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Abstract The cerebral cortex is organized along a dominant sensorimotor-to-association (S–A) axis, anchored by modality-specific primary sensorimotor areas at one end and transmodal association areas forming distributed networks that support abstract cognition at the other1,2,3,4,5,6,7,8,9,10,11. The developmental mechanisms shaping this axis remain unclear9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24.
Age is the most important risk factor for the transition from relapsing multiple sclerosis (R-MS) to secondary-progressive MS (SP-MS).1 Primary progressive MS (PP-MS) does not occur in pediatric cases and it typically presents at an older age than R-MS.2 Notably, the older the age the presentation of R-MS the greater the likelihood for transition to SP-MS.1, 3 This association of disability progression with aging has implicated age-related neurodegenerative processes as pathological...
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