Jun Lin
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Articles by Jun Lin
GENIE: a multi-agent system for closed-loop autonomous microscopy
Abstract Microscopy is foundational to biology, enabling direct observation of otherwise inaccessible cellular structures and processes. Artificial intelligence has advanced microscopy through acquisition control, image analysis, and natural language instrument operation. No system has unified these steps into a complete experimental loop.
A nuclear clock synchronized to 229 Th
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Abstract Atomic clocks have made time and frequency the most precisely measured quantities in physics, progressing from microwave standards that realize the SI second1 to optical clocks with unprecedented precision2.
By Beichen Huang, Gaowei Yan, Qi Xiao, Wenhao Bu, Chengchun Zhao, Zhen Zhang, Zhi-Ang Chen, Peixiong Zhang, Gleb Penyazkov, Zhenhai Zhan, Lingfeng Yan, Yuefei Wang, Lin Li, Shanming Li, Dapeng Jiang, Xiaobo Qian, Xuegang Liu, Qiange He, Taoxiang Sun, Haochen Tian, Bingkun Lu, Ningyuan Ma, Juxian Li, Yanzhang Wu, Qiaorui Gong, Yuxiang Li, Haoyu Shi, Xiangliang Li, Longsheng Ma, Shining Zhu, Yuxiang Mo, Jun Lin, Yige Lin, Xibo Zhang, Yin Hang, Liangbi Su, Shiqian Ding
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Nature
Verified
Fatigue Failure Mechanism of Low-Frequency Vibration-Assisted Self-Piercing Riveted CFRP/Aluminum Structures
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, , and , “Past, Present and Future Prospective of Global Carbon Fibre Composite Developments and Applications,” Composites Part B-Engineering 250 (2023): 110463, https://doi.org/10.1016/j.compositesb.2022.110463.
Visible-Light-Mediated Hydro-Pentafluoroethylation of Terminal Alkenes With Chloropentafluoroethane
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description ejoc70872-sup-0001-SuppData-S1.pdf3.7 MB Supporting Information for this article is available online.
Multivariate approach of metal-chiral covalent organic frameworks for leaching-resistant asymmetric transfer hydrogenation
Abstract Achieving precise integration of chiral microenvironments and catalytic metals in covalent organic frameworks (COFs) remains a formidable challenge, often resulting in amorphous materials with poor stability and metal leaching. Here, we introduce a modular multivariate approach strategy coupled with post-synthetic metalation to engineer metal-chiral COFs (MCCOFs) with tunable crystallinity, porosity, and stereocontrol.
MASP1‑METTL3‑HAS2 axis aggravates liver fibrosis through HMW‑HA‑mediated senescence inhibition and LMW‑HA‑induced activation of hepatic stellate cells
Abstract The hepatic microenvironment undergoes dynamic remodelling in advanced liver fibrosis. Hyaluronic acid (HA), a key component of this fibrotic microenvironment, plays a key role in disease progression. While cellular senescence is one of the fates that activated HSCs undergo and is associated with fibrosis resolution, the relationship between HA and HSC senescence in advanced liver fibrosis remains unclear.
Splenic infarction after endoscopic glue injection for gastric varices: proportion, exploratory correlates, and clinical outcomes from a propensity score-matched analysis
Abstract Background and aim: Splenic infarction after endoscopic cyanoacrylate injection for gastric varices (GV) is poorly characterized. We estimated its proportion among computed tomography (CT)-evaluable patients and explored clinical features and short-term outcomes. Methods: We retrospectively screened 255 adult patients undergoing endoscopic glue injection for GV between January 2018 and February 2025.
Continuous care based on hierarchical nursing for cirrhosis rehabilitation: a retrospective cohort study
Abstract Objective: Cirrhosis is a progressive chronic liver disease characterized by extensive hepatic fibrosis, portal hypertension, and liver failure. This study aimed to evaluate the associations of continuous care based on hierarchical nursing with the rehabilitation and quality of life of patients with liver cirrhosis. Methods: In this retrospective cohort study, we reviewed the records of 115 patients with liver cirrhosis.
Radical Innovation Validation: Delivering Value in Radical Innovation Development
1 Introduction The advent of novel digital technologies and intelligent solutions has profoundly transformed the competitive landscape, disrupting conventional industry logic (El Samra et al. 2024). To survive and thrive, companies must embrace radical innovation (RI) and prioritize it as a fundamental element of their innovation strategy, with significant transformations to their operations (Colombo et al. 2017; Yang et al. 2025).
A microbial metabolite inhibits the HIF-2 α -ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH
Main text (Cell Metabolism 36, 1823–1838.e1–e6; August 6, 2024) In the original version of the article, we identified several data-processing errors during a routine review of the data associated with the published article. Specifically, copy-paste errors were found in the control and ATM groups in Figure 2R, the TRF+Abx group in Figure S1K, the Control+Abx group in Figures S1O and S1P, and the LV-HIF-2α+Rt group in Figure S3Y.
Копирование сделок торгового сигнала Forex Tree для MetaTrader 4
Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 272 Прибыльных трейдов: 234 (86.02%) Убыточных трейдов: 38 (13.97%) Лучший трейд: 64.16 USD Худший трейд: -34.24 USD Общая прибыль: 492.26 USD (23 071 pips) Общий убыток: -214.14 USD (11 304 pips) Макс. серия выигрышей: 23 (16.95 USD) Макс. прибыль в серии: 208.45 USD (9) Коэффициент Шарпа: 0.15 Торговая активность: n/a Макс.
Serum creatinine to cystatin C ratio and risk of incident digestive diseases in middle-aged and older adults: a prospective national cohort study
Abstract Evidence regarding the association between the serum creatinine–to–cystatin C ratio (CCR) and digestive disease risk remains limited. This study examined whether CCR is associated with incident digestive diseases among middle-aged and older adults in China. This prospective cohort study included 5,234 participants from the China Health and Retirement Longitudinal Study (CHARLS). CCR was calculated as serum creatinine divided by cystatin C.
Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities
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Abstract Understanding the complex cellular and spatial organization of glioblastoma (GBM) and its microenvironment is crucial for improving diagnosis and treatment. Here we integrated 121 spatial transcriptomics, single-cell RNA sequencing, single-cell assay for transposase-accessible chromatin using sequencing and patch sequencing profiles from 100 patients to characterize primary GBM tissue.
By Jun Lin, Chunpeng Chen, Shouzhen Li, Liu Chen Verified, Minghao Fang, Shuqi Fu, Kaixing Chen, Hao Xu, Chen Jiang, Meifang Tang, Zitian Liu, Shuyan Wang, Ke Liu, Chaoshi Niu, Xu Liu, Chuandong Cheng, Ai-Hui Tang, Kun Qu, Fenghuan Zhang, Rirui Wang
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Nature
Verified
A Novel CT Habitat Radiomics Approach for HER2 Status Prediction in Gastric Cancer
Abbreviations AUC (area under the receiver operating characteristic curve) BMI (body mass index) CI (confidence intervals) cT (CT-detected T stage) cN (CT-detected N stage) DCA (decision curve analysis) GC (Gastric cancer) HER2 (human epidermal growth factor receptor 2) ex-vad (external validation) SHAP (SHapley Additive exPlanations) Radscore (radiomics score) ROC (receiver operating characteristic) ROI (regions of interest) IHC (immunohistochemistry) FISH (fluorescence in situ...
Nlrp12-driven PANoptosis exacerbates liver injury in ConA-induced autoimmune hepatitis - Genes & Immunity
Abstract Autoimmune hepatitis (AIH) involves chronic liver injury from abnormal immune responses, leading to hepatocyte death and inflammation. Currently, the role of pyroptosis in AIH has not been fully elucidated. Emerging evidence indicates that Nlrp12, a cytosolic sensor of damage-associated molecular patterns (DAMPs), participates in inflammasome assembly and pyroptotic signalling. Therefore, this study aims to investigate the role of Nlrp12 in AIH.
Predictors of pathological upstaging to pT3a after nephrectomy for cT1 renal tumors: a systematic review and meta-analysis
Abstract Background: The potential predictors and clinical implications of postoperative pathological upstaging in patients with clinical stage T1 (cT1) renal cell carcinoma (RCC) remain insufficiently characterized. Methods: This systematic review was performed in accordance with the PRISMA guidelines. Databases including PubMed, Web of Science and Embase databases were searched.
One-Pot Cyclocondensation Approach to Form 4-Amino-2-Pyridones via Ammonium Acetate as a Nitrogen Source
Cite Jump to ExpandCollapse NoteDecember 3, 2025 One-Pot Cyclocondensation Approach to Form 4-Amino-2-Pyridones via Ammonium Acetate as a Nitrogen Source Click to copy article linkArticle link copied! Safomuddin Abduahadi Safomuddin Abduahadi State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, P. R. China University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R.
One-Pot Cyclocondensation Approach to Form 4-Amino-2-Pyridones via Ammonium Acetate as a Nitrogen Source
The Journal of Organic Chemistry Cite this: J. Org. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Счет История сделок Статистика Риски Проскальзывание Описание Отзывы Новости Авторизуйтесь или зарегистрируйтесь и получите доступ к текущим сделкам поставщика Средства Просадка Всего трейдов: 6 Прибыльных трейдов: 6 (100.00%) Убыточных трейдов: 0 (0.00%) Лучший трейд: 3.51 USD Худший трейд: 0.00 USD Общая прибыль: 8.77 USD (890 pips) Общий убыток: -0.18 USD Макс. серия выигрышей: 6 (8.77 USD) Макс. прибыль в серии: 8.77 USD (6) Коэффициент Шарпа: 1.38 Торговая активность: n/a Макс.
Risk of major adverse cardiovascular events among traditional Chinese medicine users: a cohort study with a subgroup analysis of male patients with sexual dysfunction
Ayuda Buscar en la ayuda Buscar en la ayuda Risk of major adverse cardiovascular events among traditional Chinese medicine users: a cohort study with a subgroup analysis of male patients with sexual dysfunction Wen-Chieh Yang [1] ; Heng-Jun Lin [2] [1] 1Department of Traditional Chinese Medicine, Taipei Veterans General Hospital Hsinchu Branch, 310403 Hsinchu, Taiwan [2] 2Management Office for Health Data, Clinical Trial Research Center, China Medical University Hospital, 404333 Taichung,...
Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression
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1Department of Endocrinology and Metabolism, State Key Laboratory of Female Fertility Promotion, Cancer Center, Beijing Key Laboratory for Interdisciplinary Research in Gastrointestinal Oncology (BLGO), Peking University Third Hospital, Beijing 100191, China 2Department of General Surgery, Peking University Third Hospital, Beijing 100191, China 3Institute of Advanced Clinical Medicine, Peking University, Beijing 100191, China 4Cancer Innovation Laboratory, Center for Cancer Research, National...
By Ruize Qu, Yi Zhang, Bora Kim, Pengcheng Wang, Weike Shaoyong, Ying Huang, Wanwan Guo, Yang Chen, Ping Wang, Qing Yang, Siyi Lu, Xin Zhou, Jing Yi Weng, Jinkun Xu, Jun Lin, Kai Wang, Yanpeng Ma, Shogo Takahashi, Yuhong Luo, Xiaoting Yu, Kristopher W. Krausz, Tianpei Hong, Zhipeng Zhang, Wei Fu, Frank Gonzalez, Lulu Sun, Guangyi Zeng, Guangyi Zeng
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Cell Metabolism
Verified
Zn Lattice Site-Dependent Emission of Sb3+-Doped (ETBT)2ZnBr4 Organic–Inorganic Halide Perovskite for Tunable Lighting and Night-Vision Applications
Introduction Click to copy section linkSection link copied! Organic–inorganic halide perovskite crystals (OIHPCs) have garnered significant attention in the field of materials science due to their exceptional optoelectronic properties and versatile applications.
Mediating Role of Nurses' Perceived Professional Benefits Between ICU Nurses' Emotional Intelligence and Spiritual Care Competency: A Multicentre Cross‐Sectional Study
• , , , , , and . . “ The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies .” Annals of Internal Medicine , no. : – . https://doi.org/10.7326/0003-4819-147-8-200,710,160-00010. • , , , and . . “ The Effect of Perceived Professional Benefits on Health Professionals' Job Engagement: The Role of Psychological Availability and Future Perceived Professional Benefits .” BMC Health Services Research , no. : .
Temporal Enhancement of Top-N Recommendation on Heterogeneous Graphs
1. Introduction Recommender systems, especially top-N recommender systems, play a key role in our daily life [1]. Traditional models of recommender systems recommend interest items to different users based on historical feedback information [2,3] based on methods such as collaborative filtering [2]. Recently, more and more auxiliary data have also been applied in recommender systems for improving their performance [4,5].
Injectable bioadhesive and lubricating hydrogel with polyphenol mediated single atom nanozyme for rheumatoid arthritis therapy - Nature Communications
Abstract Rheumatoid arthritis (RA) is a common chronic autoimmune condition accompanied by lubrication dysfunction, inflammatory infiltration, and cartilage wear. Long-term improvements in joint lubrication, inflammation elimination, and worn cartilage repair are crucial for effective RA treatment.
Chemical interaction and compatibility of uranium mononitride and alumina forming austenitic stainless steel
The lead cooled fast reactor (LFR) is one of the generation IV nuclear reactors currently under development by Westinghouse in the United States (Westinghouse LFR) and by NIKIET in Russia (BREST-OD-300) [1,2]. Uranium dioxide (UO ) has been selected as the prototype fuel for Westinghouse's LFR, while final fuel selection is still ongoing [2].
MX precipitate behavior in an irradiated advanced Fe-9Cr steel: Helium sequestration and cavity swelling performance
Reduced activation ferritic/martensitic (RAFM) steels are able to achieve superior mechanical properties and reduced radioactivity during operation for fusion applications [1]. An important microstructural feature in RAFM steels is MX precipitates (M=metal, X=C/N), which is produced in the microstructure through compositional tailoring and thermomechanical treatment (TMT) as a means to improve high temperature mechanical properties [1,2].
Short communication: Characterization of Mo-rich precipitates in δ-ferrite of thermally aged Mo-bearing cast austenitic stainless steel
Long-term operation of cast austenitic stainless steels (CASSs) at high temperatures in nuclear power plants results in embrittlement due to δ-ferrite hardening from nanoscale precipitates, with Mo addition further accelerating the embrittlement through enhanced spinodal decomposition and G-phase precipitation. Meanwhile, the formation of distinct Mo-rich precipitates in δ-ferrite during thermal aging are occasionally reported, but they were not clearly characterized.
Inhibitory effect on endometrial cancer: Collagen type XII α1 chain
CCK-8: Cell counting kit-8 CD86/68: Cluster of differentiation 86/68 COL12A1: Collagen type XII α1 chain DMEM: High-glucose Dulbecco’s modified eagle medium EC: Endometrial cancer ECM: Extracellular matrix EMT: Epithelial-mesenchymal transformation GAPDH: Glyceraldehyde- 3-phosphate dehydrogenase HESCs: Human endometrial mesenchymal stromal cells IFN-γ: Interferon-gamma IL: Interleukin LPS: Lipopolysaccharides PMA: Phorbol 12-myristate 13-acetate TAMs: Tumor-associated macrophages
Fully Automatic Surface Defect Detection of CFRP Using Computer Vision and an Augmented YOLOv8 Model
This website uses cookies to ensure you get the best experience on our website. Learn more Skip to main content Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement All data, models, or code generated or used during the study are available from the corresponding author by request. Keyu Chen: Methodology; Writing–original draft. Jun Lin: Methodology; Writing–original draft.
Privacy-Preserving Hierarchical Top-k Nearest Keyword Search on Graphs
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Effect of different UV absorbers on the aging performance of poly (butylene adipate‐co‐terephthalate)/poly (propylene carbonate) degradable mulch films
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES 1, , , , , . Development trend analysis of plastic mulching film based on bibliometric analysis. J China Agricultural Univ. 2020; 25(9): 90-103. doi:10.11841/j.issn.1007-4333.2020.09.10 2, , , et al.
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH
In the original Figure 6K, an erroneous version of the representative image of the Sirius Red-stained slice for the Rt-treated group was inadvertently included during the assembly process. This has now been corrected online. This error has no impact on the main results or conclusions of the publication. The authors apologize for this error and any confusion it may have caused.
Determination of threshold of asphalt pavement structure crack damage rate to quantify the severity of structural crack damage
ABSTRACT Cracks in asphalt pavement are typically identified by analyzing electromagnetic or mechanical wave propagation. Validation is done by examining core samples obtained through drilling. This study proposes a threshold based on the structure crack damage rate (SCDR) collected by ground-penetrating radar (GPR) to quantify the severity of structure cracks. The Fuzzy c-means (FCM) algorithm categorises SCDR into different severity levels.
Great Gerbils (Rhombomys opimus) in Central Asia Are Spreading to Higher Latitudes and Altitudes
1 Introduction Global changes, represented by climate change, have profound impacts on ecosystem stability and species richness aspects (Fei et al. 2017). As global warming intensifies, climate change poses severe challenges to the survival of flora and fauna (Mori, Furukawa, and Sasaki 2013; Weiskopf et al. 2020). These challenges are evident in population fluctuations (Dullinger et al. 2012; Wan et al. 2022), habitat alterations (An et al. 2023; Niskanen et al.
Optimized psilocybin production in tryptophan catabolism‐repressed fungi
INTRODUCTION Psilocybin, a mushroom indolylethylamine alkaloid, represents the chemically stable prodrug of the psychotropic 4-dephosphoryl analog psilocin (Hofmann et al., 1959). The latter is structurally related to serotonin and acts as a partial agonist of the human serotonin receptor 2B (5-HT2B) (Fricke et al., 2019).
Whole genome analysis of Paenibacillus campinasensis from blood of a h
Introduction Paenibacillus campinasensis (P. campinasensis) is a Gram-variable bacillus, first isolated from soil in Brazil by Yoon et al in 1998.1 Since its discovery, it has been generally utilized in the industrial production of β-cyclodextrin glucanosyltransferase, xylanase, and cellulase.1–3 There is only one report of its isolation from the prostatic fluid of a patient with chronic prostatitis, with no literature on clinical infections caused by P. campinasensis.4 Table 1 P.
A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH
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A microbial metabolite inhibits the HIF-2α-ceramide pathway to mediate the beneficial effects of time-restricted feeding on MASH
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China Center for Obesity and Metabolic Disease Research, School of Basic Medical Sciences, Peking University, Beijing, China Department of Immunology, School of Basic Medical Sciences, State Key Laboratory of Female Fertility Promotion, Peking University, Beijing, China NHC Key Laboratory of Medical Immunology, Peking...
Thermomechanical bending of functionally graded carbon nanotubes reinforced composite plate by meshless method
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1. Helical microtubules of graphitic carbon. Nature. 1991; 354: 56-58. doi:10.1038/354056a0 2, , , . Dynamic buckling optimization of laminated aircraft conical shells with hybrid nanocomposite martial. Aerosp Sci Technol. 2020; 98:105656. doi:10.1016/j.ast.2019.105656 3, , . Dynamic analysis in beam element of wave-piercing catamarans undergoing slamming load based on mathematical modelling. Ocean Eng. 2021; 234:109269.
Rotation Culture of Macroalgae Based on Photosynthetic Physiological Characteristics of Algae
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Nanosponge for Iron Chelation and Efflux: A Ferroptosis‐Inhibiting Approach for Myocardial Infarction Therapy
1 Introduction Ischemic heart disease (IHD), particularly myocardial infarction (MI), is the leading cause of mortality globally.[1] During cardiac ischemia, the death of cardiomyocytes and their replacement by fibroblasts contribute to irreversible cardiac damage and impaired heart ejection function.[2] Imbalanced iron homeostasis plays a significant pathophysiological role in this process.
Structural Damage Detection Based on the Correlation of Variational Autoencoder Neural Networks Using Limited Sensors
1. Introduction Scholars across diverse disciplines have extensively researched and experimentally validated damage identification methods for Structural Health Monitoring (SHM) [1]. Bridge SHM is fundamentally about identifying, detecting, and diagnosing the true structural condition, which is crucial for research in structural damage detection and identification [2].
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