Sohani Das Sharma

Keywords glioma glioma microenvironment excitatory neurons mTOR inhibition glioma-associated neuronal alterations glioma-induced plasticity dendritic spines neuronal hyperexcitability brain tumors alterations in neuronal activity brain tumor microenvironment Get full text access Log in, subscribe or purchase for full access. References 1. Rudà, R. ∙ Bello, L. ∙ Duffau, H. ... Seizures in low-grade gliomas: natural history, pathogenesis, and outcome after treatments Neuro-Oncology. 2012; 14:iv55-iv64 2.

Abstract Gliomas are highly aggressive brain tumors characterized by poor prognosis and composed of diffusely infiltrating tumor cells that intermingle with non-neoplastic cells in the tumor microenvironment, including neurons. Neurons are increasingly appreciated as important reactive components of the glioma microenvironment, due to their role in causing hallmark glioma symptoms, such as cognitive deficits and seizures, as well as their potential ability to drive glioma progression.