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Articles by Xiaoyu Su
Geranylgeranylation is required for B-cell proliferation and plasma cell survival implications for autoimmune therapy Original
Abstract Tissue-resident long-lived plasma cells, whose current therapies fail to effectively eliminate them, are now recognized as key factors in refractory and relapsed autoimmune diseases such as systemic lupus erythematosus (SLE). In this study, we discovered that the most commonly used cholesterol-lowering drugs in clinical practice, particularly lipophilic statins, can deplete antibody-secreting cells (ASCs) by triggering endoplasmic reticulum stress (ERS)-mediated apoptosis.
Is the Conversational Agent an Effective Story Listener? A Comparative Study of Doubao and Human Listener Responses
Abstract As AI agents increasingly serve as digital listeners for affective companionship, understanding their ability to respond naturally and appropriately is essential. This study examines whether an AI agent can listen like humans by comparing its verbal responses with those of human listeners during spoken storytelling about everyday personal experiences. The analysis focuses on response timing, patterns, and action types.
Within-Person Coupling Among Information Processing, Emotion Regulation, and Social Connection Vulnerabilities: A Three-Wave Random-Intercept Cross-Lagged Panel Model with Exploratory Tests of Information-Environment Homogeneity
You are already at the latest version In information-saturated digital environments, students' vulnerabilities in information processing, emotion regulation, and social connection may fluctuate together within individuals, yet the role of information-environment homogeneity remains uncertain.
Machine learning-assisted self-powered ear tag for animal welfare
Abstract Metabolic health serves as a crucial indicator of animal welfare, yet nutritional imbalances in intensive farming diets often induce metabolic dysregulation. However, precise identification of metabolically abnormal animals within intensive production systems remains challenging. Here we report a machine learning-assisted self-powered ear tag that enables streamlined large-scale deployment in livestock production, providing continuous monitoring of ion homeostasis.
Scalability of Chat-Based Cessation—Reply
In Reply We thank Xu and colleagues for their thoughtful comments on our recent article regarding mobile chat messaging for smoking relapse prevention.1 They raised important points regarding the specific contributions of counselor-led chat vs the chatbot in the hybrid intervention, and the scalability of such an intervention. We appreciate the opportunity to address these points.
Modulation of the mevalonate pathway by TCR engagement regulates T follicular helper cell generation in homeostasis and autoimmunity
Keywords T follicular helper cells geranylgeranyl diphosphate surface protein expression CXCR5 RAB35 pitavastatin autoimmune diseases Introduction CXCR5-expressing CD4+ T follicular helper (Tfh) cells are crucial for humoral immunity and the orchestrators of the germinal center (GC) reaction by providing critical signals that promote B cell survival, proliferation, class switching, and affinity maturation.1,2 While Tfh cell activity is integral to the protective humoral response elicited by...
Machine learning-enabled implantable plant biomarker sensor for early detection and classification of acid and salt stress
Abstract Abiotic stresses, particularly acid and salt stress, severely limit plant productivity. Conventional detection is often hindered by physiological lags and phenotypic latency. Here, we develop a machine learning-enabled implantable plant biomarker sensor (MLIPBS) for early stress diagnosis. Featuring a foldable design, MLIPBS enables conformal integration into plant tissues for continuous monitoring of H2O2, K+, and pH.
Microinterventional in-sensor computing system for real-time metabolic health assessment
Abstract Microneedle biosensors enable dynamic monitoring of interstitial fluid biomarkers, but remain constrained by sensing interface susceptibility to motion artifacts and the prohibitive energy consumption of wireless cloud-based processing. Here, we report a bio-inspired, self-anchoring microinterventional in-sensor computing system.
Acoustic shape-morphing micromachines - Nature Communications
Abstract Shape-morphing mechanisms help organisms adapt to their environment and have inspired applications in advanced systems. Designing microrobots that are both miniaturized and capable of fast shape changes is challenging, as performance can be weakened at small scales. Ultrasound offers advantages such as fast response, repeatability, and programmability, making it suitable for enabling shape-morphing microrobots.
Genome-Wide Identification, Cloning and Expression Analysis of DFR Gene Family in Lonicera japonica Thunb. under Drought and Salt Stress
Based on the genome and transcriptome data of Lonicera japonica Thunb., this study identified six LjDFR gene family members at the genome-wide level. These genes were located on Chr.04 and Chr.09, and the full-length coding sequences of LjDFR1 to LjDFR6 were successfully cloned. The proteins encoded by the cloned genes are all hydrophilic, with secondary structures dominated by α-helices and random coils.
Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation
Main text (Developmental Cell 59, 2626–2642.e1–e6; October 7, 2024) In our recent paper entitled “Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation” (DEVCEL_5945), we regret that in supplementary figure 5, the last two panels of the representative flow cytometry plots for CD127– clonal output (ILC-Mono/Mac-Mast cell-cDC (18)) were inadvertently duplicated in the CD127+ clonal output (ILC-Mono/Mac-cDC (4)) section, as well...
A hybrid snake optimizer with crisscross learning strategy for constrained structural optimization
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. Abstract Structural optimization aims to minimize material usage and construction costs while ensuring comfort, safety and durability.
A Signal-On Microelectrode Electrochemical Aptamer Sensor Based on AuNPs-MXene for Alpha-Fetoprotein Determination
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Comprehensive Transcriptomic and Physiological Insights into the Response of Root Growth Dynamics During the Germination of Diverse Sesame Varieties to Heat Stress
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Pituitary hyperplasia secondary to primary hypothyroidism in adolescents: A medical case report and literature review
1 INTRODUCTION Pituitary hyperplasia secondary to primary hypothyroidism (PHPH) represents a relatively uncommon endocrine pathology, with a higher prevalence in adults compared to adolescents.1 This condition emerges from a reduction in thyroid hormone (TH) production, which in turn precipitates an increase in thyroid-stimulating hormone (TSH) levels, leading to the hyperplasia of pituitary TSH cells. Clinically, PHPH can closely resemble a pituitary adenoma in both imaging and laboratory tests.
ADENYLATE CYCLASE 3 MEDIATES CAROTID BODY ACTIVATION AND AUTONOMIC DYSFUNCTION IN A SLEEP APNEA MODEL
Abstract Patients with obstructive sleep apnea (OSA) experience chronic intermittent hypoxia (CIH). OSA patients and CIH-treated rodents exhibit autonomic dysfunction, characterized by overactive sympathetic nervous system and hypertension, mediated through hyperactive carotid body (CB) chemoreflex. Activation of olfactory receptor 78 (Olfr78) by hydrogen sulfide (H2S) is implicated in CB activation and autonomic responses to CIH, but the downstream signaling pathways remain unknown.
Human yolk sac-derived innate lymphoid-biased multipotent progenitors emerge prior to hematopoietic stem cell formation
Highlights • Progenitors with non-NK lymphoid potential exist in human yolk sac before HSC onset • Human yolk sac lymphoid progenitors before HSC emergence show ILC and DC potential • ILC potential before HSC onset is stronger in human yolk sac than in embryo proper • Early fetal liver lymphoid progenitors share characteristics with those from yolk sac Summary Hematopoietic stem cell (HSC)-independent lymphopoiesis has been elucidated in murine embryos.
Forests | Free Full-Text | Cunninghamia lanceolata Canopy Relative Chlorophyll Content Estimation Based on Unmanned Aerial Vehicle Multispectral Imagery and Terrain Suitability Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
A laser‐Engraved Wearable Electrochemical Sensing Patch for Heat Stress Precise Individual Management of Horse
1 Introduction Heat stress, a non-specific physiological response, is frequently observed in animals.[1-3] Normally, the animals present limited adaptability to environmental temperatures, rendering them vulnerable to heat stress when exposed to temperatures beyond their tolerance limits.[4-6] Heat stress reveals adverse influence on the psychological and physiological of animals, and potentially endangering their health in husbandry breeding.[7, 8] Especially, as a specific mammalian...
An adaptive sliding mode controller for electro‐hydraulic servo systems combining offline training and online estimation
CONFLICT OF INTEREST STATEMENT The authors declare no potential conflict of interests. REFERENCES 1, , and , Constrained sampled-data arc for a class of cascaded nonlinear systems with applications to motor-servo systems, IEEE Trans. Ind. Inform. 15 (2018), no. 2, 766–776. 2, , and , A model-free control strategy for vehicle lateral stability with adaptive dynamic programming, IEEE Trans. Ind. Electron. 67 (2019), no. 12, 10693–10701.
A ratiometric electrochemical sensor for detecting lead in fish based on the synergy of semi-complementary aptamer pairs and Ag nanowires@zeolitic imidazolate framework-8
A ratiometric electrochemical sensor for detecting lead in fish based on the synergy of semi-complementary aptamer pairs and Ag nanowires@zeolitic imidazolate framework-8 Kuiguo Han, liang chen, Wen Zhang, yanqun tong, Jiyong Shi, Xiaoyu Su and Xiaobo Zou Abstract Abstract This work describes the synergistic application of semi-complementary aptamer pairs and signals on-off ratio strategies on glassy carbon electrodes (GCE) for detecting lead ions (Pb2+) in fish.
Applied Sciences | Free Full-Text | Generalized Super-Twisting Backstepping Sliding Mode Control for Electro-Hydraulic Servo Systems Considering the Coexistence of Matched and Mismatched Uncertainties
Abstract : Aiming at the problem of the coexistence of matching and mismatching uncertainties in electro-hydraulic servo systems, disturbance observers and a backstepping sliding mode controller based on the generalized super-twisting algorithm (GSTA) are proposed in this paper. First, in order to compensate for the uncertainty in the controller, two generalized super-twisting disturbance observers (GSTDOs) are constructed to effectively reduce the discontinuous gain of the controller.
Sponge-liked Silica Nanoporous Particles for Sustaining Release and Long-Term Antibacterial Activity of Natural Essential Oil
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Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Speed tracking control for hydraulic transformer system based on active regulating common pressure rail © The Institution of Engineering and Technology This study investigates the speed tracking control problem for the new hydraulic transformer controlled system based on the active regulating common pressure rail with both input delay and strong interference.
Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Speed tracking control for hydraulic transformer system based on active regulating common pressure rail © The Institution of Engineering and Technology This study investigates the speed tracking control problem for the new hydraulic transformer controlled system based on the active regulating common pressure rail with both input delay and strong interference.
Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Speed tracking control for hydraulic transformer system based on active regulating common pressure rail © The Institution of Engineering and Technology This study investigates the speed tracking control problem for the new hydraulic transformer controlled system based on the active regulating common pressure rail with both input delay and strong interference.
Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Speed tracking control for hydraulic transformer system based on active regulating common pressure rail © The Institution of Engineering and Technology This study investigates the speed tracking control problem for the new hydraulic transformer controlled system based on the active regulating common pressure rail with both input delay and strong interference.
linking academia, business and industry through research
Home Full-text access for editors Sliding mode control design for active suspension systems using quantum particle swarm optimisation by Shouwei Wei; Xiaoyu Su International Journal of Vehicle Design (IJVD), Vol. 81, No. 1/2, 2019 Abstract: In this paper, the problem of sliding mode control design for nonlinear 1/4 active suspension under road excitation most in line with the real situation is investigated. By using the theory of differential geometry, the suspension model is linearised.
Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Inspec keywords: valves; neurocontrollers; fuzzy neural nets; nonlinear control systems; adaptive control; closed loop systems; tracking; function approximation; robust control; control system synthesis; delays; Lyapunov methods Other keywords: input delay; hydraulic swing motor; virtual control signals; pi-sigma fuzzy neural network; function approximator; speed tracking control problem; robust...
Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Inspec keywords: valves; neurocontrollers; fuzzy neural nets; nonlinear control systems; adaptive control; closed loop systems; tracking; function approximation; robust control; control system synthesis; delays; Lyapunov methods Other keywords: input delay; hydraulic swing motor; virtual control signals; pi-sigma fuzzy neural network; function approximator; speed tracking control problem; robust...
Exercise Activates p53 and Negatively Regulates IGF-1 Pathway in Epidermis within a Skin Cancer Model
Exercise has been previously reported to lower cancer risk through reducing circulating IGF-1 and IGF-1-dependent signaling in a mouse skin cancer model. This study aims to investigate the underlying mechanisms by which exercise may down-regulate the IGF-1 pathway via p53 and p53-related regulators in the skin epidermis. Female SENCAR mice were pair-fed an AIN-93 diet with or without 10-week treadmill exercise at 20 m/min, 60 min/day and 5 days/week.
Speed tracking control for hydraulic transformer system based on active regulating common pressure rail
Home > Journals & magazines > IET Control Theory & Applications > Volume 14, Issue 20 > Article Speed tracking control for hydraulic transformer system based on active regulating common pressure rail © The Institution of Engineering and Technology Received 21/01/2020, Accepted 11/11/2020, Revised 28/09/2020, Published 16/12/2020 This study investigates the speed tracking control problem for the new hydraulic transformer controlled system based on the active regulating common pressure rail...
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