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Articles by Philipp Euskirchen
Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease
ArticleOnline now102651Open access Affiliations & Notes 1Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain 2Universitat Pompeu Fabra (UPF), Barcelona, Spain 3Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Frankfurt, Germany 4Goethe University Frankfurt, University Hospital, Department of Neurology, Frankfurt, Germany 5Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Frankfurt, Germany 6Goethe...
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
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ArticleOnline nowOpen access 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 3Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany 4Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany 5Division of Pediatric...
By Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Leonille Schweizer, Rouzbeh Banan, David E. Reuss, Abigail K. Suwala, Andrey Korshunov, Damian Stichel, Annika K Wefers, Ann-Christin Hau, Henning Boldt, Patrick N. Harter, Zied Abdullaev, Jamal Benhamida, Daniel Teichmann, Arend Koch, Jürgen Hench, Stephan Frank, Martin Hasselblatt, Sheila Mansouri, Jonathan Serrano, Jonas Ecker, Michael Taylor Verified, Vijay Ramaswamy, Anna S. Berghoff, Brigitte Bison, Mirjam Blattner-Johnson, Ivo Buchhalter, Gabriele Calaminus, Nicola Dikow, Hildegard Dohmen, Philipp Euskirchen, Gudrun Fleischhack, Amar Gajjar, Nicolas U. Gerber, Marco Gessi, Gerrit H. Gielen, Astrid K. Gnekow, Nicholas G Gottardo, Christine Haberler, Stefan Hamelmann, Jordan Hansford, Christian Hartmann, Frank L. Heppner, Pablo Hernáiz Driever, Katja von Hoff, Ulrich W. Thomale, Michael C. Frühwald, Christof M. Kramm, Ulrich Schüller, Jens Schittenhelm, Martin Schuhmann, Marco Stein, Petra Ketteler, Marc Ladanyi, Nada Jabado, Barbara Jones, Chris Jones, Matthias A. Karajannis, Uwe Kordes, Annekathrin Reinhardt, Christian Kölsche, Katrin Lamszus, Peter Lichter, Sybren L.N. Maas, Christian Mawrin, Michel Mittelbronn, Camelia-Maria Monoranu, Wolf Mueller, Martin Mynarek, Paul A. Northcott, Kristian W. Pajtler, Werner Paulus, Arie Perry, Ingmar Blümcke, Karl H. Plate, Michael Platten, Matthias Preusser, Torsten Pietsch, Marco Prinz, Guido Reifenberger, Bjarne W. Kristensen, Marcel Kool, Volker Hovestadt, David Ellison, Thomas Jacques, Pascale Varlet, Nima Etminan, Michael Weller, Christine White, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro M. Krieg, Wolfgang Wick, Matija Snuderl, Sebastian Brandner, Cynthia Hawkins, Craig M Horbinski, Christian Thomas, Pieter Wesseling, Andreas von Deimling, David Capper, Stefan M. Pfister, Felix Sahm, Florian Selt, Rolf Buslei, Volkmar Hans, Stephan Tippelt, Ralf Ketter, Patricia Kohlhof, Ken Aldape
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Cell Press
Verified
Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
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ArticleVolume 44, Issue 2p340-354.e2Open access 1Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany 2Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany 3Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany 4Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany...
By Martin Sill, Daniel Schrimpf, Areeba Patel, Dominik Sturm, Natalie Jäger, Philipp Sievers, Leonille Schweizer, Rouzbeh Banan, David E. Reuss, Abigail K. Suwala, Andrey Korshunov, Damian Stichel, Annika K Wefers, Ann-Christin Hau, Henning Boldt, Patrick N. Harter, Zied Abdullaev, Jamal Benhamida, Daniel Teichmann, Arend Koch, Jürgen Hench, Stephan Frank, Martin Hasselblatt, Sheila Mansouri, Jonathan Serrano, Jonas Ecker, Florian Selt, Michael Taylor Verified, Vijay Ramaswamy, Anna S. Berghoff, Brigitte Bison, Mirjam Blattner-Johnson, Ivo Buchhalter, Rolf Buslei, Gabriele Calaminus, Nicola Dikow, Hildegard Dohmen, Philipp Euskirchen, Gudrun Fleischhack, Amar Gajjar, Nicolas U. Gerber, Marco Gessi, Gerrit H. Gielen, Astrid K. Gnekow, Nicholas G Gottardo, Christine Haberler, Stefan Hamelmann, Volkmar Hans, Jordan Hansford, Christian Hartmann, Frank L. Heppner, Pablo Hernáiz Driever, Katja von Hoff, Ulrich W. Thomale, Stephan Tippelt, Michael C. Frühwald, Christof M. Kramm, Ulrich Schüller, Jens Schittenhelm, Martin Schuhmann, Marco Stein, Petra Ketteler, Marc Ladanyi, Nada Jabado, Barbara Jones, Chris Jones, Matthias A. Karajannis, Ralf Ketter, Patricia Kohlhof, Uwe Kordes, Annekathrin Reinhardt, Christian Kölsche, Katrin Lamszus, Peter Lichter, Sybren L.N. Maas, Christian Mawrin, Michel Mittelbronn, Camelia-Maria Monoranu, Wolf Mueller, Martin Mynarek, Paul A. Northcott, Kristian W. Pajtler, Werner Paulus, Arie Perry, Ingmar Blümcke, Karl H. Plate, Michael Platten, Matthias Preusser, Torsten Pietsch, Marco Prinz, Guido Reifenberger, Bjarne W. Kristensen, Marcel Kool, Volker Hovestadt, David Ellison, Thomas Jacques, Pascale Varlet, Nima Etminan, Michael Weller, Christine White, Olaf Witt, Christel Herold-Mende, Jürgen Debus, Sandro M. Krieg, Wolfgang Wick, Matija Snuderl, Ken Aldape, Sebastian Brandner, Cynthia Hawkins, Craig M Horbinski, Christian Thomas, Pieter Wesseling, Andreas von Deimling, David Capper, Stefan M. Pfister, Felix Sahm
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Cell Press
Verified
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine
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Abstract Molecular data integration plays a central role in central nervous system (CNS) tumor diagnostics but currently used assays pose limitations due to technical complexity, equipment and reagent costs, as well as lengthy turnaround times. We previously reported the development of Rapid-CNS2, an adaptive-sampling-based nanopore sequencing workflow. Here we comprehensively validated and further developed Rapid-CNS2 for intraoperative use.
By Areeba Patel, Lisa Pfeifer, Philipp Euskirchen, Jo Van Dorpe, Siebe Loontiens, Franceska Dedeurwaerdere, Inswasti Cahyani, Sebastian Brandner, Stephan Frank, Natalie Jäger, Simon Paine, Stuart Smith, Christel Herold-Mende, Wolfgang Wick, Stefan M. Pfister, Einar O. Vik-Mo, Andreas von Deimling, Sandro M. Krieg, Matthias Schlesner, Martin Sill, Kirsten Göbel, Paul Kerbs, Claus Hultschig
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Nature
Verified
Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma
The transcription factor ZEB1 has gained attention in tumor biology of epithelial cancers because of its function in epithelial-mesenchymal transition, DNA repair, stem cell biology and tumor-induced immunosuppression, but its role in gliomas with respect to invasion and prognostic value is controversial.
Corticosteroids alter CGRP and melatonin release in cluster headache episodes
Background Calcitonin gene-related peptide (CGRP) is a marker of trigeminal activation in acute cluster headache (CH). Melatonin production is altered in CH patients and may reflect hypothalamic dysfunction. We assessed the effects of short-term CH prevention with corticosteroids on CGRP and melatonin release in a prospective observational cohort study hypothesizing that corticosteroids influence the interictal activity of both systems indicated by the change of these biomarkers.
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