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Yuki Aoi on Muck Rack

Yuki Aoi

As seen in: Nature, Science Magazine, BioRxiv, Cell Reports, Cell Press, The Journal of Clinical Investigation
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Articles

Mitochondrial l -2-hydroxyglutarate is a physiological signalling metabolite

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By Ram P. Chakrabarty, Yuki Aoi, Taylor A Poor, Gregory S. McElroy, Karthik Vasan, Shimaa Soliman, Marta Iwanaszko, Rogan A. Grant, Benjamin Howard, Colleen R. Reczek, Anjali Chandel, Michael D. Kahl, Zhaofa Xu, Kathryn A. Helmin, Qiushi Jin, Dongmei Wang, Peng Gao, Jenna Blum, Zachary Sebo, Feng Yue, Shawn M. Davidson, Steven Gygi, Samuel E. Weinberg, Benjamin D. Singer, Seung Hye Han, Ali Shilatifard, Navdeep S. Chandel, Jonathan G. Van Vranken, Yongchao C. Ma
| Nature Verified
Abstract l-2-Hydroxyglutarate (l-2-HG) is a low-abundance metabolite in mammals because the mitochondrial enzyme l-2-HG dehydrogenase (L2HGDH) oxidizes l-2-HG to 2-oxoglutarate (2-OG) to prevent its accumulation1. In humans, a lack of L2HGDH activity leads to l-2-HG accumulation and causes l-2-hydroxyglutaric aciduria2. Thus, l-2-HG is often classified as a toxic metabolite2,3,4,5. However, whether l-2-HG has any physiological function is unclear.
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BRD2 bridges TFIID and MOF-H4K16ac-containing nucleosomes to promote transcriptional initiation

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By Bin Zheng, Ruxuan Qiu, Sarah Gold, Marta Iwanaszko, Yuki Aoi, Benjamin Howard, Madhurima Das, Ali Shilatifard
| Cell Press Verified
Keywords transcription chromatin RNA polymerase II BRD2 BRD4 TFIID MOF H4K16ac transcription initiation gene expression BET inhibitors JQ1 dBET6 Introduction The BET (bromodomain and extraterminal domain) family proteins BRD2, BRD3, BRD4, and BRDT are multifunctional transcription coactivators that have been proposed as therapeutic targets for a variety of diseases, including cancer.1,2,3,4 The two tandem bromodomains present in all BET family proteins each confer the capacity to bind histone...
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Defective RNA processing and ELOA-mediated transcriptional elongation in reversible cellular senescence suggest aging by transcription

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By Saeid Mohammad Parast, Simai Wang, Marta Iwanaszko, Yue He, Deniz G. Olgun, Sarah Gold, Jacob M. Zeidner, Yuki Aoi, Benjamin Howard, William R. Thakur, Vijay Ramani, Ali Shilatifard
| Cell Press Verified
Keywords transcription mRNA processing gene expression transcriptional elongation cellular senescence aging Get full text access Log in, subscribe or purchase for full access. References 1. Aoi, Y. ∙ Shilatifard, A. Transcriptional elongation control in developmental gene expression, aging, and disease Mol. Cell. 2023; 83:3972-3999 2. Aoi, Y. ∙ Smith, E.R. ∙ Shah, A.P. ... NELF Regulates a Promoter-Proximal Step Distinct from RNA Pol II Pause-Release Mol. Cell. 2020; 78:261-274.e5 3. Tufan, T.
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