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Articles by Yichen Wu
Computer Science > Computation and Language
Linear attention replaces growing KV caches with fixed-size recurrent states, yet these persistent states can become a substantial memory bottleneck under concurrent serving. Directly quantizing recurrent states to low precision often leads to severe accuracy degradation, as quantization errors propagate through successive state updates.
Embryonic loss of hexokinase 2 promotes cortical progenitor proliferation and causes autism-like behaviors in mice
Abstract Neurodevelopmental disorders are increasingly associated with metabolic abnormalities, but how metabolic pathways regulate cortical development remains unclear. In particular, whether glycolytic enzymes control neural progenitor behavior during embryonic corticogenesis is still poorly understood.
Interpretable agentic AI system with localized reasoning for radiology
Abstract Medical AI has produced many radiology models, particularly for chest X-rays (CXR), each excelling at isolated tasks like lesion detection or report generation. However, these models have disparate capabilities and limited generalizability due to training on restricted datasets, making clinical integration challenging. Large language models (LLMs) now enable interfacing heterogeneous models within agentic frameworks that automatically interpret and unify outputs in natural language.
Three-dimensional scene boundary representations for wall orientation and distance are represented distinctly in the human visual cortex
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Wu Y, Li S (2026) Three-dimensional scene boundary representations for wall orientation and distance are represented distinctly in the human visual cortex. PLoS Biol 24(3): e3003541.
Allosteric activation of the glutamate receptor mGlu2 by the serotonin receptor 5-HT2A - Nature Communications
Abstract G protein-coupled receptor (GPCR) dimers and higher-order oligomers are the subject of intense debates. The complexes formed between two or more different GPCRs enable the cell to integrate several signals. But the mechanisms of the allosteric interaction within these oligomers remain unclear. Here, we use as a model the heteromer formed in the brain between two targets of anti-psychotic drugs, the metabotropic glutamate receptor 2 (mGlu2) and the serotonin receptor 5-HT2A.
Multiscale Synergistic Mechanism Study on the Regulation of Resistive Response Stability and Mechanical Behavior of Graphene/EPDM Rubber Composite Materials
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description app70218-sup-0001-Supinfo.docxWord 2007 document , 430.8 KB Data S1: app70218-sup-0001-Supinfo.docx. References 1, “Helical Microtubules of Graphitic Carbon,” Nature 354 (1991): 56–58, https://doi.org/10.1038/354056a0.
The role of mesolimbic circuitry in aversive signaling and opioid dependence
Keywords opioid use disorder mesolimbic system negative reinforcement dopamine chronic pain Get full text access Log in, subscribe or purchase for full access. References 1. Koob, G.F. Negative reinforcement in drug addiction: the darkness within Curr. Opin. Neurobiol. 2013; 23:559-563 2. Koob, G.F. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement Biol. Psychiatry. 2020; 87:44-53 3.
EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes
1 Introduction In recent years, significant advancements in early cancer detection, medical technologies, and therapeutic strategies have led to a marked decline in cancer mortality.[1] However, these clinical benefits are often counterbalanced by severe treatment-related side effects, particularly cardiovascular complications.[2, 3] Among chemotherapeutic agents, anthracyclines—especially doxorubicin (DOX)—remain a cornerstone in treating both solid and hematological malignancies.[4, 5]...
Rh-Catalyzed Enantioselective Hydrosilylation of Unactivated Alkenes
Rh-Catalyzed Enantioselective Hydrosilylation of Unactivated Alkenes Here, we report a highly efficient rhodium-catalyzed enantioselective hydrosilylation of unactivated alkenes, achieving excellent regioselectivity and high enantioselectivity.
Direct Coupling of Polyfluoroarenes with Acylsilanes Under Metal‐Free Conditions
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Photoinduced Copper‐Catalyzed Cross‐Coupling of Acylsilanes with Heteroarenes via Bimetallic Relay
1 Introduction Metal carbenes have emerged as highly versatile intermediates, involving many efficient reactions, such as cyclopropanation, C─H and X─H bond insertion reactions, tandem cyclization, etc.[1-4] In view of the great success in this context, metal carbene species with electron-deficient (carbonyl, nitro group, etc.) and electron-neutral (aryl, alkenyl, alkynyl group, etc.) substituents have been well established due to the ready accessibility of corresponding stable carbene...
Tudor-SN exacerbates pathological vascular remodeling by promoting the polyubiquitination of PTEN via NEDD4-1 - Journal of Biomedical Science
To examine the expression pattern of Tudor-SN in healthy human coronary arteries, we utilized RNA-seq data of 240 human samples from the Genotype-Tissue Expression (GTEx) project [17]. Meanwhile, diseased human artery samples were analyzed using data from the Gene Expression Omnibus (GEO) database.
Development and Application of SPOSiPs: A Class of Diphosphine Ligands Based on SPOSiOL
C2-Symmetric chiral diphosphine ligands have been one type of the most widely used ligands or catalysts in asymmetric catalysis with outstanding performances in a wide range of enantioselective transformations (1) since the development of the first C2-symmetric diphosphine ligand DIOP by Kagan et al..
Topology Prediction of Gas‐Separating Metal−Organic Frameworks with Low Symmetry Vertices
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202402314-sup-0001-SuppMat.pdf5.9 MB Supporting Information smll202402314-sup-0002-cif.zip963.8 KB Supporting Information References 1, , , , , , Nature 2003, 423, 705. 2, , , , , , , ACS Cent. Sci. 2020, 6, 1255. 3, , , , Acc. Chem. Res. 2005, 38, 176. 4, , , Angew. Chem., Int. Ed. 2004, 43, 2334. 5, Chem. Soc. Rev. 2008, 37, 191. 6, , , , Chem. Rev. 2012, 112, 1001. 7, , Chem. Rev. 2012, 112, 933.
Catalytic Kinetic Resolution of Monohydrosilanes via Rhodium‐Catalyzed Enantioselective Intramolecular Hydrosilylation
Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
High-Resolution Temperature Evolution Maps of Bangladesh via Data-Driven Learning
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Symmetric Double-Supplemented Nested Array for Passive Localization of Mixed Near-Field and Far-Field Sources
1. Introduction Signal source localization technology has been an important technical development [1], which is widely used in the fields of radar [2,3,4], remote sensing [5,6,7,8], microphone systems [9], unmanned aerial vehicles [], and autonomous vehicles []. In source localization techniques, array aperture and degrees of freedom (DOFs) are critical in determining the accuracy of estimating the direction of arrival (DOA) for signal sources [].
Pd(II)-Catalyzed 1,2-Oxyarylation of Alkenes with O-Acylhydroxylamines as the Oxygen Source
O-Acylhydroxylamine has been widely employed as an electrophilic amination reagent in transition-metal-catalyzed C–N coupling reactions, but its use as an electrophilic oxygen source has not been disclosed. Here, we report a Pd-catalyzed 1,2-oxyarylation of alkenes with O-acylhydroxylamines as an oxidant and an oxygen source for the first time. With simple amide as the monodentate directing group, this method features a broad substrate scope, good functional group tolerance, and mild conditions.
Pd(II)-Catalyzed 1,2-Oxyarylation of Alkenes with O-Acylhydroxylamines as the Oxygen Source
O-Acylhydroxylamine has been widely employed as an electrophilic amination reagent in transition-metal-catalyzed C–N coupling reactions, but its use as an electrophilic oxygen source has not been disclosed. Here, we report a Pd-catalyzed 1,2-oxyarylation of alkenes with O-acylhydroxylamines as an oxidant and an oxygen source for the first time. With simple amide as the monodentate directing group, this method features a broad substrate scope, good functional group tolerance, and mild conditions.
Electrolyte migration through electrochemical membranes: Potential source of error in batch electrochemical cells
1 INTRODUCTION Much research effort has been directed towards applications and material improvements of electrochemical membranes (ECMs) and porous electrodes for water treatment.[1-5] ECMs are formed by coating conventional membranes with one or a combination of electrically-conductive materials including carbon nanotubes (CNTs),[6, 7] other graphitic materials,[8, 9] conductive polymers[10, 11] and metals.[12] ECMs have gained increasing attention and importance in comparison with...
Target Design of Multinary Metal-Organic Frameworks for Near-Infrared Imaging and Chemodynamic Therapy
CCDC 2287003–2287004 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033. Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions.
Ligand‐Enabled Ni(II)‐Catalyzed Hydroxylarylation of Alkenes with Molecular Oxygen
Abstract The use of molecular oxygen as the terminal oxidant in transition metal catalyzed oxidative process is an appealing and challenging task in organic synthetic chemistry. Here, we report a Ni-catalyzed hydroxylarylation of unactivated alkenes enabled by a β-diketone ligand with highly efficient and excellent regioselectivity employing molecular oxygen as the oxidant and hydroxyl source.
Ligand‐Enabled NiII‐Catalyzed Hydroxylarylation of Alkenes with Molecular Oxygen
The use of molecular oxygen as the terminal oxidant in transition metal catalyzed oxidative process is an appealing and challenging task in organic synthetic chemistry. Here, we report a Ni-catalyzed hydroxylarylation of unactivated alkenes enabled by a β-diketone ligand with high efficiency and excellent regioselectivity employing molecular oxygen as the oxidant and hydroxyl source.
China Introduces Rules For Antitrust Review Of Non-Reportable Transactions And Other Antitrust Regulations - Antitrust, EU Competition - China
In Short The Development: China's State Administration for Market Regulation ("SAMR") recently released four regulations ("Regulations") that implement 2022 amendments to the Anti-Monopoly Law of China ("AML"). The most significant changes address "hub-and-spoke" agreements, antitrust leniency applications for individuals, SAMR's review of non-reportable M&A deals, and gun jumping.
China Introduces Rules for Antitrust Review of Non-Reportable Transactions and Other Antitrust Regulations | JD Supra
In Short The Development: China's State Administration for Market Regulation ("SAMR") recently released four regulations ("Regulations") that implement 2022 amendments to the Anti-Monopoly Law of China ("AML"). The most significant changes address "hub-and-spoke" agreements, antitrust leniency applications for individuals, SAMR's review of non-reportable M&A deals, and gun jumping.
China's Antitrust Enforcer Adopts First Remedies In Domestic M&A Deals - Antitrust, EU Competition - China
For the first time, SAMR has required remedies in two recent transactions involving domestic Chinese companies. SAMR recently permitted Wanhua Chemical's acquisition of Yantai Juli Fine Chemical to proceed, subject to remedies; and in late 2022, SAMR conditionally approved a joint venture between Shanghai Airport and Eastern Air Logistics, two state-owned enterprises. SAMR has a long history with remedies, but only in conditional antitrust approvals of deals involving foreign companies.
China's Antitrust Enforcer Adopts First Remedies in Domestic M&A Deals | JD Supra
The State Administration for Market Regulation's ("SAMR") remedies decisions in two recent domestic transactions are the first conditional antitrust M&A settlements in the 15-year history of antitrust enforcement under China's Anti-Monopoly Law ("AML"). For the first time, SAMR has required remedies in two recent transactions involving domestic Chinese companies.
Generation of Site-Selective Structural Vacancies in a Multinary Metal-Organic Framework for Enhanced Catalysis
Generating structural vacancies in metal–organic frameworks (MOFs) by partially removing the inorganic and organic units from the scaffolds is an effective strategy to modulate the pore parameters of the extended structures. However, pore enlargement is accomplished at the cost of loss in the number of active sites in typical MOFs, since dissociations of coordination linkages to create vacancies are not site-selective.
China's Supreme Court Ruling Likely to Prompt More Follow-on Antitrust Litigation | JD Supra
In Short The Development: China's Supreme People's Court recently ruled for the plaintiff in Miao Chong v. SAIC-GM, which marked a rare triumph for a plaintiff in antitrust litigation as a follow-on to an administrative penalty decision. The plaintiff-consumer alleged that a joint venture between General Motors China and SAIC adopted resale price maintenance in the sale of cars that harmed competition.
DIFFERENTIATED EMBRYONIC CHONDROCYTE EXPRESSED GENE-1 IS A CENTRAL SIGNALING COMPONENT IN THE DEVELOPMENT OF COLLAGEN-INDUCED RHEUMATOID ARTHRITIS
Experimental procedures Chemical and reagents Chicken type II collagen and Complete Freund Adjuvant were purchased from Chondrex (WA, USA). H&E staining kit was from Jiancheng Bio. (Nanjing, China). Safranine red & Fast green staining kit was from Solarbio (Beijing, China). Dulbecco modified Eagle medium (DMEM) was from Gibco (NY, USA). Fetal bovine serum (FBS) was from Wisent (Canada). Diaminobenzidine peroxidase substrate kit was from Vector Laboratories (CA, USA).
Effect of Noninvasive Static Human Data on Maximum Data in Exercise
Open AccessArticle by Yichen Wu 1,2,3 and Yining Sun 1,* 1 Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China 2 Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230031, China 3 School of Electronic and Information Engineering, Anhui Jianzhu University, Hefei 230601, China * Author to whom correspondence should be...
Water‐Harvesting Metal-Organic Frameworks with Gigantic Al24 Units and their Deconstruction into Molecular Clusters
Graphical Abstract A dual-linkage strategy to make single crystalline metal–organic frameworks (MOFs) gives porous solids with gigantic Al24 units. Selective linkage replacement rigidifies the MOFs resulting in outstanding water-harvesting behaviour. The selective linkage dissociation of the MOF provides a new route to prepare highly symmetrical clusters.
Cu/SaBox‐Catalyzed Photoinduced Coupling of Acylsilanes with Alkynes
Graphical Abstract The coupling of alkynes with the Fischer-type copper carbene species has been achieved, by harnessing α-siloxyl carbene intermediates that were in situ generated from acylsilanes. Mechanistic studies suggested that the side-arm modified bisoxazoline (SaBox) ligands are crucial for this coupling reaction.
China Amends Anti-Monopoly Law: What You Need to Know | JD Supra
In late June 2022, the 13th National People’s Congress Standing Committee adopted the First Amendments to China’s Anti-Monopoly Law (“AML”). The amendments will take effect on August 1, 2022.
Enantioselective Synthesis of Silicon‐Stereogenic Monohydrosilanes by Rhodium‐Catalyzed Intramolecular Hydrosilylation
Research Article Yu-Hao Huang, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS, 345 Lingling Road, Shanghai, 200032 P. R. China These authors contributed equally to this work.
An Imine‐Linked Metal-Organic Framework as a Reactive Oxygen Species Generator
Research Article PDF ShareShare Abstract A new metal–organic framework (MOF) with both coordination linkages and covalent linkages is prepared by coordinating CuI with pyrazolate for an aldehyde‐functionalized trinuclear complex, and subsequent imine condensation with p‐phenylenediamine, a reaction typical for covalent organic framework (COF) synthesis. This MOF×COF collaboration yields FDM‐71 with honeycomb layers stacked in eclipsed fashion.
High electrostrictive properties and energy storage performances with excellent thermal stability in Nb-doped Bi0.5Na0.5TiO3-based ceramics
High electrostrictive properties and energy storage performances with excellent thermal stability in Nb-doped Bi0.5Na0.5TiO3-based ceramics† Yichen Wu, ab Genshui Wang,*bcd Zheng Jiao,a Yuzhu Fan,b Ping Pengb and Xianlin Dongbcd Author affiliations * Corresponding authors a School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China b Key Laboratory of Inorganic Functional Materials and Devices, Shanghai Institute of Ceramics, Chinese Academy of Sciences,...
Redox‐Neutral Nickel(II) Catalysis: Hydroarylation of Unactivated Alkenes with Arylboronic Acids
Communication Wang Feng State key laboratory of organometallic chemistry, Center for excellence in molecular synthesis, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai, 200032 P. R. China Search for more papers by this author Tao Liu State key laboratory of organometallic chemistry, Center for excellence in molecular synthesis, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Road, Shanghai, 200032 P. R. China Search for more papers by this author Prof.
Para-selective arylation and alkenylation of monosubstituted arenes using thianthrene S-oxide as a transient mediator
Para-selective arylation and alkenylation of monosubstituted arenes using thianthrene S-oxide as a transient mediator Using thianthrene S-oxide (TTSO) as a transient mediator, para-arylation and alkenylation of mono-substituted arenes have been demonstrated using a para-selective thianthrenation/Pd-catalyzed thio-Suzuki-Miyaura coupling sequence under mild conditions. This reaction features broad substrate scope, functional group and heterocycle tolerance.
Deep learning in microscopy
Three-dimensional virtual refocusing of fluorescence microscopy images using deep learning Deep-Z uses deep learning to go from a two-dimensional snapshot to three-dimensional fluorescence images. The method improves imaging speed while reducing light dose, and was shown to be useful for accurate structural and functional imaging of neurons in Caenorhabditis elegans.
Para-Selective Borylation of Monosubstituted Arenes Using a Transient Mediator
Abstract Herein, we conceptualized a transient mediator approach that has the capability of para-selective C–H functionalization of monosubstituted aromatics. This approach is enabled by in situ generation of a versatile sulfonium salt via highly electrophilic phenoxathiine or thianthrene radical cation intermediate which can be readily generated from its sulfoxide with trifluoromethanesulfonic anhydride.
Resolution enhancement in scanning electron microscopy using deep learning
Abstract We report resolution enhancement in scanning electron microscopy (SEM) images using a generative adversarial network. We demonstrate the veracity of this deep learning-based super-resolution technique by inferring unresolved features in low-resolution SEM images and comparing them with the accurately co-registered high-resolution SEM images of the same samples.
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