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Articles by Robert Brink
NK cell dysfunction and interferon gamma production underlie autoinflammation in mevalonate kinase deficiency
Keywords natural killer cell protein prenylation autoinflammation interferon gamma cytolytic granule MCMV Rab GTPase JAK inhibitor mevalonate Introduction Protein prenylation is a form of post-translational modification that is necessary for the membrane tethering and function of more than 300 proteins, particularly the superfamily of small GTPases such as Rab and Rho GTPases.1 These proteins act as molecular switches, regulating signaling pathways that control diverse cellular functions,...
Skateboarding Offers Powerful Community Connections in Delaware
“I never thought I’d see a day where Delaware would have public skate parks,” says Mike Cordrey of Wilmington. Cordrey, 51, has been skateboarding since the mid-’80s and is ecstatic Wilmington finally got a park. “Many of us advocated and volunteered for years trying to get that skate park,” he says. As a kid, Cordrey and his friends built portable quarter-pipes and sliders to skate in the streets, as well as a renegade half-pipe that mysteriously appeared under a well-known bridge.
Best of Delaware: Community and Media in 2025
Editors: Alexis Harris Alexis Harris developed First State Destinations as a lifestyle brand made up of social media accounts, events, and initiatives, all to celebrate and promote Delaware’s vibrant food and culture scene. Through First State Destinations, Harris, who moved to Delaware from North Carolina in 2019, highlights Delaware’s hidden treasures and aims to foster community connections, all in the name of showing people how to experience all that the First State has to offer.
Macrophages direct location-dependent recall of B cell memory to vaccination
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Keywords memory vaccine germinal center plasma cells broadly neutralizing antibodies affinity maturation immune imprinting original antigenic sin SARS-CoV-2 subcapsular sinus macrophage Introduction Vaccines protect from recurrent infection and disease by inducing the secretion of neutralizing antibodies by long-lived plasma cells (PCs)1 and by generating memory B cells (Bmems).2 Long-lived PCs are terminally differentiated and can only secrete antibodies of fixed specificity and affinity for...
By Rama Dhenni, Arnold Reynaldi, Wunna Kyaw, Abigail K. Grootveld, Yuki Honda Keith, Nayan Bhattacharyya, Andrew McCorkindale, Seyhan Yazar, Christina Bui, James Smith, Weng Hua Khoo, Mollie Boyd, Brad Milner, Mitchell Starr, Fabienne Brilot, Vanessa Milogiannakis, Anouschka Akerman, Anupriya Aggarwal, Miles P Davenport, Elissa K. Deenick, Christine Chaffer, Peter Croucher, Robert Brink, Leonard D. Goldstein, Deborah Cromer, Stuart Turville, Anthony D. Kelleher, Vanessa Venturi, Tri Giang Phan, Alexandra Carey Hoppé, Nathalie Tricia Handoko, Holly I. Ahel, Aiden Josiah Telfser, Solange Obeid
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Cell Press
Verified
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease
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Keywords hepatitis C virus cryoglobulinemic vasculitis somatic mutation B lymphocyte rheumatoid factor autoantibody antigenic mimicry antibody affinity superselectivity Introduction Viral infection is postulated to trigger many autoimmune diseases, yet their connection is poorly understood.
By Clara Young, Katherine Jackson, Matt Field, Timothy Peters, Stefano Angioletti-Uberti, Daan Frenkel, Shyamsundar Ravishankar, Money Gupta, Jing Wang, David Agapiou, Megan L. Faulks, Ghamdan Al-Eryani, Fabio Luciani, Tom Gordon, Joanne H. Reed, Mark Danta, Andrew Carr, Anthony D. Kelleher, Gregory J. Dore, Gail Matthews, Robert Brink, Rowena A. Bull, Dan Suan, Christopher C. Goodnow, Mandeep Singh
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Cell Press
Verified
Summer Skin Rescue with Art of Skin MD San Diego
Celebrate 13 Years of Summer Skin Rescue with Art of Skin MD and the Best Packages and Pricing of the Year! Summer Skin Rescue 2024 is going to be our biggest event and best of the year! Here at Art of Skin MD we can’t wait to connect with our beloved patients and friends and offer you the best treatment and packages of the year! Event Details: 17 days: from September 4-20, 2024 Live Instagram Q & A seminar with @DrMelaniePalm on Wednesday, September 4.
The unique biology of germinal center B cells
Abbott R.K. Lee J.H. Menis S. Skog P. Rossi M. Ota T. Kulp D.W. Bhullar D. Kalyuzhniy O. Havenar-Daughton C. et al. Precursor frequency and affinity determine B cell competitive fitness in germinal centers, tested with germline-targeting HIV vaccine immunogens. Immunity. 2018; 48: 133-146.e6 Afshar-Sterle S. Zotos D. Bernard N.J. Scherger A.K. Rödling L. Alsop A.E. Walker J. Masson F. Belz G.T. Corcoran L.M. et al.
Illegal Civ Is Not Making Movies for Everyone
Curated by Highsnobiety and presented during the time period formerly known as Paris Men’s Fashion Week, Not In Paris 3 is our third in a series of bi-annual digital exhibitions celebrating creativity in the age of remote interactions. Head here for the full series and cop our new merch via our online store.
Robert Brink column: The commonwealth's shameful lawn ornaments
Robert Brink column: The commonwealth's shameful lawn ornaments 1 of 4 In March 2010, then-House Majority Leader H. Morgan Griffith, R-Salem, talked on a phone as he sat at the feet of the statue of former Gov. and U.S. Sen. Harry F. Byrd at Capitol Square in Richmond. In February 2020, people walked the grounds of Capitol Square near the statue of Dr. Hunter Holmes McGuire. The statue of Gov. William “Extra Billy” Smith in Capitol Square, as seen in February 2016.
COMMENTARY: The commonwealth's lawn ornaments; Culpeper's "Extra Billy"
COMMENTARY: The commonwealth's lawn ornaments; Culpeper's "Extra Billy" 1 of 3 The statue of Gov. William ‘Extra Billy’ Smith, a former Confederate officer, stands in Capitol Square. In March 2010, House Majority Leader H. Morgan Griffith, R-Salem, talks on a phone as he sits at the feet of U.S. Sen. Harry F. Byrd's statue in Richmond's Capitol Square. In February 2020, people walk the grounds of Capitol Square near its statue of Dr. Hunter Holmes McGuire, the Confederate army surgeon.
Keith Hufnagel
Words by Robert Brink It always begins with skateboarding. And when Keith Hufnagel first entered public consciousness in the early ‘90s, it was an era synonymous with the technical and the progressive. He who flipped and spun his board the most, in the baggiest, brightest clothes—no matter how ridiculously unappealing it looked—won. But Keith skated fast. He was quick-footed. He could ollie—high, with seemingly little effort.
Skate for Dylan
Words by Robert Brink, photos by Ryan Allan “I’ve experienced a lot of loss in my life and Makenna experienced losing her brother—the closest person to her. Some people never recover from something like that, but seeing her shaking before we started and watching her cry at the end, knowing how special it was to her—the day felt so full.” “The most I ever ran was 10 miles,” says Makenna, “and that was only three days before.
Will ‘life of the law’ be experience … or AI?
By: Robert J. Brink June 11, 2020 In his seminal 1897 article, “The Path of the Law,” Oliver Wendell Holmes coined one of his many memorable epigrams: “The prophecies of what the courts will do in fact, and nothing more pretentious, are what I mean by law.” What “we call the law,” he explained, is “systemized prediction.” Had artificial intelligence been around when Holmes ...
2014, AS DICTATED BY SOCIAL MEDIA EXCESS
Making an interesting year-end list is tough. Unless you’re on some Oprah-level shit, most people nowadays don’t care what you liked or how you think the past year went anyway. They do, after all, have their own opinions and share them publicly all day long. So let’s just have some user-generated fun and empower the people instead. Here’s some of what seemed to be the best of 2014, as told by the social media feeds of millions. Best diet: Pears Rick Ross lost 100 lbs. this year.
Robert Brink column: Virginia elections: preparing for 2019 and beyond
Virginia’s election machinery faces extraordinary challenges in the coming months. How we respond to those challenges will test whether we can maintain the efficient, accessible, secure and transparent elections that the commonwealth’s citizens expect and deserve. I know we will be up to the test. One challenge is the result of an encouraging development for those of us who believe robust voter participation is good for our country. Virginia has seen a huge increase in voter turnout.
Weed, Skateboarding, and the Olympics? Part 3 of 3
Words by Robert Brink; photography by Andrew Peters; additional photography courtesy Phantom Farms Never say never. Change, progress and evolution, are not only inevitable, they drive skateboarding. Don’t ever underestimate the will of skateboarder. The following interviews comprise a cross-section of six different perspectives on cannabis, skateboarding and the Olympics, and, as much as we wanted to appease the naysayers, we came up short.
Weed, Skateboarding, and the Olympics? Part 1 of 3
Words by Robert Brink, photography by Andrew Peters, additional photography courtesy Phantom Farms That the usual band of skateboarding blowhards—and even the clueless types outside of skateboarding—could be heard saying (or seen typing) things like, ‘Skateboarding will never be in the Olympics because no one will pass the drug tests!’ Or, ‘Good luck getting anyone to give up weed to even get close to competing in the Olympics!’ But here we are, in 2019, and the Olympic debut of skateboarding...
Brink and Edds: Let's set the record straight on Capitol Square
By Robert Brink and Margaret Edds Brink, a Democrat, represented Arlington in the House of Delegates for 17 years. He is a member of the Capitol Square Preservation Council. Edds, a retired journalist, is the author of “We Face the Dawn,” a biography of Oliver Hill and Spottswood Robinson. On the grounds of Capitol Square in Richmond, a few hundred yards separate the statue honoring Harry F. Byrd Sr., erected in 1976, and the Virginia Civil Rights Memorial, dedicated in 2008.
Opinion | Let’s set the record straight on Capitol Square
The Harry F. Byrd Sr. statue in Richmond. (Gregory Schneider/The Washington Post) January 18 at 4:13 PM Robert Brink, a Democrat, represented Arlington in the Virginia House of Delegates for 17 years. He is a member of the Capitol Square Preservation Council. Margaret Edds, a retired journalist, is the author of “We Face the Dawn,” a biography of Oliver Hill and Spottswood Robinson. On the grounds of Capitol Square in Richmond, a few hundred yards separate the statue honoring Harry F.
The zany story of the courthouse zodiac
The zany story of the courthouse zodiac By: Robert J. Brink June 29, 2017 I recently read a quirky 1939 story from the old Boston Daily Globe regarding a controversy involving the fortune-telling signs of the zodiac, which, oddly, had been engraved as symbols of justice on the façade of the “new” Suffolk County Courthouse, completed only a year earlier in Pemberton Square. On viewing friezes of Libra, Taurus, Scorpio, ... 4:23 pm Thu, June 29, 2017 Massachusetts Lawyers Weekly
Excellent judges: a description and prescription
Excellent judges: a description and prescription By: Robert J. Brink November 23, 2016 A few Fridays ago I fielded a request from Ukraine for permission to translate the Flaschner Judicial Institute’s book “Excellent Judges” into Ukrainian. That same day, the Supreme Judicial Court and the Appeals Court convened at the Social Law Library for their annual Massachusetts Appellate Court Conference sponsored by the Flaschner Institute. The two occurrences are actually ...
Declarations, Cobb Houses and constitutions
“This Day,” John Adams wrote from Philadelphia to a friend in Boston, the Continental “Congress has passed the most important Resolution, that ever was taken in America.” Two days later, Adams wrote that it was a declaration of “total absolute Independence.” He likened himself to Moses, the lawgiver leading his oppressed people to freedom in the ...
B-cell specific STAT3-deficiency: insight into the molecular basis of autosomal dominant Hyper IgE syndrome
Publication HistoryPublished Online: June 10, 2016Accepted: May 20, 2016; Received in revised form: April 24, 2016; Received: September 16, 2015;
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