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Articles by Xiaoping Miao
The RAB32-USP13 axis facilitates TOM40 mitochondrial localization to promote non-small cell lung cancer progression
Abstract Mitochondria are semi-autonomous organelles whose functions critically depend on nucleus-encoded proteins. TOM40 is the core β-barrel protein of the translocase of the outer mitochondrial membrane (TOM) complex that mediates the import of most nucleus-encoded mitochondrial proteins. Here, we show that the small GTPase RAB32 facilitates the mitochondrial localization of TOM40 and the mitochondrial protein homeostasis in non-small cell lung cancer (NSCLC) cells.
Author Correction: An atlas of genetic effects on cellular composition of the tumor microenvironment
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Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01945-3, published online 2 September 2024. In the version of the article initially published, the tumor growth curve for the shControl and shCCL2 group in Fig. 7h was generated using incorrect tumor volume data. The authors have corrected the corresponding Source Data and generated an updated Fig. 7h. During the preparation of the Source Data for Fig.
By Yimin Cai, Zequn Lu, Can Chen, Ying Zhu, Zhirui Chen, Jingyi Peng, Xuanyu Zhu, Ziying Liu, Ming Zhang, Jinyu Huang, Yanmin Li, Yizhuo Liu, Qianying Ma, Chunyi He, Shuoni Chen, Wen Tian, Caibo Ning, Hui Geng, Bin Xu Verified, Haijie Li, Xu Zhu, Jun Fang, Xiaoyang Wang, Shaokai Zhang, Meng Jin, Chaoqun Huang, Xiaojun Yang, Jianbo Tian, Xiaoping Miao, Zuyou Wu, Linyun Fan
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Nature
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Genetic variations interact with polybrominated diphenyl ether exposure to alter lipid homeostasis - Nature Communications
Abstract Polybrominated diphenyl ethers (PBDEs) are implicated in dyslipidemia, but the molecular basis of individual susceptibility remains elusive. Here we report an analysis based on the China National Human Biomonitoring cohort, where we integrate exposome, genomic, and metabolomic data to identify 3,571 genetic variants that interact with PBDE exposure to influence dyslipidemia risk. Metabolomic analysis highlights glycine and glycerophosphate as key mediators.
Genetic profiling of the circulating proteome in common diseases suggests causal proteins and improves risk prediction - Nature Communications
Abstract Elucidating the genetic regulation of protein expression in specific disease states is important for understanding how genetic variation impact disease pathology. To this end, we conduct a large-scale genome-proteome-wide pQTL analysis on 2901 plasma proteins among 7626 healthy individuals and 28,064 patients across 42 disease statuses.
Genetic architecture of bone marrow fat fraction implies its involvement in osteoporosis risk - Nature Communications
Abstract Bone marrow adipose tissue, as a distinct adipose subtype, has been implicated in the pathophysiology of skeletal, metabolic, and hematopoietic disorders. To identify its underlying genetic factors, we utilized a deep learning algorithm capable of quantifying bone marrow fat fraction (BMFF) in the vertebrae and proximal femur using magnetic resonance imaging data of over 38,000 UK Biobank participants.
Design, fabrication and application of bioengineering vascular networks based on microfluidic strategies
Design, fabrication and application of bioengineering vascular networks based on microfluidic strategies Vascularization is a critical component of tissue engineering research and is essential for enhancing the success rate of tissue construction and function. Over the past decade, researchers have explored various methods to construct in vitro vascular networks, including 3D printing, cell sphere technology, and microfluidics.
Utilizing photosynthetic oxygen-releasing biomaterials to modulate blood vessel growth in the chick embryo chorioallantoic membrane
Utilizing photosynthetic oxygen-releasing biomaterials to modulate blood vessel growth in the chick embryo chorioallantoic membrane† Effective vascularization is crucial for the success of tissue engineering and is influenced by numerous factors.
Utilizing Photosynthetic Oxygen-Releasing Biomaterials to Modulate Blood Vessel Growth in Chick Embryo Chorioallantoic Membrane
Utilizing Photosynthetic Oxygen-Releasing Biomaterials to Modulate Blood Vessel Growth in Chick Embryo Chorioallantoic Membrane Effective vascularization is crucial for the success of tissue engineering, influenced by numerous factors.
Highlights • CAV1-CAV2 locus associates with pancreatic ductal adenocarcinoma (PDAC) prognosis. • rs10249656 enhances CAV2 expression through abolishing miR-548s binding. • CAV2 upregulation is significantly correlated with the poor prognosis of PDAC. • CAV2 promotes PDAC cells migration and metastasis without affecting proliferation. • CAV2 perturbs the focal adhesion and extracellular matrix organisation pathways.
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies
Based on a GWAS meta-analysis approach to pool two published Chinese GWAS, and followed by two-stage replications (more than 10?000 samples), we identified two novel signals associated with the risk of non-cardia gastric cancer. The first one rs7712641 maps to the intron of the long non-coding RNA, lnc-POLR3G-4 (XLOC_004464). Further analysis showed that rs7712641 had significantly lower expression in non-cardia gastric tumour compared with matched normal tissue.
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies Zhaoming Wang1,2,3, Juncheng Dai3, Nan Hu1, Xiaoping Miao4, Christian C Abnet1, Ming Yang5, Neal D Freedman1, Jinfei Chen6, Laurie Burdette1,2, Xun Zhu3, Charles C Chung1,2, Chuanli Ren3,7, Sanford M Dawsey1, Meilin Wang8, Ti Ding9, Jiangbo Du3, Yu-Tang Gao10, Rong Zhong4, Carol Giffen11, Wenting Pan5, Woon-Puay Koh12, Ningbing Dai3, Linda M Liao1,...
Ablation of the Sox11 Gene Results in Clefting of the Secondary Palate Resembling the Pierre Robin Sequence
Mouse gene inactivation has shown that the transcription factor Sox11 is required for mouse palatogenesis. However, whether Sox11 is primarily involved in the regulation of palatogenesis still remains elusive. In this study, we explored the role of Sox11 in palatogenesis by analyzing the developmental mechanism in cleft palate formation in mutants deficient in Sox11. Sox11 is expressed both in the developing palatal shelf and in the surrounding structures, including the mandible.
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