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Articles by Min Yan
The Five Phases of cancer cells
Keywords PHASE biological processes mutual interaction cancer hallmarks cancer therapy PHASE and the interactive nature of cancer cell biology As our understanding of cancer deepens, a growing array of cancer hallmarks has been proposed to characterize the diverse traits and functional capabilities of malignancy. Recent comprehensive reassessments have taken steps to enrich this concept by incorporating interconnected dimensions of biological complexity and contextual dependence [1–3].
Cipepofol combined with esketamine for anesthetic management of patients with extensive severe burns: a retrospective case series
Abstract Background: Patients with extensive severe burns are prone to both hypermetabolic tachycardia and anesthesia-induced hypotension, and their pain is often inadequately controlled with opioids alone. Cipepofol, a novel intravenous hypnotic structurally related to propofol, has shown greater hemodynamic stability than propofol, whereas esketamine provides analgesia and has indirect sympathomimetic activity.
Entinostat plus exemestane for hormone receptor-positive advanced breast cancer: long-term overall survival results from the EOC103A3101 randomized controlled trial
Abstract The addition of entinostat, a histone deacetylase inhibitor, to exemestane has demonstrated improved progression-free survival (PFS) in hormone receptor-positive (HR + ), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) following endocrine therapy failure in the EOC103A3101 randomized trial (NCT03538171). This study reports long-term overall survival (OS) results.
Gui Gan Shen Mai Yin attenuates cardiac hypertrophy and dysfunction in association with mitochondrial homeostasis and the PI3K/AKT1 signaling pathway
Abstract This study aimed to evaluate the effects of Gui Gan Shen Mai Yin (GGSMY) on cardiac hypertrophy and dysfunction and to explore associated mechanisms. The chemical profile of the GGSMY aqueous extract was characterized using UPLC-MS. Candidate active ingredients and potential targets were analyzed by network pharmacology, and molecular docking was used to evaluate predicted interactions between representative components and AKT1.
Neoadjuvant anti-HER2 antibody-drug conjugate SHR-A1811 in Hormone Receptor-positive, HER2-low Breast Cancer: A Phase 2 Clinical Trial (HELEN-015)
Abstract As an anti-HER2 antibody-drug conjugate, SHR-A1811 has exhibited significant antitumor activity in patients with HER2-low advanced breast cancer. This trial aims to explore the efficacy and safety profile of SHR-A1811 as a neoadjuvant therapy for hormone receptor-positive, HER2-low (HR + /HER2-low) breast cancer.
Analytical and Laboratory Investigation of Groundwater Pumping in Strip Island Aquifers With Single-Sided Land Reclamation
1 Introduction Small islands constitute critical habitats for millions of people worldwide and host highly distinctive ecological, social, and economic systems (Connell, 2013; Kier et al., 2009; Nurse et al., 2014). On many of these islands, groundwater stored in buoyant freshwater lenses overlying denser saline water is often the primary and most reliable source of potable water, due to limited surface water availability and the high costs for desalination or bulk water transport (A.
Lactate-to-albumin ratio improves prediction of perioperative mortality in lung transplant patients
Abstract Backgrounds: Perioperative mortality remains elevated among lung transplant recipients. The lactate-to-albumin ratio (LAR) is a prognostic indicator, but its role in predicting mortality in lung transplant patients remains unclear. The study aims to assess the incremental prognostic value of LAR and develop a more accurate prediction model for perioperative mortality in lung transplant patients.
Dalpiciclib synergizes with pyrotinib to inhibit HR−/HER2+ breast cancer via CTGF targeting in the hippo pathway
Abstract The efficacy of pyrotinib monotherapy in HER2-positive breast cancer cells is limited, exhibiting a low response rate. Prolonged exposure to pyrotinib induces drug resistance. As downstream effectors of HER2 signaling, CDK4/6 contribute to resistance against HER2-directed therapies. Conversely, combination therapy significantly improves drug efficacy and extends the duration of treatment.
From privacy to infrastructure regulation: rethinking the ethical foundations and functions of data protection in the information age
Abstract This article argues that data protection should be reconceptualised as a regulatory regime for data infrastructure, rather than replicating the prohibitive logic of privacy. Despite increasing recognition within European legal discourse, data protection is still widely conflated with privacy in transnational contexts. This conceptual conflation undermines regulatory coherence, erodes normative legitimacy and constrains the capacity of data protection law to address collective harms.
Prediction of massive intraoperative blood transfusion requirement in lung transplantation
Abstract Background: Massive transfusion (MT) during lung transplantation (LTx) is associated with primary graft dysfunction and increased risk of post-LTx mortality and morbidity. To date, predictive factors for MT during LTx are unknown. This study aimed to establish a predictive model for intraoperative MT in patients undergoing LTx to provide personalized risk prediction.
Min Yan | Authors | CancerNetwork
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Study on the synergistic control effect of composite reagent water spray on gas and coal dust
Abstract Gas and coal dust, as potentially hazardous substances (PHSs) produced during mining, are considered two serious threats to safe mining and the health of miners because of their explosive and pathogenic properties.
Reviving Hope: Overcoming Deep Brain Stimulation Failure With Partial Cranial Nerve Radiofrequency Ablation in Primary Meige Syndrome
1 Introduction Primary Meige syndrome (PMS) is a segmental craniocervical dystonia characterized by involuntary, axisymmetric movement of craniocervical muscles (LeDoux 2009). Although the condition was first described over a century ago (Henry 1910), its management remains a significant clinical challenge due to its obscure pathogenesis and the lack of specific oral pharmacotherapies. While local botulinum toxin (BoNT) injections offer effective symptomatic relief (Jochim et al.
SHR-A1811, a novel HER2-targeting antibody-drug conjugate, in advanced solid tumors (HORIZON-X): a global phase 1 trial
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Abstract SHR-A1811, an antibody‒drug conjugate consisting of the anti-HER2 antibody trastuzumab conjugated via a cleavable linker to a topoisomerase I inhibitor payload, demonstrated substantial antitumor activity in patients with heavily treated HER2-expressing or mutated advanced solid tumors. The main analysis was reported, and this is a long-term follow-up of the HORIZON-X trial (NCT04446260).
By Herui Yao, Min Yan, Zhongsheng Tong, Xinhong Wu, Yongmei Yin, Min-Hee Ryu, John Park, Shusuan Jiang, Jee Hyun Kim, Shouman Wang, Yahua Zhong, Mark Voskoboynik, Jian Zhang, Andreas Kaubisch, Caigang Liu, Yu Chen, Seock-Ah Im, Lingying Wu, Yingbin Liu, Vinod Ganju, Minal Barve, Hui Li, Guangyu Yao, Lequn Bao, Yiming Zhao Verified, Jianli Zhao, Yu Shen, Xiaoyu Zhu, Erwei Song, Mudan Yang, Kaijing Zhao, Shangyi Rong
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Nature
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Pyrotinib or placebo in combination with trastuzumab and docetaxel for HER2 positive metastatic breast cancer: long term survival results from randomised phase 3 PHILA trial
Research BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-087259 Cite this as: BMJ 2026;392:e087259 Fei Ma, professor, Min Yan, professor, Wei Li, professor, Quchang Ouyang, professor, Zhongsheng Tong, professor, Yuee Teng, professor, Yongsheng Wang, professor, Shusen Wang, professor, Cuizhi Geng, professor, Ting Luo, professor, Jincai Zhong, professor, Qingyuan Zhang, professor, Qiang Liu, professor, Xiaohua Zeng, professor, Tao Sun, professor, Qinguo Mo, professor, Shoubing Zhou,...
Author Correction: Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype - Nature Communications
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Correction to: Nature Communications https://doi.org/10.1038/ncomms10180, published online 19 January 2016 In the version of the article initially published, in both “1st” panels in Fig. 6e, the images labelled “1” were incorrect due to an error in figure preparation (they were sourced from a different but methodologically similar mammosphere experiment done on the same day). The corrected Fig. 6 is shown below.
By Feimeng Zheng, Caifeng Yue, Guohui Li, Wei Cheng, Xi Wang, Min Yan, Zijie Long, Wanshou Qiu, Zhongyu Yuan, Jie Xu, Bing Liu, Qian Shi, Eric Lam Verified, Mien-Chie Hung, Quentin Liu
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Nature
Verified
Vunakizumab for IL-17A–Mediated Diseases: A Review in Psoriasis and Spondyloarthritis
Back to Journals » Biologics: Targets and Therapy » Volume 20 Authors Yan H, Chen Y , Song Y, Yan M, Yan K Received 31 January 2026 Accepted for publication 26 May 2026 Published 8 June 2026 Volume 2026:20 500475 DOI https://doi.org/10.2147/BTT.S500475 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Shein-Chung Chow Hongzhuo Yan,1,2,* Yu Chen,3,* Yali Song,1 Min Yan,1 Kexiang Yan1 1Dermatology Diagnosis and...
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