Pan Li
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Articles by Pan Li
SAR object detection via adaptive shift-wise downsampling and frequency-spatially modulated feature fusion
Abstract Object detection in synthetic aperture radar (SAR) imagery is challenged by speckle noise, background clutter, and large variations in target scale. We present ASCE-SAR, a YOLO11-based detector that coordinates adaptive shift-wise downsampling with frequency-spatially modulated multi-scale fusion. In the backbone, the Adaptive Downsampling with Shift-Wise Convolution (ADSC) block combines structure-preserving downsampling and enlarged receptive-field modeling.
Knockdown of SPAG6 regulates triglyceride metabolism via the P38 MAPK/ERK/PPARα axis in acute myeloid leukemia
Abstract Numerous studies have already revealed that the development of acute myeloid leukemia (AML) is closely related to the dysregulation of lipid metabolism. The aim of this study was to elucidate the biological role and molecular mechanisms of Sperm Associated Antigen 6(SPAG6) in AML. Our research found that the expression level of SPAG6 was significantly elevated in clinical samples of AML compared to normal samples.
CGP60474, a novel MITD1-targeted inhibitor for bladder cancer progression via CDK4/cyclin D1 pathway modulation
Abstract Targeted therapy holds promise for advanced bladder cancer, but its development is limited by a lack of therapeutic targets. Here, we show that MITD1 is elevated in bladder cancer and associated with poor patient prognosis. We find that MITD1 drives cancer progression by interacting with the CDK4/cyclin D1 complex to regulate the cell cycle. Genetic deletion of MITD1 inhibits tumor growth, confirming its key role.
Apendiceal bleeding diagnosed by cholangioscope through the operative channel of a colonoscope: a case report
Short communicationArticles in PressOpen access Affiliations & Notes 1Department of Gastroenterology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China 2Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China Article Info Publication History: Received January 12, 2026; Revised February...
Social disconnection integrates genetic and proteomic risks in suicidal ideation and depression
Abstract Suicidal ideation (SI) and major depressive disorder (MDD) are complex psychiatric conditions arising from the interplay of genetic liability, molecular processes, and psychosocial factors. While these dimensions have been extensively studied in isolation, their joint contribution to SI and MDD remains unclear. This study integrates multi-modal data to elucidate these synergistic effects and develop robust models for individual-level risk stratification.
Geo-Hete-HyperGNN as a prior-free molecular hypergraph representation learning strategy
Abstract Molecular representation learning is a cornerstone of AI-driven chemical discovery. However, most molecular hypergraph models define hyperedges using expert-crafted rules and often overlook three-dimensional molecular geometry.
Dense soccer video captioning with global context and player position awareness
Abstract Sports video captioning plays an important role in understanding and describing dynamic visual content, and it is particularly challenging for long soccer broadcasts. Existing dense captioning methods often rely on local clips and may miss match-level temporal context or player-position cues, which can lead to captions with insufficient spatial and event-sequence detail.
An epithelial-derived epigenetic clock reveals pathway-level aging mechanisms in chronic lung disease
Abstract Biological aging is strongly associated with tissue vulnerability in the respiratory system, yet existing epigenetic clocks remain limited by insufficient tissue specificity and poor mechanistic interpretability. We developed and validated tissue-specific PathwayAge clocks for airway epithelium and pulmonary parenchyma by projecting DNA methylation profiles onto gene ontology pathways.
IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder
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Abstract Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD patients. The plasticity of Tregs and microenvironmental reprogramming mechanisms remain elusive, highlighting the need for pathology-driven biomarkers and targeted interventions.
By Yao Gao, Zihan Lei, Xianyan Zhan, Yifan Ren, Zirong Chen, Qingyan Ma, Wei Qing Wang, Yunpeng Wang, Yijie Guo, Yuan Gao Verified, Feng Zhu, Xiancang Ma, Pan Li
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Nature
Verified
A controlled in silico benchmark for GNN prediction of tissue dynamics
Abstract Graph Neural Networks (GNNs) are promising tools for predicting tissue dynamics, but choosing the right architecture remains difficult because experimental datasets are limited, noisy, and system-specific. We introduce a controlled in silico benchmark for comparing GNN architectures on a vertex-model task: predicting relaxed cell–cell interface lengths after a cell neighbor exchange.
Case Report: Basal ganglia brain abscess caused by Nocardia farcinica
Abstract We report a rare case of Nocardia farcinica brain abscess in the basal ganglia, detailing its diagnosis, management, and rehabilitation. Diagnosing brain abscess based solely on clinical and imaging findings remains extremely challenging. Fortunately, metagenomic next-generation sequencing (mNGS) proved valuable in this case by rapidly identifying the pathogen, thereby facilitating targeted antibiotic therapy.
SphereDiff-TS: Sphere Space Diffusion Modeling for Accurate 3D Transition State Geometry Prediction Click to copy article link Article link copied!
1. Introduction Click to copy section linkSection link copied! The transition state corresponds to a high-energy, transient configuration through which reactants must pass along the minimum energy path to form products, characterized as a first-order saddle point on the potential energy surface.
Hematuria following arginine growth hormone stimulation testing in a child: a case report and literature review
Abstract Background: Arginine growth hormone (GH) testing is a commonly used and generally safe pediatric procedure for assessing GH deficiency. The occurrence of gross hematuria following this testing is a rare adverse drug reaction that had not been previously encountered at our institution, raising significant concerns among both patients and clinicians. Case presentation: An 11-year-and-3-month-old boy presented with short stature.
Washed Microbiota Transplantation as a Rescue Therapy for Refractory Unidentified Pathogen Intestinal Infections: Findings From a National Multi-Centre, Real-World Study
1 Introduction Intestinal bacterial infections result in a spectrum of symptoms ranging from self-limiting diarrhoea to life-threatening conditions such as severe dehydration, shock, malnutrition and even death (Petri Jr. et al. 2008). The primary treatment for enteric infections involves antibiotics, which paradoxically can exacerbate dysbiosis and provoke antimicrobial resistance, consequently contributing to the emergence of refractory infections (Shakoor et al. 2019; Timsit et al. 2025).
Correction: Dosage suppressors of gpn2ts mutants and functional insights into the role of Gpn2 in budding yeast
There are errors in the Funding statement. The correct Funding statement is as follows: This work was supported by grants from the National Key Research and Development Program of China (2023YFD1401500 to F.Z.), the National Natural Science Foundation of China (no. 32070574 to F.Z.), the Hebei Provincial Science Foundation for Outstanding Young Scholars (C2023204155 to F.Z.), and Operation Expenses for Universities’ Basic Scientific Research of Hebei Province (KY2024043 to F.Z.). Reference 1.
Dual-Modal Fusion Based on Peptide Sequence and Molecular Graph with Bidirectional Cross-Attention for Precise Peptide Toxicity Prediction
Abstract Click to copy section linkSection link copied! Peptide drugs have become an important direction in new drug development due to their high specificity, designability, and good biocompatibility. However, toxicity risk remains a key bottleneck limiting the translation of peptides from lead peptides to clinical applications. Therefore, there is an urgent need to develop a high-precision and scalable toxicity assessment framework.
Specialized aldo-keto reductases trigger complete degradation of mycotoxin deoxynivalenol - Nature Communications
Abstract The mycotoxin deoxynivalenol (DON) poses severe threats to human and animal well-being globally. Enzymatic degradation is the most effective way to eliminate DON toxicity, yet no catalytic process for complete degradation of DON has been uncovered. Here, we show that a metabolic pathway initiated by C3-epimerization and C8-reduction is responsible for complete degradation of DON in the DON-metabolizing bacterium Nocardioides sp. S5-5.
The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model
Loading metrics Open Access Peer-reviewed Research Article Citation: Zhou Z, Lu Y, Li P, Liu X, Cheng W, Chen H-N, et al. (2026) The lipid-metabolic enzyme HSD17B12 drives lysosomal degradation of PD-L1 potentiating anti-tumor immunity in a mouse model. PLoS Biol 24(1): e3003603.
Correction: Research progress on biot-mercury interactions in the periphyton: environmental processes, ecological effects and restoration applications
A Correction on Research progress on biot-mercury interactions in the periphyton: environmental processes, ecological effects and restoration applications by Li P, Xu M, Xu Y, Zhao W, Miao L and Zhou J (2026). Front. Environ. Sci. 13:1693766. doi: 10.3389/fenvs.2025.1693766 Affiliations 1. Guangxi Key Laboratory of Environmental Pollution Control Theory and Technology, Guilin University of Technology, Guilin, 541006, China; 2.
Water‐Soluble Metal Phthalocyanines Enable Molecularly Dispersed Heterogeneous Electrochemical CO2 Conversion
1 Introduction The development of efficient electrocatalysts for electrochemical CO2 conversion has attracted considerable attention over the past decades, driven by the growing demand for sustainable technologies that mitigate carbon emissions and enable renewable energy storage [1, 2]. Among the diverse classes of CO2 reduction electrocatalysts, molecular catalysts represent a particularly important category due to their well-defined active sites and precisely tunable structures [3-7].
Frontiers | Melanoma vaccines: current R&D landscape, translational hurdles, and future outlook—a perspective drawn from 442 clinical trials
1 Introduction Melanoma is the most aggressive subtype of skin cancer, characterized by strong invasiveness and metastatic potential. It can spread to distant organs such as the lungs, liver, and brain via lymphatic and hematogenous pathways even at an early stage, resulting in an extremely poor prognosis for patients (1).
Refining small object detection in aerial images with PF-DETR: a progressive fusion approach
Refining small object detection in aerial images with PF-DETR: a progressive fusion approach Xijing University, Xi’an, Shannxi, China DOI 10.7717/peerj-cs.3470 Academic Editor Davide Chicco Subject Areas Artificial Intelligence, Computer Vision, Data Mining and Machine Learning Keywords Small object detection, Spatial-frequency modeling, Multi-scale feature fusion, RT-DETR, Aerial images Copyright © Licence This is an open access article distributed under the terms of the Creative Commons...
Multi‐Band Electrochromic Smart Window via Synergistic Heterojunction and Electrode Design for Dynamic Solar‐Thermal Radiation Modulation
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
Oral frailty subtypes and influencing factors in older patients with ischemic stroke: a latent profile analysis
1 Introduction The number of older people is increasing due to society’s rapid aging. The United Nations Population Division projects that the proportion of older adults will double over the next three decades, accounting for 16% to 22% of the world’s population by 2050 (1). This demographic shift will have a significant impact on public health services and socioeconomic development. Oral frailty is a relatively new concept that has garnered increased attention recently.
Branching Strategies Based on Subgraph GNNs: A Study on Theoretical Promise versus Practical Reality
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
CD4+ T cell dysregulation in major depressive disorder is associated with sleep disturbance
1 Introduction Major depressive disorder (MDD), a prevalent neuropsychiatric condition affecting 10-20% of the global population, constitutes the leading cause of disability-adjusted life years worldwide (1–3).
Excessive Use of Polygonatum sibiricum Causes No Acute Lethality but Induces Multiple Toxic Effects in Mice
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description jat70013-sup-0001-Supplementary_Material.docxWord 2007 document , 2.5 MB Figure S1: Network pharmacology analysis of PS-induced hepatotoxicity. A. PPI network of the intersection targets (STRING 12.0). B. Top 10 hub targets ranked by MCC. C.
Belobog: Move Language Fuzzing Framework For Real-World Smart Contracts
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Protein Glycosylation: An Emerging Regulator of Allergic Diseases
1 Introduction Type 2 (T2) inflammation is a central immunopathological mechanism driving allergic disorders like asthma, atopic dermatitis (AD), allergic rhinitis (AR), eosinophilic esophagitis (EoE), and food allergy. It often arises from the chronic dysregulation of the innate and adaptive immune systems triggered by environmental, genetic, and epithelial barrier disruption factors.
Mass Diffusion‐Dominated Phase Separation Enabling On‐Demand and Repeatable Lifetime Programming of Room‐Temperature Phosphorescence Polymer Hydrogels
Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article.
The Experiences and Needs of Patients With Malignant Fungating Wounds: A Meta‐Synthesis of Qualitative Studies
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement All data generated or analysed in this study is included in the published article. Peer Review The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/jan.70397. Supporting Information Filename Description jan70397-sup-0001-DataS1.docxWord 2007 document , 29.4 KB Data S1: Search strategy.
Cartier卡地亞Tank手錶推介｜7款Cartier Tank熱門選擇2025價錢及介紹
很多人以為Cartier（卡地亞）的Tank手錶專為女士而設戴，這是大錯特錯！Tank其實是一款雄糾糾的男裝錶，錶名叫Tank，設計當然跟坦克有關，這源於品牌當年掌舵人Louis Cartier，因為在第一次世界大戰期間見到新發明的坦克車，粗獷巨大又霸氣十足，因而設計出這款方形腕錶，在當年屬極大膽前衛的設計。源自坦克的男人浪漫，Tank腕錶不只又靚又易認，價位亦有一定吸引力，以下介75款Tank手錶，你又有沒有興趣入手一枚？ 1Cartier Tank Must SolarBeat™ (WSTA0120) Cartier Tank Must SolarBeat™是Cartier Tank 系列中創新環保的代表作，於2021年推出時為品牌首款太陽能供電腕錶。這款大腕錶以不鏽鋼錶殼打造，尺寸為33.7 mm x 25.5 mm，厚度僅6.6 mm，輕薄舒適，適合日常佩戴。設計上保留Tank 經典元素，包括垂直側邊支架（brancards）、珠狀錶冠鑲嵌合成尖晶石，以及銀色錶盤配以藍鋼劍形指針和羅馬數字刻度。獨特之處在於SolarBeat™...
Research progress on biot-mercury interactions in the periphyton: environmental processes, ecological effects and restoration applications
1 Introduction Mercury (Hg) is a widespread global pollutant, found throughout the natural environment, posing a health threat to millions of people worldwide. In 2010, the World Health Organization identified mercury as one of the top ten chemicals of major concern for public health (Zhang, 2022).
This paper presents a comprehensive optimization of tuning capability and noise characteristics in 1018-nm distributed Bragg reflector (DBR) single-frequency fiber lasers. By implementing an advanced doped fiber design and a dual-stage precision thermal control system, for the first time, we demonstrate a fusion-spliced DBR fiber laser incorporating an 8-mm Yb-doped fiber that achieves >2 nm mode-hop-free continuous tuning across an extended temperature range of −20 °C to 175 °C.
Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Li P, Lee S, Choi K-Y, Rubin JE, Kim JK (2025) Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias. PLoS Comput Biol 21(7): e1013318. https://doi.org/10.1371/journal.pcbi.1013318 Editor: Christian I.
TRAF6 regulates ubiquitination-independent TDP-43 condensation and related neurodegeneration - Molecular Psychiatry
Abstract Cytoplasmic aggregates of TDP-43 are hallmarks of multiple neurodegenerative diseases. However, the underlying mechanisms driving TDP-43 pathological aggregation remain elusive. In this study, we revealed that TNF receptor-associated factor 6 (TRAF6) promotes TDP-43 condensation, and disrupting TRAF6-TDP-43 interactions effectively suppresses its aggregation.
Synergistic Efficiency‐Stability Enhancement in Sn-Pb Narrow‐Bandgap Perovskite Solar Cells via Molecular Chain‐Length Engineering
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202506017-sup-0001-SuppMat.docx22.6 MB Supporting Information References 1, , , , , , , , , , , , , , , , , , , , , , , , , , , , Nat. Photonics 2025, 19, 170. 2, , , , , , , , , , , , , , , , Nature 2024, 628, 306. 3, , , , , , , , , , , Nat. Energy 2022, 7, 744. 4, , , , , , , , , , , , , , , , , , , , , , , , Nat. Mater. 2025, 24, 252. 5, , , , , , , , , , , Nat. Commun. 2024, 15, 6887.
Study on the Screening of Anti‐Osteoporosis Components in Processed Epimedium‐Based on Spectrum‐Effect Analysis
BPI base peak intensity EP Epimedium KGB kidney governing bone KYDS Kidney-Yang deficiency syndrome REP raw Epimedium SEP stir-frying Epimedium SOEP suet oil processed Epimedium TCM traditional Chinese medicine TFC total flavonoid content UPLC–QQQ–MS/MS ultrahigh-performance liquid chromatography coupled with triple–quadrupole mass spectrometry WEP wine-processed Epimedium WSOEP wine and suet oil processed Epimedium 1 Introduction Epimedium (EP), a traditional Chinese herb, was first recorded...
Whole chloroplast genomes reveal a complex genetic legacy of lost lineages, past radiations and secondary contacts in the dominant temperate deciduous tree genus Fagus
Abstract Major northern temperate tree genera emerged in the Eocene and now have vast ranges across the Northern Hemisphere. However, few sufficiently high-resolution studies have been done to understand the biogeographic history shaping modern day temperate forests. Here we undertake a multi-discipline study to provide unprecedented insights into the formation of a dominant temperate tree genus, Fagus L..
Phylogenomics of Aristolochia subg. Siphisia (Aristolochiaceae) reveals widespread incomplete lineage sorting and supports a novel pollinator-filtering hypothesis
Abstract Aristolochia subgenus Siphisia constitutes a monophyletic lineage of predominantly lianescent species, with occasional shrubs or herbs, and is characterized by remarkable diversity in perianth morphology. Members of Siphisia serve as larval hosts for endangered Lepidoptera and are widely used in traditional medicine.
De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses
Keywords nuclear bodies nuclear stress bodies satellite III NFIL3 inflammatory response transcription regulation Get full text access Log in, subscribe or purchase for full access. References 1. Maxwell, B.A. ∙ Gwon, Y. ∙ Mishra, A. ... Ubiquitination is essential for recovery of cellular activities after heat shock Science. 2021; 372, eabc3593 2. Mahat, D.B. ∙ Salamanca, H.H. ∙ Duarte, F.M. ... Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation Mol. Cell.
Construction of a predictive model for relapse of primary autoimmune hemolytic anemia: a retrospective cohort study
Abstract Objectives To develop a machine learning-based model to predict the relapse risk of Primary Autoimmune Haemolytic Anaemia (AIHA) after the last remission. Methods A retrospective study was conducted on primary AIHA cases who visited the Affiliated Hospital of Southwest Medical University and Xuyong County People’s Hospital from May 2017 to May 2022. Cases were categorized as relapsed or non-relapsed based on the 1-year outcomes.
Comparative study on the efcacy of low‑dose and full‑dose BCG bladder perfusion therapy
Ayuda Buscar en la ayuda Buscar en la ayuda Comparative study on the efcacy of low‑dose and full‑dose BCG bladder perfusion therapy Chaohu Chen [1] ; Guangrui Fan [1] ; Pan Li [1] ; Enguang Yang [1] ; Suoshi Jing [1] ; Yibo Shi [1] ; Yuwen Gong [1] ; Luyang Zhang [1] ; Zhiping Wang [1] [1] Institute of Urology, Lanzhou University Second Hospital, No.82 Linxia Road, Chengguan District, Lanzhou 730030, China Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 27, Nº. 5, 2025, págs.
Risks Identification and Fire Scenarios Determination of Ship Fires Based on Improved Text Mining and K‐Means Algorithm
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , , , and , “Long Wavelength Video Detection of Fire in Ship Compartments,” Fire Safety Journal 41, no. 4 (2006): 315–320. 2, , , and , “The Fire Risk Assessment of Ship Power System Under Engine Room Fire,” Trends in Maritime Technology and Engineering (2022): 231–240. 3 Allianz, “Safety and Shipping Review,” (2023), https://commercial.allianz.com/news-and-insights/reports/shipping-safety.html.
Effect of smoking on the recurrence and progression of non‑muscle‑invasive bladder cancer
Ayuda Buscar en la ayuda Buscar en la ayuda Effect of smoking on the recurrence and progression of non‑muscle‑invasive bladder cancer Chaohu Chen [1] ; Guangrui Fan [1] ; Pan Li [1] ; Enguang Yang [1] ; Suoshi Jing [1] ; Yibo Shi [1] ; Yuwen Gong [1] ; Luyang Zhang [1] ; Zhiping Wang [1] [1] Institute of Urology, Lanzhou University Second Hospital, Chengguan District, No.82 Linxia Road, Lanzhou 730030, People’s Republic of China Localización: Clinical & translational oncology, ISSN 1699-048X,...
Molecular dynamics analyses of CLDN15 pore size and charge selectivity
Abstract Claudin-15 (CLDN15) molecules form channels that directly regulate cation and water transport. In the gastrointestinal tract, this transport indirectly impacts nutrient absorption. However, the mechanisms governing ion transport through these channels remain poorly understood. We addressed this question by building on our previous cell culture studies and all atom molecular dynamic simulation model of CLDN15.
Improved adhesion between glass fiber and PAAm/SA hydrogel via a synergy strategy
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description pc29877-sup-0001-supinfo.docxWord 2007 document , 2.6 MB Data S1. Supporting Information. REFERENCES 1, . Advances in engineering hydrogels. Science. 2017; 356(6337):eaaf3627. 2, , , , . Repair of volumetric bone defects with a high strength BMP-loaded-mineralized hydrogel tubular scaffold. J Mater Chem B. 2017; 5(28): 5588-5596. 3. In: P Fratzl, ed. Collagen: Structure and Mechanics.
Case Report: Blau Syndrome With Thrombocytopenia
References 1, , , , and , “Tofacitinib, a Suppressor of NOD2 Expression, Is a Potential Treatment for Blau Syndrome,” Frontiers in Immunology 14 (2023): 1211240, https://doi.org/10.3389/fimmu.2023.1211240. 2, “Familial Granulomatous Arthritis, Iritis, and Rash,” Journal of Pediatrics 107, no. 5 (1985): 689–693, https://doi.org/10.1016/s0022-3476(85)80394-2. 3, , , et al., “Gene Mutations and Clinical Phenotypes in Chinese Children With Blau Syndrome,” Science China. Life Sciences 60, no.
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