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Articles by Pascal Barbry
IRF7 signalling in tanycytes controls brain–body–immune response across the ovarian cycle
Abstract Sex-specific differences in metabolic and immune function are shaped by endocrine–immune interactions, yet the complexity of this relationship remains poorly understood. Here, we identify an immune cell-like state of tanycytes, an ependymoglial cell type lining the third ventricle that mediates brain–body communication1,2 in both mice and humans.
Tanycytic degeneration impairs tau clearance and contributes to Alzheimer’s disease pathology
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Immunohistology For human hypothalamus immunolabeling, a citrate-buffer antigen retrieval step, 10mM Citrate in TBS-Triton 0.1% pH 6 for 30 min at 70°C, was performed on 20μm sections. After 3 washes of 5 min with TBS-Triton 0.1%, sections were blocked in incubation solution (ICS: 10% normal donkey serum, 3 mg/mL BSA in TBS-Triton 0.3% pH 7,4) for 1 h. Blocking was followed with primary antibody incubation (Table S3) in ICS for 48h at 4°C.
By Ricardo Martínez-Gómez, Yvon Mbouamboua, Gaetan Ternier, Sreekala Nampoothiri, Elian Dupré, Lolie Garcia, Marie Couralet, Clément Danis, S. Rasika, Marc Dhenain, Young-Bum Kim, Philippe Ciofi, Luc Buée, Isabelle Landrieu, Florence Pasquier, Matthieu Lilamand, Claire Paquet, Paolo Giacobini, Pascal Barbry, Claude-Alain Maurage, Rubén Nogueiras, Markus Schwaninger, Vincent Prevot, Florent Sauvé, Julie Dewisme, Thibaud Lebouvier
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Cell Press
Verified
Aging affects reprogramming of pulmonary capillary endothelial cells after lung injury in male mice - Nature Communications
Abstract Aging increases the risk of developing fibrotic diseases by hampering tissue regeneration after injury. Using longitudinal single-cell RNA-seq and spatial transcriptomics, here we compare the transcriptome of bleomycin (BLM) -induced fibrotic lungs of young and aged male mice, at 3 time points corresponding to the peak of fibrosis, regeneration, and resolution. We find that lung injury shifts the transcriptomic profiles of three pulmonary capillary endothelial cells (PCEC) subpopulations.
Épidémiologie moléculaire par séquençage des acides nucléiques d’origine virale présents dans les eaux usées
Accueil Tous les numéros Volume 41 / Numéro 6-7 (Juin-Juillet 2025) Med Sci (Paris), 41 6-7 (2025) 585-592 Full HTML Numéro Med Sci (Paris) Volume 41, Numéro 6-7, Juin-Juillet 2025 Page(s) 585 - 592 Section Repères DOI https://doi.org/10.1051/medsci/2025083 Publié en ligne 7 juillet 2025 Med Sci (Paris) 2025; 41 : 585–592 Épidémiologie moléculaire par séquençage des acides nucléiques d’origine virale présents dans les eaux usées 1,2, 1,2, 1,3, 1,3, 1,3 et 1,3,4* 1 Université Côte d’Azur, CNRS...
Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis
Keywords cell cycle variant cyclins APC/C centriole single-cell transcriptomics multiciliated cells cilia cancer meiosis ciliopathies Research topic(s) CP: Cell biology CP: Developmental biology Introduction Shared factors regulate centriole and DNA duplication processes throughout the cell cycle, and centriole over-duplication is typically associated with genomic instability, accelerating tumor formation and increasing tumor invasiveness (review in Nigg and Holland1).
An integrated cell atlas of the lung in health and disease - Nature Medicine
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Abstract Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of individual studies and capture the variability present in the population.
By Lisa Sikkema, Tessa Gillett, Luke Zappia, Nikolay S. Markov, Laure-Emmanuelle Zaragosi, Marie-Jeanne Arguel, Christophe Bécavin, Kemal Inecik, Amanda Oliver, Michael von Papen, Linh Bui Verified, Leander Dony, Minzhe Guo, Austin J. Gutierrez, Ignacio Ibarra, Mohammad Lotfollahi, Kyle J. Travaglini, Kaylee B. Worlock, Masahiro Yoshida, Yohan Bossé, Tushar Desai, Naftali Kaminski, Mark A. Krasnow, Robert Lafyatis, Marko Nikolic, Orit Rozenblatt-Rosen, Max A. Seibold, Dean Sheppard, Don D. Sin, Wim Timens, Jeffrey A. Whitsett, Yan Xu, Pascal Barbry, Kerstin B Meyer, Jonathan A. Kropski, Dana Pe’er, Herbert Schiller, Purushothama Rao Tata, Sara A. Teichmann, Alexander V. Misharin, Martijn C. Nawijn, Malte D. Luecken
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Nature
Verified
Les robo-advisors réinterprêtent le conseil financier
Les robo-advisors, en dépit de la personnalisation que sous-tend cette appellation, sont des algorithmes permettant au client de définir son profil de risque, ses objectifs et son allocation d’actifs en quelques clics. Le client obtient une proposition concrète basée sur ses avoirs financiers actuels et sur sa capacité d’épargne. L’objectif est de lui offrir une meilleure rentabilité que les produits d’épargne classiques ou les fonds en euros.
A single-cell and spatial atlas of early human olfactory development
Abstract The human nasal region arises from neural crest and placodal lineages, yet its early development remains poorly understood owing to limited fetal tissue access and structural complexity. Here we present an integrated single-nucleus and spatial transcriptomic atlas of the human fetal nasal region, generated from male and female fetuses between 7 and 12 post-conceptional weeks.
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