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Articles by Pengfei Shi
β3GnT2-mediated N-glycosylation of EGFR and LDLR drives glioblastoma progression and can be targeted by AST-1306
Abstract Glioblastoma (GBM) is the most aggressive primary brain tumor, characterized by a poor prognosis and limited therapeutic options. In this study, we identify β3GnT2 (β-1,3-N-acetylglucosaminyltransferase 2) as a critical driver of GBM progression and a potential therapeutic target. β3GnT2 is significantly upregulated in GBM tissues, and its high expression correlates with unfavorable patient survival.
PHKA2-AS1 promotes leukemic proliferation and is associated with poor prognosis in acute myeloid leukemia
Abstract Acute myeloid leukemia remains a highly aggressive hematological malignancy with poor clinical outcomes. Long non-coding RNAs are increasingly recognized as regulators of leukemia biology, but the role of PHKA2-AS1 in AML remains unclear. MCOLN1-related lysosome–mitochondria stress and zinc homeostasis have been implicated in cancer cell fate; however, whether AML-associated lncRNAs are transcriptionally associated with this axis has not been fully explored.
A hybrid underwater crack image enhancement method
Abstract This study proposes a hybrid underwater crack image processing method. The first half of the algorithm is based on traditional image processing, which analyzes and judges the color of an image, establishes the image chromaticity factor K, and performs color correction when K is greater than a threshold value. A quadtree analysis method is used to estimate the background light of the image.
A FRET-Mediated AIE Biosensor Based on Functionalized Peptide-Stabilized Gold Nanoclusters for Sensitive Detection of Matrix Metalloproteinase-2 Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleJune 28, 2026 A FRET-Mediated AIE Biosensor Based on Functionalized Peptide-Stabilized Gold Nanoclusters for Sensitive Detection of Matrix Metalloproteinase-2 Click to copy article linkArticle link copied! Qinhui Dong Qinhui Dong Shandong Provincial Key Laboratory of Tumor Imaging Equipment Development and Diagnosis & Treatment Integration Technology, College of Medicine, Linyi University, Linyi 276000, China Pengfei Shi* Pengfei Shi Shandong Provincial Key...
Preparation and Property Modulation of Vanillin-Derived Epoxy Vitrimers
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description pola70223-sup-0001-supinfo.docxWord 2007 document , 8.6 MB Data S1: Supporting Information. Figure S1: 1H NMR spectra (CDCl3) and 13C NMR spectra (CDCl3) of 2-methoxy-4-vinylphenol.
A Back‐Trace Numerical Method for Calculating the Numerical Solution of the True Total Contributing Area for Real‐World Terrains
1 Introduction Total Contributing Area (TCA) is an important terrain attribute with great hydrological, geomorphological and ecological implication (Kok et al., 2018).
Oxygen-Participated Interfacial Behaviors and Bonding Mechanisms of Amorphous Carbon Films in Friction by First-Principles and Molecular Dynamics
Cite Jump to ExpandCollapse ArticleDecember 23, 2025 Oxygen-Participated Interfacial Behaviors and Bonding Mechanisms of Amorphous Carbon Films in Friction by First-Principles and Molecular Dynamics Click to copy article linkArticle link copied! HuiPing Shu HuiPing Shu School of Mechanical Engineering, Sichuan University, Chengdu 610065, China XinRan Miao XinRan Miao School of Mechanical Engineering, Sichuan University, Chengdu 610065, China State Key Laboratory of Tribology, Tsinghua...
An Optimal Energy Window of Silica Deposition Revealed by Reactive Molecular Dynamics Simulations
C: Physical Properties of Materials and InterfacesDecember 19, 2025 Junting Li Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, China Research Institute of Frontier Science, Southwest Jiaotong University, Chengdu 610031, China * Pengfei Shi Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, China School of Mechatronics and Vehicle Engineering, Chongqing Jiaotong...
Coordination and Click Chemistry Dual-Driven Self-Assembled Copper-DNA Nanoparticles for Tumor Imaging and Therapy
Cite Jump to ExpandCollapse ArticleNovember 26, 2025 Coordination and Click Chemistry Dual-Driven Self-Assembled Copper-DNA Nanoparticles for Tumor Imaging and Therapy Click to copy article linkArticle link copied! Haoming Yuan Haoming Yuan School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, Shandong, P. R. China Ziyong Wu Ziyong Wu School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, Shandong, P. R.
Interfacial Diffusion‐Reaction Coupling Strategy for CO2 Reduction on Copper Surface in Acidic Medium
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie202513306-sup-0001-SuppMat.docx6.9 MB Supporting Information References 1, , Nature 2012, 488, 294–303. 2, , , , , , Science 2019, 364, eaav3506. 3, , , , , , Nat. Energy 2016, 1, 1–13. 4, , , , , , , , , , , , Proc. Natl. Acad. Sci. USA 2019, 116, 9735–9740. 5, , , , , , , Adv. Mater. 2019, 31, e1807166. 6, , , , , Acc. Chem. Res. 2018, 51, 910–918. 7, , , , , ChemSusChem 2016, 9, 1972–1979.
Exploring the causal relationship between long-term exposure to particulate matter 2.5 and risk of thyroid disorders: a Mendelian randomization analysis
ABSTRACT Particulate matter 2.5 (PM2.5) has been increasingly linked to thyroid dysfunction, yet causal evidence remains limited. This study employs a two-sample Mendelian Randomization (MR) approach to assess the causal relationship between long-term PM2.5 exposure and thyroid disorders. Genetic instruments for PM2.5 exposure were sourced from the UK Biobank, while outcome data on thyroid dysfunction and its subtypes were obtained from the FinnGen consortium.
Rational Synthesis of Isomeric Graphdiyne Frameworks toward Single‐Ruthenium Catalysts and High‐Performance Nitrogen Reduction
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202502980-sup-0001-SuppMat.docx35.6 MB Supporting Information References 1, , , , , , Chem. Commun. 2010, 46, 3256. 2a) , , , , , Chem. Soc. Rev. 2022, 51, 2681; b) , , , , Chem. Soc. Rev. 2019, 48, 908. 3a) , , , , , , , Chem. Rev. 2018, 118, 7744; b) , , , , , , Acc. Chem. Res. 2017, 50, 2470. 4a) , , , , , , , Angew. Chem., Int. Ed. 2018, 57, 774; b) , , , , , , Adv. Mater.
Integrated Electrochemical Biomass Oxidation and CO2 Reduction over Ultra‐wide Potential Window
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Heteroarchitectural Gas Diffusion Layer Promotes CO2 Reduction Coupled with Biomass Oxidation at Ampere‐Level Current Density
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Chaotic laser time series prediction based on an improved logistic mapping algorithm echo state network
Chaos synchronization plays vital functions in the fields of optical chaos secure communication. The synchronization performance can be significantly degraded by parameter mismatches between the chaotic transmitter and receiver. In this paper, the Deep-Logistical Mapping Echo State Network (D-LMESN) is proposed to enhance the performance of chaos synchronization. The network is upgraded by using an improved logical mapping algorithm and a deep reserve pool structure with phase space reconstruction.
Two‐Dimensional Silver-Isocyanide Frameworks - Jiang - Angewandte Chemie International Edition - Wiley Online Library
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
A comprehensive prognostic and immune infiltration analysis of UBA1 in pan‐cancer: A computational analysis and in vitro experiments
1 INTRODUCTION Vacuoles, E1 ubiquitin-activating enzyme, X-linked, autoinflammatory somatic (VEXAS) syndrome is a newly discovered disease caused by somatic mutations in the Ubiquitin like modifier activating enzyme 1 (UBA1) gene, leading to refractory autoimmune features, often accompanied by cellular reduction.1 In December 2020, researchers from the National Institutes of Health in the United States first described this type of disease.2 The current prevalence of VEXAS syndrome is unknown...
Prior disulfide bond-mediated Ser/Thr ligation
Prior disulfide bond-mediated Ser/Thr ligation† In this work, we developed a novel strategy, prior disulfide bond-mediated Ser/Thr ligation (PD-STL), for the chemical synthesis of peptides and proteins. This approach combines disulfide bond-forming chemistry with Ser/Thr ligation (STL), converting intermolecular STL into intramolecular STL to effectively proceed regardless of concentrations.
Short-Term Photovoltaic Power Prediction Based on a Digital Twin Model
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Selective detection of NO using the perovskite-type oxide LaMO3 (M = Cr, Mn, Fe, Co, and Ni) as the electrode material for yttrium-stabilized zirconia-based electrochemical sensors
Selective detection of NO using the perovskite-type oxide LaMO3 (M = Cr, Mn, Fe, Co, and Ni) as the electrode material for yttrium-stabilized zirconia-based electrochemical sensors Yttrium-stabilized zirconia-based electrochemical gas sensors have good application prospects in NO high-temperature detection systems due to their stability under extreme conditions.
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Research Paper Volume 16, Issue 11 pp 9547—9557 1 Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei, China https://doi.org/10.18632/aging.205882 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | This is an open access article distributed under the terms of the...
Neratinib stimulates senescence of mammary cancer cells by reducing the levels of SIRT1
Research Paper Volume 16, Issue 11 pp 9547—9557 1 Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, Hubei, China https://doi.org/10.18632/aging.205882 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | Copyright: © 2024 Li et al.
Complete recovery of valuable metals from chlorinated titanium-white waste acids: Focus on solvent extraction for recovery and preparation of battery-grade manganese sulfate (MnSO4·H2O) from lab to pilot scale
Chlorination titanium-white waste acid (CTWA) refers to the wastewater resulting from the acid dissolution of chlorinated slag during the production of titanium dioxide via the chlorination process.[1], [2], [3] The acid generated during the treatment of chlorination slag is an inevitable byproduct, which contains a significant number of metals (vanadium (V), scandium (Sc), iron (Fe), manganese (Mn), etc.).
A novel dual-mode aptasensor based on multiple amplification system for ultrasensitive fluorescence and surface-enhanced Raman spectroscopy detection of lead ion
A novel dual-mode aptasensor based on multiple amplification system for ultrasensitive fluorescence and surface-enhanced Raman spectroscopy detection of lead ion In this work, we develop a fluorescence and surface-enhanced Raman scattering (FL-SERS) dual recycling amplification aptasensor for sensitive and rapid detection of lead ions (Pb2+). The aptasensor allows targeted cleavage of substrates through specifically binding with the Pb2+-dependent aptamer (M-PS2.M).
Synthesis, Optical Properties and Cellular Toxicity of Water-Soluble Near Infrared-II Fluorescent Assemblies Based on Pillar[5]arene
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Effect of Bovine MEF2A Gene Expression on Proliferation and Apoptosis of Myoblast Cells
Open AccessArticle by Jinkui Sun 1,2, Yong Ruan 1,2, Jiali Xu 1,2, Pengfei Shi 1,2 and Houqiang Xu 1,2,* 1 Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, China 2 College of Animal Science, Guizhou University, Guiyang 550025, China * Author to whom correspondence should be addressed.
The Recent Research Progress of NF-κB Signaling on the Proliferation, Migration, Invasion, Immune Escape and Drug Resistance of Glioblastoma
Abstract : Glioblastoma multiforme (GBM) is the most common and invasive primary central nervous system tumor in humans, accounting for approximately 45–50% of all primary brain tumors. How to conduct early diagnosis, targeted intervention, and prognostic evaluation of GBM, in order to improve the survival rate of glioblastoma patients, has always been an urgent clinical problem to be solved.
Joule heating activation of template‐mediated carbon fibers with significantly enhanced capacitive performance
Abstract Carbon fibers (CFs) have been innovated in the application of fiber-shaped and wearable energy storage devices recently. However, time- and energy-consuming activation process under harsh conditions is generally required to modify the surface structure of the CF. In this paper, a fast and effective Joule heating activation method has been proposed with the Ni-Co LDH derived nano metal particles as the template.
Metal organic frameworks MOF-808-based solid-state electrolytes for lithium-ion batteries
Metal organic frameworks MOF-808-based solid-state electrolytes for lithium-ion batteries Chunmei Wang, Jia Zhang, Pengfei Shi, Zhiyuan Zhou, Yao Zhang and Yanfang Gao Abstract MOF-808-based solid-state electrolytes demonstrated outstanding ionic conductivity, with a value of 3.08×10-3 S cm-1 at 25oC, high lithium-ion transference number of 0.77, and wide potential window ranging from 1.5 to 4.8 V.
An Overview of Key SLAM Technologies for Underwater Scenes
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by 1,*, 2, 2, 2 and 2 1 School of Computer and Information, Hohai University, Nanjing 210000, China 2 School of Information Science and Engineering, Hohai University, Changzhou 213002, China * Author to whom correspondence should be addressed. Remote Sens.
Hyperspectral Characteristic Band Selection and Estimation Content of Soil Petroleum Hydrocarbon Based on GARF-PLSR
Abstract : With continuous improvements in oil production, the environmental problems caused by oil exploitation are becoming increasingly serious. Rapid and accurate estimation of soil petroleum hydrocarbon content is of great significance to the investigation and restoration of environments in oil-producing areas. In this study, the content of petroleum hydrocarbon and the hyperspectral data of soil samples collected from an oil-producing area were measured.
Complementary DNA Significantly Enhancing Signal Response and Sensitivity of a Molecular Beacon Probe to Aflatoxin B1
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Analysis of Promoter Methylation of the Bovine FOXO1 Gene and Its Effect on Proliferation and Differentiation of Myoblasts
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Association Analysis of PRKAA2 and MSMB Polymorphisms 2 and Growth Traits of Xiangsu Hybrid Pigs
Open AccessArticle by Jiali Xu 1,2,3, Yong Ruan 1,2,3, Jinkui Sun 1,2,3, Pengfei Shi 1,2,3, Jiajin Huang 1,2,3, Lingang Dai 1,2,3, Meimei Xiao 1,2,3 and Houqiang Xu 1,2,3,* 1 Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang 550025, China 2 Guizhou Provincial Key Laboratory of Animal Genetics, Breeding and Reproduction, Guizhou University, Guiyang 550025, China 3 College of Animal Science, Guizhou...
Exonuclease III-propelled electrochemical sensor for highly efficient microRNA-155 detection
Exonuclease III-propelled electrochemical sensor for highly efficient microRNA-155 detection Bingyin Yan, Xiangjiang Zheng and Pengfei Shi Abstract MicroRNA-155 is highly expressed in tumor cells such as lung cancer, liver cancer and lymphoma，which was increasingly used for the early diagnosis and monitoring of cancer diseases. Herein, we designed an exonuclease III-propelled electrochemical sensor coupling with multiple signal amplification for highly efficient microRNA-155 detection.
Rapid and label-free detection of aflatoxin B1 by using a rationally truncated aptamer and via circular dichroism measurement We describe a simple aptamer assay for rapid analysis of aflatoxin B1 (AFB1), a potently carcinogenic fungal metabolite. Original anti-AFB1 aptamer was rationally truncated, obtaining a short aptamer that displayed better performance. Different concentrations of AFB1 were detected by measuring circular dichroism spectra of this short aptamer.
Substructure Modeling and Loading-Control Techniques for the Test of a Full-Scale Spatial RC Frame with Buckling-Restrained Braces Subjected to Bidirectional Loading | Journal of Structural Engineering | Vol 147, No 9
Professor, School of Civil Engineering and Architecture, Wuhan Univ. of Technology, Wuhan 430070, China (corresponding author). Email: Doctoral Candidate, School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China. Senior Engineer, China Construction Science and Technology Group Corp. Ltd., Beijing 100195, China. Professor, School of Civil Engineering and Architecture, Wuhan Univ. of Technology, Wuhan 430070, China. Professor, China State Construction Engineering Corp.
Significant Land Contributions to Interannual Predictability of East Asian Summer Monsoon Rainfall
Abstract Marked by large interannual variability, East Asian summer monsoon (EASM) rainfall has profound socio-economic impacts through its dominant influence on floods and droughts. Improving predictions of the interannual variations of EASM rainfall has important implications for over 20% of the world's population.
Experimental Performance of a Full-Scale Spatial RC Frame with Buckling-Restrained Braces Subjected to Bidirectional Loading
Doctoral Candidate, School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China. Doctoral Supervisor, School of Civil Engineering, Harbin Institute of Technology, Harbin 150090, China; Professor, School of Civil Engineering and Architecture, Wuhan Univ. of Technology, Wuhan 430070, China (corresponding author). Email: Senior Engineer, China Construction Science and Technology Group Corporation Ltd., Si-Chuan Branch, Beijing 100195, China.
Ruthenium-catalyzed C-H functionalization of enamides with isocyanates: easy entry to pyrimidin-4-ones
Ruthenium-catalyzed C–H functionalization of enamides with isocyanates: easy entry to pyrimidin-4-ones Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to the conventional strategies for pyrimidin-4-ones synthesis. High step- and atom-economy was achieved for the rapid construction of such privileged scaffolds found in a multitude of pharmaceutical compounds.
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