Yi Qiu
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Articles by Yi Qiu
Non-adaptive evolutionary forces predominantly shape nucleotide composition near human transcription start sites
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Qiu Y, Hebraud E, Pouyet F, Palazzo AF (2026) Non-adaptive evolutionary forces predominantly shape nucleotide composition near human transcription start sites. PLoS Biol 24(10): e3004063.
Automated voxel-based prostate volumetry improves PSA density–based detection of clinically significant prostate cancer in the PSA gray zone: comparison with manual segmentation and the ellipsoid formula
Abstract Purpose: To investigate whether voxel-based prostate volume can improve the diagnostic performance of prostate-specific antigen density (PSAD) for detecting clinically significant prostate cancer (csPCa) in patients within the prostate-specific antigen (PSA) gray zone (4–10 ng/mL), and to compare it with conventional formula-based estimation. Methods: In this retrospective study, 489 patients with PSA levels of 4–10 ng/mL who underwent prostate MRI were included.
A Frequency Segmented Accelerated Vibration Test Method for Seat Frames Using Damage Rate Ratio: A Comparative Study with IPL and FDS
Submitted: 19 September 2026 Posted: 21 September 2026 You are already at the latest version To address the issues of lengthy vibration durability test cycles for seat frames and poor consistency of damage equivalence at different locations under multiaxial excitation in existing acceleration methods, this paper proposes a frequency-segmented accelerated vibration test method based on damage rate equivalence.
From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity
Abbreviations Enh5, enhancer 5 eRNA, enhancer-associated RNA HERVK, human endogenous retrovirus K lncRNA, long non-coding RNA NMD, nonsense-mediated decay PROMPT, promoter upstream transcript rRNA, ribosomal RNA snoRNA, small nucleolar RNA Introduction: two divisions of life Life on Earth can be broadly divided into two categories: non-nucleated prokaryotes (eubacteria and archaea) and nucleated eukaryotes.
Mitochondrial SUMOylation of NDUFA9 drives ClpP-dependent degradation and complex I dysfunction in a Leigh syndrome–associated mutation
Abstract Mitochondrial complex I (CI) dysfunction causes many inherited mitochondrial diseases, including Leigh syndrome, yet how post-translational modifications control CI subunit proteostasis remains unclear. Here we identify NDUFA9 as a mitochondrial SUMOylation substrate. SUMO1 conjugation at Lys370 promotes NDUFA9 binding to ClpP through the SIM motifs of ClpP and accelerates ClpP-dependent degradation.
Preoperative Plasma and Cerebrospinal Fluid SNAP-25 Levels Predict Delayed Neurocognitive Recovery in Elderly Patients: A Prospective Observational Study
1 Introduction Delayed neurocognitive recovery (DNR) is a common central nervous system complication following anesthesia and surgery, characterized by impairments in memory, information processing, and attention, often accompanied by emotional and personality changes [1]. Advanced age is one of the most important risk factors for the development of DNR [2].
Targeting cariogenic virulence of Streptococcus mutans by pinosylvin: a promising anti-cariogenic natural agent
Abstract Dental caries continues to be a serious worldwide public health issue, with Streptococcus mutans (S. mutans) identified as the primary etiological pathogen. This study aimed to evaluate the anti-cariogenic potential of pinosylvin (PIN) against S. mutans. A combination of in vitro and in vitro experiments was performed to characterize the anti-cariogenic effects of PIN.
Risk factors for postoperative cognitive dysfunction in geriatric trauma: a dual-pathway perspective
Abstract Postoperative cognitive dysfunction (POCD) is common in geriatric trauma patients and involves complex underlying mechanisms. Most existing studies have focused on isolated risk factors, with limited attention to how these factors interact. In this perspective article, we propose a dual-pathway theoretical model—central nervous system vulnerability and peripheral stress amplification—to reframe the understanding of POCD pathogenesis. In older adults, POCD rarely stems from a single cause.
Combined effect of vibration magnitude and backrest inclination on the apparent masses of seated human body
Abstract Vibration magnitudes and backrest inclination affect apparent masses of the seated human body, yet their interaction remains unexplored. In this study, the in-line fore-aft, lateral, and vertical apparent masses were studied experimentally with a series of vibration magnitudes (0.25, 0.5, and 1.0 ms−2 r.m.s. in three translational directions, respectively) and backrest inclination angles (0°, 10°, and 20°).
A STAT3 degrader demonstrates efficacy in venetoclax resistant acute myeloid leukemia - Leukemia
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Abstract Acute myeloid leukemia (AML) is an aggressive myeloid malignancy with a poor prognosis. Venetoclax (Ven), a BCL2 inhibitor, has shown promising results but often leads to relapse due to mitochondrial dysregulation, particularly due to upregulation of the anti-apoptotic protein MCL1. Overexpression of the transcription factor STAT3 has been linked to poor survival in AML patients.
By Samarpana Chakraborty, Claudia Morganti, Kimberly Zaldana, Bianca Pena, Bianca Peña, Divij Verma, Nadege Gitego, Feiyang Ma, Srinivas Aluri, Kith Pradhan, Shanisha Gordon-Mitchell, Ioannis Mantzaris, Mendel Goldfinger, Eric Feldman Verified, Kira Gritsman, Stefan E. Hubner, Yi Qiu, Brandon Brown, Abdullah Khasawneh, Anna Skwarska, Marina Konopleva, Yoko Tabe, Evripidis Gavathiotis, Simona Colla, Jared Gollob, Joyoti Dey, Steven Kornblau, Sergei B Koralov, Keisuke Ito, Aditi Shastri
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Nature
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Numerical Analysis of Fluid-Structure Interaction in Open and Closed Saddle‐Shaped Membrane Structures: A New Framework Based on Vortex Dynamics
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. References 1, , , , , and , “Analysis of Wind-Induced Vibration of a Spoke-Wise Cable-Membrane Structure,” Journal of Marine Science and Engineering 8 (2020): 8.
Protective effects of Exocarpium Citri Grandis against sepsis-induced acute lung injury via PANoptosis inhibition
ORIGINAL RESEARCH article Volume 12 - 2025 | https://doi.org/10.3389/fnut.2025.1661404 1 Introduction Sepsis is a life-threatening syndrome characterized by organ dysfunction due to a dysregulated host response to infection, accounting for nearly 20% of global mortality (1, 2). The lungs are among the most vulnerable organs, with acute lung injury (ALI) frequently developing in the early stages and significantly contributing to patient mortality (3, 4).
Neutrino Flavor Transformation in Neutron Star Mergers
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Music audio emotion regression using the fusion of convolutional neural networks and bidirectional long short-term memory models
Today’s youth appear to be more sensitive and fragile compared to previous generations. In recent years, they have experienced a range of psychological issues, including elevated stress levels, anxiety, depression, loneliness, and social media addiction (Wang et al., 2021). It is crucial to pay attention to the emotional changes occurring in young people, as this understanding can shed light on their attitudes and emotional tendencies.
Interfacial Sodiopobicity Regulating for Dendrite‐Free Solid‐State Sodium Metal Batteries
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm70041-sup-0001-SuppMat.docx9.1 MB Supporting Information References 1a) , , , , , Joule 2018, 2, 1747; b) , , , , , , , , , Energy Storage Mater. 2024, 70, 103511. 2a) , , , , , , , , , , , , , , , , , , , , eScience 2023, 3, 100175; b) , , , Kafalas Mater. Res. Bull. 1976, 11, 203. 3a) , , , , , , J. Mater. Chem. A 2021, 9, 5134; b) , , , , , , , , , , , , , , , , Nat. Commun. 2022, 13, 2854.
Systemic Integration of EV and Autonomous Driving Technologies: A Study of China’s Intelligent Mobility Transition
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Genetic variations and carcinogenicity analysis of E6/E7 oncogenes in HPV31 and HPV35 in Taizhou, China - Virology Journal
The infection rates of the HPV31 and HPV35 types are extremely low among Chinese women. HPV31 and HPV35 infection rates were approximately 7.0% and 5.5%, respectively, either alone or in combination with other types [8, 9, 10, 11]. Between 2013 and 2023, a single HPV31 infection was detected in 150 women (median age 42.0 years; range 20–69 years) and a single HPV35 infection was detected in 133 women (median age 44.0 years; range 21–71 years) were selected in this study.
Relationship between body composition and hypertension in postmenopaus
Back to Journals » Diabetes, Metabolic Syndrome and Obesity » Volume 18 Authors Jiang S , Fu Y, Chen L, Qiu Y Received 3 January 2025 Accepted for publication 5 May 2025 Published 14 May 2025 Volume 2025:18 Pages 1587—1598 DOI https://doi.org/10.2147/DMSO.S515563 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Jae Woong Sull Shu Jiang,1,* Yu Fu,2,* Lu Chen,2 Yi Qiu2 1Department of Echocardiography...
Selenization Strategy of Phenazine‐based Non‐Fullerene Acceptors Promotes Photon Harvesting and Reduces Voltage Loss in Organic Solar Cells
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202413259-sup-0001-SuppMat.docx4.1 MB Supporting Information References 1, , , , , , , Adv. Mater. 2023, 35, 2305240. 2, , , , , , , , , , Energy Environ. Sci. 2023, 16, 3119. 3, , , , , , , , , , , , , , , , , Angew. Chem. 2023, 135, e202308832. 4, , , , , , , , , , , , Adv. Mater. 2024, 36, 2406690. 5, , , , , , , , , , Angew. Chem. 2024, 136, e202407007. 6, , , , J. Mater. Chem. A 2022, 10, 17968.
Selenization Strategy of Phenazine‐based Non‐Fullerene Acceptors Promotes Photon Harvesting and Reduces Voltage Loss in Organic Solar Cells
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202413259-sup-0001-SuppMat.docx4.1 MB Supporting Information References 1, , , , , , , Adv. Mater. 2023, 35, 2305240. 2, , , , , , , , , , Energy Environ. Sci. 2023, 16, 3119. 3, , , , , , , , , , , , , , , , , Angew. Chem. 2023, 135, e202308832. 4, , , , , , , , , , , , Adv. Mater. 2024, 36, 2406690. 5, , , , , , , , , , Angew. Chem. 2024, 136, e202407007. 6, , , , J. Mater. Chem. A 2022, 10, 17968.
Isogeometric Topology Optimization of Multi-Material Structures under Thermal-Mechanical Loadings Using Neural Networks
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Genetic and selective constraints on the optimization of gene product diversity
Abstract RNA and protein expressed from the same gene can have diverse isoforms due to various post-transcriptional and post-translational modifications. For the vast majority of alternative isoforms, It is unknown whether they are adaptive or simply biological noise. As we cannot experimentally probe the function of each isoform, we can ask whether the distribution of isoforms across genes and across species is consistent with expectations from different evolutionary processes.
Phylogenetic analysis and antigenic epitope prediction for E6 and E7 of Alpha-papillomavirus 9 in Taizhou, China - BMC Genomics
This study was ethically approved by the Institutional Medical Ethics Review Board of Taizhou Hospital, China. Cervical exfoliated cells were collected from women who underwent cervical cancer screening at Taizhou Hospital. The specimens were collected by cervical scraping and stored in 2.5 ml of cell preservation buffer at -20 °C. Before specimen collection, written informed consent was obtained from all participants, and the participants’ privacy was strictly protected.
Numerical Simulation Study on the Impact of Excavation on Existing Subway Stations Based on BIM-FEM Framework
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Linear versus nonlinear modeling of black hole ringdowns
The ringdown (RD) phase of gravitational waves is of prime interest for testing general relativity (GR). The modeling of the linear quasinormal modes (QNMs) within the Kerr spectrum—or with agnostic parametrized deviations to that GR spectrum—has become ordinary; however, specific attention has recently emerged to calibrate the effects of nonlinear perturbations for the predominant quadrupolar l=2, m=2 mode.
The GC-content at the 5'ends of human protein-coding genes is undergoing mutational decay
Abstract In vertebrates, most protein-coding genes have a peak of GC-content near their 5' transcriptional start site (TSS). This feature promotes both the efficient nuclear export and translation of mRNAs. Despite the importance of GC-content for RNA metabolism, its general features, origin, and maintenance remain mysterious.
Strong Second-Harmonic Generation Induced by a Triphenylamine-Based Bismuth-Organic Framework for Photocatalytic Activity Enhancement
Download Hi-Res ImageDownload to MS-PowerPointCite This:ACS Appl. Mater. Interfaces 2024, XXXX, XXX CCDC 2257836 (Bi-NTB) contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via https://www.ccdc.cam.ac.uk/structures. Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions.
Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma
Non‐aqueous Liquid Electrolyte Additives for Sodium‐Ion Batteries
Sodium-ion batteries (SIBs) have been recognized as one of the most promising new energy storage devices for their rich sodium resources, low cost and high safety.The electrolyte, as a bridge connecting the cathode and anode electrodes, plays a vital role in determining the performance of SIBs, such as coulombic efficiency, energy density and cycle life.
Revealing and Eliminating the Light‐Soaking Issue in Metal Oxide‐Based Inverted Organic Solar Cells
Abstract Inverted organic solar cells (i-OSCs) provide an exciting opportunity for commercialization owing to their excellent device air stability. However, light soaking (LS) issue generally occurs in metal oxide based i-OSCs, causing drastically decreased performance. The underlying root of LS effect is not clearly clarified until now.
Cervical carcinogenesis risk association of HPV33 E6 and E7 genetic variations in Taizhou, Southeast China - Virology Journal
Characteristics of the study population From February 2014 to December 2020, a total of 189 women with a single HPV33 infection were selected. The average age was 42.3 years (range 19–73 years). A total of 185 (97.9%) sequences of the entire E6 and E7 genes from HPV33 were successfully obtained. Due to the small number of HPV copies, the remaining 4 (2.1%) sequences were excluded.
FEFD-YOLOV5: A Helmet Detection Algorithm Combined with Feature Enhancement and Feature Denoising
Open AccessArticle by †, † and * Institute of Information Science, Beijing Jiaotong University, Beijing 100044, China * Author to whom correspondence should be addressed. † These authors contributed equally to this work.
NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology - Leukemia
Abstract C-terminal mutation of Nucleophosmin 1 (NPM1C+) was thought to be a primary driving event in acute myeloid leukemia (AML) that reprograms leukemic-associated transcription programs to transform hematopoietic stem and progenitor cells (HSPCs). However, molecular mechanisms underlying NPM1C+-driven leukemogenesis remain elusive. Here, we report that NPM1C+ activates signature HOX genes and reprograms cell cycle regulators by altering CTCF-driven topologically associated domains (TADs).
Effect of new urbanization on cities’ innovation in China: Evidence from a quasi-natural experiment of a comprehensive pilot
Loading metrics Open Access Peer-reviewed Research Article Abstract Urbanization drives the concentration of innovation elements and knowledge diffusion, which is conducive to enhancing regional innovation capacity. To meet the developmental needs of the new era, China has released the National New Urbanization Plan (2014–2020) to test the effect of this policy on urban innovation. The 2014 comprehensive pilot project of China’s new urbanization strategy is considered a quasi-natural experiment.
Revealing and Eliminating the Light‐Soaking Issue in Metal Oxide‐Based Inverted Organic Solar Cells
Abstract Inverted organic solar cells (i-OSCs) provide an exciting opportunity for commercialization owing to their excellent device air stability. However, light soaking (LS) issue generally occurs in metal oxide based i-OSCs, causing drastically decreased performance. The underlying root of LS effect is not clearly clarified until now.
Synthesis, Crystal Structures and Semiconducting Properties of New Hexacyanidomettallates
Synthesis, Crystal Structures and Semiconducting Properties of New Hexacyanidomettallates Xianji Qiao, Yi Qiu, Junjie Xin, Chen Da, Zili Ma, Alex Corkett, Guohong Cai, Guanqun Cai, Shangqing Qu, Yuchao Wang, Zhenyu Zhu, Yiman Gao, Zhigang Wang, Richard Dronskowski, Guobao Li and Junliang Sun Abstract We describe the synthesis and properties of a number of mixed hexacyanidometallatesmetal ferrocyanides with the formula A2[MFe(CN)6]·xH2O (A = Na, K; M = Mg, Ca, Sr and Ba).
Prediction of Ride Comfort of High-Speed Trains Based on Train Seat–Human Body Coupled Dynamics Model
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Heng Li , Xu Zheng *, Wenqiang Dai and Yi Qiu College of Energy Engineering, Zhejiang University, Hangzhou 310027, China * Author to whom correspondence should be addressed. Appl. Sci.
Ionic liquid-containing coordination polymer: solvent-free synthesis, incongruent melting, and glass formation
Ionic liquid-containing coordination polymer: solvent-free synthesis, incongruent melting, and glass formation† Tomoyuki Mochida, *ab Yi Qiu,a Yusuke Funasako, cd Makoto Inokuchi,c Mariko Noguchi, e Hiroki Fujimorie and Yoshitomo Furushima f Abstract An ionic-liquid-containing 2D coordination polymer was synthesized via a solvent-free reaction. The material exhibited incongruent melting at 112 °C, forming a solid–liquid mixture; further heating to 240 °C led to complete melting.
Transgenic pigs expressing near infrared fluorescent protein-A novel tool for noninvasive imaging of islet xenotransplants
ORIGINAL ARTICLE Elisabeth Kemter, Corresponding Author Elisabeth Kemter kemter@genzentrum.lmu.de Department of Veterinary Sciences and Gene Center, Chair for Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany Department of Veterinary Sciences, Center for Innovative Medical Models (CiMM), LMU Munich, Oberschleißheim, Germany German Center for Diabetes Research (DZD), Neuherberg, Germany Correspondence Elisabeth Kemter, Chair for Molecular Animal Breeding and...
Highly Conducting Organic-Inorganic Hybrid Copper Sulfides CuxC6S6 (x=4 or 5.5): Ligand‐Based Oxidation‐Induced Chemical and Electronic Structure Modulation - Huang - - Angewandte Chemie International Edition - Wiley Online Library
Research Article Dr. Xing Huang Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Insititute of Chemistry, Chinese Academy of sciences, Beijing, 100190 China University of Chinese Academy of Sciences, Beijing, 100049 China These authors contributed equally to this work.
Non‐Interpenetrated Single‐Crystal Covalent Organic Frameworks
Research Article Lin Liang State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000 China These authors contributed equally to this work. Search for more papers by this author Yi Qiu College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing, 100871 China These authors contributed equally to this work. Search for more papers by this author Prof.
Paramagnetic Conducting Metal-Organic Frameworks with Three‐Dimensional Structure
Communication Zhijun Chen Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry Chinese Academy of Sciences, Beijing, 100190 China University of Chinese Academy of Science, Beijing, 100049 China Search for more papers by this author Dr. Yimeng Sun Corresponding Author E-mail address: sunyimeng@iccas.ac.cn http://orcid.org/0000-0003-3557-6133 Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids,...
Non‐Interpenetrated Single‐Crystal Covalent Organic Frameworks
Research Article Lin Liang State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu, 730000 China These authors contributed equally to this work. Search for more papers by this author Yi Qiu College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences, Peking University, Beijing, 100871 China These authors contributed equally to this work. Search for more papers by this author Prof.
CTCF-mediated genome organization and leukemogenesis
Abstract Recent technological advancements and genome-wide studies provide compelling evidence that dynamic chromatin interaction and three-dimensional genome organization in nuclei play an important role in regulating gene expression. Mammalian genomes consist of many small functional domains termed topologically associated domains (TADs), many of them organized by CCCTC-binding factor (CTCF) and the cohesion complex.
Biocrude Oil Production through the Maillard Reaction between Leucine and Glucose during Hydrothermal Liquefaction
RETURN TO ARTICLES ASAPPREVArticleNEXT Yi Qiu Yi Qiu State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, Zhejiang 310027, People’s Republic of China Aersi Aierzhati Aersi Aierzhati Department of Agricultural and Biological Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States Jun Cheng* Jun Cheng State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, Zhejiang 310027, People’s Republic of China...
MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition
MOF Induces LSD1 Acetylation and Is Required for Acetylation of Endogenous LSD1 in Epithelial Cells Acetylation of LSD1 Disrupts Its Association with Nucleosomes and Demethylation of Nucleosomal Substrates In Vitro Acetylation-Mimicking Mutant LSD1 Is Compromised for Chromatin Association, H3K4 Demethylation, and Repression of Target Genes in Cells MOF Dissociates LSD1 from Chromatin and Activates E-Cadherin Expression at Least in Part via Suppression of LSD1 Function MOF Expression Is...
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