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Articles by Jiaming Cao
Decoding the chemical space of fast-ion conductors via a descriptor-guided transfer learning framework
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Fast-ion conductors (FICs) are key components for next-generation high-performance batteries, yet predicting ion mobility remains challenging because of the unclear transport mechanisms.
Neural competition between prefrontal and auditory cortex constrains novel sound strategy learning
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In nature, animals learn to replace predisposed behaviors with new strategies, yet the neural constraints on these transitions are unclear.
A comprehensive and accessible database of jawed-vertebrate ohnologs
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Whole-genome duplications (WGDs) profoundly shaped early vertebrate evolution. The set of paralogs retained from these events—“ohnologs”—has had lasting impacts on genome structure and function, including disease gene enrichment.
On-chip waveguide-integrated light sources using MoS 2 /WSe 2 moiré superlattices on a silicon photonic platform
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Moiré superlattices have been widely explored as a unique platform for investigating exotic physics, but their potential applications in integrated photonics remain unexplored.
ZPY-CpG-Ch, a broad coverage vaccine against Streptococcus pneumoniae
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Existing licensed pneumococcal vaccines, including Prevnar-13 and its higher-valency successors, have played a major role in reducing invasive pneumococcal disease worldwide.
Periodic extreme rainfall in a warmer climate due to stronger convectively coupled waves
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Tropical regions may experience periodic extreme precipitation and suffer from associated periodic deluges in a warmer climate.
Start, speed, and direction of secondary forest succession
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Succession is a foundational concept in ecology, describing changes in populations, communities, and ecosystems over time following a disturbance. Predicting successional pathways is challenging because of high spatiotemporal variability.
Global distribution and amplitudes of internal solitary waves revealed by SWOT
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Internal solitary waves (ISWs) are powerful underwater disturbances that can vertically displace water by more than 200 meters, driving ocean mixing and affecting offshore engineering. Yet, their global distributions and vertical imprints remain poorly characterized.
Biomimetic hierarchical heterogeneity endows layered nanocomposite with excellent mechanical and electrical insulating properties
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Aramid-based nanopapers with high mechanical and electrical insulating properties, together with high-temperature stability, are urgently desired for electrical safety but are challenging to be constructed.
Ribosomal protein bL27 protects translating ribosomes from tmRNA-SmpB
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Bacterial ribosomal protein bL27 is universally conserved, and its amino terminus is adjacent to the peptidyl transfer center, yet its roles in translation remain unclear.
Interaction-driven flat band and charge order in Fe 5 GeTe 2
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Flat electronic bands enable fascinating emergent phenomena such as superconductivity and charge orders. A prevailing approach to realizing flat bands is to engineer lattice geometric constraints in twisted or kagome-like materials.
Monolithically integrating polarization-doped InGaN p-FET and GaN n-FET for complementary logic circuitry
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Low-efficiency p-type impurity doping has long impeded the practical adoption of wide-bandgap semiconductors in integrated circuits (ICs).
Transposable elements and homotypic niches drive immune dynamics and resistance in melanoma epigenetic-based immunotherapy
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Melanoma plasticity drives immune evasion and therapy resistance through dynamic cell-state transitions beyond genetic alterations. Although epigenetic remodeling is central to this process, its impact under therapeutic pressure remains unclear.
By Xin Yang, Jiaming Cao, Holly V. Moeller, Erika Ciervo, Francesco Ceccarelli, Piera Grisolia, Alessia Covre, Zein Mersini Besharat, Antonio De Falco, Francesca Caruso, Luigi Laezza, Luigi Ferraro, Gloria Martin, Daniel Bilbao, Sion Williams, Benjamin B. Currall, Maria Fortunata Lofiego, Elisabetta Ferretti, Yan Guo, Sean Holden, Ines Simeone, Roberta Mortarini, Andrea Anichini, Michele Maio, Tommaso Sani
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Ferroelectric control of the Mott insulator–topological metal transition
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments: Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Correlated and topological phases often coexist or compete in van der Waals materials, yet achieving an electrically switchable and reversible conversion between them remains a substantial challenge.
Uncovering PFAS and halogenated chemicals using nontargeted analysis and the PFAS IMplementer for mass spectrometry (PIMMS)
Abstract INTRODUCTION RESULTS AND DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Per- and polyfluoroalkyl substances (PFASs) are synthetic chemicals of considerable epidemiological concern.
Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments.
Two contrasting atmospheric circulation patterns linked to Kuroshio Extension variability
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The influence of Kuroshio Extension (KE) variability on North Pacific atmospheric circulation has been increasingly recognized in high-resolution observations and models.
Formation of tertiary lymphoid structures drives Parkin antitumor immunity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mitochondria activate immunity, but the role in cancer is unknown.
Structural insights into a substrate translocation pathway revealed by the RND efflux pump complex MexJK from Pseudomonas aeruginosa
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Resistance–nodulation–cell division (RND) efflux pumps are the major cause of multidrug resistance in Pseudomonas aeruginosa. The inner membrane protein MexK from P. aeruginosa is a narrow-spectrum RND transporter.
Optical isolation and circulation using quantum frequency conversion on a chip
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Breaking electromagnetic reciprocity enables directional control of light and is essential for both classical and quantum photonic systems.
Direct visualization of RNA virus and evaluation of drug effect in living cells by catalytically transformable DNA cube
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In situ visualization of viral RNA in living cells is critical for understanding infection dynamics and evaluating antiviral responses, yet offline methods such as polymerase chain reaction are incompatible with real-time analysis.
Glacier retreat shapes organic nutrient availability across lake succession
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Glacier retreat is rapidly transforming landscapes, creating thousands of new lakes that act as natural laboratories of ecological succession.
Erratum for the Research Article “Forecast attribution reveals enhanced heat mortality from climate change in British Columbia heatwave” by C.Y. Shapland et al .
Information & Authors Metrics & Citations View Options References Figures Tables Media Share There were errors in the originally published versions of the main text, Figs. 1, 4, and 5, and figs. S8 and S9 in the Research Article “Forecast attribution reveals enhanced heat mortality from climate change in British Columbia heatwave” by C.Y. Shapland et al.
Distributed burst firing mediates optimized cortical encoding of natural self-motion
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action.
Gaseous liquid nitrogen–assisted cryo-printing strategies for challenging volumetric anisotropic tissues fabrication
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Engineering physiologically relevant anisotropic tissues remains a major challenge due to limitations in replicating native structural cues across complex geometries.
The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Altered glucose metabolism is an auspicious feature of solid tumors, but is it an intrinsic property of tumor cells or a metabolic adaptation to the tumor microenvironment?
By Xin Yang, Jiaming Cao, Holly V. Moeller, Kevin Tharp, Sangwoo Park, Greg A. Timblin, Alicia Richards, Jordan Berg, Nicholas Twells, Nicholas Riley, Kyle Patrick Alvarez, Allen Lee, D. Judy Shon, Erica Stevenson, Francesco Palomba, Nadia M.E. Ayad, Johanna ten Hoeve, Kevin Healy, Michelle A. Digman, Egan L. Peltan, Kimberly Tsui, Austin E. Y. T. Lefebvre, Ross W. Soens, Jaya L. Thangaraj, Joseph A. Rhodenhiser
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Submillennial timescales of eruptible rhyolite magma: Converging evidence from Aira Caldera, Japan
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Recent studies debate whether caldera-forming silicic magma is primarily stored in a crystal-poor, eruptible state for >100,000 years (kyr) (“warm storage”) or exists as a crystal-rich “mush” with defrosting events causing brief periods (<1 kyr) of eruptibility (“cold storage”).
Environmental tuning of thyroid hormone signaling drives developmental plasticity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Vertebrate developmental transitions unfold in environments increasingly altered by global change.
T cell–nanodrug conjugates synchronize vascular normalization and immune activation for solid tumor therapy
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Adoptive T cell therapy requires T cells to infiltrate vascular tissues and preserve immune function. In solid tumor treatment, however, the surrounding microenvironment produces abnormal vasculature that impedes T cell infiltration.
Deep learning reveals a neurocomputational mechanism predicting depression risk in adolescents
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Early detection and prevention of psychiatric disorders, particularly depression, remain as major global health challenges, yet reliable tools for identifying individuals before symptom onset are lacking.
By Xin Yang, Jiaming Cao, Holly V. Moeller, Han Lu, Xiaoqian Yan, Benjamin Becker, Andreas Heinz, Barbara Sahakian, Christelle Langley, Luolong Cao, Zuo Zhang, Lauren Robinson, Nilakshi Vaidya, Jeanne M Winterer, Sinead King, Charlotte Walton, Tobias Banaschewski, Gareth Barker, Arun Bokde, Rüdiger Brühl, Herta Flor, Hugh Garavan, Penny Gowland, Antoine Grigis, Zhaoyu Zuo
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Experimental violation of a Bell-like causal inequality in a photonic quantum switch
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Indefinite causal order can be realized by a quantum switch, yet its experimental certification has so far relied on assumptions about the devices.
APOE + macrophages and POSTN + CAFs form immune-exclusion niche driving immunotherapy resistance in clear-cell renal carcinoma
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Tumor immune barriers (TIBs) are spatially organized stromal-immune niches that restrict lymphocyte entry.
MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The molecular mechanisms by which KMT2A-rearranged (KMT2A-r) leukemias maintain the oncogenic FLT3 expression remain largely unclear, limiting therapeutic opportunities.
Continuous contributions of the dorsolateral striatum to movement initiation and execution
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Spikes in the dorsolateral striatum (DLS) of the basal ganglia (BG) correlate with forelimb and whole-body movements, but the extent to which they contribute to movement remains unclear.
TRIM29-dependent AKR1B10 degradation ameliorates MASH
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Metabolic dysfunction–associated steatohepatitis (MASH) is a prevalent and life-threatening liver disease with limited effective therapies, necessitating the urgent identification of previously unidentified molecular targets and effective pharmacologic agents.
3D genome organization in tissue regeneration involves long-range chromatin loops
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The three-dimensional (3D) organization of the genome plays a fundamental role in gene expression regulation, yet how changes in genome architecture influence transcriptional responses during tissue regeneration remains poorly understood.
Tunable dislocations overcome mechano-functional tradeoff in perovskite oxides
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Recent advancements in dislocation engineering are reshaping the traditional view towards ceramics being brittle.
Language-like statistical structure arises in learned signaling: evidence from birdsong
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract All languages have statistically coherent subsequences (e.g., words) whose frequency distribution follows a power law.
High-resolution mapping of embryonic genome activation unveils a decoupling of transcription activation from precocious H3K4me3 removal
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The lack of temporal resolution in transcriptomic data during mammalian embryonic genome activation (EGA) has precluded the comprehensive understanding of the functional relationships between the various gene regulatory mechanisms governing this process.
Emergent metabolic parasitism driven by organelle sequestration
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Stable acquisitions of metabolism, such as the endosymbiotic incorporation of eukaryotic chloroplasts, are thought to proceed through mechanisms that increase the genetic repertoire of the host and allow for vertical integration of new metabolism.
Higher-order trade-offs in hypergraph community detection
Abstract INTRODUCTION COMMUNITY DETECTION AND DETECTABILITY LIMITS FOR HYPERGRAPHS GENERALIZED DETECTABILITY LIMITS FOR HYPERGRAPH COMMUNITY STRUCTURE ADDITIONAL TRADE-OFFS FOR DETECTING HYPERGRAPH COMMUNITY STRUCTURE EXPERIMENTS ON EMPIRICAL DATA DISCUSSION Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Extending community detection from pairwise networks to hypergraphs introduces...
Capsid stabilization reprograms the nuclear fate of the HIV genome
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Capsid stabilization, induced by low-nanomolar concentrations of Lenacapavir (LEN)—a first-in-class capsid inhibitor—impedes HIV-1 replication in macrophages without disrupting reverse transcription or nuclear import.
By Xin Yang, Jiaming Cao, Holly V. Moeller, Thierry Mourer, Mohamad Harastani, Celine Cuche, Stephane Tachon, Guillaume Corre, Maria Julia Maristany, Jean-Yves Tinevez, Anastasia D. Gazi, Valentina Poletti, Rosana Collepardo-Guevara, Anna Sartori-Rupp, Francesca Di Nunzio, Jose Ignacio Perez-Lopez, Salvatore Tornambe
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Periodic extreme rainfall in a warmer climate due to stronger convectively coupled waves
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Tropical regions may experience periodic extreme precipitation and suffer from associated periodic deluges in a warmer climate.
Intermediate stages in the origin of metabolism at a phosphorylating hydrothermal vent
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Abstract INTRODUCTION RESULTS AND DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The origin of life required the emergence of metabolism, an autocatalytic network of enzymatic reactions that synthesize amino acids, nucleotides, and cofactors. At the origin of metabolism, there were no enzymes—how did it start?
By Xin Yang, Jiaming Cao, Holly V. Moeller, Natalia Mrnjavac, Nadja Hoffmann, Loraine Schwander, Carolina Garcia Verified, Mike Steel, Daniel H. Huson, Sabine Metzger, Quentin Dherbassy, Bernhard Schink, Mirko Basen, Joseph Moran, Harun Tüysüz, Martina Preiner, William Martin, Manon L. Schlikker, Maximilian Burmeister, Max Brabender
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Mastering Complexity toward High-Performance Multi-Principal Element Alloy-Based Films and Coatings: A Review on Microstructural Regulation and Property Optimization
1 Introduction High-performance metallic materials are the backbone of modern engineering, underpinning critical advancements in transportation, aerospace, energy, mining, and advanced manufacturing. As industries push the boundaries of performance and durability, the demand for metals that achieve exceptional strength and ductility/toughness has never been greater.
Efficacy of Weight‐Lowering Agents on Fat Distribution: A Systematic Review and Network Meta‐Analysis of Randomized Controlled Trials
1 Introduction According to World Health Organization estimates, worldwide, 39% of adults are overweight, and 13% are obese [1], with prevalence rising to over 40% in certain regions [2]. Obesity and overweight are major worldwide health concerns [3] that are linked to a broad spectrum of ailments, including type 2 diabetes (T2DM) and cardiovascular diseases [4, 5]. The hallmark of T2DM, apart from obesity and atherosclerosis, is insulin resistance.
A lipid atlas of the human kidney
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Tissue atlases provide foundational knowledge on the cellular organization and molecular distributions across molecular classes and spatial scales.
By Xin Yang, Jiaming Cao, Holly V. Moeller, Melissa Farrow, Leonore Tideman, Elizabeth Neumann, Lukasz G. Migas, Nathan Patterson, Madeline E. Colley, Jamie Allen, Ellie L. Pingry, Martin Dufresne, Haichun Yang, Maya Brewer, Emilio Rivera, Carrie E. Romer, Katerina Djambazova, Kavya Sharman, Angela Kruse, Danielle Gutierrez, Raymond Harris, Agnes B. Fogo, Richard M. Caprioli, Mark P. de Caestecker, Raf Van de Plas
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Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus M Pro inhibitors with potent in vivo efficacy
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The main protease (MPro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a validated drug target.
By Xin Yang, Jiaming Cao, Holly V. Moeller, Tyler C. Detomasi, Gilles Degotte, Sijie Huang, Rahul Suryawanshi, Amy Diallo, Luca Lizzadro, Francisco J. Zapatero-Belinchon, Jiapeng Li, Alicia Richards, Eric R. Hantz, Zain Alam, Mauricio Montano, Maria McCavitt-Malvido, Rajesh Gumpena, James Partridge, Galen J. Correy, Yusuke Matsui, Annemarie F. Charvat, Jezrael Revalde, Julia Rosecrans, Dashiell Anderson
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Single-cell analysis reveals Mycobacterium tuberculosis ESX-1–mediated accumulation of permissive macrophages in infected mouse lungs
Abstract INTRODUCTION RESULTS DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mycobacterium tuberculosis (MTB) ESX-1, a type VII secretion system, is a key virulence determinant contributing to MTB’s survival within lung mononuclear phagocytes (MNPs), but its effect on MNP recruitment and differentiation remains unknown.
Biomolecules | Free Full-Text | Novel Angiotensin-Converting Enzyme-Inhibitory Peptides Obtained from Trichiurus lepturus: Preparation, Identification and Potential Antihypertensive Mechanism
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