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Articles by Ke Hao
Synergistic effects of nicotine and hyperlipidemia induce cardiac damage via dynamic cardiomyocyte-based biosensing
Abstract Cigarette smoking and hyperlipidemia are major risk factors for cardiovascular disease. However, the mechanisms underlying their synergistic cardiotoxic effects remain insufficiently elucidated, particularly at the cellular electrophysiological level. To address this, we developed an electrophysiological biosensing platform to establish a real-time co-exposure model that simulates the combined stress of nicotine and palmitic acid-induced hyperlipidemia on the primary rat cardiomyocytes.
A multidimensional muscle-fat-metabolism model for severity stratification in COPD: a multi-center cross-sectional study
Abstract Background: Chronic obstructive pulmonary disease (COPD) is a systemic disorder characterized by significant body composition alterations, including muscle loss (sarcopenia) and abnormal fat distribution. These changes contribute to a high metabolic burden, with increased resting energy expenditure and systemic inflammation accelerating disease progression. Traditional assessments like body mass index (BMI) fail to capture these complex interactions.
AI-guided multi-omics analysis identifies NPC1-modulated susceptibility to SARS-CoV-2 infection under PM 2.5 exposure
Abstract Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncover shared transcriptional signatures between PM2.5 exposure and SARS-CoV-2 infection.
Sphenopalatine Ganglion Block for Postdural Puncture Headache in the Obstetric Population: A Narrative Review
Back to Journals » Journal of Pain Research » Volume 19 Review Acute Pain and Perioperative Care Authors Hao K, Jiang W Received 6 March 2026 Accepted for publication 28 May 2026 Published 6 June 2026 Volume 2026:19 607406 DOI https://doi.org/10.2147/JPR.S607406 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Karina Gritsenko Ke Hao, Weilong Jiang Department of Anesthesiology, The First Affiliated Hospital,...
Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques
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Abstract Carotid stenosis causes ischemic stroke in both sexes, but the clinical presentation and plaque characteristics differ. Here we run deep single-cell sequencing of 7,690 human carotid plaque cells from male and female patients. While we found no sex differences in major cell types, we identified a predominance of the osteogenic phenotype in smooth muscle cells, immunomodulating macrophages (MPs) and endothelial cells (ECs) undergoing endothelial-to-mesenchymal transition in females.
By Katyayani Sukhavasi, Giuseppe Mocci, Lijiang Ma, Chani J. Hodonsky, Lars Muhl, Jianping Liu, Byambajav Buyandelger, Simon Koplev, Urban Lendahl, Michael Vanlandewijck, Tiit Örd, Mustafa Beter, Ilakya Selvarajan, Johanna P. Laakkonen, Marika Väli, Mete Civelek, Ke Hao, Christer Betsholtz, Jason C. Kovacic, Clint Miller, Casey E. Romanoski, Minna Kaikkonen, Johan L. M. Björkegren, Ernest Diez Benevante, Sonja Gustafsson, Prosanta Singha, Hester M. den Ruijter, Arno Ruusalepp, Heli Järve
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Nature
Verified
Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia - Nature Cardiovascular Research
Abstract Fibromuscular dysplasia (FMD) is a poorly understood disease affecting 3–5% of adult females. The pathobiology of FMD involves arterial lesions of stenosis, dissection, tortuosity, dilation and aneurysm, which can lead to hypertension, stroke, myocardial infarction and even death. Currently, there are no animal models for FMD and few insights as to its pathobiology.
A Three-Stage Stochastic Model to Improve Resilience with Lateral Transshipment in Multi-Period Emergency Logistics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth - Nature Genetics
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Abstract A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.
By Robin Beaumont, Christopher Flatley, Marc Vaudel, JING CHEN, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Sole-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, Katerina Trajanoska, David Westergaard, Sundararajan Srinivasan, José Ramón Bilbao, Catherine Allard, Teemu Kuulasmaa, Frédérique White, Haoxiang Cheng, Ke Hao, Ole A. Andreassen, Bjørn Olav Åsvold, Ben Michael Brumpton, Søren Brunak, Jonas Bybjerg-Grauholm, Paul Elliott, Christian Erikstrup, Marisa Estarlich Estarlich, Frank Geller, Jakob Grove, David M. Hougaard, Eero Kajantie, Mette Nyegaard, Ole Birger Pedersen, Fernando Rivadeneira, Sylvain Sebert, Camilla Stoltenberg, Bjarni J Vilhjálmsson, Cristen J. Willer, Timo A Lakka, Torben Frøstrup Hansen, Ewan R Pearson, Sisse R. Ostrowski, Craig E Pennell, Janine F. Felix, Andrew T. Hattersley, Deborah A. Lawlor, Thomas Werge, Henriette Svarre Nielsen, David Evans, Bo Jacobsson, Marjo-Riitta Järvelin, Marie-France Hivert, Stefan Johansson, Rachel M Freathy, Bjarke Feenstra, Marika Groleau, Dorte Gybel-Brask
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Nature
Verified
Bottom Distribution of F-Based Additives in Perovskite Films and Their Effects on Photovoltaic Performance
RETURN TO ARTICLES ASAPPREVEnergy, Environmenta...Energy, Environmental, and Catalysis ApplicationsNEXT Lili Gao College of Metallurgical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, Shaanxi, P. R. China , Ke Hao College of Metallurgical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, Shaanxi, P. R. China , Ping Hu College of Metallurgical Engineering, Xi’an University of Architecture and Technology, Xi’an 710055, Shaanxi, P. R.
Prioritization of potential causative genes for schizophrenia in placenta - Nature Communications
Abstract Our earlier work has shown that genomic risk for schizophrenia converges with early life complications in affecting risk for the disorder and sex-biased neurodevelopmental trajectories. Here, we identify specific genes and potential mechanisms that, in placenta, may mediate such outcomes.
Placental multi-omics integration identifies candidate functional genes for birthweight - Nature Communications
Abstract Abnormal birthweight is associated with increased risk for cardiometabolic diseases in later life. Although the placenta is critical to fetal development and later life health, it has not been integrated into largescale functional genomics initiatives, and mechanisms of birthweight-associated variants identified by genome wide association studies (GWAS) are unclear.
Sex-Stratified Gene Regulatory Networks Reveal Female Key-Driver Genes of Atherosclerosis Involved in Smooth Muscle Cell Phenotype Switching
Robin J. G. Hartman Robin J. G. Hartman https://orcid.org/0000-0002-0367-652X Laboratory of Experimental Cardiology, University Medical Center Utrecht, The Netherlands , Katherine Owsiany Katherine Owsiany https://orcid.org/0000-0001-7917-3411 Robert M.
Wuhan offers hope on virus front; Italy nears stark toll
In this March 18, 2020 photo released by China's Xinhua News Agency, people applaud as departing medical workers enter Wuhan Tianhe International Airport in Wuhan in central China's Hubei Province. Last month, Wuhan was overwhelmed with thousands of new cases of coronavirus each day.
Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts
Introduction Cadmium (Cd) is a toxic heavy metal that is released into the environment from mining and industrial processes, the application of phosphate fertilizers, and fossil fuel combustion; it accumulates in soils and is readily taken up by plants (ATSDR 2012). Human exposure primarily occurs via consumption of contaminated foods or through using tobacco products (Järup and Åkesson 2009).
Epigenome-wide association study links site-specific DNA methylation changes with cow’s milk allergy
Publication HistoryPublished Online: April 25, 2016Accepted: January 29, 2016; Received in revised form: December 8, 2015; Received: September 25, 2015;
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