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Articles by Ziwei Wang
Dual-Biofluid Metabolomics Combined With Machine Learning Enables Noninvasive Diagnosis of Drug Resistance in Benign Prostatic Hyperplasia
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll75787-sup-0001-SuppMat.docx6.3 MB Supporting File: smll75787-sup-0001-SuppMat.docx. References 1, “Etiology, Epidemiology, and Natural History,” Urologic Clinics of North America 36, no.
Global burden, trends, and projections of five major upper gastrointestinal diseases, 1990–2046: an analysis of GBD 2021
Abstract Background: Upper gastrointestinal (GI) diseases, including gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), gastritis and duodenitis (GD), stomach cancer, and esophageal cancer, pose significant global health and economic challenges. This study analyzes their trends, regional disparities, risk factors, and future projections from 1990 to 2046.
Computer Science > Machine Learning
Electroencephalography (EEG)-based brain-computer interfaces (BCIs), particularly steady-state visual evoked potential (SSVEP) systems, are highly vulnerable to noise and artifacts, which severely degrade decoding accuracy. Although recent denoising approaches have shown promise, they are fitted without paired ground truth, can settle on reproducing their input, and are optimized on waveform distance alone, which says nothing about whether the output stays decodable.
Global research trends and emerging themes of ketamine in perioperative neurocognitive disorders: a bibliometric analysis
Abstract Background: Within the contemporary perioperative neurocognitive disorder (PND) framework, postoperative neurocognitive outcomes include postoperative delirium, delayed neurocognitive recovery, and postoperative neurocognitive disorder. Interest in ketamine and its enantiomers has increased, but the clinical literature on perioperative neurocognitive outcomes remains heterogeneous.
Energy Transition, Greenhouse Gas Emissions, and Biodiversity: Global Assessment
References , , and . 2025. “Financial Sector Performance and Environmental Sustainability: Assessing the Moderating Effect of Social Responsibility.” International Journal of Sustainable Development and Planning 20: 1005–1013. , , and . 2024. “Role of Economy, Technology, and Renewable Energy Toward Carbon Neutrality in China.” Journal of Economy and Technology 2: 138–154. , and . 2025.
Computer Science > Artificial Intelligence
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Created Ex Nihilo: A Near-Infrared Afterglow Luminescent Framework of Imidazole Derivatives for Bioimaging
1 Introduction Optical imaging can visualize pathological and physiological processes at the molecular level and is an indispensable tool for preclinical research and biomedical applications [1-4]. However, traditional fluorescence imaging is hindered by the tissue's own fluorescence, which reduces the imaging sensitivity, specificity, and penetration depth [5-8].
First-line anlotinib versus bevacizumab plus CapeOX in RAS/BRAF wild-type unresectable metastatic colorectal cancer (ANCHOR): a multicenter, prospective, randomized, phase 3 trial
Abstract Bevacizumab plus chemotherapy is the standard first-line therapy for metastatic colorectal cancer (mCRC). To date, no phase 3 trial has compared first-line oral multitargeted TKI versus bevacizumab plus chemotherapy in RAS/BRAF wild-type mCRC. The open-label, noninferiority, randomized, phase 3 trial (ANCHOR; NCT04854668; CTR20210940) evaluated first-line anlotinib versus bevacizumab plus oxaliplatin and capecitabine (CapeOX) in this setting.
Calculation Method for the Detachment Range and Contact Stress of Horizontal Joints of Precast Concrete Wind Turbine Tower
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1 GWEC, “ Global Wind Report,” (2025). 2, “ LWST Phase I Project Conceptual Design Study: Evaluation of Design and Construction Approaches for Economical Hybrid Steel/Concrete Wind Turbine Towers,” National Renewable Energy Lab, (2005), https://doi.org/10.2172/15011444.
Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance
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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary A dysregulated intestinal microbiome has been linked to development of food allergy, suggesting that approaches to manipulate the microbiome may have a therapeutic value. Here, Rachid et al. investigated whether fecal microbiome transplantation (FMT) could increase tolerance to peanuts in adults with peanut allergies.
By Zhao Li, Ziyi Zhou, Lyandysha Zholudeva, Rima Rachid, Mónica Martínez-Blanco, Gavin A. Kuziel, Emmanuel Stephen-Victor, Mathieu Groussin, Askarbek Orakov, Mathilde Poyet, Zhussipbek Mukhatayev, Christina Yee, Rayan Kteish, Farida Abi Farraj, Ziwei Wang, Suzanne E. Dahlberg, Morgan Ryan Verified, Meghan Fitzgerald, Wendy Elverson, John Lee, Lynda Schneider, Andrew J. MacGinnitie, Elena Crestani, Ebla Abdel Rahman
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Science Magazine
Verified
Learning from failures of co-owned firms: common ownership and information disclosure fraud
This study focuses on learning effects between firms connected by common ownership. We explore the learning effects in a certain setting that how decision-makers in focal firms learn from punishments for fraudulent disclosure in their co-owned firms. Baseline results show that punishments for fraudulent disclosure in co-owned firms reduce information disclosure fraud in focal firms. The effects still exist after excluding other potential channels of learning.
A Nomogram for Predicting 28-Day Mortality in Critically Ill Patients With Prostate Cancer: A Retrospective Cohort Study Based on the MIMIC-IV Database
Background: Despite their clinical complexity, patients with prostate cancer (PCa) requiring intensive care remain an understudied demographic for which precision prognostic instruments are lacking. We sought to establish and verify a robust nomogram tailored to predict the 28-day mortality risk for this specific cohort. Methods: We utilised retrospective data from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database.
Cell-Type–Specific Regulation of Ferroptosis in Atherosclerosis: Mechanisms and Therapeutic Potential of Natural Products
Ziwei Wang and Xuchun Zhong contributed equally to this work and share first authorship Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. References 1, , , et al., “Molecular Mechanisms of Cell Death: Recommendations of the Nomenclature Committee on Cell Death 2018,” Cell Death & Differentiation 25, no.
Ultrafast Photon Spin-Waves Generated From Photonic Crystal Cavities
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article. Supporting Information Filename Description lpor71567-sup-0001-SuppMat.pdf628.8 KB Supporting File: lpor71567-sup-0001-SuppMat.pdf.
Cropland Suitability–Use Mismatches and Differentiated Zoning Regulation in the North China Plain: Implications for Spatially Optimised and Sustainable Land Use
1 Introduction Food security has long been a core issue of global concern (Hultgren et al. 2025; Meyfroidt 2018; Pearson et al. 2024). As the spatial basis of agricultural production and food supply, changes in cropland directly affect agricultural productivity and the level of food security (Kuang et al. 2022; Wang et al. 2022). Under continued global population growth, changing consumption patterns and climate change, food demand keeps rising (Perez et al.
A study on peer effects in energy poverty among rural households in China
Abstract Drawing on data from the China Family Panel Studies (CFPS), this study examines the impact of peer effects on rural household energy poverty in China and explores its underlying mechanisms. The results indicate that a household’s energy poverty status is significantly influenced by peer effects within the same village, with this influence being particularly pronounced for low-income and elderly households.
Spatiotemporal transcriptome atlas of human embryos after gastrulation
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Abstract The comprehensive spatiotemporal atlas of gene expression during early human embryonic development is critical for insights into embryogenesis1, organogenesis2 and disease origins3,4.
By Jiexue Pan, Yuejiao Li, Zhongliang Lin, Qing Lan, Ying Zhang, Huixi Chen, Man Zhai, Gaochen Zhang, Yi Cheng, Yunhui Tang, Qingchen Wang, Yue Xu, Guoling Li, Chunyan Xu, Haoqi Yan, Xingxia Wang, Yiping Zhu, Qinfang Chen, Yichun Guan, Nan Meng, Chang Wang, Xiangjuan Li, Tingting Zheng, Xiaoying Yao, Tingyu Yang, Xuan Chen, Qiuyu Qin, Bin Jiang, Yuxing Ren, Xinmei Liu, Yuxin Zhang, Minghui Yu, Lifang Wang, Yanrong Wei, Meiqi Luo, Ziwei Wang, Zhihua Ou, Ying Lei, Xin Jin, Jianzhong Sheng, Congjian Xu, Yanting Wu, Chenming Xu, Lijian Zhao, HongBo Yang, Ya Gao, Guolian Ding, Xun Xu, Hefeng Huang, Shengwei Sui, Haiqian Lu, Ji Nancuo, Fuhe Ma
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Nature
Verified
Promoting prosocial intention in university students: a mixed-methods examination of rational and affective drivers
Abstract The prosocial behavior of university students not only reflects their moral quality and social responsibility but also has significance for the construction of the moral education system and the accumulation of social capital in universities. Although the theory of planned behavior (TPB) has been widely used to predict prosocial intentions, it has paid insufficient attention to intrinsic emotional factors.
A long-term dataset of dietary patterns and associated environmental effects in China from 1987 to 2023
Abstract The global food system is undergoing a profound transformation, with significant implications for human health and environmental sustainability. Systematic analysis of dietary evolution and its environmental effects is essential for sustainable food system development.
Integrating multimodal clinical data with a large model for prostate cancer diagnosis
Abstract Accurate prostate cancer (PCa) diagnosis remains difficult because of tumor heterogeneity and the challenge of integrating multimodal clinical information. We developed Prost-LM, a multimodal large language model that jointly embeds MRI-derived features, numerical PSA values, and free-text clinical reports into a unified semantic space to enable deep cross-modal reasoning.
Computer Science > Computation and Language
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
TPPU protects against seizures and seizure-associated comorbidities by inhibiting the Akt/mTOR signaling pathway in KA-induced convulsant mice
Abstract Background: Shared pathophysiological mechanisms exist between epilepsy and its associated comorbidities, with neuroinflammation playing a key role. 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) is a soluble epoxide hydrolase (sEH) inhibitor that exhibits potent, broad-spectrum anti-inflammatory effects by preventing the hydrolysis of epoxyeicosatrienoic acids (EETs).
Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction (Adv. Sci. 19/2026)
How to cite Elkins, L. J., & Spiegelman, M. (2021). pyUserCalc: A revised Jupyter notebook calculator for uranium-series disequilibria in basalts. Earth and Space Science, 8, e2020EA001619. https://doi.org/10.1029/2020EA001619 How to cite text copied to clipboard! COPY TEXT Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click on download.
Comprehensive UAV and ground data for typical semiarid sites in the midstream of the Heihe River Basin
Abstract Understanding land surface processes in arid and semiarid environments is crucial for ecosystem dynamics and water management. This data descriptor presents a comprehensive dataset collected during the MUlti-Scale Observation Experiment on land Surface temperature using UAV remote sensing (MUSOES-UAV).
The effects of perceived labor rights protection on job performance in platform flexible employees: The role of career resilience and person–environment fit
Abstract Within the context of labor market transformations driven by the digital economy, the protection of platform flexible employees’ rights has emerged as a critical issue requiring comprehensive analysis. While existing research predominantly focuses on the legal frameworks and institutional structures governing rights protection, there is a significant gap in understanding how perceived labor rights protection influences the job performance of platform flexible employees.
Machine learning identifies antimicrobial peptide candidate for ulcerative colitis
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent intestinal inflammation, abdominal pain and diarrhoea. Although current treatments, including 5-aminosalicylic acid, antibiotics and biologics, can control or ameliorate symptoms, many patients experience incomplete responses or adverse effects. The search for safer and more effective therapies remains a major challenge. Source: By Hui Miao, Ziwei Wang, Pengfei Cui, et al.
A strategy of microglia replacement alleviates microgliopathy in a CSF1R I794T hotspot mutation mouse model of CSF1R-related disorder
Keywords CSF1R CSF1R-RD leukoencephalopathy microglia microglia replacement Introduction The colony-stimulating factor 1 receptor (CSF1R) is a tyrosine kinase receptor predominantly expressed on microglia within the central nervous system (CNS). Autosomal dominant mutations in CSF1R cause a progressive leukodystrophy known as adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP),1,2,3,4 characterized by dementia with motor impairments and neuropsychiatric deficits.
Cognatiyoonia denitrificans sp. nov., isolated from seawater
Volume 76, Issue 1 Article metrics loading... /content/journal/ijsem/10.1099/ijsem.0.007036 Metrics References Wirth JS, Whitman WB. Phylogenomic analyses of a clade within the roseobacter group suggest taxonomic reassignments of species of the genera Aestuariivita, Citreicella, Loktanella, Nautella, Pelagibaca, Ruegeria, Thalassobius, Thiobacimonas and Tropicibacter, and the proposal of six novel genera.
Zinc isotopes record lunar magmatic outgassing and surface processes in different Chang’e-5 samples - Communications Earth & Environment
Abstract The Moon is depleted in moderately volatile elements compared with Earth, likely due to high-temperature processes during its formation. How this depletion evolved and the role of later surface processes remain unclear. Here we report high-precision zinc isotope measurements of basalt fragments and soils collected by the Chang’e-5 (CE-5) mission from a ~ 2-billion-year-old volcanic region.
Hidden Role of Trophic Cascade Effects for Soil Carbon Sequestration in Alpine Tundra
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data supporting the findings of this study are openly available in DRYAD at https://doi.org/10.5061/dryad.6t1g1jxcv. Supporting Information Filename Description gcb70663-sup-0001-FigureS1-S7.docxWord 2007 document , 2.2 MB Figures S1–S7: gcb70663-sup-0001-FigureS1-S7.docx. References , , , , and . 2021.
Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer
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Keywords medulloblastoma Otx2 DNA hypomethylation TET3 treatment Introduction Medulloblastoma (MB) accounts for approximately 25% of childhood brain malignancies,1 which has been classified into four subgroups, including WNT, SHH, Group_3 (G3-MB), and Group_4 (G4-MB).2,3 G3-MB patients suffer from a high metastasis rate and the poorest prognosis, with a 5-year survival rate of less than 50%.1 Recent studies show that MBs with high cellular plasticity are prone to distant dissemination.4 G3-MB...
By Xuan Chen, Ziwei Wang, Yu An Su, Yahui Zhao, Jiankang Li, Wei Wang, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Yanan Wang, Fei Liu, Kaiwen Deng, Dongming Han, Zijia Liu, Meiyu Li, Liam D Hendrikse, EVAN WANG, Dongyang Wang, Zhaoyang Feng, Yanong Li, Zitong Zhao, Hongyu Yuan, Youliang Sun, Yifei Jiang, Yanfeng Shi, Tao Yang, Xueling Qi, Yong Hou, Chunde Li, Yong-qiang Liu, Yu Tian, Shuaicheng Li, Xiaoguang Qiu, Michael Taylor, Tao Jiang, Hailong Liu, Alexandra Rasnitsyn
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Cell Reports Medicine
Verified
Probing the "Psyche'' of Large Reasoning Models: Understanding Through a Human Lens
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Does Cutting Carbon Emissions Reduce Tail Risk Spillovers? A Quantile LSTM‐KAN‐CoVaR Approach
This paper evaluates the association between carbon emissions and tail-risk spillovers in European futures markets. We propose an innovative quantile LSTM-KAN model to capture the time-varying, nonlinear dynamics of tail-risk spillover networks. Using data from 29 EU futures markets, we find that tail-risk spillovers increase significantly during key events, including the 2016 Brexit referendum and the 2020 COVID-19 pandemic.
Weakly‐Solvated and Co‐Intercalation‐Free Ether‐Based Electrolytes Enhance the Low‐ Temperature and Fast‐Charging Performance of LiFePO4||Graphite Batteries
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie70224-sup-0001-SuppMat.docx42.5 MB Supporting Information References 1, , , , , , , , , , , , , , , , Angew. Chem. Int. Ed. 2020, 59, 534–538, https://doi.org/10.1002/anie.201913923. 2, , , , , Nat. Energy 2023, 8, 329–339, https://doi.org/10.1038/s41560-023-01221-y. 3, , , , , Nat. Energy 2018, 3, 267–278, https://doi.org/10.1038/s41560-018-0107-2.
Advances in plant polysaccharides in cancer therapy targeting ferroptosis
Abstract Cancer is a global health public issue with an increasing morbidity and mortality. Ferroptosis is a form of regulated cell death characterized by iron accumulation and lipid peroxidation, providing a novel and promising strategy for cancer treatment. Plant polysaccharides possess low toxicity, minimal side effects, and significant therapeutic potential, particularly in antioxidation, immune regulation, and cancer suppression.
Layered Double Hydroxide‐Based Janus Particles
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Frontiers | Long-term oncological outcomes of laparoscopic versus transanal total mesorectal excision for mid-low rectal cancer: a propensity score matching analysis
Introduction Colorectal cancer is the third most common cancer globally in terms of incidence (new cases) and the second most common cause of cancer-related death worldwide (1). Current treatment methods for rectal cancer (RC) include chemotherapy, radiotherapy, surgery, and immunotherapy, with surgery playing a dominant role.
A Metalloporphyrin Nanosystem Enables Non‐Invasive Visualization and Specific Treatment for Thrombosis and Ischemic Stroke
1 Introduction An ischemic stroke (IS) is a medical emergency resulting from cerebral artery occlusion by thrombosis, which leads to inadequate oxygen and blood supply to the brain, causing long-term disability and death.[1] The major goal of IS treatment is to achieve successful reperfusion of blood flow and to salvage the ischemic penumbra in order to minimize the area of tissue death (infarction) and eventually to ameliorate neurological dysfunction.[2] Currently, thrombolysis and...
Statistical Sampling‐Driven Design for Supported Bimetallic Nanocatalysts for CO2 Reduction
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie202513744-sup-0001-SuppMat.docx108 MB Supporting Information References 1, , Chem. Rev. 2011, 111, 3713–3735, https://doi.org/10.1021/cr1002529. 2, , , Chem. Rev. 2008, 108, 845–910, https://doi.org/10.1021/cr040090g. 3, , Acc. Chem. Res. 2013, 46, 1759–1772. https://doi.org/10.1021/ar300356m. 4, , , , , , , , , Nat. Commun. 2021, 12, 1549, https://doi.org/10.1038/s41467-021-21555-z.
Gate-tunable double-dome superconductivity in twisted trilayer graphene - Nature Physics
Abstract Graphene moiré systems are ideal environments for investigating complex phase diagrams and gaining fundamental insights into the mechanisms that underlie them, as they permit controlled manipulation of electronic properties. Magic-angle twisted trilayer graphene has emerged as a key platform for exploring moiré superconductivity due to the robustness of its superconducting order and the ability to tune its energy bands with an electric field.
LIBS-Tri-Fusion with DOWA-extracted LIPA for enhanced water pollution identification
The accuracy and robustness of laser-induced breakdown spectroscopy (LIBS) in water pollutant identification are limited, mainly due to its reliance on single-source signals. To address this issue, this study innovatively proposes an optimized tri-modal fusion approach that integrates laser-induced plasma acoustic (LIPA) signals, images, and spectral data.
Identification of Shared Biomarkers and Pathways in Diabetic Nephropat
Back to Journals » Journal of Inflammation Research » Volume 19 Original Research Diabetes and Inflammation Authors Zhang J , Wang Z, Cao H, Zhang H, Chen J Received 5 September 2025 Accepted for publication 6 January 2026 Published 20 January 2026 Volume 2026:19 Pages 1—17 DOI https://doi.org/10.2147/JIR.S560821 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Quan Zhang Juan Zhang,1,* Ziwei Wang,2,* Huimin...
Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation
1 Introduction The mechanisms by which environmental and other risk factors contribute to human cancer development remain incompletely understood.
Effect of magnesium sulphate on persistent pulmonary hypertension of the newborn: a systematic review and meta-analysis
Hostname: page-component-6bb9c88b65-6scc2 Total loading time: 0 Render date: 2025-07-24T03:35:39.119Z Has data issue: false hasContentIssue false Published online by Cambridge University Press: 24 July 2025 Show author details Abstract References Keywords Magnesium sulphateneonatepersistent pulmonary hypertension of the newbornmeta-analysis Information Type Original Article Information Cardiology in the Young , Volume 35 , Issue 6 , June 2025 , pp. 1225 - 1232 Copyright © The Author(s), 2025.
Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR‐Chemiluminescence Imaging
1 Introduction The genesis of a thrombus (a blood clot) within the vasculature is the main culprit of numerous critical cardiovascular pathologies which constitute the foremost cause of global morbidity and mortality for humanity.[1-3] Current treatments for thrombosis mainly involve drug therapy[4] and surgery.[5] However, these treatments have limitations and drawbacks. Surgery is effective but invasive and risky.
De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase
Abstract Alpinetin ((2S)-7-Hydroxy-5-methoxyflavan-4-one) is a natural flavonoid found in various medicinal herbs and is frequently used in Chinese patent medicines. It exhibits a wide range of bioactivities, including anti-inflammatory, cardiovascular protective, lung protective, antiviral, hepatoprotective, and antitumor effects. Alpinetin features a 5-methyl group on the A ring, a rare characteristic among methylated flavonoids.
Using Levothyroxin‐Loaded Zn‐Curcumin MOF to Achieve Collaborative Treatment of Hypothyroidic Encephalopathy through Reducing Oxidative Stress and Re‐Building Synaptic Plasticity
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202505935-sup-0001-SuppMat.docx3.6 MB Supporting Information References 1, , , , , Otolaryngol Head Neck Surg 2008, 138, 98. 2, , Best Pract Res Clin Endocrinol Metab 2019, 33, 101319. 3, , , , , , , , , , , , , , Ann. Intern. Med. 2024, 177, 101. 4, , , Biomolecules 2024, 14, 198. 5, , , , , , , , , , , , , , , , , , , , , , , , , , , , Cell 2024, 187, P5679.
Adverse effects of intravenous LNP-mediated mRNA therapy in clinical trials: a systematic review and meta-analysis
ABSTRACT Introduction Intravenous LNP-mediated mRNA therapy holds promise for treating various diseases, yet its safety, particularly regarding adverse events, remains a critical concern. This review systematically evaluates the adverse effects associated with this therapeutic approach. Methods A comprehensive search of PubMed was conducted for clinical trials on intravenous LNP-mediated mRNA therapies. Data extraction focused on study design, participant demographics, and adverse events.
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