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Articles by Song Lin
A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility
Abstract Chronic stress disrupts emotional homeostasis, leading to resilience or susceptibility through unclear mechanisms. Here, we identify a dual-pathway mechanism in the dorsomedial prefrontal cortex (dmPFC)-lateral habenula (LHb) circuit in male mice, where glutamatergic and GABAergic projections coordinately regulate stress responses.
Cutting the cord for high-throughput electrochemistry - Nature Chemical Engineering
Song Lin and Paul McEuen discuss the challenges and opportunities of running electrochemical reactions on microliter scales in massive parallel. This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 digital issues and online access to articles $119.00 per year only $9.92 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF.
Design Thinking, Serendipity, and Digital Innovation
1 Introduction Anna Yang, the founder of the clothing brand ANNAKIKI, is a famous Chinese independent designer who has participated in Milan Fashion Week many times. As a sensitive, creative, and maverick designer, Anna Yang clearly has a strong design thinking (Brown 2008; Rylander Eklund et al. 2022; Verma et al. 2023). For example, she has user empathy and effectively balances avant-garde design with customer needs.
Electrochemical Activation of α-Carbonyl Alkoxyamines for Direct Nucleophilic Substitution
2,2,6,6-Tetramethylpiperidin-1-oxyl (TEMPO)-derived alkoxyamines (alkyl-TEMPO) are frequently encountered in the methodology literature, most often obtained when the persistent aminoxyl radical TEMPO captures an in situ generated C-centered radical. (1,2) The utility of alkyl-TEMPO species has traditionally been limited to either oxidation to ketones using m-chloroperoxybenzoic acid or reduction to free alcohols using zinc.
Effect of Targeted Probiotics on Anesthesia‐Induced Sleep Disturbances via Modulating the Gut Microbiome and Metabolites
1 Introduction Quality sleep is essential for physical and mental health, and is beneficial for cognition, memory consolidation, immunity, and hormone regulation (Baranwal et al. 2023). Around 60% of surgical patients experience pre- and post-operative sleep disturbances, including inadequate sleep duration, poor sleep quality, and high sleep latency (Butris et al. 2023).
Experimental investigation on residual gas re-explosion behaviors following primary fuel-rich explosions of methane-bituminous coal powder mixtures
ABSTRACT This study aims to identify the re-explosion hazard after a primary explosion of a fuel-rich methane and bituminous coal powder mixture. Primary and re-explosion experiments were conducted using a spherical explosion testing apparatus. The results reveal that once the mixture of methane and bituminous coal powder reaches a certain degree of fuel enrichment, an explosion can occur under the condition of reintroducing a certain volume of air and igniting.
Bright light exposure suppresses feeding and weight gain via a visual circuit linked to the lateral hypothalamus - Nature Neuroscience
Abstract Environmental light regulates nonimage-forming functions like feeding, and bright light therapy shows anti-obesity potential, yet its neural basis remains unclear. Here we show that bright light treatment effectively reduces food intake and mitigates weight gain in mice through a visual circuit involving the lateral hypothalamic area (LHA).
Hollow Keggin-Type Hybrid Polyoxometalate as a Stable Redox Electrode for Safe and Fast-Charging Lithium-Ion Batteries
Crystal Growth & Design Cite this: Cryst. Growth Des. 2025, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Nip it in the bud: the role of vigilant leadership, knowledge sharing, and safety performance
1 Introduction Maintaining safety and reliability is a perpetual theme for reliability-seeking organizations, striving to minimize or cut down the possibility of catastrophe close to zero (1, 2). Such organizations have been reported to include nuclear power plants (3), healthcare (4), airline/rail transportation (5), construction corporations (6), fire departments (7), and police departments (8).
Multisensory integration in the mouse ventral visual thalamus mediates stress coping via locus coeruleus-related circuits
Keywords stress coping visual thalamus locus coeruleus enriched environment Get full text access Log in, subscribe or purchase for full access. References 1. Cannon, W.B. ORGANIZATION FOR PHYSIOLOGICAL HOMEOSTASIS Physiol. Rev. 1929; 9:399-431 2. Russell, G. ∙ Lightman, S. The human stress response Nat. Rev. Endocrinol. 2019; 15:525-534 3. Sumitomo, I. ∙ Sugitani, M. ∙ Fukuda, Y. ... Properties of cells responding to visual stimuli in the rat ventral lateral geniculate nucleus Exp. Neurol. 1979; 66:721-736 4.
Do More Likes Lead to More Clicks? Evidence from a Social Advertising Field Experiment
Social media has transformed how brands interact with consumers, making platforms like Instagram and Facebook critical for advertising success. As businesses invest billions into social ads, understanding how users engage with these ads is more important than ever. But how do social signals such as likes influence user behavior? A new Journal of Marketing study finds that the first like on a social ad has a profound impact, significantly boosting both clicks and likes.
Deoxygenative Cyanofunctionalization of Aldehydes and Ketones Enabled by Electrochemical Reduction
Cite Jump to ExpandCollapse CommunicationOctober 7, 2025 Deoxygenative Cyanofunctionalization of Aldehydes and Ketones Enabled by Electrochemical Reduction Click to copy article linkArticle link copied! Yi Wang Yi Wang Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States Bofei Wang Bofei Wang Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States Song Lin* Song Lin Department of Chemistry and...
Frontiers | Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration
1 Introduction Hypertension is a preeminent cardiovascular burden that affects billions of people globally and is intimately associated with life-threatening complications like stroke and heart failure (World Health Organization, 2023). Hypertension-induced myocardial remodeling involves structural and functional changes to the heart muscle, including hypertrophy, fibrosis, and inflammation.
Electrochemical ⍺‐C─H Functionalization of Nitramines for Accessing Bifunctional Energetic Heterocycles
Introduction Energetic materials (EMs) play a vital role in applications ranging from civil construction and pyrotechnics to space exploration and defense.[1-5] These critical applications have driven the design of numerous high-energy organic compounds with innovative structures—often containing canonical energetic functional groups, including nitro groups, nitrogen-rich heteroarenes, and strained rings—to achieve desired properties.[6-8] Despite these advances, the synthesis of organic EMs...
Considerations in Pursuing Reaction Scope Generality
1 Introduction Reaction development is the cornerstone of synthetic chemistry, driven either by practical needs (i.e., promising disconnections for streamlining a target-oriented synthesis) or by mechanistic design aimed at exploring new reactivity concepts. When disclosing new methods resulting from these goals, chemistry research papers include illustrative examples to demonstrate the reaction scope and inform readers about the method's possible tolerance to substrate deviation.
Reduced neural suppression at occipital cortex in subthreshold depression - Translational Psychiatry
Abstract Impaired visual perception and biochemical changes in the occipital cortex have been observed in major depression. However, the neural basis underlying these abnormalities remains yet elusive. Importantly, it remains unknown whether these abnormalities are present in the early stage of depression, known as subthreshold depression (SD). Recognized as a precursor of major depression, SD has gained a growing attention in both research and clinical fields.
Bright-light treatment ameliorates motor and non-motor deficits through distinct visual circuits in a mouse model of Parkinson’s disease
Keywords bright-light treatment Parkinson’s disease visual thalamus superior colliculus Research topic(s) CP: Neuroscience Introduction Light signals in the environment are powerful modulators of physiological and behavioral functions, influencing aspects such as circadian rhythms, mood, cognition, and non-visual sensory perceptions.1,2,3,4,5,6 In the clinic, bright-light therapy appears to improve both motor and non-motor symptoms (e.g., depressive symptoms and impairment of cognition) of...
Non-linear relationship between social jetlag and depressive symptoms among Chinese college students - Scientific Reports
Abstract This study aims to elucidate the relationship between social jetlag and depressive symptoms in college students, with a focus on identifying specific cut points that significantly heighten the risk of depression. A cross-sectional study was conducted among 2,006 students from Jiangsu College of Nursing between October and November 2024. Social jetlag was calculated based on the difference between the midpoints of sleep on workdays and weekends.
Efficient and sustained photosynthetic hydrogen production by algae under high light intensity
Keywords algae high light intensity hydrogen graphene oxide thermosensitive polymer Introduction Hydrogen has tremendous potential as a clean, sustainable energy carrier. It could also serve as a fuel in a future transition from the existing carbon-based economy to a hydrogen-based economy [1]. Currently, hydrogen is primarily produced through water electrolysis or methane steam reforming, both of which are energy intensive and generally involve high production costs [2].
314m domestic trips made during May Day holidays amid tourism boom
An aerial drone photo taken on May 3, 2025 shows tourists visiting the Fuzimiao scenic area in Nanjing, east China's Jiangsu Province. People across China enjoy the ongoing May Day holiday in various ways. (Xinhua) China's five-day May Day holidays, which ended on Monday, have seen a surge in domestic travel and spending, with 314 million trips made nationwide as local governments launched various tourism products, cultural activities and consumer-friendly measures.
Chinese provinces step up policy support to unlock Q2 consumption potential after strong Q1 start
A customer shops at a supermarket in Congjiang County, southwest China's Guizhou Province, March 9, 2024. Photo: Xinhua Provincial-level economic figures for the first quarter are being released across China, with many regions delivering a solid start to the year despite a complex global economic backdrop. Local governments have pledged to further prioritize efforts to boost domestic demand and accelerate the impact of supportive policies.
A-shares end higher on Tuesday as China acts swiftly to ensure stock market stability
A large screen displays real-time stock market data on April 8, 2025 in Shanghai. Photo: VCG After global markets were hit by a "Black Monday" sell-off, China's financial regulators acted swiftly to calm investors, while the state-backed "national team" decisively stepped in, injecting both capital and confidence. All three major A-share indexes closed higher on Tuesday.
The Dual Role of Urban Vegetation: Trade-Offs Between Thermal Regulation and Biogenic Volatile Organic Compound Emissions
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
US auto tariffs send ‘disastrous signal’ for free, rules-based trade: German industry leader
New vehicles are parked at the Port of Baltimore in Maryland, the US, on March 6, 2025. Photo: VCG New US tariffs of 25 percent on all imported passenger cars and light commercial vehicles send a "disastrous signal" for free, rules-based trade, Hildegard Müller, president of the German Association of the Automotive Industry (VDA), told the Global Times on Thursday.
Chinese automakers unveil new models, smart tech to stay ahead
Robots weld bodyshells of cars at a workshop of Chinese electric vehicle (EV) maker Li Auto Inc. in Changzhou, east China's Jiangsu Province, Jan. 10, 2024. (Xinhua/Ji Chunpeng) Building on their stellar performance last year, Chinese automakers have maintained strong momentum in 2025, rolling out new technologies at a rapid pace to drive industry-wide upgrades and stay ahead in the global competition.
Hong Kong stock market homes 1,478 Chinese mainland-based companies by end-2024: CPPCC member
A view of Hong Kong File Photo: VCG By the end of last year, 1,478 Chinese mainland companies were listed on the Hong Kong Stock Exchange (HKEX), making up over 80 percent of the total market's capitalization and nearly 90 percent of daily trading volume, Irons Sze, a member of the 14th National Committee of the Chinese People's Political Consultative Conference (CPPCC), told reporters at a group interview on Monday.
Chinese departments specify pro-growth measures, convey confidence in achieving GDP target
Zheng Shanjie, head of the National Development and Reform Commission, Lan Fo'an, minister of finance, Wang Wentao, minister of commerce, Pan Gongsheng, governor of the People's Bank of China, and Wu Qing, chairman of the China Securities Regulatory Commission, attend a press conference on economy for the third session of the 14th National People's Congress (NPC) in Beijing, capital of China, March 6, 2025.
China to redouble efforts to expand job offerings, eyeing on emerging industries to create more jobs: experts
People participate in a job fair in the Xiong'an New Area in North China's Hebei Province on January 15, 2025. This job fair targets individuals with employment difficulties, members of zero-employment families, and unemployed college graduates who have left school. The fair is carried out in a combination of online and offline formats, covering the needs of job seekers and enterprises.
China’s tech hub Shenzhen eyes 5.5% growth in 2025 as economic powerhouses take lead in driving industrial upgrades
A modular flying car is on display at the 2024 Shenzhen eVTOL Expo on September 23, 2024. The three-day event, which is being held in Shenzhen, South China's Guangdong Province from September 23 to 25, will focus on promoting the high-quality development of the low-altitude economy.
Light-activated hypervalent iodine agents enable diverse aliphatic C–H functionalization - Nature Chemistry
Abstract The functionalization of aliphatic C–H bonds is a crucial step in the synthesis and transformation of complex molecules relevant to medicinal, agricultural and materials chemistry. As such, there is substantial interest in the development of general synthetic platforms that enable the efficient diversification of aliphatic C–H bonds. Here we report a hypervalent iodine reagent that releases a potent hydrogen atom abstractor for C–H activation under mild photochemical conditions.
DeepSeek frenzy sparks global focus on Chinese assets
stock market Photo:VCG The DeepSeek craze continues to spread globally, driving a sharp rise in Chinese asset prices, including US-listed Chinese stocks. An analyst noted on Sunday that Chinese assets have entered a new phase, with capital flows out of US stocks and into A-shares and Hong Kong stocks becoming increasingly evident. US stocks experienced a sell-off on Friday, with all three major indexes posting significant losses.
DeepSeek-related companies’ shares keep surging in A-share market as new model stirs investment excitement
deepseek Global financial institutions are getting bullish on China's stock market, as the rise of Chinese artificial intelligence (AI) start-up DeepSeek is driving global investors to re-evaluate Chinese tech shares while a booming consumer market during the Spring Festival holidays highlighted the vitality and momentum of the world's second-largest economy.
Over 2.3 billion interregional trips recorded during Chinese Spring Festival holiday
Passengers are seen at the waiting hall of Wuhan Railway Station in Wuhan, central China's Hubei Province, Jan. 20, 2025. As this year's Spring Festival travel rush began on Jan. 14, China Railway Wuhan Bureau Group Co., Ltd. has scheduled to add 47 overnight high-speed trains daily towards major cities from Jan. 20 to 27, in an effort to better cater for passengers.
Major state insurers to allocate 30% of new premiums to A-shares annually as China pushes for long-term investment
stock market Photo:VCG Chinese financial regulators on Thursday further elaborated on an implementation plan issued a day earlier aimed at boosting the inflow of long-term funds into the stock market, saying that they will guide major state-owned insurers to increase both the scale and proportion of their investments in A-shares. Major state-owned insurers will strive to allocate 30 percent of their new premiums annually to invest in A-shares, starting 2025.
Chinese Vice Premier calls for multilateralism, inclusive development at WEF
The World Economic Forum logo is seen at the Congress Center in Davos, Switzerland, on January 18, 2025. Photo: VCG Member of the Standing Committee of the Political Bureau of the CPC Central Committee and Vice Premier Ding Xuexiang delivered a special address at the World Economic Forum （WEF）Annual Meeting 2025 held in Davos, Switzerland on Tuesday.
MIIT to launch new growth plans for 10 key industries, increase support for major industrial provinces
Workers of HBIS Group Shijiazhuang Iron and Steel Co., Ltd. hoist steel for transport in Shijiazhuang, north China's Hebei Province, Jan. 2, 2025. Enterprises across China are operating at full capacity to meet production demands at the start of the new year.
China’s provincial-level regions report 2024 GDP growth, bolstering national economic confidence
A view of the Lujiazui area in Shanghai Photo: VCG Chinese provincial-level regions have begun releasing their 2024 economic results. Despite multiple challenges, some major economic provinces continued to lead the way, while some others reached new milestones, strengthening confidence in China's GDP growth for the year.
Chinese app RedNote tops US store as American users flock to platform ahead of TikTok ban
Xiaohongshu Photo: CFP Amid growing concerns over a potential TikTok ban in the US, Chinese social media app "RedNote," or Xiaohongshu, has quickly risen in popularity, securing a top spot on Top Free Apps list in Apple App Store in the US. At Chinese A-share market's opening on Tuesday, RedNote-related stocks surged, with companies like Foshan Yowant Technology and Inly Media Co reaching their daily limit during pre-market bidding.
Enhanced Antibacterial Activity of Hydrophobic Modified Lysozyme Against Gram-Negative Bacteria Without Accumulated Resistance
2. Results and Discussion 2.1. Construction and Characterization of HML The precursor of HML bactericides is the natural lysozyme extracted from hen egg whites. As is demonstrated in Figure 1a, the natural lysozyme experienced a process of amination, and the coupling agents used were 1,3-diaminopropane/1,6-diaminohexane/1,8-Diaminooctane with alkyl chains of different lengths of 3, 6, and 8 C-C bonds.
Light-harvesting microelectronic devices for wireless electrosynthesis - Nature
Abstract High-throughput experimentation (HTE) has accelerated academic and industrial chemical research in reaction development and drug discovery and has been broadly applied in many domains of organic chemistry1,2. However, application of HTE in electrosynthesis—an enabling tool for chemical synthesis—has been limited by a dearth of suitable standardized reactors3,4,5,6,7.
Profits of China's major industrial enterprises improve in Oct thanks to incremental pro-growth policies: NBS
Robots carry solar modules inside a photovoltaic plant in Jinhua, East China's Zhejiang Province on August 30, 2024. In the first seven months of this year, solar power's cumulative power generation capacity increased by 49.8 percent to 740 million kilowatts in the country, data showed. Photo: VCG Backed by the sustained effects of the government's existing and incremental pro-growth policies, China's major industrial enterprises saw stable production growth in October.
Improved fundamentals boost foreign institutions’ bullish outlook on Chinese assets for 2025
An aerial view of Shanghai File photo: VCG As 2024 comes to a close, financial institutions are rolling out their investment outlooks for the year ahead. Despite recent market volatility, foreign institutions continue to give optimistic reports on Chinese assets. Economists point to strengthening expectations for improved macroeconomic fundamentals, forecasting significant upside potential for China's A-shares in 2025, despite the complexities faced by the global economy.
China prepares for year-end shopping rush with fresh round of consumer vouchers
This photo taken by Catherine Gulua, an attendee of the sixth World Media Summit, shows the interior view of a shopping mall in Urumqi, northwest China's Xinjiang Uygur Autonomous Region, Oct. 13, 2024. (Photo: Xinhua) As the year-end shopping season approaches, cities in China have rolled out new rounds of consumption vouchers tailored to local needs, regional characteristics and consumer preferences, to boost market activity and support the recovery of consumption.
China ramps up energy supply efforts as winter cold spell looms
People walk in snow in Urumqi, northwest China's Xinjiang Uygur Autonomous Region, Nov. 14, 2024. A cold front has ushered in significant drop in temperature and snowfall across Xinjiang. (Photo: Xinhua) China's National Meteorological Center (NMC) issued a blue alert on Sunday for a cold spell as the season's first chill sets in.
Apple sees double-digit y-o-y decline in iPhone sales during China’s ‘Double 11’shopping festival, models retain top spot: report
An Apple store in Chengdu, Southwest China's Sichuan Province. Photo: IC Apple experienced a double-digit year-on-year decline in iPhone sales during China's recently concluded "Double 11" online shopping festival, but its iPhone 16 Pro and iPhone 16 Pro Max were still the best-selling models, according to an industry report released on Wednesday.
China reaffirms commitment to achieving 2024 goals
China reaffirms commitment to achieving 2024 goals By Song Lin and Chen Qingrui (Global Times) 10:01, November 20, 2024 With 2024 nearing an end amid the complex and evolving domestic and global economic landscape, the National Development and Reform Commission (NDRC), the country's top economic planner, on Tuesday reaffirmed its commitment to achieving the year's economic growth goal of about 5 percent.
China reaffirms commitment to achieving 2024 goals
Industrial robots carry out welding operations in an intelligent workshop of an automobile manufacturer located in Jiangdu Hi-tech Industrial Development Zone, Yangzhou, East China's Jiangsu Province, on October 18, 2024. China's GDP grew 4.8 percent year on year in the first nine months of 2024, data from the National Bureau of Statistics (NBS) showed on the day.
China’s policy package expected to help drive ‘V-shaped’ recovery in Q4; annual targets expected to be met: economist
Robots weld bodyshells of cars at a workshop of Chinese electric vehicle (EV) maker Li Auto Inc. in Changzhou, east China's Jiangsu Province, Jan 10, 2024. Photo:Xinhua China has recently introduced a set of incremental policy measures aimed at stabilizing growth, expanding domestic demand, and mitigating risks.
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