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Zhangying Cai on Muck Rack

Zhangying Cai

As seen in: Cell Reports
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Articles

Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

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By Jinchao Hou, Yingyue Zhou, Zhangying Cai, Marina Terekhova
| Cell Reports Verified
Franklin R.J.M. Ffrench-Constant C. Regenerating CNS myelin - from mechanisms to experimental medicines. Nat. Rev. Neurosci. 2017; 18: 753-769https://doi.org/10.1038/nrn.2017.136 Multiple sclerosis pathology. Cold Spring Harb. Perspect. Med. 2018; 8a028936https://doi.org/10.1101/cshperspect.a028936 Sarbu N. Shih R.Y. Jones R.V. Horkayne-Szakaly I. Oleaga L. Smirniotopoulos J.G. White matter diseases with radiologic-pathologic correlation. Radiographics.
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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer

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By Zeyu Chen, Eri Arai, Omar Khan, Zhen Zhang, Shin Foong Ngiow, Yuan He, Hua Huang, Sasikanth Manne, Zhendong Cao, Amy Baxter, Mohammed Ali, Josephine Giles, Jennifer E. Wu, Allison R. Greenplate, Zhangying Cai, Elizabeth Freilich, Mohamed A. Hakee
| ScienceDirect Verified
Highlights • OpTICS In vivo CD8+ T cell CRISPR screening platform developed for focused gene discovery • OpTICS identifies genes involved in effector versus exhausted CD8+ T cells • The Fli1 transcription factor represses optimal effector CD8+ T cells during exhaustion • Fli1 antagonizes epigenetic accessibility at ETS-RUNX sites limiting Runx3 activity Summary Improving effector activity of antigen-specific T cells is a major goal in cancer immunotherapy.
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