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Articles by Kan Wu
Algorogenic thumbprints in literary translation: an epistemic network analysis of LLM translations of classical Chinese fantasy
Abstract This study examines algorogenic thumbprints in literary translation, referring to recurrent and reproducible stylistic patterns in large language model (LLM) outputs.
The impact of the global budget payment on healthcare fund expenditure in integrated delivery systems: evidence from China’s county-level medical alliance reform
Abstract Background: The global budget payment is a key policy tool for incentivizing integrated healthcare delivery systems to pursue financial sustainability. However, there is little empirical evidence showing its effects. This study evaluates the impact of the health insurance global budget payment reform implemented under China’s county-level integrated healthcare consortium model on the efficiency of health insurance fund expenditure.
Sonic Hedgehog-Gli1 signaling promotes microglial activation via the IKKβ/NF-κB pathway
Abstract The Sonic Hedgehog (Shh)–Gli1 signaling axis is essential for neuronal development, cell proliferation and homeostasis. However, its roles in microglial activation and neuroinflammation remain poorly defined. Here, we report that Shh is expressed in neurons and astrocytes and is markedly upregulated in the substantia nigra of MPTP-challenged Parkinson’s disease (PD) mouse models.
Digital Transformation and Sustainable Production in BRICS: Economic, Innovation and Clean-Energy Drivers of ICT-Enabled Growth
References , , , and . 2024. “Explaining the Environmental Efficiency Capability of Energy Mix Innovation Among the Nordic Countries.” Energy Reports 11: 233–239. https://doi.org/10.1016/j.egyr.2023.11.051. , , and . 2019. “Dynamic Impact of Trade Policy, Economic Growth, Fertility Rate, Renewable and Non-Renewable Energy Consumption on Ecological Footprint in Europe.” Science of the Total Environment 685: 702–709. https://doi.org/10.1016/j.scitotenv.2019.05.139. , and . 2023.
Digital Transformation and Sustainable Production in BRICS: Economic, Innovation and Clean‐Energy Drivers of ICT‐Enabled Growth
References , , , and . 2024. “Explaining the Environmental Efficiency Capability of Energy Mix Innovation Among the Nordic Countries.” Energy Reports 11: 233–239. https://doi.org/10.1016/j.egyr.2023.11.051. , , and . 2019. “Dynamic Impact of Trade Policy, Economic Growth, Fertility Rate, Renewable and Non-Renewable Energy Consumption on Ecological Footprint in Europe.” Science of the Total Environment 685: 702–709. https://doi.org/10.1016/j.scitotenv.2019.05.139. , and . 2023.
Empowering sustainable development: green growth, digital economy, and gender equality in education to address energy poverty
Advanced search International Journal of Sustainable Development & World Ecology Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/13504509.2025.2598394?needAccess=true ABSTRACT This study investigates the relationships among energy poverty, green growth, the digital economy, and gender equality in education, with a focus on the Renewable Energy Country Attractiveness Index...
Economic Determinants of Renewable Energy Consumption in China: Integrating Green Infrastructure, Urban Agglomeration, and Environmental Stressors
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The authors have nothing to report. References 2017. “A Note on the Limit Theory of a Dickey–Fuller Unit Root Test With Heavy Tailed Innovations.” Statistics & Probability Letters 126: 198–204. https://doi.org/10.1016/j.spl.2017.02.032. , , , et al. 2025.
Tunable terahertz signal generation based on an on-chip wideband electro-optic frequency comb
We demonstrate a low-noise, tunable terahertz (THz) source based on an electro-optic frequency comb. In this approach, the lithium niobate electro-optic comb serves as the master laser, and two distributed feedback (DFB) lasers serve as slave lasers. Through master–slave injection locking, selected coherent comb lines are preserved and amplified, and the resulting THz signal is generated via down-conversion.
A rare Zinner syndrome combined with testicular cancer: a case report
Introduction Zinner syndrome is a rare male urogenital malformation resulting from abnormal early embryonic development. Zinner first reported this disease in 1914 (1). This syndrome is typically characterized by seminal vesicle cysts, ejaculatory duct obstruction, and absence of the ipsilateral kidney. For this reason, patients may experience multiple symptoms such as difficulty urinating, frequent urination, painful ejaculation, epididymitis, and infertility.
When martial artists speak: A stylometric analysis of orality features in English translations of Wuxia fiction
This study employs stylometric analysis to investigate orality features in English translations of Chinese Wuxia fiction. Analyzing eight commercially published Wuxia translations, the study identified significant variations in orality features between works translated in the 1990s/2000s and those in the 2010s/2020s. These differences are primarily influenced by translators’ professional habitus and motivations, as well as publishers’ marketing strategies.
Platicons in lithium niobate microresonators with the photorefractive effect
Platicon microcombs have been demonstrated on various material platforms, offering wide spectral bandwidth, excellent spectral flatness, and efficient power conversion, which are of interest for numerous applications. Lithium niobate (LN) with its Pockels and Kerr effects has become a promising platform for both generating and controlling microcombs. The photorefractive (PR) effect intrinsic to LN significantly influences the dynamics of Kerr frequency comb generation in microresonators.
Ultra‐Flat Broadband Low‐Noise Frequency Comb in a Fiber Fabry‐Perot Resonator
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description lpor202400180-sup-0001-SuppMat.docx1 MB Supporting Information lpor202400180-sup-0002-GIF1.gif807.6 KB Supporting Information lpor202400180-sup-0003-GIF2.gif788.4 KB Supporting Information References 1, , , , , , Nat. Photonics 2010, 4, 471. 2, , , , , , , Nat. Photonics 2013, 8, 145. 3, , , , , Nat. Photonics 2021, 15, 536. 4, , , , , , Opt. Lett. 2021, 46, 512. 5, , , , , Optica 2021, 8, 861.
Stochastic Multi-Objective Multi-Trip AMR Routing Problem with Time Windows
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Construction of High-Precision and Complete Images of a Subsidence Basin in Sand Dune Mining Areas by InSAR-UAV-LiDAR Heterogeneous Data Integration
1. Introduction Characterized by a shallow burial depth, thick coal seam, low hardness of surrounding rock, thick sandy soil-cap, etc., a coal mine in a sand dune area can easily induce different scales of deformation during the processes of large-scale and high-intensity mining.
Monolithic tunable dual-wavelength laser utilizing erbium-doped lithium niobate on an insulator
We demonstrate a monolithic tunable dual-wavelength laser fabricated on erbium-doped lithium niobate on an insulator (Er:LNOI). The dual-wavelength laser enables independent tuning with a continuously linear electro-optic (EO)-modulated tuning range of 11.875 GHz at a tuning efficiency of 0.63 pm/V. Tunable microwave generation within 50 GHz with a maximum extinction ratio of 35 dB is experimentally demonstrated by further exploring the charge accumulation effect in LNOI.
Impact of Drug-Linker on Method Selection for Analytical Characterization and Purification of Antibody-Drug Conjugates
Impact of Drug-Linker on Method Selection for Analytical Characterization and Purification of Antibody-Drug Conjugates In addition to traditional characterization methods of hydrophobic interaction (HIC) and reverse phase (RP) chromatography, an anion exchange chromatography (AIEX) was developed to analyze and purify antibody drug conjugates (ADCs).
Topic-Specific Political Stance Inference in Social Networks With Case Studies
Table 1 lists the comprehensive comparison of different stance inference methods. TABLE 1 Comparison of Stance Inference Methods The feature-based methods only captured the features of the users or their posting text. The advantage of them was that they supported inference for new users, not in the training dataset. The drawback was that they could not capture the user dependencies and topic dependencies.
Genetic Insights into Intestinal Microbiota and Risk of Infertility: A Mendelian Randomization Study
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The Multi-Trip Autonomous Mobile Robot Scheduling Problem with Time Windows in a Stochastic Environment at Smart Hospitals
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1, 1,*, 2 and 1 1 Faculty of Science, Kunming University of Science and Technology, Kunming 650500, China 2 Business Analytics Research Center, Chang Gung University, Taoyuan City 33302, Taiwan * Author to whom correspondence should be addressed. Appl. Sci.
Near-zero-dispersion soliton and broadband modulational instability Kerr microcombs in anomalous dispersion - Light: Science & Applications
Author notes These authors contributed equally: Zeyu Xiao, Tieying Li Authors and Affiliations State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Electronic Information and Electrical Engineering, Department of Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China Zeyu Xiao, Tieying Li, Minglu Cai, Hongyi Zhang, Yi Huang, Chao Li, Kan Wu & Jianping Chen Key Laboratory of Optical Fibre Sensing and Communications (Education Ministry...
A Novel Deformation Extraction Approach for Sub-Band InSAR and Its Application in Large-Scale Surface Mining Subsidence Monitoring
Open AccessArticle by Xinpeng Diao 1,2,*, Quanshuai Sun 2, Jing Yang 3, Kan Wu 1,2 and Xin Lu 4 1 Jiangsu Key Laboratory of Resources and Environmental Information Engineering, Xuzhou 221116, China 2 School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221116, China 3 Geophysical and Geochemical Exploration Institute of Ningxia Hui Autonomous Region, Yinchuan 750021, China 4 Gucheng Coal Mine, Lu’an Chemical Group Co., Ltd., Changzhi 046000,...
Re: Umberto Capitanio, Jens Bedke, Laurence Albiges, et al. A Renewal of the TNM Staging System for Patients with Renal Cancer To Comply with Current Decision-making: Proposal from the European Association of Urology Guidelines Panel. Eur Urol. In press.
A proposal by the European Association of Urological Guidelines Panel suggests that stage T1a renal cell carcinoma should be redefined as ≤3 cm to better guide clinical practice []. However, there seems to be a lack of sufficient evidence to support this classification. If survival is not compromised, there is no doubt that focal therapy and active surveillance (AS) are more patient-friendly treatment modalities than immediate surgery for patients with small renal masses (SRMs).
Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease
Our study reveals the trans-acting impact of 6p24.1 with another CAD locus on 10q11.21 and is associated with intensified endothelial injury. We generated induced pluripotent stem cells (iPSCs) from CAD patients (AA risk genotype at rs6903956) and normal controls (GG non-risk genotype at rs6903956).
Monolithic coherent LABS lidar based on an integrated transceiver array
Abstract We demonstrate a monolithic frequency-modulated continuous-wave (FMCW) lidar chip with an integrated transceiver array based on lens-assisted beam steering (LABS) technology. It enables beam emitting, steering, receiving, and coherent detecting on a single chip with simultaneous distance and velocity detection. An integrated transceiver is designed with a composite structure of a Bragg grating in the middle and a U-shaped photodetector (PD) surrounding it.
The computational models of AlphaFold2 and RoseTTAfold carry protein foldability information
New Results doi: https://doi.org/10.1101/2022.01.27.477978 Abstract Protein folding has been a “holy grail” problem of biology for fifty years, and the recent breakthrough from AlphaFold2 and RoseTTAfold set a profound milestone for solving this problem. AlphaFold2 and RoseTTAfold were successful in predicting protein structures from peptide sequences with high accuracy.
Monolithic transceiver for lens-assisted beam-steering Lidar
Abstract We demonstrate a monolithic transceiver based on a CMOS-compatible silicon photonic platform for lens-assisted beam-steering (LABS) light detecting and ranging (Lidar) application. By implementing an on-chip two-dimensional transceiver array and off-chip lens, beam emitting, steering, and receiving are realized simultaneously on a single chip.
Single-frequency integrated laser on erbium-doped lithium niobate on insulator
Abstract The erbium-doped lithium niobate on insulator (Er:LNOI) platform has great promise in the application of telecommunication, microwave photonics, and quantum photonics, due to its excellent electro-optic, piezo-electric, nonlinear nature, as well as the gain characteristics in the telecommunication C-band. Here, we report a single-frequency Er:LNOI integrated laser based on a dual-cavity structure.
Fracture Hits and Hydraulic-Fracture Geometry Characterization Using Low-Frequency Distributed Acoustic Sensing Strain Data
The propagation process and geometry of hydraulic fractures depend on complex interactions among the induced fractures and the pre-existing rock fabric, the heterogeneous rock properties, and the stress state. Accurate characterization of the resulting complex hydraulic-fracture geometry remains challenging. Fiber-optic-based distributed acoustic sensing (DAS) measurements have been used for monitoring hydraulic fracturing in adjacent treatment wells.
Changes in the characteristics of dental emergencies under the influence of SARS-CoV-2 pandemic: a retrospective study
Abstract Background Further understanding of the distribution and changing characteristics of dental diseases is of great significance for all dental emergency centers for strengthening the medical staff’s treatment knowledge abilities and effective use of emergency resources in the face of public health emergencies involving highly infectious respiratory diseases.
Predicting Inorganic Photovoltaic Materials with Efficiencies >26% via Structure-Relevant Machine Learning and Density Functional Calculations
(Cell Reports Physical Science 1, 100179-1–17; September 23, 2020) In the originally published version of this article, a comma was inadvertently added to Equation 11. The corrected equation now appears with the paper online and is also displayed below. fr=e(Eg−Egda/kT), (Equation 11) The production team apologizes for the error. Article Info Identification DOI: https://doi.org/10.1016/j.xcrp.2020.100236 Copyright © 2020 The Author(s).
Lidar system based on lens assisted integrated beam steering
Abstract We present a demonstration of solid-state light detection and ranging (Lidar) at 1550 nm by applying integrated two-dimensional (2D) lens assisted beam-steering (LABS) technology. LABS has O(logN) power consumption for N antennas and allows a simple control complexity with digital signal input. A time-of-flight coaxial Lidar is demonstrated with this beam-steering technology. The integrated beam-steering chip and lens both transmit and receive the light.
Predicting Inorganic Photovoltaic Materials with Efficiencies >26% via Structure-Relevant Machine Learning and Density Functional Calculations
Highlights Fast and atomic-level accuracy prediction of photovoltaic materials is proposed The theoretical PCE exceeds 26%, comparable to the champion light-absorbing layer Summary Discovering new inorganic photovoltaic materials becomes an efficient way for developing a new generation of solar cells with high efficiency and environmental stability.
Manifold of self-assembly of a de novo designed peptide: amyloid fibrils, peptide bundles, and fractals
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Residual cavity hydrops initially misdiagnosed as recurrent hepatic echinococcosis
Kan Wu, MM Xi Feng, MD Xu Liu, MD Prof Wentao Wang, MD Wentao Wang Correspondence Correspondence to: Prof Wentao Wang, Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Affiliations Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China Search for articles by this author Published:May, 2019DOI:https://doi.org/10.1016/S1473-3099(18)30677-7 A 37-year-old woman presented to our liver surgery clinic with a...
Proactively Reducing Anti‐Drug Antibodies via Immunomodulatory Bioconjugation
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Communication Proactively Reducing Anti‐Drug Antibodies via Immunomodulatory Bioconjugation Prof.
Metabolites Involved in Aerobic Degradation of the A and B Rings of Estrogen
Biodegradation Kan Wu, Tzong-Huei Lee, Yi-Lung Chen, Yu-Sheng Wang, Po-Hsiang Wang, Chang-Ping Yu, Kung-Hui Chu, Yin-Ru Chiang Volker Müller, Editor DOI: 10.1128/AEM.02223-18 ABSTRACT Various bacteria, mainly actinobacteria and proteobacteria, are capable of aerobic estrogen degradation. In a previous study, we used the obligate aerobic alphaproteobacterium Sphingomonas sp.
Proactively Reducing Anti‐Drug Antibodies via Immunomodulatory Bioconjugation
The full text of this article hosted at iucr.org is unavailable due to technical difficulties.
Identification of metabolites involved in the aerobic degradation of estrogen A/B-rings
ABSTRACT Various bacteria, mainly actinobacteria and proteobacteria, are capable of aerobic estrogen degradation. In a previous study, we used the obligate aerobic alphaproteobacterium, Sphingomonas sp. strain KC8 as a model microorganism to identify initial metabolites involved in the oxygenolytic cleavage of the estrogen A-ring: 4-hydroxyestrone, a meta-cleavage product, and a dead-end product pyridinestrone acid.
Author Correction: All-optical control of light on a graphene-on-silicon nitride chip using thermo-optic effect
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
A new model for simulating particle transport in a low‐viscosity fluid for fluid‐driven fracturing
Fluid‐driven fracture (i.e., Hydraulic fracturing) is an important way to stimulate the well productivity in the development of unconventional reservoirs. A low‐viscosity fluid called slickwater is widely used in the unconventional fracturing. It is a big challenge to simulate the particle (or proppant) transport in the low‐viscosity fluid in a field‐scale fracture. A new model to simulate particle transport in the low‐viscosity fluid in a field‐scale fracture is developed.
Mitigation of Inflammatory Immune Responses with Hydrophilic Nanoparticles
While hydrophobic nanoparticles (NPs) have been long recognized to boost the immune activation, whether hydrophilic NPs modulate an immune system challenged by immune stimulators and how their hydrophilic properties may affect the immune response is still unclear. To answer this question, three polymers, poly(ethylene glycol)(PEG), poly(sulfobetaine)(PSB) and poly(carboxybetaine)(PCB) are studied.
Simulation of shale gas transport and production with complex fractures using embedded discrete fracture model
The goal of this study is to develop a new model to simulate gas and water transport in shale nanopores and complex fractures. A new gas diffusivity equation was first derived to consider multiple important physical mechanisms such as gas desorption, gas slippage and diffusion, and non‐Darcy flow. For complex fractures, a state‐of‐the‐art embedded discrete fracture model (EDFM) was implemented.
Simulation of Shale Gas Transport and Production with Complex Fractures using Embedded Discrete Fracture Model
The goal of this study is to develop a new model to simulate gas and water transport in shale nanopores and complex fractures. We first derive a new gas diffusivity equation to consider multiple important physical mechanisms such as gas desorption, gas slippage and diffusion, and non-Darcy flow. For complex fractures, we implement a state-of-the-art embedded discrete fracture model (EDFM).
A Semi-analytical Model for Simulating Real Gas Transport in Nanopores and Complex Fractures of Shale Gas Reservoirs
An efficient gridless semi-analytical model was developed to simulate real gas transport in shale formation with nanopores and complex fracture geometry. This model incorporates multiple physics such as gas desorption, adsorbed gas porosity, gas slippage and diffusion, residual water saturation, non-Darcy flow, choke skin, and pressure-dependent matrix permeability and fracture conductivity.
Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication
The genome-wide siRNA library consists of pools of four siRNAs per gene (siGENOME, ThermoScientific) arrayed in a series of 384-well plates. siRNA pools against SCARB2 and MMP20 were added to empty wells of each 384-well plate to serve as positive (EV71-inhibitory) controls while a non-targeting (NT) siRNA pool serves as the negative control (Supplementary Fig. 1).
PLOS ONE: Increased Biological Effective Dose of Radiation Correlates with Prolonged Survival of Patients with Limited-Stage Small Cell Lung Cancer: A Systematic Review
Thoracic radiotherapy (TRT) is a critical component of the treatment of limited-stage small cell lung cancer (LS-SCLC). However, the optimal radiation dose/fractionation remains elusive. This study reviewed current evidence and explored the dose-response relationship in patients with LS-SCLC who were treated with radiochemotherapy. A quantitative analysis was performed through a systematic search of PubMed, Web of Science, and the Cochrane Library.
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