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Articles by Melanie Soderstrom
Racial/ethnic disparities in police recovery of stolen property: A previously unexplored facet of police/victim interaction
Though police are expected to protect and serve, they face an extremely daunting task in maintaining public order and solving the many crimes brought to their attention. Many police departments quietly acknowledge that they only function because most citizens are law-abiding and are willing to aid in police investigations when necessary (Reisig, Wolfe, & Holtfreter, 2011; Tankebe, 2013; Tyler, 2006).
Unsupervised embedding of trajectories captures the latent structure of scientific migration | Proceedings of the National Academy of Sciences
Unsupervised embedding of trajectories captures the latent structure of scientific migration Edited by Peter Bearman, Columbia University, New York, NY; received April 3, 2023; accepted November 13, 2023 Significance We show that the word embedding technique word2vec is mathematically equivalent to the gravity law of mobility, making it ideal for learning dense representations from migration data that can be distributed, re-used, and studied.
Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants | Proceedings of the National Academy of Sciences
Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants Zhongfeng Ye https://orcid.org/0000-0003-0383-7247, Srinivasa Reddy Bonam https://orcid.org/0000-0002-2888-2418, Lindsay G. A. McKay https://orcid.org/0000-0003-0369-9067, +16 , Jessica A.
Promoting C–F bond activation via proton donor for CF4 decomposition | Proceedings of the National Academy of Sciences
Promoting C–F bond activation via proton donor for CF4 decomposition Edited by Alexis Bell, University of California, Berkeley, CA; received July 21, 2023; accepted November 15, 2023 Significance Tetrafluoromethane (CF4), also known as carbon tetrafluoride, is a permanent potent greenhouse gas. It finds extensive use in semiconductor manufacturing and is the main by-product released during the smelting of electrolytic aluminum and rare earth metals.
Engineering contact curved interface with high-electronic-state active sites for high-performance potassium-ion batteries | Proceedings of the National Academy of Sciences
Engineering contact curved interface with high-electronic-state active sites for high-performance potassium-ion batteries Xuan Li, Yaxin Wang, Junxiong Wu, +10 , Lijuan Tong, Shuling Wang, Xiaoyan Li xiaoyanli1985@126.com, Chuanping Li, Manxi Wang, Manxian Li, Weiwei Fan, Xiaochuan Chen, Qinghua Chen, Guoxiu Wang https://orcid.org/0000-0003-4295-8578 Guoxiu.Wang@uts.edu.au, and Yuming Chen yumingc126@126.com -10Authors Info & Affiliations Edited by Alexis Bell, University of California,...
Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection | Proceedings of the National Academy of Sciences
Infectious virus shedding duration reflects secretory IgA antibody response latency after SARS-CoV-2 infection Sho Miyamoto, Takara Nishiyama https://orcid.org/0009-0007-7729-8705, Akira Ueno https://orcid.org/0000-0003-3768-9983, +38 , Hyeongki Park, Takayuki Kanno https://orcid.org/0000-0002-5151-3012, Naotoshi Nakamura https://orcid.org/0000-0002-4798-3660, Seiya Ozono, Kazuyuki Aihara https://orcid.org/0000-0002-4602-9816, Kenichiro Takahashi, Yuuki Tsuchihashi...
HEI10 is subject to phase separation and mediates RPA1a degradation during meiotic interference-sensitive crossover formation | Proceedings of the National Academy of Sciences
Y. X. Wang, G. P. Copenhaver, Meiotic recombination: Mixing it up in plants. Annu. Rev. Plant Biol. 69, 577–609 (2018). S. Gray, P. E. Cohen, Control of meiotic crossovers: From double-strand break formation to designation. Annu. Rev. Genet. 50, 175–210 (2016). A. H. Sturtevant, The behavior of the chromosomes as studied through linkage. Z. indukt. Abstamm. Vererbungsl. 13, 234–287 (1915). R. Mercier, C. Mezard, E. Jenczewski, N. Macaisne, M. Grelon, The molecular biology of meiosis in plants. Annu. Rev. Plant Biol.
Closed ecosystems extract energy through self-organized nutrient cycles | Proceedings of the National Academy of Sciences
E. P. Odum, Fundamentals of Ecology (WB Saunders, Philadephia, ed. 3, 1971). C. J. Cleveland, R. Kaufmann, T. Lawrence, Fundamental principles of energy. Encycl. Earth 79, 79–87 (2008). M. L. Messager, B. Lehner, G. Grill, I. Nedeva, O. Schmitt, Estimating the volume and age of water stored in global lakes using a geo-statistical approach. Nat. Commun. 7, 13603 (2016). J. P. Grotzinger, A. H. Knoll, Stromatolites in Precambrian carbonates: Evolutionary mileposts or environmental dipsticks? Annu. Rev. Earth Planet. Sci.
Winning a noble race | Proceedings of the National Academy of Sciences
There are some competitions decidedly worth winning. One of the noblest is the competition to be the nation with the highest quality science and innovation, given the critical role of R&D to public health, quality of life, national security, and economic competitiveness. America has for many decades prided itself on the pre-eminence of its science enterprise. However, confidence that American science will continue to lead the world, and even the certainty that it currently does, is waning (1).
Radiation and temperature drive diurnal variation of aerobic methane emissions from Scots pine canopy | Proceedings of the National Academy of Sciences
Radiation and temperature drive diurnal variation of aerobic methane emissions from Scots pine canopy Lukas Kohl https://orcid.org/0000-0002-5902-9444 lukas.kohl@uef.fi, Salla A. M. Tenhovirta https://orcid.org/0000-0001-5600-6274, Markku Koskinen https://orcid.org/0000-0002-9473-6064, +8 , Anuliina Putkinen, Iikka Haikarainen, Tatu Polvinen, Luca Galeotti, Ivan Mammarella, Henri M. P.
Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition | Proceedings of the National Academy of Sciences
Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition Ikki Sakuma, Rafael C. Gaspar, Panu K. Luukkonen https://orcid.org/0000-0003-2085-679X, +8 , Mario Kahn, Dongyan Zhang https://orcid.org/0000-0002-4036-3987, Xuchen Zhang, Sue Murray, Jaya Prakash Golla, Daniel F. Vatner https://orcid.org/0000-0003-2073-0273, Varman T.
The hydrogen-bonding dynamics of water to a nitrile-functionalized electrode is modulated by voltage according to ultrafast 2D IR spectroscopy | Proceedings of the National Academy of Sciences
A. J. Orr-Ewing, Taking the plunge: Chemical reaction dynamics in liquids. Chem. Soc. Rev. 46, 7597–7614 (2017). M. Maroncelli, J. MacInnis, G. R. Fleming, Polar solvent dynamics and electron-transfer reactions. Science 243, 1674–1681 (1989). H. Heitele, Dynamic solvent effects on electron-transfer reactions. Angew. Chem. Int. Ed. Engl. 32, 359–377 (1993). R. Jimenez, G. R. Fleming, P. Kumar, M. Maroncelli, Femtosecond solvation dynamics of water. Nature 369, 471–473 (1994). J.
Sulfion oxidation assisting self-powered hydrogen production system based on efficient catalysts from spent lithium-ion batteries | Proceedings of the National Academy of Sciences
Sulfion oxidation assisting self-powered hydrogen production system based on efficient catalysts from spent lithium-ion batteries Boran Wang https://orcid.org/0009-0004-8566-2173, Xiao Xiao, Junfeng Li, +6 , Mengtian Zhang, Miaolun Jiao, Zhiyang Zheng, Tongtong Li, Qi Zhang, Xuan Zhang https://orcid.org/0000-0002-7537-4002, and Guangmin Zhou https://orcid.org/0000-0002-3629-5686 guangminzhou@sz.tsinghua.edu.cn -6Authors Info & Affiliations Edited by Alexis Bell, University of California,...
ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer | Proceedings of the National Academy of Sciences
ENPP1 is an innate immune checkpoint of the anticancer cGAMP–STING pathway in breast cancer Songnan Wang https://orcid.org/0000-0002-4276-2965, Volker Böhnert, Alby J. Joseph https://orcid.org/0009-0001-6596-1078, +10 , Valentino Sudaryo https://orcid.org/0000-0002-5816-9955, Gemini Skariah, Jason T. Swinderman, Feiqiao B. Yu https://orcid.org/0000-0003-3416-3046, Vishvak Subramanyam https://orcid.org/0000-0002-6144-8322, Denise M. Wolf, Xuchao Lyu https://orcid.org/0000-0003-1967-3902, Luke A.
Why the simplest explanation isn’t always the best | Proceedings of the National Academy of Sciences
As datasets in neuroscience increase in size and complexity, interpreting these high-dimensional data is becoming more critical. However, developing an intuition for patterns or structures in such datasets is hard. Dimensionality reduction methods aim to find patterns in these high-dimensional datasets, sometimes transforming them into simpler and more “interpretable” descriptions of the data (1).
Social feedback biases emerge during recall but not prediction and shift across the development of social anxiety | Proceedings of the National Academy of Sciences
D. L. Schacter, The seven sins of memory. Insights from psychology and cognitive neuroscience. Am. Psychol. 54, 182–203 (1999). U. Neisser, “Nested structure in autobiographical memory” in Autobiographical Memory, D. C. Rubin, Ed. (Cambridge University Press, 1986), pp. 71–81. F. C. Bartlett, Remembering: A Study in Experimental and Social Psychology (Cambridge University Press, 1932). E. F. Loftus, Memories of things unseen. Curr. Dir. Psychol. Sci. 13, 145–147 (2004). D. L. Schacter, S. A. Guerin, P. L.
Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response | Proceedings of the National Academy of Sciences
J. Dahlhamer et al., Prevalence of chronic pain and high-impact chronic pain among adults—United States, 2016. MMWR Morb Mortal. Wkly Rep. 67, 1001–1006 (2018). A. Alon et al., Identification of the gene that codes for the sigma2 receptor. Proc. Natl. Acad. Sci. U.S.A. 114, 7160–7165 (2017). J. J. Sahn, G. L. Mejia, P. R. Ray, S. F. Martin, T. J. Price, Sigma 2 Receptor/Tmem97 agonists produce long lasting antineuropathic pain effects in mice. ACS Chem. Neurosci. 8, 1801–1811 (2017). A.
Distinct guard cell–specific remodeling of chromatin accessibility during abscisic acid– and CO2-dependent stomatal regulation | Proceedings of the National Academy of Sciences
R. J. Schmitz, E. Grotewold, M. Stam, Cis-regulatory sequences in plants: Their importance, discovery, and future challenges. The Plant Cell 34, 718–741 (2022). W. K. M. Lai, B. F. Pugh, Understanding nucleosome dynamics and their links to gene expression and DNA replication. Nat. Rev. Mol. Cell Biol. 18, 548–562 (2017). T. C. Voss, G. L. Hager, Dynamic regulation of transcriptional states by chromatin and transcription factors. Nat. Rev. Genet. 15, 69–81 (2014). J. L. Nemhauser, F. Hong, J.
Drift on holey landscapes as a dominant evolutionary process | Proceedings of the National Academy of Sciences
Significance We found that empirical estimations of how quantitative genetic variation is distributed do not correspond to typical Gaussian representations of fitness landscapes. These Gaussian landscapes underpin major areas of evolutionary biology and how selection is estimated in natural populations. Rather than being consistent with evolution on Gaussian landscapes, empirical estimates of genetic variation are, instead, consistent with evolution on high-dimensional “holey” landscapes.
Roles of the Rlim–Rex1 axis during X chromosome inactivation in mice | Proceedings of the National Academy of Sciences
Roles of the Rlim–Rex1 axis during X chromosome inactivation in mice Feng Wang https://orcid.org/0000-0002-1603-2184, Ashmita Chander, Yeonsoo Yoon, +6 , Janelle M. Welton https://orcid.org/0000-0002-5756-4507, Mary C. Wallingford, Carmen Espejo-Serrano https://orcid.org/0000-0003-4127-510X, Francisco Bustos https://orcid.org/0000-0001-5457-4956, Greg M.
Divergent bleaching and recovery trajectories in reef-building corals following a decade of successive marine heatwaves | Proceedings of the National Academy of Sciences
O. Hoegh-Guldberg et al., The human imperative of stabilizing global climate change at 1.5 °C. Science 365, eaaw6974 (2019). L. Muscatine, J. W. Porter, Reef corals: Mutualistic symbioses adapted to nutrient-poor environments. Bioscience 27, 454–460 (1977). L. Muscatine, L. R. McCloskey, R. E. Marian, Estimating the daily contribution of carbon from zooxanthellae to coral animal respiration. Limnol. Oceanogr. 26, 601–611 (1981). N.
Tiam1 methylation by NSD2 promotes Rac1 signaling activation and colon cancer metastasis | Proceedings of the National Academy of Sciences
F. Bray et al., Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018). J. Y. Douillard et al., Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N. Engl. J. Med. 369, 1023–1034 (2013). A. P.
Projections of human kinship for all countries
Significance Rapid demographic change is expected to transform the supply of kin worldwide. Changes in the size and composition of kinship networks matter because relatives provide important informal support by exchanging resources and time, even in settings with advanced welfare systems. But kin supply does not equal kin availability. For example, we project that great-grandparents will be more common in the future, but they may be too old and frail to provide support.
Next-generation even-denominator fractional quantum Hall states of interacting composite fermions | Proceedings of the National Academy of Sciences
Next-generation even-denominator fractional quantum Hall states of interacting composite fermions Contributed by Loren N. Pfeiffer; received August 17, 2023; accepted October 10, 2023; reviewed by Ajit Coimbatore Balram, Bertrand I. Halperin, and Dieter Weiss Significance In a large perpendicular magnetic field, electrons confined in a plane occupy quantized, (Landau) energy levels.
Geostationary satellite observations of extreme and transient methane emissions from oil and gas infrastructure | Proceedings of the National Academy of Sciences
Geostationary satellite observations of extreme and transient methane emissions from oil and gas infrastructure Edited by Mark Thiemens, University of California San Diego, La Jolla, CA; received July 3, 2023; accepted November 9, 2023 Significance Decreasing atmospheric methane emissions is an urgent priority to slow near-term climate change.
A dicer-related helicase opposes the age-related pathology from SKN-1 activation in ASI neurons | Proceedings of the National Academy of Sciences
H. Motohashi, M. Yamamoto, Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10, 549–557 (2004). G. P. Sykiotis, D. Bohmann, Stress-activated cap’n’collar transcription factors in aging and human disease. Sci. Signal. 3, re3 (2010). L. C. D. Pomatto et al., Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. Redox Biol. 24, 101194 (2019). C. Tonelli, I. I. C. Chio, D. A. Tuveson, Transcriptional regulation by Nrf2. Antioxid. Redox Signal.
Strong enhancement of magnetic ordering temperature and structural/valence transitions in EuPd3S4 under high pressure | Proceedings of the National Academy of Sciences
Strong enhancement of magnetic ordering temperature and structural/valence transitions in EuPd3S4 under high pressure Shuyuan Huyan https://orcid.org/0000-0003-0999-2440, Dominic H. Ryan https://orcid.org/0000-0003-3858-1894 dominic.ryan@mcgill.ca, Tyler J. Slade, +10 , Barbara Lavina https://orcid.org/0000-0002-8556-7916, Greeshma Jose, Haozhe Wang https://orcid.org/0000-0003-4820-833X, John M. Wilde https://orcid.org/0000-0002-1753-3589, Raquel A.
Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response | Proceedings of the National Academy of Sciences
Listerin promotes cGAS protein degradation through the ESCRT pathway to negatively regulate cGAS-mediated immune response Fei Qin, Baoshan Cai, Runyu Cao, +11 , Xuemei Bai, Jiahua Yuan, Yuling Zhang, Yaxing Liu, Tian Chen, Feng Liu, Wanwei Sun https://orcid.org/0000-0001-5909-3828, Yi Zheng, Xiaopeng Qi, Wei Zhao https://orcid.org/0000-0001-8440-2274, Bingyu Liu liubingyu@sdu.edu.cn, and Chengjiang Gao cgao@sdu.edu.cn -11Authors Info & Affiliations Edited by Veit Hornung,...
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells | Proceedings of the National Academy of Sciences
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells Alina Ulezko Antonova, Silvia Lonardi, Matilde Monti, +21 , Francesco Missale, Changxu Fan, Matthew L. Coates, Mattia Bugatti, Natalia Jaeger, Patrick Fernandes Rodrigues, Simone Brioschi, Tihana Trsan, José L. Fachi, Khai M. Nguyen, Ryan M. Nunley, Daniele Moratto, Stefania Zini, Lingjia Kong, Jacques Deguine https://orcid.org/0000-0001-9218-3040, Mark E.
Mechanism of eukaryotic origin unwinding is a dual helicase DNA shearing process | Proceedings of the National Academy of Sciences
A. Costa, J. F. X. Diffley, The initiation of eukaryotic DNA replication. Ann. Rev. Biochem. 91, 107–131 (2022). M. Kanke, Y. Kodama, T. S. Takahashi, T. Nakagawa, H. Masukata, Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components. EMBO J. 31, 2182–2194 (2012). F. van Deursen, S. Sengupta, G. De Piccoli, A. Sanchez-Diaz, K. Labib, Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation. EMBO J. 31, 2195–2206 (2012). G. Watase, H.
The role of tropical rainfall in driving range dynamics for a long-distance migratory bird | Proceedings of the National Academy of Sciences
J. P. Sexton, P. J. McIntyre, A. L. Angert, K. J. Rice, Evolution and ecology of species range limits. Annu. Rev. Ecol. Evol. Syst. 40, 415–436 (2009). C. Parmesan, G. Yohe, A globally coherent fingerprint of climate change impacts across natural systems. Nature 421, 37–42 (2003). M. W. Tingley, M. S. Koo, C. Moritz, A. C. Rush, S. R. Beissinger, The push and pull of climate change causes heterogeneous shifts in avian elevational ranges. Glob. Change Biol. 18, 3279–3290 (2012). J. A. Lee-Yaw, J. L. McCune, S. Pironon, S. N.
Intrinsic circuitry of the rhombicbrain (central nervous system’s intermediate sector) in a mammal | Proceedings of the National Academy of Sciences
Significance Embryology suggests the vertebrate brain has two primary divisions with different structure-function properties. In adults, one primary division consists of forebrain and midbrain, and the other is called rhombicbrain, with three familiar components: pons, cerebellum, and medulla. We created a benchmark dataset for the 52,670 possible axonal connections between 230 gray matter regions in adult rhombicbrain and clarified its neural network architecture with network science methods.
Stability of hydrides in sub-Neptune exoplanets with thick hydrogen-rich atmospheres | Proceedings of the National Academy of Sciences
Stability of hydrides in sub-Neptune exoplanets with thick hydrogen-rich atmospheres Edited by Francis Nimmo, University of California, Santa Cruz, CA; received June 11, 2023; accepted October 27, 2023 Significance Many sub-Neptune exoplanets are believed to have thick atmospheres dominated by hydrogen, surrounding the interiors with mainly silicates and oxides, assuming no reaction between them.
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2 | Proceedings of the National Academy of Sciences
Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2 Xia Rao, Runchu Zhao, Zhou Tong https://orcid.org/0000-0002-9867-2838, +21 , Shuxin Guo, Weiyu Peng, Kefang Liu, Shihua Li, Lili Wu, Jianyu Tong, Yan Chai, Pu Han, Feiran Wang, Peng Jia, Zhaohui Li, Xin Zhao, Dedong Li, Rong Zhang, Xue Zhang, Weiwei Zou, Weiwei Li, Qihui Wang https://orcid.org/0000-0003-3768-0401, George Fu Gao...
Regulating phase behavior of nanoparticle assemblies through engineering of DNA-mediated isotropic interactions | Proceedings of the National Academy of Sciences
Regulating phase behavior of nanoparticle assemblies through engineering of DNA-mediated isotropic interactions Edited by Jasna Brujic, New York University, New York, NY received February 6, 2023; accepted November 14, 2023 by Editorial Board Member Daan Frenkel Significance Revealing relationships between interaction potential and the resulting structure is a continuously developing area due to its importance for atomic, nanoscale, and microscale material systems, highly relevant for...
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma | Proceedings of the National Academy of Sciences
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma Qiang Cheng, Lukas Farbiak https://orcid.org/0000-0003-4107-1676, Amogh Vaidya https://orcid.org/0000-0003-0712-659X, +11 , Erick Guerrero, Eunice E. Lee, Elysha K. Rose, Xu Wang, Joshua Robinson, Sang M. Lee https://orcid.org/0000-0001-7658-6229, Tuo Wei https://orcid.org/0000-0002-2823-9721, William E.
Cu2+ coordination-induced in situ photo-to-heat on catalytic sites to hydrolyze β-lactam antibiotics pollutants in waters | Proceedings of the National Academy of Sciences
I. Braschi et al., Persistence and degradation of new beta-lactam antibiotics in the soil and water environment. Chemosphere 93, 152–159 (2013). R. Andreozzi et al., Antibiotics in the environment: Occurrence in Italian STPs, fate, and preliminary assessment on algal toxicity of amoxicillin. Environ. Sci. Technol. 38, 6832–6838 (2004). Z. Zhang et al., Assessment of global health risk of antibiotic resistance genes. Nat. Commun. 13, 1553–1563 (2022). S.
Recovering intestinal redox homeostasis to resolve systemic inflammation for preventing remote myocardial injury by oral fullerenes | Proceedings of the National Academy of Sciences
Recovering intestinal redox homeostasis to resolve systemic inflammation for preventing remote myocardial injury by oral fullerenes Wang Jia https://orcid.org/0009-0008-6464-5111, Jiacheng Sun, Xinran Cao, +7 , Yuan Xu, Zhanfeng Wu, Chen Zhou, Jiawei Huo https://orcid.org/0000-0002-9695-513X, Shenge Su, Mingming Zhen zhenmm@iccas.ac.cn, Chunru Wang https://orcid.org/0000-0001-7984-6639 crwang@iccas.ac.cn, and Chunli Bai https://orcid.org/0000-0002-5253-3656 clbai@cas.cn -7Authors Info &...
How a natural antibiotic uses oxidative stress to kill oxidant-resistant bacteria | Proceedings of the National Academy of Sciences
J. A. Imlay, Diagnosing oxidative stress in bacteria: Not as easy as you might think. Curr. Opin. Microbiol. 24, 124–131 (2015). J. A. Imlay, S. M. Chin, S. Linn, Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro. Science 240, 640–642 (1988). L. C. Seaver, J. A. Imlay, Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli. J. Bacteriol. 183, 7173–7181 (2001). A. Sen, J. A.
Nonspecificity fingerprints for clinical-stage antibodies in solution | Proceedings of the National Academy of Sciences
Nonspecificity fingerprints for clinical-stage antibodies in solution Edited by David Baker, University of Washington, Seattle, WA; received April 28, 2023; accepted November 6, 2023 Significance Monoclonal antibody drugs successfully target cancer as well as autoimmune and infectious diseases. However, the optimization of target affinity often comes at the cost of increased nonspecific interactions, which can compromise successful application.
A transcriptional program underlying the circannual rhythms of gonadal development in medaka | Proceedings of the National Academy of Sciences
A transcriptional program underlying the circannual rhythms of gonadal development in medaka Tomoya Nakayama https://orcid.org/0000-0003-4175-3167, Miki Tanikawa https://orcid.org/0009-0006-9770-2405, Yuki Okushi https://orcid.org/0009-0001-4368-8314, +14 , Thoma Itoh https://orcid.org/0000-0003-2582-1000, Tsuyoshi Shimmura https://orcid.org/0000-0002-9136-2976, Michiyo Maruyama https://orcid.org/0000-0002-8821-5756, Taiki Yamaguchi https://orcid.org/0000-0002-9895-4739, Akiko Matsumiya, Ai...
A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities | Proceedings of the National Academy of Sciences
D. Russler, J. Mangos, Micropuncture studies of the osmoregulation in the nauplius of Artemia salina. Am. J. Physiol. 234, R216–R222 (1978). C. W. Holliday, D. B. Roye, R. D. Roer, Salinity-induced changes in branchial Na+/K+-ATPase activity and transepithelial potential difference in the brine shrimp Artemia sauna. J. Exp. Biol. 151, 279–296 (1990). F. P. Conte, Molecular domains in epithelial salt cell NaCl of crustacean salt gland (Artemia). Int. Rev. Cell Mol. Biol. 268, 39–57 (2008). F. P. Conte, S. R. Hootman, P. J.
Commentary: A little baby talk is good for your toddler
WINNIPEG, Canada: Has anyone ever told you: “Don’t baby talk to your baby?” Parents of young infants often tell us that they have heard this advice from friends, family and even health care professionals. Advertisement Advertisement As the lead researchers in a study of over 2,200 infants across 67 laboratories in 16 countries, we have good reason to give you the opposite advice.
Why baby talk is good for your toddler
By Melanie Soderstrom and Michael C. Frank 11m ago Has anyone ever told you: “Don’t baby talk to your baby?” Parents of young infants often tell us that they have heard this advice from friends, family and even health care professionals. As the lead researchers in a study of over 2200 infants across 67 laboratories in 16 countries, we have good reason to give you the opposite advice.
Why a little baby talk is good for your toddler
Babies around the world love ‘baby-talk’ and it can help them learn language too. Credit: Richard Sagredo/Unsplash Has anyone ever told you: "Don't baby talk to your baby?" Parents of young infants often tell us that they have heard this advice from friends, family and even health care professionals. As the lead researchers in a study of over 2,200 infants ac … ries in 16 countries, we have good reason to give you the opposite advice.
Why A Little Baby Talk Is Good For Your Toddler
Babies around the world love ‘baby-talk’ and it can help them learn language too. (Richard Sagredo/Unsplash) Has anyone ever told you: “Don’t baby talk to your baby?” Parents of young infants often tell us that they have heard this advice from friends, family and even health care professionals. As the lead researchers in a study of over 2,200 infants across 67 laboratories in 16 countries, we have good reason to give you the opposite advice.
Difficult parenting relationships leave some children needing more from their educators
Researchers from New York University (NYU) have found that children who are characterised as having a high need for reassurance and support from their early childhood educators are often those who have difficulties in relationships with their mothers.
Why A Little Baby Talk Is Good For Your Toddler
Written by Melanie Soderstrom and Michael C. Frank Babies around the world love ‘baby-talk’ and it can help them learn language too. (Richard Sagredo/Unsplash) Has anyone ever told you: “Don’t baby talk to your baby?” Parents of young infants often tell us that they have heard this advice from friends, family and even health care professionals. As the lead researchers in a study of over 2,200 infants across 67 laboratories in 16 countries, we have good reason to give you the opposite advice.
Why a little baby talk is good for your toddler
Has anyone ever told you: “Don’t baby talk to your baby?” Parents of young infants often tell us that they have heard this advice from friends, family and even health care professionals. As the lead researchers in a study of over 2,200 infants across 67 laboratories in 16 countries, we have good reason to give you the opposite advice.
(Baby)Talk to Me
Since the mid-20th century, scientists have observed unique features in speech, facial expression, and content directed to infants and toddlers in comparison to speech directed to adults. Whereas much research has studied the characteristics of so-called infant-directed speech and speculated about its significance for language learning, research directly testing these ideas has been more limited until recently.
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