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Articles by Nathaniel Anderson
Embryonic origin of cancer in newborn twins
Abstract Studying monozygotic twins who present with identical cancers informs on the developmental origins of childhood tumours. Here, we perform whole genome sequencing on multiple tumour, normal, and placental samples to reconstruct the phylogeny of a soft tissue cancer that spread in utero between monozygotic twins. We demonstrate the origin of the tumour from one twin and time its diversification and transplacental spread to the other twin, showing that the spread occurred only once.
Extensive and differential platinum chemotherapy mutagenesis in livers of children
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Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share This article has 0 eLetter . Editor’s summary Pediatric cancers are now more treatable than they have ever been before, but the treatments come with their own risks. Survivors of pediatric cancer can experience multiple long-term health consequences, some of which are not fully understood.
By Monica Sharma, Noriyuki Kawasaki, Anna Wenger, Jean-Baptiste Vannier, Henry Lee-Six, Giulia Emanuelli, Manas Dave, Mehdi Layeghifard, Andrew Lawson, Federico Abascal, Pantelis Nicola, Taryn D Treger, Toochi Ogbonnah, Conor Parks, Thomas Oliver, Jonathan Kennedy, Angus Hodder, Nathaniel Anderson, Mi K Trinh, Thomas Dowe, Robin Loesch, Marwo Habarwaa, James J. Sun, Sergio Assia-Zamora, Miriam Cortes-Cerisuelo
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Science Magazine
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Prior therapy defines mutation profiles in childhood cancer at relapse
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Abstract Children with cancer develop many short- and long-term side-effects of treatment1, but the amount of DNA damage associated with chemotherapy exposure is unclear2. Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a multi-institutional cohort for which therapy dose and total exposure were uniformly collected3,4,5.
By Mehdi Layeghifard, Marcos Díaz-Gay, Erik Bergström, Mathepan Mahendralingam, Nicholas Light, Sasha Blay, Joshua Nash, Nathaniel Anderson, Jessica Au, Scott Davidson, S. Islam, Azhar Khandekar, Burcak Otlu, Ledia Brunga, Rawan Hammad, Nirav Thacker, Noemi Fuentes-Bolanos, Marie Wong-Erasmus, Max Levine, Katherine Miller Verified, Neerav Shukla, Michael D. Kinnaman, Dominik Glodzik, Carol Portwine, Mariam Mikhail, Conrad V. Fernandez, Laura Wheaton, Gunes Gundem, Andrew Kung, Uri Tabori, Chelsea Mayoh, Elli Papaemmanuil, Mark Cowley, David Malkin, Anita Villani, Ludmil B. Alexandrov, Adam Shlien, Pedro L. Ballester, Timmy Wen, Syed Kashif Daud, Lisa-Monique Edward, Shimaa Nassif, Tara Feltham, Sabrina Millson, Alexandra P. Zorzi
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Nature
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Single cell transcriptional evolution of myeloid leukemia of Down syndrome
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Abstract Children with Down syndrome have a 150-fold increased risk of developing myeloid leukaemia (ML-DS). Unusually for a childhood leukaemia, ML-DS arises from a preleukaemic state, termed transient abnormal myelopoiesis (TAM), via a conserved sequence of mutations. Here, we examine the relationship between the genetic and transcriptional evolution of ML-DS from natural variation; a rich collection of primary patient samples and foetal tissues with a range of constitutional karyotypes.
By Mi K Trinh, Konstantin Schuschel, Hasan Issa, Rebecca Thomas, Conor Parks, Agnes Oszlanczi, Di Zhou, Lira Mamanova, Elena Prigmore, Angus Hodder, Anna Wenger, Nathaniel Anderson, Holly Whitfield Verified, Taryn D Treger, José Gonçalves-Dias, Karin Straathof, David H. O’Connor, Matthew Young Verified, Laura Jardine, Stuart Adams, Jan-Henning Klusmann, Jack Bartram, Sam Behjati, Toochi Ogbonnah, Emilia R. Robertson
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Nature
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Single-cell transcriptional consequences of leukaemogenic SETBP1 mutations
To the Editor, Cellular effects of oncogenic mutations are traditionally studied in model systems, such as cell lines or animal models. While these approaches afford precise control over confounders and enable experimental manipulation, their inherent weakness is the non-native habitat in which mutations are placed. Natural genetic variation, by contrast, enables the investigation of mutations within their pathophysiological context.
A non-canonical lymphoblast in refractory childhood T-cell leukaemia - Nature Communications
Abstract Refractory cancers may arise either through the acquisition of resistance mechanisms or represent distinct disease states. The origin of childhood T-cell acute lymphoblastic leukaemia (T-ALL) that does not respond to initial treatment, i.e. refractory disease, is unknown. Refractory T-ALL carries a poor prognosis and cannot be predicted at diagnosis. Here, we perform single cell mRNA sequencing of T-ALL from 58 children (84 samples) who did, or did not respond to initial treatment.
Drought and Wildfire Legacies Highlight Vulnerability of a Mediterranean Climate‐Type Forest
Conflicts of Interest The authors declare no conflict of interests. Supporting Information Filename Description aec70011-sup-0001-DataS1.docxWord 2007 document , 171.7 KB Data S1. References , and . 1986. Ecology of Jarrah (Eucalyptus marginata) in the Northern Jarrah Forest of Western Australia. Perth, Western Australia: Department of Conservation and Land Management. , and . 2002.
Examining the Association between Psychopathic Traits and Fearlessness among Maximum-Security Incarcerated Male Adolescents
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A Review of Biomass-to-Bioenergy Supply Chain Research Using Bibliometric Analysis and Visualization
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Putting bacteria on the cancer map
In a study recently in Nature, Galeano Niño et al. use spatial profiling and single-cell RNA sequencing to delineate the spatial organization of microbiota in cancer. Their findings demonstrate that tumor-associated microbiota coalesce in micro-niches where they may mediate immune and epithelial oncogenic roles.
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis - Nature Communications
Abstract Li-Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome associated with germline TP53 pathogenic variants. Here, we perform whole-genome sequence (WGS) analysis of tumors from 22 patients with TP53 germline pathogenic variants. We observe somatic mutations affecting Wnt, PI3K/AKT signaling, epigenetic modifiers and homologous recombination genes as well as mutational signatures associated with prior chemotherapy.
Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Genome and Epigenome Ana Stosic, Fabio Fuligni, Nathaniel D. Anderson, Scott Davidson, Richard de Borja, Meryl Acker, Vito Forte, Paolo Campisi, Evan J. Propst, Nikolaus E. Wolter, Rose Chami, Ozgur Mete, David Malkin, Adam Shlien and Jonathan D. Wasserman DOI: 10.1158/0008-5472.CAN-21-0761 Published November 2021 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below.
Diverse Oncogenic Fusions and Distinct Gene Expression Patterns Define the Genomic Landscape of Pediatric Papillary Thyroid Carcinoma
Genome and Epigenome Ana Stosic, Fabio Fuligni, Nathaniel D. Anderson, Scott Davidson, Richard de Borja, Meryl Acker, Vito Forte, Paolo Campisi, Evan J. Propst, Nikolaus E. Wolter, Rose Chami, Ozgur Mete, David Malkin, Adam Shlien and Jonathan D. Wasserman DOI: 10.1158/0008-5472.CAN-21-0761 Abstract Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease. Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains highly favorable.
Diverse oncogenic fusions and distinct gene expression patterns define the genomic landscape of pediatric papillary thyroid carcinoma
Research Article Ana Stosic, Fabio Fuligni, Nathaniel D. Anderson, Scott Davidson, Richard de Borja, Meryl Acker, Vito Forte, Paolo Campisi, Evan J. Propst, Nikolaus E. Wolter, Rose Chami, Ozgur Mete, David Malkin, Adam Shlien and Jonathan D. Wasserman DOI: 10.1158/0008-5472.CAN-21-0761 Abstract Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease. Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains highly favorable.
Machine learning of brain gray matter differentiates sex in a large forensic sample
Differences between males and females have been extensively documented in biological, psychological, and behavioral domains. Among these, sex differences in the rate and typology of antisocial behavior remains one of the most conspicuous and enduring patterns among humans. However, the nature and extent of sexual dimorphism in the brain among antisocial populations remains mostly unexplored.
Machine learning of brain gray matter differentiates sex in a large forensic sample
The full text of this article hosted at iucr.org is unavailable due to technical difficulties. RESEARCH ARTICLE Machine learning of brain gray matter differentiates sex in a large forensic sample Nathaniel E.
Recovering from the Mountain Pine Beetle
Beginning in the late 1990s, the pine forests of Montana began to experience the largest mountain pine beetle outbreak in recorded history. Large swaths of forests began to turn red, then gray as the beetles ate their way through Pacific Northwest stands. At their peak in 2009, this native insect infested nearly 3.7 million acres statewide, leaving dead or dying trees in their wake.
Access To Care And Affordability Have Improved Following Affordable Care Act Implementation; Problems Remain
Access To Care And Affordability Have Improved Following Affordable Care Act Implementation; Problems Remain
Uninsurance Disparities Have Narrowed For Black And Hispanic Adults Under The Affordable Care Act
Uninsurance Disparities Have Narrowed For Black And Hispanic Adults Under The Affordable Care Act Stacey McMorrow1,*, Sharon K. Long2, Genevieve M. Kenney3 and Nathaniel Anderson4 1Stacey McMorrow (SMcMorrow{at}urban.org) is a senior research associate in the Health Policy Center of the Urban Institute, in Washington, D.C. 2Sharon K. Long is a senior fellow in the Health Policy Center of the Urban Institute. 3Genevieve M.
The link between income and the environments that promote child health
The higher your income, the better your health—and not just because higher-income families can afford better medical care. Income also affects the environments that people live in and the many factors that add up to good health. This relationship between income and health begins before conception, exists at birth and persists throughout childhood and into adulthood. So just how does income get under our skin to affect our health and survival?
How Many Nongroup Policies Were Canceled? Estimates From December 2013
Last fall, news reports focused on consumer discontent over “cancellation” notices of health insurance policies that did not meet the new minimum standards under the Affordable Care Act (ACA), but it’s difficult to determine exactly how many consumers were affected.
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