S. Wolf
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Articles by S. Wolf
Seasonal variation in resting heart rate and heart rate variability is attenuated with advancing age
Abstract The factors driving seasonal variation in cardiovascular physiology are poorly understood. Using one year of continuous wearable data from 16,415 U.S. adults (5,884,872 person-days), we characterized seasonal variation in resting heart rate (RHR) and heart rate variability (HRV) and tested behavioral covariates (physical activity, sleep) and individual moderators (age, sex, BMI, habitual physical activity).
Astrophysics > Earth and Planetary Astrophysics
[Submitted on 5 Aug 2026 ( v1 ), last revised 5 Oct 2026 (this version, v2)] Title:Spatial distribution of water ice in the protoplanetary silhouette disk d216-0939 View a PDF of the paper titled Spatial distribution of water ice in the protoplanetary silhouette disk d216-0939, by J. S. Martin and S. Wolf and A. Potapov and H. Linz and Th. Henning and H. Terada and M. B.
Tocilizumab provides a potential therapeutic option for the management of hyperhaemolysis syndrome in sickle cell disease: A case series and brief narrative overview of the literature
1 BACKGROUND Hyperhaemolysis syndrome (HHS) is a rare but life-threatening complication of transfusion with limited treatment options. It is characterised by rapid haemolysis of both donor and recipient red cells, and most cases are associated with sickle cell disease.
Cardiovascular challenges of aging in a hotter environment: A narrative review
Corresponding Author: Rachel M. Cottle, 228 Noll Laboratory, University Park, PA 16802-6900, Phone: 814-863-8557, Email: rmc5808@psu.edu Department of Kinesiology, The Pennsylvania State University
Global influence of soil texture on ecosystem water limitation - Nature
Abstract Low soil moisture and high vapour pressure deficit (VPD) cause plant water stress and lead to a variety of drought responses, including a reduction in transpiration and photosynthesis1,2. When soils dry below critical soil moisture thresholds, ecosystems transition from energy to water limitation as stomata close to alleviate water stress3,4. However, the mechanisms behind these thresholds remain poorly defined at the ecosystem scale.
Comment on “Impact of Ultraviolet Radiation on Cardiovascular and Metabolic Disorders: The Role of Nitric Oxide and Vitamin D”
To the Editor, We read with interest the review article by Quan et al. [1], discussing the potential mechanisms by which ultraviolet (UV) radiation may have beneficial effects on cardiovascular and metabolic function. We agree with the authors' overarching premise that, notwithstanding the negative consequences of overexposure to UV radiation (e.g., photoaging and skin cancer), sun exposure has important beneficial effects for cardiometabolic health.
Sex differences in heat stress vulnerability among middle-aged and older adults (PSU HEAT Project)
Global warming has resulted in more frequent, longer, and more severe environmental heat waves (1). Men and women over the age of 65 yr are the most vulnerable population during severe environmental heat events, experiencing significantly worse health outcomes than any other age cohort (2–4). Extensive laboratory data define the mechanistic underpinnings of decreased thermoregulatory function in older adults (5–8).
The Tour de France, but make it recreational: Possible for mortals
Crossmark Copyright & Permissions Copyright © 2024, Journal of Applied Physiology https://doi.org/10.1152/japplphysiol.00014.2024 PubMed38205549 History Received 8 January 2024 Accepted 8 January 2024 Published online 11 January 2024 Smart Citations Citing PublicationsSupportingMentioningContrasting See how this article has been cited at scite.ai scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports,...
Heat stress vulnerability and critical environmental limits for older adults - Communications Earth & Environment
Abstract The present study examined heat stress vulnerability of apparently healthy older vs. young adults and characterized critical environmental limits for older adults in an indoor setting at rest (Rest) and during minimal activity associated with activities of daily living. Critical environmental limits are combinations of ambient temperature and humidity above which heat balance cannot be maintained (i.e., becomes uncompensable) for a given metabolic heat production.
Chaleur et humidité : leurs effets sur notre corps se font sentir plus tôt que prévu
Sous l’effet du changement climatique, les vagues de chaleur gagnent en puissance – elles durent plus longtemps, deviennent plus fréquentes et, surtout, leurs températures atteignent des niveaux de plus en plus élevés. Une question est désormais sur toutes les lèvres : « À partir de quand la chaleur nous empêchera-t-elle de mener à bien des activités quotidiennes considérées comme normales à l’heure actuelle, même si nous sommes jeunes et en bonne santé ?
As heat records fall, how hot is too hot for the human body?
Extreme heat has been breaking records across Europe, Asia and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit a temperature of 128 degrees on July 16 – not quite the world’s hottest day on record, but close.
How Hot Is Too Hot for the Human Body?
By: W. Larry Kenney, Daniel Vecellio, Rachel Cottle & S. Tony Wolf | Extreme heat has been breaking records across Europe, Asia and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit a temperature of 128 degrees Fahrenheit (53.3 degrees Celsius) on July 16, 2023 — not quite the world’s hottest day on record, but close.
As heat records fall, how hot is too hot for the human body? Don't discount humidity - Local News Matters
EXTREME HEAT HAS been breaking records across Europe, Asia and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit 128 degrees Fahrenheit (53.3 degrees Celsius) on July 16, 2023 — not quite the world’s hottest day on record, but close.
As Heat Records Fall, How Hot Is Too Hot for the Human Body?
The Conversation — Extreme heat has been breaking records across Europe, Asia, and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit a temperature of 128° F (53.3° C) on July 16, 2023 – not quite the world’s hottest day on record, but close.
As Heat Records Fall, How Hot Is Too Hot for the Human Body?
The Conversation — Extreme heat has been breaking records across Europe, Asia, and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit a temperature of 128° F (53.3° C) on July 16, 2023 – not quite the world’s hottest day on record, but close.
Onset of cardiovascular drift during progressive heat stress in young adults (PSU HEAT project)
Over the past several decades, average global temperatures have increased and are expected to continue increasing throughout the 21st century (1). The increase in average global temperatures has resulted in an increase in the frequency, duration, and severity of heat waves (2). As a result of this warming climate, the number of excess deaths during extreme heat events has increased significantly, from ∼752 deaths in 2008 to ∼2,337 in 2011 in the United States alone (3).
As heat records fall, how hot is too hot for the human body?
The biggest risks aren't always the biggest numbers on the thermometer - humidity gets dangerous faster than many people realize.
As heat records fall, how hot is too hot for the human body?
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)
As heat records fall, how hot is too hot for the human body?
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)
As heat records fall, how hot is too hot for the human body? Original
Extreme heat has been breaking records across Europe, Asia and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit 128 degrees Fahrenheit (53.3 degrees Celsius) on July 16, 2023 – not quite the world’s hottest day on record, but close.
As heat records fall, how hot is too hot for the human body?
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) W. Larry Kenney, Penn State; Daniel Vecellio, Penn State; Rachel Cottle, Penn State, and S. Tony Wolf, Penn State kAmW%wt r~}'t#$p%x~}X tIEC6>6 962E 92D 366?
As heat records fall, how hot is too hot for the human body?
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) W. Larry Kenney, Penn State; Daniel Vecellio, Penn State; Rachel Cottle, Penn State, and S. Tony Wolf, Penn State kAmW%wt r~}'t#$p%x~}X tIEC6>6 962E 92D 366?
As heat records fall, how hot is too hot for the human body?
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) W. Larry Kenney, Penn State; Daniel Vecellio, Penn State; Rachel Cottle, Penn State, and S. Tony Wolf, Penn State kAmW%wt r~}'t#$p%x~}X tIEC6>6 962E 92D 366?
When Is the Temperature Outside Too High for Your Body?
REMO CASILLI By W. Larry Kenney, Daniel Vecellio, Rachel Cottle, and S. Tony Wolf Extreme heat has been breaking records across Europe, Asia and North America, with millions of people sweltering in heat and humidity well above “normal” for days on end. Death Valley hit a temperature of 128 degrees Fahrenheit (53.3 degrees Celsius) on July 16, 2023—not quite the world’s hottest day on record, but close.
How hot is too hot for the human body? (Opinion)
W. Larry Kenney, Daniel Vecellio, Rachel Cottle and S. Tony Wolf June 16, 2023 Heat waves are becoming supercharged as the climate changes – lasting longer, becoming more frequent and getting just plain hotter. One question a lot of people are asking is: “When will it get too hot for normal daily activity as we know it, even for young, healthy adults?” The answer goes beyond the temperature you see on the thermometer. It’s also about humidity.
Nitric oxide‐mediated cutaneous microvascular function is not altered in middle‐aged‐to‐older adults following mild SARS‐CoV‐2 infection: A pilot study
2 METHODS The Institutional Review Board at The Pennsylvania State University approved all experimental procedures and protocols. Verbal and written informed consent were voluntarily obtained from all participants before participation and in accordance with the guidelines set forth by the Declaration of Helsinki. Participants All participants underwent a complete medical screening, including a blood chemistry analysis (Quest Diagnostics).
Generalized Gleason theorem and a finite amount of information about the measurement context
Abstract Quantum processes cannot be reduced, in a nontrivial way, to classical processes without specifying the context in the description of a measurement procedure. This requirement is implied by the Kochen–Specker theorem in the outcome-deterministic case and, more generally, by the Gleason theorem. The latter establishes that there is only one noncontextual classical model compatible with quantum theory, the one that trivially identifies the quantum state with the classical state.
Hot and getting hotter - 5 essential reads on high temps and human bodies Original
Launching the and the heat.gov site on July 26, 2022, the Biden administration cited heat waves and the warming climate as serious health threats. As the new initiative promises a “science informed response” to hotter conditions, five stories from The Conversation’s archive explain what researchers know about heat and health. 1. It’s the humidity Heat waves can be deadly in a variety of ways, wrote William Calvin, who teaches physiology and neuroscience at the University of Washington.
How Hot Is Too Hot for the Human Body?
The following essay is reprinted with permission from The Conversation, an online publication covering the latest research. Heat waves are becoming supercharged as the climate changes – lasting longer, becoming more frequent and getting just plain hotter. One question a lot of people are asking is: “When will it get too hot for normal daily activity as we know it, even for young, healthy adults?” The answer goes beyond the temperature you see on the thermometer. It’s also about humidity.
Heat and humidity are a dangerous combination
Heat waves are becoming supercharged as the climate changes — lasting longer, becoming more frequent, and getting just plain hotter. One question a lot of people ask is: “When will it get too hot for normal daily activity as we know it, even for young, healthy adults?” The answer goes beyond the temperature you see on the thermometer. It’s also about humidity. Our research shows the combination of the two can get dangerous faster than scientists previously believed.
How hot is too hot for the human body? – New Hampshire Bulletin
Heat waves are becoming supercharged as the climate changes – lasting longer, becoming more frequent, and getting just plain hotter. One question a lot of people are asking is: “When will it get too hot for normal daily activity as we know it, even for young, healthy adults?” The answer goes beyond the temperature you see on the thermometer. It’s also about humidity. Our research shows the combination of the two can get dangerous faster than scientists previously believed.
How hot is too hot for the human body? Heat + humidity gets dangerous fast
Heat waves are becoming supercharged as the climate changes—lasting longer, becoming more frequent and getting just plain hotter. One question a lot of people are asking is: “When will it get too hot for normal daily activity as we know it, even for young, healthy adults?” The answer goes beyond the temperature you see on the thermometer. It’s also about humidity. Our research shows the combination of the two can get dangerous faster than scientists previously believed.
Rising Heat and Humidity in Today’s Heatwaves Are More Insidiously Lethal Than We Thought
By W. Larry Kenney, Daniel Vecellio, Rachel Cottle, and S. Tony Wolf. Heat waves are becoming supercharged as the climate changes—lasting longer, becoming more frequent and getting just plain hotter. One question a lot of people are asking is: “When will it get too hot for normal daily activity as we know it, even for young, healthy adults?” The answer goes beyond the temperature you see on the thermometer. It’s also about humidity.
How hot is too hot for the human body? These Penn State experts explain | Opinion
▪ You must give Pennsylvania Capital-Star credit, including https://penncapital-star.com and author. ▪ If you publish online, include the links from the story, and a link to Pennsylvania Capital-Star. ▪ Stories may be edited for in-house style or to shorten. More substantial changes should be noted as additional and conducted by your publication. ▪ You can publish our graphics and any photos that are credited to Pennsylvania Capital-Star with the stories with which they originally appeared.
How hot is too hot for the human body? Our lab found heat + humidity gets dangerous faster than many people realize
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) W. Larry Kenney, Penn State; Daniel Vecellio, Penn State; Rachel Cottle, Penn State, and S. Tony Wolf, Penn State kAmW%wt r~}'t#$p%x~}X w62E H2G6D 2C6 k2 9C67lQ9EEADi^^5@:]@C8^`_]`_bg^Dc`cef\_a_\`ehf_\fQm364@>:?8 DFA6C492C865 2D E96 4=:>2E6 492?86Dk^2m – =2DE:?8 =@?86C[ 364@>:?8 >@C6 7C6BF6?E 2?5 86EE:?8 ;FDE A=2:? 9@EE6C] ~?6 BF6DE:@? 2 =@E @7 A6@A=6 2C6 2D<:?8 :Di “(96?
Heat exposure limits for young unacclimatized males and females at low and high humidity
• None . Heat stress and strain. Threshold limit values and biological exposure indices for chemical substances and physical agents. : . ACGIH.. Heat stress and strain. Threshold limit values and biological exposure indices for chemical substances and physical agents. • None , , . On the problems related to natural wet bulb temperature indirect evaluation for the assessment of hot thermal environments by means of WBGT . Ann Occup Hyg. 56(9): – . • None , .
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection
There have been over 45 million cases of COVID-19 in the United States and 244 million worldwide (1). The clinical spectrum of COVID-19 disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is wide (2, 3). Although ∼97% of infected individuals recover from the initial infection, the short- and long-term implications of SARS-CoV-2 infection are unknown (1).
Evaluating the 35°C wet-bulb temperature adaptability threshold for young, healthy subjects (PSU HEAT Project)
In their most recent report, the Intergovernmental Panel on Climate Change stated that global temperatures have increased by ∼1°C since the preindustrial era, primarily due to anthropogenic climate change (1). This increase in global mean temperature is accompanied by higher magnitude temperature increases on some regional scales (2), along with increased heatwave frequency, duration, and magnitude (3).
Temperature regulation during exercise in the heat: insights for the aging athlete
Abstract The earth’s climate is warming, accompanied by a consequently greater frequency and severity of extreme heat events. At the same time, lifespan is increasing and people of all ages are staying increasingly active. Age-related impairments in thermoregulatory function are well-documented, leading to increased heat-related health risks and reduced exercise/athletic performance for older adults in hot environmental conditions.
Brentuximab vedotin in multifocal cutaneous anaplastic large cell lymphoma in a patient with human immunodeficiency virus following Hodgkin lymphoma
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The impact of providing blood to the scene of an accident on transfusion laboratory practice
Haemorrhage is the leading cause of mortality during trauma. In 2012, London's Air Ambulance introduced Blood on Board (BOB), transfusing group O red cells (RBC) to trauma patients at the scene. This study assessed the impact of BOB on the number of mixed field samples received by the laboratory, the number of group O RBC transfused to non‐group O patients and the ratio of RBC to fresh frozen plasma (FFP) transfused in the initial 24 h.
An insertion mutation in HOXC13 underlies pure hair and nail ectodermal dysplasia with lacrimal duct obstruction
Pure hair and nail ectodermal dysplasia (PHNED; MIM 602032, 614929, and 614931) is an autosomal recessive ED that is characterized by hypotrichosis and nail dystrophy only, without further ectodermal or non-ectodermal alterations. To date, homozygous mutations in three genes have been reported to cause PHNED: KRT85 (MIM 602767), encoding keratin, type II cuticular Hb5 like; KRT74 (MIM 608248), encoding keratin, type II cytoskeletal 74; and HOXC13 (MIM 142976), encoding Homeobox C13.
Effects of multilevel surgery on a flexed knee gait in adults with cerebral palsy
Effects of multilevel surgery on a flexed knee gait in adults with cerebral palsy C. Putz, S. I. Wolf, E. M. Mertens, A. Geisbüsch, S. Gantz, F. Braatz, L. Döderlein, T. Dreher Bone Joint J Sep 2017, 99-B (9) 1256-1264; DOI: 10.1302/0301-620X.99B9.BJJ-2016-1155.R1
Five years of EMA-approved systemic cancer therapies for solid tumours-a comparison of two thresholds for meaningful clinical benefit
Approximately, 800 drugs and vaccines are currently under investigation in clinical trials for the treatment of cancer. Roughly, 80% of those are first-in-class therapies, and around 73% are intended as personalised and, therefore, targeted medicines [16][16]. Global costs for anticancer therapies have increased in the last decade, particularly due to targeted agents and immunotherapies [[16], [17]].
Readmissions, unplanned emergency room visits, and surgical retreatment rates after anti-reflux procedures
Publication HistoryPublished online: April 06, 2017Accepted: March 13, 2017; Received: August 8, 2016;
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