the Turanza 6 delivers a best-in-class wet performance that's unmatched by its competitors.
Tyre Pressure: Understanding BAR and PSI
Proper tyre pressure is essential for safe and efficient driving, but many people are unsure of the differences between BAR and PSI. To properly look after and maintain your car tyres, it is important to understand tyre pressure and the different ways in which you can measure the pressure. What is tyre pressure? Tyre pressure refers to the amount of air inside a tyre, measured in pounds per square inch (PSI) or BAR.
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