Background Objectives Study Overview Intervention arm: Home-based pre-exposure prophylaxis (HB-PrEP) participants Complete informed consent and enrollment. Confirm baseline laboratory tests are complete (hepatitis A total b, hepatitis B sAb and sAg). Ensure interval monitoring laboratory tests are collected (HIV Ag and Ab enzyme immunoassay (EIA), serum creatinine, quantitative vs quantitative rapid plasma reagin (RPR) based on history of previous syphilis). Participant completes web-based survey.