Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Qingfeng Chen
Author Correction: Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy
Correction to: Nature Biotechnology https://doi.org/10.1038/s41587-026-03054-y, published online 18 March 2026. In the version of this article initially published, there was an error in the Fig. 4n Source Data, where an additional “anti-EGFR” dataset was accidentally included; an error in the Fig. 6d Source Data, with errors in the PBS group measurements, also affecting the plots in the article; errors in the Figs. 4o, 5b–d, h Source Data, due to data entry errors; and errors in the Fig.
Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy
Abstract Tumor immunotherapy is often compromised by an immunosuppressive tumor microenvironment (TME) characterized by abnormal vasculature and exhausted T cells. Here, given the role of nitric oxide (NO) in favorably remodeling the TME, we engineered Escherichia coli Nissle 1917 (ECN) with a synthetic arginine–NO circuit (ECN-NO) that modifies the arginine synthesis pathway to constitutively synthesize arginine and enable sustained NO production.
Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells
Abstract The thymus is the primary site for T cell maturation. While transcriptional profiling of human thymi has been reported, a high-resolution spatial atlas is needed. Here we use Stereo-seq spatial transcriptomics to generate a spatial atlas of the human fetal (13, 14, 17 or 18 weeks post-conception) and pediatric (7 weeks, and 2, 5 or 6 years old) thymi.
MDPENet: multimodal-driven prototype evolving network for few-shot semantic segmentation
With the rapid advancement of deep learning technologies, semantic segmentation has achieved remarkable progress across various fields, including medical image analysis and autonomous driving (Mo et al., 2022; Ren et al., 2024). However, the performance of most existing semantic segmentation models heavily relies on large-scale datasets with pixel-level annotations, which are costly and labor-intensive to obtain.
Molecular mechanism of phosphate import by the bacterial PstSCAB transporter - Nature Communications
Abstract Inorganic phosphate (Pi) is essential for all living organisms. PstSCAB, a bacterial high-affinity ABC transporter, imports Pi under limiting conditions via five subunits: PstA and PstC forming the transmembrane domain (TMD), periplasmic PstS that switches between free and TMD-docked forms for Pi capture and delivery, and two cytosolic PstB subunits for ATP binding and hydrolysis. Its malfunction affects the virulence of pathogenic bacteria, making it pharmaceutically attractive.
Cluster Synchronization of Delayed Complex Dynamical Networks With the Intracluster and Intercluster Link Dynamics
Conflicts of Interest The authors declare no conflicts of interest. References 1, , , et al., “Signal Propagation in Complex Networks,” Physics Reports 1017 (2023): 1–96. 2, , , , , and , “Explosive Synchronization Dependence on Initial Conditions: The Minimal Kuramoto Model,” Chaos, Solitons & Fractals 169 (2023): 113243. 3 and , “Network Neuroscience,” Nature Neuroscience 20 (2017): 353–364.
CoTD-VAE: Interpretable Disentanglement of Static, Trend, and Event Components in Complex Time Series for Medical Applications
Choose an area of interest and we will send you notifications of new preprints at your preferred frequency.
Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity
Keywords P4HA1 T cell memory T cell exhaustion mitochondria systemic immunity hypoxia PD-1 CAR T cells solid tumors cancer immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Topalian, S.L. ∙ Drake, C.G. ∙ Pardoll, D.M. Immune checkpoint blockade: a common denominator approach to cancer therapy Cancer Cell. 2015; 27:450-461 2. Wherry, E.J. ∙ Kurachi, M. Molecular and cellular insights into T cell exhaustion Nat. Rev. Immunol. 2015; 15:486-499 3. Marcotte, R.
[2410.15359] A Survey of Hallucination in Large Visual Language Models
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
[2407.13205] Transformer-based Single-Cell Language Model: A Survey
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
A high-density microfluidic bioreactor for the automated manufacturing of CAR T cells - Nature Biomedical Engineering
Abstract The manufacturing of autologous chimaeric antigen receptor (CAR) T cells largely relies either on fed-batch and manual processes that often lack environmental monitoring and control or on bioreactors that cannot be easily scaled out to meet patient demands.
Association Analysis Techniques and Applications in Bioinformatics
Advances in experimental technologies have given rise to tremendous amounts of biology data. This not only offers valuable sources of data to help understand biological evolution and functional mechanisms, but also poses challenges for accurate and effective data analysis.
Aberrant non-canonical NF-κB signalling reprograms the epigenome landscape to drive oncogenic transcriptomes in multiple myeloma - Nature Communications
Abstract In multiple myeloma, abnormal plasma cells establish oncogenic niches within the bone marrow by engaging the NF-κB pathway to nurture their survival while they accumulate pro-proliferative mutations. Under these conditions, many cases eventually develop genetic abnormalities endowing them with constitutive NF-κB activation. Here, we find that sustained NF-κB/p52 levels resulting from such mutations favours the recruitment of enhancers beyond the normal B-cell repertoire.
NGCN: Drug‐target interaction prediction by integrating information and feature learning from heterogeneous network
1 INTRODUCTION The design and development of new drugs are a long process due to their high risk, long cycle and large investment. Also, the side effects of drugs on unexpected diseases and drug interactions have been shown to be potential risks to human health.
Potentiating Gilteritinib Efficacy Using Nanocomplexation with a Hyaluronic Acid-Epigallocatechin Gallate Conjugate
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Methane Anaerobic Oxidation Potential and Microbial Community Response to Sulfate Input in Coastal Wetlands of the Yellow River Delta
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Heterogeneous Electro-Fenton-Catalyzed Degradation of Rhodamine B by Nano-Calcined Pyrite
Open AccessArticle by Yu Tan 1, Changsheng Zhao 1,*, Qingfeng Chen 2, Luzhen Li 1, Xinghua Wang 1, Beibei Guo 1, Bowei Zhang 1 and Xiaokai Wang 1 1 Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China 2 College of Geography and Environment, Shandong Normal University, Jinan 250300, China * Author to whom correspondence should be addressed. Int. J. Environ. Res.
G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma - Nature Communications
Abstract Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term adverse side-effects. However, multiple rounds of treatment are often required, increasing patient discomfort and cost.
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
The mucolipin subfamily of transient receptor potential (TRPML) channels are predominantly localized in the membranes of the late endosomes and lysosomes1, 2. Among the three isoforms of TRPML channels (TRPML1–3), TRPML1 is ubiquitously expressed in mammalian cells and has been the subject of extensive study2, 9, 10, 11, 12, 13, 14.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Qingfeng
Contact Qingfeng, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack