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Articles by Zhen Gu
Controllable gene delivery via masked adeno-associated viral vectors
Abstract Controllable gene delivery to specific tissue by adeno-associated viruses (AAVs) is a challenge in gene therapy. Here we develop masked AAVs, whose transduction is blocked and restored only on pathological activation or by activation triggered by exogenous signals.
Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis
Abstract Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis. However, its clinical translation is severely limited by the lack of efficient methods for precise and potent mitochondria transfer.
Airway administered artificial mitochondria-enriched nanovesicles for efficient and selective mitochondria transfer to intervene in pulmonary fibrosis
Abstract Mitochondrial transplantation is a promising therapeutic approach involving the transfer of exogenous mitochondria into diseased cells to restore impaired mitochondrial homeostasis. However, its clinical translation is severely limited by the lack of efficient methods for precise and potent mitochondria transfer.
Immunostimulatory lipogel implant enhances cancer immunotherapy
Abstract Cancer stem-like cells contribute to innate tumour immunoresistance and an immunosuppressive tumour microenvironment, leading to poor responses to immune checkpoint inhibitors. Chemotherapeutic agents can elicit tumour immunogenicity by inducing immunogenic cell death to reinforce the therapeutic efficacies of immune checkpoint inhibitors, but suffer from inefficient immunogenic cell death activation in highly resistant cancer stem-like cells.
Bioresponsive microneedle stent provides anastomosis and postoperative adjuvant therapy in preclinical resectable intestinal diseases
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Resection of diseased bowel requires rejoining of the remaining intestinal segments and postoperative therapy to support a regenerative environment. Here, Zhou et al.
Electroactive microneedle augmented stem cell therapy in myocardial infarction
Abstract Ischemic heart disease and related sequelae pose tremendous burdens on worldwide medical care. The excessive activation of cardiomyocytes and cardiac fibroblasts further exacerbates the prognosis after necrosis. Decades of stem cell therapy in preclinical studies suggested promising results in cardiomyocyte regeneration and tissue remodeling. However, few formulations achieved clinical translation due to the limited stem cell engraftment and insufficient arousal of resident cardiomyocytes.
Ciprofol-etomidate versus propofol-etomidate for gastrointestinal endoscopy: a randomized, double-blind controlled clinical trial
Abstract Objective: Explore the clinical efficacy and safety of ciprofol-etomidate (C-E) versus propofol-etomidate (P-E) for gastrointestinal endoscopy sedation, and generate hypotheses for subsequent prospective pre-registered trials. Methods: A prospective, double-blind, randomized, positive-controlled exploratory trial enrolled 240 adults (120 per group). Exploratory outcomes included hemodynamics, adverse events, and Chalder Fatigue Questionnaire (CFQ) scores.
M2 type macrophages promote OSCC progress via conferring resistance to Erastin-induced ferroptosis
Abstract M2 type macrophages could promote oral squamous cell carcinoma (OSCC) progress. Ferroptosis is a newly discovered type of programmed cell death and inhibition of ferroptosis in many tumor models could promote tumor progression. This study aims to investigate whether M2 type macrophages could influence the progression of OSCC by regulating the ferroptosis of tumor cells.
Towards intelligent and miniaturized drug delivery devices
Abstract Advances at the intersection of biotechnology, artificial intelligence, electronics and materials science are reshaping how drugs can be delivered inside the body. Intelligent and miniaturized drug delivery devices (IMDDDs) leverage these technologies to achieve precise pharmacokinetics, targeted distribution and programmable release while minimizing toxicity and improving patient adherence.
Ultrasensitive photodetectors enabled by pressure-induced atomic-level optimization of graphene-based heterojunctions
Abstract Photodetectors with high photoresponsivity are crucial in a wide range of emerging fields. Here, we report the realization of photodetectors based on co-assembled composite membranes consisting of copper phthalocyanine (CuPc) molecules and graphene oxide (GO) sheets, showing a photoresponsivity as high as ~ 10⁷ A/W under 3 nW illumination and a moderate external pressure (~1 atm) in the visible range.
Engineering platelets as cancer therapeutics - Nature Reviews Clinical Oncology
Abstract Accumulating evidence indicates that platelets promote cancer progression through direct interactions with malignant cells, the secretion of soluble mediators and the release of platelet-derived extracellular vesicles. In certain contexts, platelets can also suppress tumour progression by modulating immune responses, delivering antiproliferative microRNAs or releasing inhibitory factors.
3D biomimetic niche modulates embryo development in vitro - Nature Communications
Abstract Embryo development undergoes critical morphological transformations post-implantation, largely driven by the complex and dynamic microenvironment of the uterus. Despite advances, current 3D culture models inadequately recapitulate the uterine environment necessary for studying embryo-uterus interactions. In this work, we engineer a hydrogel inspired by the properties of the decidua, incorporating Matrigel to support blastocyst implantation and embryo development in vitro.
Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy
Keywords drug delivery cell therapy mast cells oncolytic adenoviruses cell-drug conjugate cancer immunotherapy Get full text access Log in, subscribe or purchase for full access. References 1. Vargason, A.M. ∙ Anselmo, A.C. ∙ Mitragotri, S. The evolution of commercial drug delivery technologies Nat. Biomed. Eng. 2021; 5:951-967 2. Lim, W.A. The emerging era of cell engineering: Harnessing the modularity of cells to program complex biological function Science. 2022; 378:848-852 3. Chen, Z. ∙ Hu, Q. ∙ Gu, Z.
Generalized Reinforcement Learning Enhanced Three‐Dimensional Impact Time Control Against Maneuvering Targets With Field‐of‐View Constraint
This paper presents a generalized three-dimensional (3D) intelligent impact time control guidance (ITCG) law for intercepting maneuvering targets under the field-of-view (FOV) constraint in the relative virtual framework (RVF). The proposed method addresses key limitations of existing guidance approaches by eliminating the need for time-to-go estimation, model linearization, and decoupling.
Spatially Programmable Electroadhesive Enables In Situ Site‐Selective Functional Coupling
1 Introduction Implantable bioelectronic devices have been widely explored for the treatment and monitoring of various conditions, ranging from cardiovascular diseases to neurological disorders.[1-4] Recent advances in integrating conductive and semiconductive functionalities into hydrogel-based biointerfaces have broadened our capability to form functional coupling to biological tissue.[5, 6] A stable tissue–device interface is essential for reliable signal acquisition and precise electrical...
Engineering of mRNA vaccine platform with reduced lipids and enhanced efficacy - Nature Communications
Abstract Lipid nanoparticles (LNPs) are the most clinically relevant vehicles for mRNA vaccines. Despite the great successes, the toxicity caused by the high dose of lipid components still represents a great challenge. The suboptimal loading capacity of mRNA in LNPs not only compromises the vaccine’s efficacy but also heightens the risk of non-specific immune responses, accelerates clearance caused by anti-PEG IgG/IgM.
Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity - Nature Communications
Abstract Extracellular matrices of living tissues exhibit viscoelastic properties, yet how these properties regulate chromatin and the epigenome remains unclear. Here, we show that viscoelastic substrates induce changes in nuclear architecture and epigenome, with more pronounced effects on softer surfaces.
An engineering-reinforced extracellular vesicle-integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury
Abstract The local delivery of mesenchymal stem cell–derived extracellular vesicles (EVs) via hydrogel has emerged as an effective approach for spinal cord injury (SCI) treatment. However, achieving on-demand release of EVs from hydrogel to address dynamically changing pathology remains challenging. Here, we used a series of engineering methods to further enhance EVs’ efficacy and optimize their release pattern from hydrogel.
Streptococcus mutans regulates ubiquitin modification of Candida albicans in the bacterial-fungal interaction
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Zhang Y, Gu Z, Li Z, Wu Q, Xu X, Peng X (2025) Streptococcus mutans regulates ubiquitin modification of Candida albicans in the bacterial-fungal interaction. PLoS Pathog 21(2): e1012887. https://doi.org/10.1371/journal.ppat.1012887 Editor: Chengshu Wang, Chinese Academy of Sciences, CHINA Received: January 29, 2024; Accepted: January 4, 2025; Published: February 3, 2025 Copyright: © 2025 Zhang et al.
Advances in adhesion of microneedles for bioengineering
Advances in adhesion of microneedles for bioengineering Microneedles have provided promising platform in various fields for their safety, painless, minimally invasive and easy to operate. The excellent adhesion of microneedle is the key characteristics to achieve long-term and comfort treatment. However, the complex environment, such as the roughness of skin, various body fluids in vivo, and the movement of body, presents great challenges to the adhesion characteristics of microneedles.
Advanced Physical Layer Metasurface‐Empowered Cryptography with Robustness, High Capacity, and Enhanced Security
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description lpor202402046-sup-0001-SuppMat.docx811.5 KB Supporting Information References 1, Comput. Networks 2022, 216, 109246. 2, , , , , , , IEEE Wirel. Commun. 2022, 30, 36. 3, , , , , , , , IEEE Internet Things J. 2022, 9, 359. 4, , , , IEEE Commun. Mag. 2017, 55, 26. 5, , , , , , IEEE Commun. Surv. Tutorials 2017, 19, 1054. 6, , , , , , IEEE Access 2014, 2, 1510. 7, , , , , , , , IEEE Commun. Surv.
Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors - Signal Transduction and Targeted Therapy
Abstract The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells. Here, we developed a bacterial-based adjuvant approach that augments the efficacy of adoptive T-cell therapy for solid tumor treatment. Our study reveals that intratumor injection of E.
Electroacupuncture inhibits NLRP3 - mediated microglial pyroptosis to | JPR
Back to Journals » Journal of Pain Research » Volume 18 Original Research Integrative/Acupuncture Authors Kui W, Li Y, Gu Z, Xie L, Huang A, Kong S, Song L, Li L, Yu J, Xue CC, Wang K Received 17 November 2024 Accepted for publication 1 March 2025 Published 7 March 2025 Volume 2025:18 Pages 1115—1129 DOI https://doi.org/10.2147/JPR.S506569 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Dr Houman Danesh Wenyun Kui,...
An artificial intelligence-assisted digital microfluidic system for multistate droplet control - Microsystems & Nanoengineering
Abstract Digital microfluidics (DMF) is a versatile technique for parallel and field-programmable control of individual droplets. Given the high level of variability in droplet manipulation, it is essential to establish self-adaptive and intelligent control methods for DMF systems that are informed by the transient state of droplets and their interactions. However, most related studies focus on droplet localization and shape recognition.
Emerging chemophysiological diversity of gut microbiota metabolites
Highlights Tryptophan metabolites exhibit chemical diversity and engage multiple receptors, resulting in pleiotropic effects that modulate tumor development, therapeutic response, host defense against pathogens, regulation of metabolic syndrome, and potential correlations with neurological disorders.
An optically responsive cancer vaccine for inducing robust anti-tumor immunity by apoptotic body carrying nanoadjuvants
Cancer vaccines induce tumor antigen-specific immunological responses and simultaneously provide long-term protective immunological memory against the antigen compared with non-specific immunotherapies such as immune checkpoint inhibitors [1], [2], [3]. Cancer vaccines can be used to trigger host immunity to specifically attack tumors by collecting and processing the patient's own tumor cells containing a variety of tumor-associated antigens [4].
Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation - Nature Communications
Abstract Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformulate lipid nanoparticles (LNPs) through adjustments in lipid material structures and compositions to systematically achieve the pulmonary and hepatic (respectively) targeted mRNA distribution and expression.
Engineering cells for therapy and diagnosis - Nature Reviews Bioengineering
Abstract Personalized therapy offers tailored treatment solutions for individual patients to minimize treatment-associated side effects and improve prognosis. In particular, endogenous cells, exogenous cells and bacterial cells can be designed to enable precise disease diagnosis and personalized therapy, capitalizing on inherent and engineered functions and properties of different cell types.
Multi‐Wavelength Metasurface Empowered Cryptography for Heightened Security and Improved Fidelity
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description lpor202301014-sup-0001-SuppMat.docx1.6 MB Supporting Information References 1, , , , , , , , , , , , , , , , , , , , , , , , Nature 2020, 582, 501. 2, , , , , , , , , , , Sci. Adv. 2022, 8, eadd1980. 3, , , , , , Nat. Commun. 2023, 14, 3005. 4, , , , , , , , , , Light Sci. Appl. 2023, 12, 79. 5, , , , , , , Science 2011, 334, 333. 6, , , , , , Nature Mater 2012, 11, 426. 7, , Nat. Mater. 2012, 11, 917.
Association between reversal agents (sugammadex vs. neostigmine) for neuromuscular block and postoperative pulmonary complications: A retrospective analysis - Ren - British Journal of Clinical Pharmacology - Wiley Online Library
What is known about this subject Postoperative pulmonary complications are common and exert a substantial negative influence on patient outcomes. Residual neuromuscular blockade may increase the risk of pulmonary complications. Sugammadex provides a more rapid and complete reversal of neuromuscular blockade than traditional anticholinesterase, neostigmine.
Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review
Download Hi-Res ImageDownload to MS-PowerPointCite This:Biomacromolecules 2024, XXXX, XXX This article has not yet been cited by other publications.
Microneedle biomedical devices - Nature Reviews Bioengineering
Abstract Microneedle (MN) technologies have gained interest for biomedical applications, ranging from drug delivery to sensing and tissue sampling in skin and internal organs. The microscale feature of MN systems allows the accommodation of therapeutics from small drugs to macromolecule biologics and even living cells. Additionally, it permits body fluid extraction when inserted into tissues.
Stretchable graphene–hydrogel interfaces for wearable and implantable bioelectronics - Nature Electronics
Abstract Soft, stretchable and biocompatible conductors are required for on-skin and implantable electronics. Laser-induced graphene (LIG) can offer tuneable physical and chemical properties, and is of particular value in the development of monolithically integrated multifunctional stretchable bioelectronics. However, fabricating LIG-based nanocomposites with thin features and stretchable performance remains challenging.
An in situ dual-anchoring strategy for enhanced immobilization of PD-L1 to treat autoimmune diseases - Nature Communications
Abstract Immune checkpoints play key roles in maintaining self-tolerance. Targeted potentiation of the checkpoint molecule PD-L1 through in situ manipulation offers clinical promise for patients with autoimmune diseases. However, the therapeutic effects of these approaches are often compromised by limited specificity and inadequate expression.
BumbleBee: Secure Two-party Inference Framework for Large Transformers
Paper 2023/1678 , Ant Group , Ant Group , Alibaba Group (China) , Zhejiang University , Zhejiang University , Zhejiang University , Ant Group , Ant Group , Ant Group Large transformer-based models have realized state- of-the-art performance on lots of real-world tasks such as natural language processing and computer vision. However, with the increasing sensitivity of the data and tasks they handle, privacy has become a major concern during model deployment.
Pre-activated nanoparticles with persistent luminescence for deep tumor photodynamic therapy in gallbladder cancer - Nature Communications
Abstract Phototherapy of deep tumors still suffers from many obstacles, such as limited near-infrared (NIR) tissue penetration depth and low accumulation efficiency within the target sites. Herein, stimuli-sensitive tumor-targeted photodynamic nanoparticles (STPNs) with persistent luminescence for the treatment of deep tumors are reported.
Author Correction: Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-37253-x, published online 05 April 2023 The original version of this Article contained errors in Fig. 4. In particular, the Y-axes of original Fig. 4E and 4G were mislabelled. Figure 4 has now been corrected and replaced in both the PDF and HTML versions of the Article. In addition, inaccuracies have been found in the original Source data for Figs. 2F, 2G, 4D, 4E, 4F, 4G and for Supplementary Fig. 18A and 18B.
Site-selective superassembly of biomimetic nanorobots enabling deep penetration into tumor with stiff stroma - Nature Communications
Abstract Chemotherapy remains as the first-choice treatment option for triple-negative breast cancer (TNBC). However, the limited tumor penetration and low cellular internalization efficiency of current nanocarrier-based systems impede the access of anticancer drugs to TNBC with dense stroma and thereby greatly restricts clinical therapeutic efficacy, especially for TNBC bone metastasis.
Mimosa‐inspired Stimuli‐responsive Curling Bioadhesive Tape Promotes Peripheral Nerve Regeneration
Research Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as https://doi.org/10.1002/adma.202212015 Abstract Trauma often results in peripheral nerve injuries.
Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours - Nature Nanotechnology
Abstract Adoptive T-cell therapy against solid tumours is limited by the apoptosis resistance mechanisms of tumour cells and by the extracellular, immunosuppressive tumour microenvironment. Here we report a temperature-sensitive genome-editing nanodevice that can deliver a Cas9 editor with an external trigger which can be used to edit the genome of tumour cells to reduce resistance to apoptosis and modulate the tumour microenvironment via a mild heating trigger.
Localized nuclear reaction breaks boron drug capsules loaded with immune adjuvants for cancer immunotherapy - Nature Communications
Abstract Boron neutron capture therapy (BNCT) was clinically approved in 2020 and exhibits remarkable tumour rejection in preclinical and clinical studies. It is binary radiotherapy that may selectively deposit two deadly high-energy particles (4He and 7Li) within a cancer cell. As a radiotherapy induced by localized nuclear reaction, few studies have reported its abscopal anti-tumour effect, which has limited its further clinical applications.
FFT-less TFHE: Simpler, Faster and Scale-invariant
Paper 2023/357 FFT-less TFHE: Simpler, Faster and Scale-invariant , Alibaba Group (China) , Alibaba Group (China) , Alibaba Group (China) Abstract Fully homomorphic encryption FHE has been one of the most promising cryptographic tools for secure two-party computation and secure outsourcing computation in recent years. However, the complex bootstrapping procedure in FHE schemes is the main bottleneck of it practical usage, and the TFHE scheme is the state-of-the-art for efficient bootstrapping.
Multifunctional DNA Hydrogels with Hydrocolloid‐Cotton Structure for Regeneration of Diabetic Infectious Wounds
Research Article Liping Zhou, Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083 China Search for more papers by this author Wei Pi, Department of Orthopaedics and Trauma, Peking University People's Hospital, Beijing, 100044 China Search for more papers by this author Siyang Cheng, Beijing Key Laboratory for Bioengineering and Sensing...
Electrochemical Sensing in Contact Lenses
Review Huixin Liu, Shanghai Environmental Protection Key Laboratory for Environmental Standard and Risk Management of Chemical Pollutants, School of Resources & Environmental Engineering, East China University of Science & Technology, Shanghai, 200237 PR China State Environmental Protection Key Lab of Environmental Risk Assessment and Control on Chemical Processes, School of Resources & Environmental Engineering, East China University of Science & Technology, Shanghai, 200237 PR China Search...
Nanodevices for cancer vaccination
An elaborate DNA origami tubular nanodevice encapsulating antigens and adjuvants protects mice from cancer through tumour-specific immunomodulation. Vaccines train the immune system to precisely eliminate pathogens from harming the human body and so far they have saved numerous lives1. Cancer vaccines are designed to prevent and combat tumours by eliciting a tumour-specific humoral and cellular immunity2.
Today, about 50% of men and 15-30% of women suffer from hair loss as well as the associated psychological impact. Drug therapy, especially through topical administration, is the main treatment strategy for stimulating hair regrowth. However, challenges exist due to the skin barrier that hinders drug penetration.
Bioengineered microenvironment to culture early embryos
Abstract The abnormalities of early post‐implantation embryos can lead to early pregnancy loss and many other syndromes. However, it is hard to study embryos after implantation due to the limited accessibility. The success of embryo culture in vitro can avoid the challenges of embryonic development in vivo and provide a powerful research platform for research in developmental biology.
Enzyme-activatable polymer-drug conjugate augments tumour penetration and treatment efficacy
Abstract A tumour microenvironment imposes barriers to the passive diffusion of molecules, which renders tumour penetration an unresolved obstacle to an effective anticancer drug delivery. Here, we present a γ-glutamyl transpeptidase-responsive camptothecin–polymer conjugate that actively infiltrates throughout the tumour tissue through transcytosis.
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