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Shanmiao Gou

As seen in: Nature, MDPI, Cell Press, Research Protocols
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Articles

HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer

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By Gengdu Qin, Haixin Yu, Yuhan Zhao, Wentao Xia, Yang Qin, Xueyi Liang, Taoyu Chen, Yuxuan Li, Tianhao Zou, Jiaying Liu, Junpeng Meng, Zhiqiang Liu, Bo Wang, Tao Yin, Shanmiao Gou, HeShui Wu, Xin Jin, Yingke Zhou, Ruozheng Wei
| Cell Press Verified
Keywords pancreatic cancer HDAC5 FOXA1 HIF1α Get full text access Log in, subscribe or purchase for full access. References 1. Bray, F. ∙ Laversanne, M. ∙ Sung, H. ... Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J. Clin. 2024; 74:229-263 2. Del Chiaro, M. ∙ Sugawara, T. ∙ Karam, S.D. ... Advances in the management of pancreatic cancer Br. Med. J. (Clin. Res. Ed). 2023; 383, e073995 3. Lupien, M. ∙ Eeckhoute, J. ∙ Meyer, C.A. ...
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Disrupting sympathetic nerve-tumor crosstalk via biomimetic nanovesicles to augment chemotherapy efficacy under chronic stress

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By Jingjie Liu, Jiaqi Qin, Wenxia Zheng, Xiaojuan Wang, Zhaohan Wei, Zixiang Xie, Xin Li Verified, Ziqiao Ding, Haojie Liu, Zhiheng Cai, Shanmiao Gou, Xiangliang Yang, Tuying Yong, Lu Gan, Tingwei Yan
| Nature Verified
Abstract Chronic stress significantly impacts cancer progression by activating the sympathetic nervous system, leading to increased tumor growth, metastasis, and resistance to chemotherapy. To address these challenges, we develop biomimetic hybrid nanovesicles (Pro@hNVs) by fusing M1 macrophage-derived vesicles with pH-sensitive liposomes (hNVs) to encapsulate the β-adrenergic receptor (ADRB) blocker propranolol (Pro).
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JMIR Research Protocols - Ligation of the Pancreatic Stump With Quantified Force During Distal Pancreatectomy for Postoperative Pancreatic Fistula: Protocol for a Single-Center Nonrandomized Controlled Clinical Study

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By Shanmiao Gou
| Research Protocols
Study Design Study Setting End Points Primary End Points Secondary End Points Definitions Patient Eligibility Inclusion Criteria Patients aged between 18 and 75 years. Patients scheduled to undergo distal pancreatectomy (including the body and tail of the pancreas) with the intended pancreatic transection line located on the left side of the portal vein. Patients who fully understand this study, agree to participate in it voluntarily, and sign the informed consent form.
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