James Lim
San Francisco
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Articles by James Lim
Trustworthy AI Is Not Valuable
1 Introduction The race to develop ‘trustworthy AI’ is on.
To Bring Cell Culture into the Future, Consider Microenvironments
Let’s face it: Nobody pursues a career in science for the joy of culturing cells. But this thankless and time-intensive task is the backbone of biological research. When it’s done extremely well, the results generated from experiments can open entirely new avenues of scientific pursuit, leading to the development of the best-performing cell therapy candidates and minimizing the need for testing animal models. But how often does our cell culture game live up to that potential?
As storms become more extreme, it’s time to rethink how we design roofs
As extreme wind events are becoming more intense across New Zealand and the Pacific, roofs are often the first point of failure. But they remain one of the most overlooked elements in discussions about resilience and safety. Storm systems such as Cyclone Gabrielle and tropical Cyclone Tam have caused widespread damage. But it’s not only cyclones we should worry about. Increasingly, non-cyclonic wind storms are revealing deep-rooted vulnerabilities in our built environment, particularly in our roofs.
The Impact of Obesity on Intraoperative Complications in Rectal Cancer
1 Introduction Obesity is a growing global health concern, with over 890 million adults affected worldwide [1]. In Australia, 31% of adults are classified as obese (BMI ≥ 30 kg/m2) [2], a trend linked to the metabolic syndrome and increasingly sedentary lifestyles [3]. Obesity poses particular challenges in surgical care, such as in rectal cancer surgery.
I Built a Bot that Trades Memecoins
I SEE ALL COINS: Diving Into The Onchain Casino If you’re on Crypto Twitter, you’ve probably seen mouthwatering posts from memecoin traders about their recent gorillion % profit off of a single memecoin trade. Many of these memecoin traders run Telegram “call channels” where they tip off (using this loosely here) their followers about the tokens they’re buying. It’s like a bat signal for quick gains — if you’re fast enough to catch it.
Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection
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Keywords B cells adaptive immune memory antibodies SARS-CoV-2 COVID-19 mRNA vaccines booster vaccination breakthrough infection hybrid immunity Research topic(s) CP: Immunology Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-encoding mRNA vaccines were developed shortly after the emergence of COVID-19 and shown to protect through the induction of potent neutralizing antibodies against the viral protein.1,2,3 The primary two-dose mRNA vaccine was also found to...
By Lela Kardava, James Lim, Clarisa M. Buckner, Xiaozhen Zhang, Wei Wang, Omar El Merhebi, Krittin Trihemasava, I-Ting Teng, Robin Carroll, Yogita Jethmalani, Mike Castro, Bob Lin, Lauren Praiss, Catherine Seamon, Peter D. Kwong, Richard A. Koup, David Nickle, Tae-Wook Chun, Susan Moir, Mattie L. Melnyk, Leonid Serebryannyy
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Experimental and Analytical Investigation of a New Three-Dimensional Seismic Isolation Under Coupled Horizontal-Vertical Excitations
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. ABSTRACT This study investigates experimentally and analytically the performance of a new Three-Dimensional Seismic Isolator (3DSI) designed to control the horizontal-vertical coupled responses of multi-story buildings.
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma
Abstract Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cutaneous malignancy arising from either ultraviolet-induced mutagenesis or Merkel cell polyomavirus (MCPyV) integration. Despite extensive research, our understanding of the molecular mechanisms driving the transition from normal cells to MCC remains limited. To address this knowledge gap, we assessed the impact of inducible MCPyV T antigens on normal human fibroblasts by performing RNA-seq.
The Palace Hotel
JAMES LIM · Follow Published in EPICUREAN JOURNEYS · 2 min read · -- Staying at a hotel can transform a trip into an unforgettable journey by creating a “home away from home” where a couple’s or family traditions are born and cherished. From sharing morning breakfasts in beautifully adorned dining rooms to gathering around cozy fire pits for evening conversations, hotels provide the perfect setting for bonding moments.
Co-design in online-safety education: creating solutions with children, not for them
Threats like cyberbullying and grooming get most of the attention, and 60% of parents say their children are exposed to online risks. However, 90% of parents also say their child benefits from being online, with schoolwork, access to information, and entertainment being key advantages.
Getting ready for 2025: Building strong readers in the early years through a structured approach to literacy
In response to this data and other literacy concerns, there’s a growing movement to use research-based methods to improve literacy learning. New Zealand is committed to teaching and learning underpinned by the science of learning, and this is evident in the refreshed Te Mātaiaho | The New Zealand English Curriculum Years 0–6, set to roll out in 2025. For reading in Phase 1 this includes systematic, explicit instruction to develop foundational reading skills and empower students to love reading.
Mind check: should schools track kids' mental health?
Having been bullied at primary school, things only got worse when she reached high school, where she was often reduced to tears in class. "Then the phone ban came in, so I didn't have an escape or a way to contact support during school hours," the now 19-year-old said. "That was my worst period." Gianna is among 40 per cent of students in Australia whose mental health at one point or another has reached crisis point.
Far from sophisticated: VCE exam blunder has hit young people hard
Australia: +61 3 9229 6200 New Zealand: +64 9 889 0303 35-37 Melville Road, Brunswick West VIC 3055 Australia PO Box 250, Brunswick West VIC 3055 Australia Having a problem?
Govt announces external review following sample exam papers blunder
Victorian students sitting final exams were able to view hidden questions on sample papers but authorities insist none gained an unfair advantage. The Victorian Curriculum And Assessment Authority (VCAA) uploads sample exam papers each year to familiarise students on details such as length and time limits. In response, the State Government has ordered a full external review of the VCAA.
Blunder didn't compromise final exams, authority says
Victorian students sitting final exams were able to view hidden questions on sample papers but authorities insist none gained an unfair advantage. The Victorian Curriculum And Assessment Authority uploads sample exam papers each year to familiarise students on details such as length and time limits. Education Minister Ben Carroll confirmed PDF sample papers allowed tech-savvy students to view some of the possible questions on actual Victorian Certificate of Education exams.
Trump's win may well spawn a rising tide of misogyny in schools: researcher
Monash University’s Professor Steven Roberts says Trump’s win has further re-ignited the influence of the ‘manosphere’, a term used to describe those individuals, forums and groups who espouse anti-feminist and anti-women ideas online. The election outcome, Roberts says, has essentially green-lighted sexist trope and is further entangling young men in damaging ideas about women and masculinity.
How porn is shaping young people’s views of sex and relationships: new study
The latest Impact of pornography on young people report from national violence prevention organisation Our Watch suggests young people now, on average, are seeing porn for the first time at age 13.6. The data, drawn from a survey of just under 1000 young people aged 16-20, found that 72 per cent said porn often showed aggression and violence against women, and 79 per cent believed that porn impacts how women were viewed in real life. Almost a third said they used porn for sex education.
Aussie teachers are nailing grammar instruction: expert
Long-time literacy educator Margaret McBride says our teachers are doing an exceptional job in working with the highly complex grammar model in the national curriculum – and her recent PhD research only confirms this. Involving four schools and 35 teachers from vastly different contexts, McBride investigated the grammar pedagogy underway in classrooms, honing on teachers’ focus on clause-level and word-level grammar.
NAPLAN scores remained stable during pandemic school closures: study
The research published earlier this year in The Economics of Education Review and appearing in print last month, analysed NAPLAN test scores across Australian states. It examined differences in student performance based on varying periods of remote learning between 2020 and 2021, with school closures ranging from 9 to 157 days.
Conservation of gene expression patterns between the amniotic epithelium at birth and a newborn's nasal epithelium
Abstract Background: Amniotic epithelial cells are foetal-derived stem cells, capable of differentiating into all three germ layers, including mature epithelial cell populations. However, the conservation between amniotic epithelium and other epithelial tissues has not been sufficiently explored. We hypothesised that the amniotic epithelium might serve as a surrogate tissue source for investigating transcriptional profiles in the respiratory epithelium of the newborn.
Improving Cell Therapy with Metabolic Engineering
Efforts to improve the performance of cell therapies inevitably focus on boosting potency through genetic engineering. The rationale is obvious; if we could just design tumor-targeting constructs and perturb exhaustion signaling pathways, surely, the resulting therapies would have the desired effect. In our view, however, there’s a more reliable and straightforward approach.
Unlocking Cell Therapy’s Full Potential by Rewiring T-Cell Metabolism
Home Resources Tutorials Unlocking Cell Therapy’s Full Potential by Rewiring T-Cell Metabolism Credit: Meletios Verras / iStock / Getty Images Plus Credit: Meletios Verras / iStock / Getty Images Plus While the use of cell therapies to treat hematological malignancies has been hailed as a clinical breakthrough, this promising new class of therapies has been far less effective in treating solid tumors.
Unlocking the Hidden Magic of Asset Management
In the pulsating realm of hospitality, asset management stands as a silent orchestrator, weaving threads of success for hotels, resorts, and properties alike.
Cybersecurity for Non-Security Leaders
I have several years of experience building and leading security teams. My teams have built security programs from scratch, helped prepare companies for their IPO, fought off active attacks, and attained compliance/alignment/certification with PCI DSS, SOC 1, SOC2, NIST CSF, etc. I still feel like an outsider in this space, but I have learned a few tricks. First, I acknowledge that cybersecurity speak is hard. There is a lot of jargon and acronyms, and it is deliberately designed to be that way.
Systematic Coarse Graining of Environments for the Nonperturbative Simulation of Open Quantum Systems
Conducting precise electronic-vibrational dynamics simulations of molecular systems poses significant challenges when dealing with realistic environments composed of numerous vibrational modes. Here, we introduce a technique for the construction of effective phonon spectral densities that capture accurately open-system dynamics over a finite time interval of interest.
Application of Elevated Atmospheric Pressure and Hypoxia Enhance Pluripotency and Stem Cell Differentiation
Abstract Physical forces regulate stem cell differentiation in-vivo, however few simple and precise methods exist to better understand this biology in-vitro. Here we describe the use of a novel bioreactor that enables addition of physical force in the form of elevated atmospheric pressure during reprogramming of human fibroblasts and culture of human induced pluripotent stem cell (iPSC) and neural stem cell (NSC) lines.
Examining Miliary Disease Etiology in a Coccidioides-Endemic Center: A Retrospective Cohort Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Noise-Assisted Digital Quantum Simulation of Open Systems Using Partial Probabilistic Error Cancellation
Popular Summary In the fields of physics, chemistry, and biology, understanding complex systems influenced by quantum effects presents a significant challenge because of their counterintuitive nature and the challenges in simulating them numerically because of the exponential growth of the Hilbert space with system size. This renders classical computer simulations inefficient. Additionally, real-world quantum systems are subject to noise, making classical computations even more challenging.
Integrative analysis reveals therapeutic potential of pyrvinium pamoate in Merkel cell carcinoma
Abstract Merkel Cell Carcinoma (MCC) is a highly aggressive neuroendocrine cutaneous malignancy arising from either ultraviolet-induced mutagenesis or Merkel cell polyomavirus (MCPyV) integration. It is the only known neuroendocrine tumor (NET) with a virus etiology. Despite extensive research, our understanding of the molecular mechanisms driving the transition from normal cells to MCC remains limited.
James Lim, PhD, on Addressing Lingering Needs in Research Process Development and Clinical Manufacturing
Although significant progress has been made in recent years, many challenges remain when it comes to culturing primary human cells for the purpose of manufacturing cell therapy products, such as chimeric antigen receptor T-cell (CAR-T) therapies. One area of interest for improvement is the development of new assays that more closely mimic physiological conditions than those assays that are currently used in the industry.
James Lim, PhD, on the Impact of Manufacturing Conditions on CAR-T Efficacy
Although numerous studies have attempted to replicate the success seen in treating hematological malignancies with chimeric antigen receptor T-cell (CAR-T) therapies in solid tumor indications, many of these studies have not been successful. Part of the reason for this lack of success is that CAR T-cells manufactured under nonphysiological conditions tend to be ineffective at killing cancer cells in the conditions of the solid tumor microenvironment.
James Lim, PhD, on Simulating the Solid Tumor Microenvironment in Cell Killing Assays
Currently, cytokine secretion assays are the gold standard for evaluating chimeric antigen receptor T-cell (CAR-T) therapy potency during the manufacturing process. Although, there are limitations to these assays’ predictive capabilities, especially for CAR-T therapies intended to target solid tumors because they do not take into account the conditions presented by the solid tumor microenvironment.
James Lim, PhD, on the Challenges Posed by the Solid Tumor Microenvironment
Many companies and organizations are attempting to replicate the success seen with chimeric antigen receptor T-cell (CAR-T) therapies for hematological malignancies in solid tumor indications. Although, a major challenge in this research, especially in the screening/preclinical stage, is that the efficacy of candidates in in vitro testing does not always translate to in vivo applications.
Structural and functional integration of human forebrain organoids with the injured adult rat visual system
Method details Maintenance of stem cell lines Cells were grown as colonies on a feeder layer of irradiated mouse embryonic fibroblasts (MEFs; Gibco).
Holographic procedural monitors during thyroid radiofrequency ablation using mixed reality headset
BJP receives grants from RSNA and serves on advisory board of Medivis outside the submitted work. TH receives honoraria from Taewoong Medical outside the submitted work. No other relevant conflicts of interest or financial disclosures. This case series has not been previously presented at SIR or elsewhere. This case series was not externally sponsored or part of a clinical trial.
Association of a Multimodal Intervention With Decreased Opioid Prescribing After Neck Dissection for Malignant Thyroid Disease With Short Hospital Stay | Endocrine Surgery | JAMA Otolaryngology-Head & Neck Surgery | JAMA Network
Key Points Question Does an intervention comprising patient needs assessment, patient-practitioner discussion, and care team education affect prescribing of opioid medication at hospital discharge after a short-stay neck dissection for thyroid cancer?
The prevalence, operations, and outcomes of carcinoid heart disease
Carcinoid heart disease (CHD) is a sequela of carcinoid liver metastases (LM). The true prevalence of CHD is unknown due to infrequent screening by transthoracic echocardiography (TTE). Octreotide is believed to protect against new and recurrent CHD, but supporting data are scant. This study determined CHD prevalence and outcomes in patients screened by TTE and treated with octreotide. Records of carcinoid patients from 2001 to 2021 were reviewed.
Ileal pouch construction - a video vignette
VIDEO CORRESPONDENCE Asiri Arachchi, Corresponding Author Asiri Arachchi asiriarachchi@gmail.com Colorectal Unit, Dandenong Hospital, Monash Health, Melbourne, Victoria, Australia Search for more papers by this author David Zula, David Zula Colorectal Unit, Dandenong Hospital, Monash Health, Melbourne, Victoria, Australia Search for more papers by this author James Lim, James Lim Colorectal Unit, Dandenong Hospital, Monash Health, Melbourne, Victoria, Australia Search for more papers by this...
Get to Know Chanel’s New Desi Models From the Paris-Bombay Show
Photo: Antoine_de_Parseval/ANTOINE_de_PARSEVAL Karl Lagerfeld’s Paris–Bombay pre-fall collection for Chanel, which walked this week, made an impact, not only with the miniature trains chugging along the banquet tables where guests sat and the faux-dreadlocks some models wore. It also made an impact because the show’s cast included an unusually high number of models of South Asian origin.
Commentary: Finding value in South Korea despite ‘Korean discount'
Despite these achievements, the South Korean stock market might be one of the cheapest in the world. We believe that the main reasons for this discount are historically weak corporate governance policies employed by South Korean companies and the inefficient capital allocation by management teams. Historically, majority shareholders and the management of South Korean companies have employed strategies that work against the benefit of all shareholders.
Video: Coco Rocha Teaches the New York Staff How to Pose Like a Model
video Nov. 1, 2011 By Ryan Jones, Sarah Frank, and James Lim Once we learned that Coco Rocha lends her modeling expertise to agencies and new faces, teaching them the tricks of the posing trade, we naturally invited her to give us a private tutorial. When she arrived, our standard office setting suddenly came alive with the potential for major fashion moments. Not only did we learn how to get fierce in a bathroom stall, but also how to emote while doing it.
First Look: Koto Bolofo Examines the World of Hermès in La Maison
It’s rare for anyone to get a glimpse of the elusive world of Hermès, but fashion photographer Koto Bolofo got unlimited access to the secretive workshops of the venerable French label for his newly released book series, La Maison. Published by Steidl, the series is comprised of eleven volumes, each exploring a different facet of the brand’s history, from its ready-to-wear collections to its iconic Kelly bag.
Meet the New Girl: Ollie Henderson Thinks She Reads Too Much Philosophy
Australian model Ollie Henderson is not afraid to have a personality — something models are often told is important just as often as they’re made afraid to be themselves. A close friend to fellow models Rachel Rutt and Myf Shepherd, Henderson was discovered as a sophomore in high school while shopping in her native Melbourne.
Asian Games: Regalado keeps gold medal bid alive in pencak silat
Filipino Cherry May Regalado earned a shot at a gold medal after qualifying to the final stage of the women’s single pencak silat in the 2018 Asian Games Saturday in Jakarta, indonesia. Regalado reached the medal round after finishing tied in second with Vuong Thi Binh of Vietnam in Group A behind Tunee Vilaysack of Laos. The 23-year-old Regalado hopes to add to the Philippines’ gold medal count on Monday.
Tyra Banks Got a Cover
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Fourteen Famous Models on Their Breakout Gigs
Imagine you’re Helena Christensen, Karen Elson, or Coco Rocha. You’ve been on countless shoots for Vogue and posed for the best Parisian couture houses. What do you make of all those photo sessions with Steven Meisel and Karl Lagerfeld? We asked a handful of our favorite faces about some of the most memorable shoots of their careers, including the first time they stepped in front of the camera.
FOBO TIRE: World's First All Bluetooth Smart TPMS
This campaign has ended and will receive all funds raised. This campaign has ended and will receive all funds raised. Flexible Funding This campaign has ended and will receive all funds raised. This campaign started on Sep 01 and closed on October 23, 2014 (11:59pm PT). Comes with 4 tire sensors and 1 in-car unit. SAVE $59 OFF the $149 retail price * Add $20 for International Shipping (Product is shipped from Malaysia) * Tax not included Did you forget to add shipping to international orders?
Katie Baron Talks About Rachel Zoe, Edward Enninful, Katie Grand, and Her Book Stylists: New Fashion Visionaries
Rachel Zoe may be ubiquitous, but she’s not necessarily the epitome of high-fashion styling. Many stylists don’t dress celebrities for award shows; instead, they lend their creativity to high-fashion work where the goal is to challenge our notions of what outfits can be, rather than playing it safe. Former British Harper’s Bazaar bookings editor Katie Baron interviews many of those people for her forthcoming book, Stylists: New Fashion Visionaries (Laurence King, 2012).
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