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Articles by Weiwei Yang
A digitalized nosocomial risk management framework during the COVID-19 pandemic: practice-based insights from a tertiary cancer hospital in Southwest China
Abstract Background: Cancer patients represent a particularly vulnerable population during infectious disease outbreaks, with substantially elevated risk of infection and mortality compared to the general population. Comprehensive nosocomial risk management frameworks for specialized oncology hospitals remain under-documented in the literature.
Electrical Engineering and Systems Science > Systems and Control
We introduce GridSFM, a framework that combines a pretrained foundation model across grid topologies with physics-informed fine-tuning for solving AC Optimal Power Flow (AC-OPF) at scale. It is a $15$ million parameter physics-inspired graph neural network pretrained across $54$ topologies of $500$ to $4{,}000$ buses.
Natural killer cells in preeclampsia: an overview of current research
Abstract Background: Preeclampsia is a pregnancy disorder endangering maternal and fetal health, often accompanied by complications such as hypertension and proteinuria. Natural killer cells are indispensable in the occurrence and development of preeclampsia. Up to now, there has been no bibliometric study on NK cells and preeclampsia. Thus, we conducted a bibliometric analysis based on a systematic literature retrieval strategy.
Electro-optic comb-empowered measurement of the dynamic frequency of a laser
Abstract Frequency-modulated lasers are widely used in spectroscopy, biology and LiDAR. The performance of these applications depends strongly on accurate tracking of the frequencies of frequency-modulated lasers. So far, real-time tracking of the frequencies of frequency-modulated lasers remains challenging.
Nutritional literacy in young and middle-aged patients with ischemic stroke: a mixed-methods study with IMB model-guided analysis
Abstract Background: Stroke incidence is rising among young and middle-aged adults, who bear major social and family responsibilities. Poor nutritional literacy is linked to unhealthy dietary behaviors and may increase stroke recurrence risk. However, evidence on nutritional literacy in this population remains limited, particularly under a validated theoretical framework.
HMGCS1 drives cholesterol-dependent membrane repair and shields tumor cells from lymphocyte attack
Abstract Cytotoxic lymphocytes use perforin to form plasma membrane (PM) pores in tumor cells, thereby enabling granzyme-mediated cell death. However, whether and how tumor metabolism enables PM repair to evade immunity is unclear. In this study, using a functional screen targeting 111 metabolic enzymes, we identified hydroxymethylglutaryl-CoA synthase 1 (HMGCS1) as critical for repairing perforin-induced PM damage.
Computer Science > Cryptography and Security
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Compression-induced metabolic adaptation drives confined tumor cell migration and distant metastasis via malate-dependent microtubule reinforcement
Abstact Metastasis, responsible for > 90% of cancer-related mortality, represents the most lethal yet least mechanistically understood phase of cancer progression. A critical bottleneck is tumor cell migration through physically confined environments, including dense extracellular matrix, narrow capillaries and endothelial gaps.
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8 + T cells
Abstract The immunosuppressive tumor microenvironment remains a major obstacle to successful immunotherapy. Pathologically activated neutrophils, alternatively termed polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), drive tumor immune evasion primarily by inducing CD8+ T cell tolerance. While direct intercellular contact between neutrophils and CD8+ T cells is essential for immunosuppressive activity, the mechanisms mediating this interaction need deeper understanding.
GridSFM: A new, small foundation model for the electric grid
Microsoft introduces GridSFM, a small foundation model that approximates AC optimal power flow in milliseconds, unlocking decisions that can directly impact up to $20B/year in congestion losses and 3.4 TWh of renewable curtailment. Beyond estimating generator dispatch and costs, GridSFM produces full AC system states, giving operators direct visibility into congestion, stability, and overall system health.
Building realistic electric transmission grid dataset at scale: a pipeline from open dataset
We construct geographically grounded, electrically coherent power grid models entirely from publicly available data and release a dataset spanning 48 U.S. states and multi-state interconnections. The models support AC optimal power flow (AC‑OPF) analysis, enabling physics-based study of congestion, capacity, and demand siting without restricted data. We demonstrate applications including transmission expansion potential, targeted line upgrades, and placement of large datacenter loads.
A qualitative study on the challenges in deprescribing for elderly patients with polypharmacy
Abstract Background: Deprescribing is a critical strategy for optimizing medication use in older adults with polypharmacy, yet its implementation in real-world clinical settings faces multifaceted challenges that require systematic understanding. This study aims to explore these barriers to inform effective service integration.
Electrical Engineering and Systems Science > Systems and Control
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Computer Science > Computation and Language
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution
Keywords methylome sequencing epigenetics deaminase 5mC 5hmC dual methylome/genome sequencing metaGPA bacteriophage DNA modification Introduction Uncovering the molecular mechanisms behind the arms race between bacteria and their viruses has provided insights into the deep evolutionary origins of eukaryotic innate immunity and epigenetics.1 Components of bacterial-phage defense and counter defense systems have become indispensable tools for biotechnology.2 The discovery of such enzymes has...
SEMA: Simple yet Effective Learning for Multi-Turn Jailbreak Attacks
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Dynamic magneto-mechanical force in lysosomes induces durable macrophage repolarization for antitumor immunity - Cell Research
Abstract Mechanical forces are emerging physical cues that regulate biochemical signals of immune cells for antitumor immunity. Owing to the lack of precise tools to impose intracellular forces, little is known about whether and how organelle-level forces trigger mechanotransduction for antitumor immunity. Here, we developed a magneto-mechanical force-triggered lysosomal membrane permeabilization (MagLMP) strategy to induce durable macrophage repolarization for in vivo applications.
Genetic and phenotypic characterization of the plasmid-encoded NDM-80 metallo-β-lactamase in Escherichia coli isolated from a pediatric patient
Abstract Introduction: Carbapenem-resistant Enterobacterales (CRE) strains carrying blaNDM variants pose a significant threat to the health of infected patients worldwide. Methods: This study isolated a carbapenem-resistant Escherichia coli (E. coli) strain carrying blaNDM–80 from a patient in an intensive care unit in China.
Frontiers | Oral health literacy and oral frailty: a parallel mediation model of self-efficacy and health-related quality of life among older adult stroke patients
Cerebrovascular Department of Henan Provincial People's Hospital, Henan Provincial Key Medicine Laboratory of Nursing, Zhengzhou University People's Hospital, Zhengzhou, Henan, China Objectives: This study aims to investigate the relationship between oral health literacy and oral frailty, as well as the mediating effect of oral health self-efficacy and oral health-related quality of life among older adult stroke patients patients. Design: A cross-sectional survey.
Measuring the burden of nosocomial infection in cancer patients: an analysis based on propensity score matching in China
1 Introduction Hospital-acquired infections (HAIs), also known as nosocomial infections, refer to infections acquired by patients or healthcare workers during hospitalization or the course of work in a hospital setting (1–3). HAI burden studies are widespread globally (4, 5). Existing research indicates that HAIs lead to an increase in patients’ length of stay and costs, imposing a serious economic burden on society (6, 7). In 2009, the U. S CDC reported that the direct medical costs of HAIs in U.
Construction and Catalytic Behavior of Nickel Catalysts Bearing Poly(Schiff Base) With Different Conjugated Structure for Ethylene Oligomerization
Conflicts of Interest The authors declare no conflicts of interest. References 1, , and , “Crystal Structures and Third-Order NLO Properties in DMF Solution of Co (II)-Bpfp Coordination Polymers (Bpfp = N,N′-Bis (Pyridylformyl) Piperazine),” Inorganica Chimica Acta 357, no. 12 (2004): 3541–3548, https://doi.org/10.1016/j.ica.2004.05.007.
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
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Keywords DLAT hepatocellular carcinoma leucine catabolism acetylation LNP-mRNA Introduction According to recent statistics, hepatocellular carcinoma (HCC) has shown remarkably increased morbidity and mortality in populations worldwide.1,2 The role of metabolic reprogramming in the progression of liver cancer is continuously being clarified.
By Ning WANG, Ziyi Cao, Huimin Li, Junting Xu, Qian Zhou, Hanrui Yin, Xianjing Zhang, Quanxin Jiang, Peihui Zhou, Liu Han, Hongtao Li, Limin Yin, Yunqing Gu, Haipeng Sun, Wei Wang, Hai-Long Piao, Yingjie Xu, Weiwei Yang, Suzhen Chen, Junli Liu, Qiqi Qian, Mijia Tao, Liaoyuan Zheng, Xuefeng Dou, Wei Wang, Qiqi Qian, Mijia Tao, Liaoyuan Zheng, Xuefeng Dou
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Cell Metabolism
Verified
Interfacial Engineering and Structural Modulation of RuO2‐Based Catalysts for Highly Active and Durable Oxygen Evolution Reaction in Acidic Environment
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie202509768-sup-0001-SuppMat.docx3.9 MB Supporting Information References 1, , , , , , , , , , , , , , , , , Angew. Chem. Int. Ed. 2022, 61, e202212341. 2, , , , , , , , , , Angew. Chem. Int. Ed. 2022, 61, e202208667. 3, , , , , , , , , , , , , Science 2023, 380, 609–616. 4, , , , , , , Energy Environ. Sci. 2018, 11, 744–771. 5, , , , , , , , Angew. Chem. Int. Ed. 2024, 63, e202413653.
Synergistic Effect of Boron and Oxygen Coordination on Ruthenium Clusters for Industrial Water Splitting in Alkaline Medium
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Flue Gas Oxygen Content Model Based on Bayesian Optimization Main-Compensation Ensemble Algorithm in Municipal Solid Waste Incineration Process
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Author Correction: LKB1 inactivation promotes epigenetic remodeling-induced lineage plasticity and antiandrogen resistance in prostate cancer - Cell Research
Correction to: Cell Research https://doi.org/10.1038/s41422-024-01025-z, published online 02 January 2025 It has come to our attention that in the version of the article initially published, in Fig. 6b, the dots of the bar plot representing vehicle-treated samples were not included; in Fig. 6j, the image for vehicle-treated PP-1 cells was mistakenly reused from the image for SAM-treated PP-2 cells. This was due to an inadvertent incorrect pasting or editing during figure panel organization.
The discovery of 5mC-selective deaminases and their application to ultra-sensitive direct sequencing of methylated sites at base resolution.
Abstract Mining phages for new enzymatic activities continues to be important for the development of new tools for biotechnology. In this study, we used MetaGPA—a method linking genotype to phenotype in metagenomic data—to identify deoxycytidine deaminases, a protein family highly associated with cytosine modifications in metaviromes.
Improve Solubility and Develop Personalized Itraconazole Dosages via Forming Amorphous Solid Dispersions with Hydrophilic Polymers Utilizing HME and 3D Printing Technologies
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Does bank FinTech spur productivity of SMEs?
ABSTRACT Financial technology (FinTech) has promoted the popularization of intelligent banking services and profoundly impacted the development of small and medium-sized enterprises (SMEs).
Flue Gas Oxygen Content Model Based on Bayesian Optimiza-Tion Main-Compensation Ensemble Algorithm in Municipal Solid Waste Incineration Process
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 24 October 2024 / Approved: 25 October 2024 / Online: 25 October 2024 (08:14:01 CEST) Yang, W.; Tang, J.; Tian, H.; Wang, T. Flue Gas Oxygen Content Model Based on Bayesian Optimiza-Tion Main-Compensation Ensemble Algorithm in Municipal Solid Waste Incineration Process. Preprints 2024, 2024101999. https://doi.org/10.20944/preprints202410.1999.v1 Yang, W.; Tang, J.; Tian, H.; Wang, T.
Author Correction: UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis - Nature
Correction to: Nature https://doi.org/10.1038/s41586-019-1340-y Published online 26 June 2019 In the Methods section “Measurement of UDP-Glc, UDP-GlcUA”, we forgot to remove the HPLC method (originally for pre-experiments) from the final version. We apologize for any confusion it may have caused. We also updated the Methods to include a detailed description of sample preparation and mass spectrometry analysis for the metabolites, as below.
Aging-related biomarkers for the diagnosis of Parkinson’s disease based on bioinformatics analysis and machine learning
Research Paper Volume 16, Issue 17 pp 12191—12208 1 Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China 2 Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, China 3 Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain...
Aging-related biomarkers for the diagnosis of Parkinson’s disease based on bioinformatics analysis and machine learning
Research Paper Volume 16, Issue 17 pp 12191—12208 1 Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, China 2 Clinical Center for Parkinson's Disease, Capital Medical University, Beijing, China 3 Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson's Disease, Parkinson Disease Center of Beijing Institute for Brain...
Research on Photovoltaic Power Generation Characteristics of Small Ocean Observation Unmanned Surface Vehicles
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Proxi-RIMS-seq2 applied to native microbiomes uncovers hundreds of known and novel m5C methyltransferase specificities.
Abstract Methylation patterns in bacteria can be used to study Restriction-Modification (RM) or other defense systems with novel properties. While m4C and m6A methylation is well characterized mainly through PacBio sequencing, the landscape of m5C methylation is under-characterized. To bridge this gap, we performed RIMS-seq2 on microbiomes composed of resolved assemblies of distinct genomes through proximity ligation.
Consolidation and Dehydration Effects of Mildly Degraded Wood from Luoyang Canal No. 1 Ancient Ship
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
DCBLD2 deletion increases hyperglycemia and induces vascular remodeling by inhibiting insulin receptor recycling in endothelial cells
Conflicts of interest The authors declare that they have no conflicts of interest. Supporting Information Filename Description febs17198-sup-0001-FigsS1-S4.pdfPDF document, 754.3 KB Fig. S1. Dcbld2 deletion decreased the transcription levels of HK2, PFK, GAPDH and PKM2 in MAEC. Fig. S2. Dcbld2 knockdown inhibited the phosphorylation of AktSer473 in HUVECs. Fig. S3. Knockdown of Rab5 upregulated the InsR content on the cell membrane and downregulated the InsR content in the cytoplasm in WT MAEC. Fig. S4.
Evaluation of Deterioration Degree of Archaeological Wood from Luoyang Canal No. 1 Ancient Ship
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Research on the Impact of Enterprise ESG Ratings on Carbon Emissions from a Spatial Perspective
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Weiwei Yang SciProfiles Scilit Preprints.org Google Scholar * and Yingying Hei SciProfiles Scilit Preprints.org Google Scholar School of Economics and Management, Beijing University of Technology, Beijing 100124, China * Author to whom correspondence should be addressed.
Facile Synthesis of Fe-Doped, Algae Residue-Derived Carbon Aerogels for Electrochemical Dopamine Biosensors
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Emerging Contaminants in the Effluent of Wastewater Should Be Regulated: Which and to What Extent?
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The Noncanonical Functions of Metabolites in Tumor Progression
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Effect of Thermal Cycles and Curing Age on Bonding Strength of Cement Mortar Using Manufactured Sand
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Single-atom Mo-tailored high-entropy-alloy ultrathin nanosheets with intrinsic tensile strain enhance electrocatalysis - Nature Communications
Abstract The precise structural integration of single-atom and high-entropy-alloy features for energy electrocatalysis is highly appealing for energy conversion, yet remains a grand challenge. Herein, we report a class of single-atom Mo-tailored PdPtNiCuZn high-entropy-alloy nanosheets with dilute Pt-Pt ensembles and intrinsic tensile strain (Mo1-PdPtNiCuZn) as efficient electrocatalysts for enhancing the methanol oxidation reaction catalysis.
SMI for early diagnosis of frozen shoulder
Weihua Xu,1 Jiayu Xu,1 Yingying Zhou,1 Weiwei Yang,1 Hui Huang,1 Jun Xue,1 Jing Zhang2 1Ultrasound Medicine Department, Zhabei Central Hospital in Jing’an District, Shanghai, People’s Republic of China; 2Ultrasound Medicine Department, Daning Community Health Service Center in Jing’an District, Shanghai, People’s Republic of China Correspondence: Weihua Xu, Ultrasound Medicine Department, Zhabei Central Hospital in Jing’an District, Shanghai, People’s Republic of China, Tel +86-13917752615,...
Occurrence, Source Apportionment, and Ecological Risk of Typical Pharmaceuticals in Surface Waters of Beijing, China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
P‐N Junction‐Driven Abnormal Electric Field Distribution in the Degraded Multilayer Ceramic Capacitors
Conflict of Interest The authors declare no conflict of interest. References 1 , , , , , , J. Adv. Ceram. 2021, 10, 1153. 2 , , , , , J. Mater. Chem. C 2019, 7, 9782. 3 , , , , , , , , RSC. Adv. 2015, 5, 8868. 4 , , , , , Ceram. Int. 2017, 43, S70. 5 , , , , Mater. Sci. Eng., B 2015, 192, 52. 6 , , , Jpn. J. Appl. Phys. 2003, 42, 1. 7 , , , Jpn. J. Appl. Phys. 2020, 59, SPPC01. 8 , , , , Jpn. J. Appl. Phys. 2019, 58, SLLC02. 9 , , , , , AIP Adv. 2018, 8, 045005. 10 , , , J. Am. Ceram. Soc. 2010, 93, 1950. 11 , , , Adv. Theor. Simul.
Research on the diffusion of green innovation behavior based on complex network evolutionary game
CONFLICT OF INTEREST STATEMENT The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper. REFERENCES , , , & (2023). The role of green innovation in achieving environmental sustainability in European Union countries: Testing the environmental Kuznets curve hypothesis. Gondwana Research, 118, 105–116. https://doi.org/10.1016/j.gr.2023.01.013 , , , & (2023).
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