Angelo D’Alessandro
As seen in:
British Journal of Cancer,
Nature,
PLOS,
PLOS ONE,
ScienceDirect,
MDPI,
PNAS,
Science Magazine,
BioRxiv,
Cell Metabolism
and
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Angelo D’Alessandro
FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia
Abstract Relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) remains a leading cause of cancer-related death in children and young adults. While CD19-directed chimeric antigen receptor T cell (CAR-T) therapy offers promise, high rates of long-term failure underscore the need to understand resistance mechanisms. Our studies found p53 inactivation promotes CAR-T resistance in human pre-B-ALL cell lines.
Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude
|
ArticleVolume 38, Issue 3p529-545.e8Open access Affiliations & Notes 1Gladstone Institutes, San Francisco, CA 94158, USA 2Center for Blood Oxygen Transport and Hemostasis, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA 3Department of Biochemistry and Molecular Genetics, University of Colorado - Anschutz Medical Campus, Aurora, CO 80045, USA 4Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA 94143, USA...
By Yolanda Marti-Mateos, Zohreh Safari, Shaun Bevers, Ayush Midha, Will Flanigan, Tej Joshi Verified, Helen Huynh, Brandon R. Desousa, Skyler Y. Blume, Alan H. Baik, Stephen Rogers Verified, Aaron Issaian, Allan Doctor, Angelo D’Alessandro, Isha Jain Verified
|
Cell Metabolism
Verified
Modeling tissue-specific Drosophila metabolism identifies high sugar diet-induced metabolic dysregulation in muscle at reaction and pathway levels - Nature Communications
Abstract Individual tissues perform highly specialized metabolic functions to maintain whole-body metabolic homeostasis. Although Drosophila serves as a powerful model for studying human metabolic diseases, modeling tissue-specific metabolism has been limited in this organism.
Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy - Nature Metabolism
Abstract Chaperone-mediated autophagy (CMA) contributes to proteostasis maintenance by selectively degrading a subset of proteins in lysosomes. CMA declines with age in most tissues, including skeletal muscle. However, the role of CMA in skeletal muscle and the consequences of its decline remain poorly understood. Here we demonstrate that CMA regulates skeletal muscle function.
Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response | Leukemia
Abstract Acute myeloid leukemia with mutations in TP53 (TP53mut AML) is fatal with a median survival of 6 months. RNA sequencing on purified AML patient samples showed that TP53mut AML had higher expression of mevalonate pathway genes.
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs - Nature
Abstract Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses1,2,3,4. Suppressing the expansion of mutant HSCs may prevent these outcomes; however, such interventions have not yet been identified.
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome - Nature Medicine
Abstract Clonal dominance characterizes hematopoiesis during aging and increases susceptibility to blood cancers and common nonmalignant disorders. VEXAS syndrome is a recently discovered, adult-onset, autoinflammatory disease burdened by a high mortality rate and caused by dominant hematopoietic clones bearing somatic mutations in the UBA1 gene. However, pathogenic mechanisms driving clonal dominance are unknown.
RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell
Citation: Haiman ZB, Key A, D’Alessandro A, Palsson BO (2025) RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell. PLoS Comput Biol 21(3): e1012109. https://doi.org/10.1371/journal.pcbi.1012109 Editor: Marc R. Birtwistle, Clemson University, UNITED STATES OF AMERICA Received: April 29, 2024; Accepted: February 4, 2025; Published: March 12, 2025 Copyright: © 2025 Haiman et al.
Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Abstract Macrophages specialize in phagocytosis, a cellular process that eliminates extracellular matter, including microorganisms, through internalization and degradation1,2. Despite the critical role of phagocytosis during bacterial infection, the fate of phagocytosed microbial cargo and its impact on the host cell are poorly understood. In this study, we show that ingested bacteria constitute an alternative nutrient source that skews immunometabolic host responses.
E Pluribus, Unum: Emergent Redox Harmony from the Chaos of Blood Cells
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Metabolic and Cellular Differences Between Sedentary and Active Individuals at Rest and During Exercise
ABSTRACT Lack of physical activity has been associated with multiple diseases including cardiovascular disease (CVD), cancer, Alzheimer’s disease (AD), type 2 diabetes (T2D), Parkinson’s disease, depression, dementia and even cancer. Mitochondrial impairment or dysfunction is associated with lack of physical activity and considered to be involved in the pathogenesis of the most prevalent non-communicable diseases (NCDs) aflicting our societies such as T2D, CVD, metabolic syndrome, and even AD.
Deleting the mitochondrial respiration negative regulator MCJ enhances the efficacy of CD8+ T cell adoptive therapies in pre-clinical studies - Nature Communications
Abstract Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we investigate methylation-controlled J protein (MCJ), an endogenous negative regulator of mitochondrial complex I expressed in CD8 cells, as a target for improving the efficacy of adoptive T cell therapies.
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation
Acute ischemic stroke is a leading cause of morbidity and mortality worldwide, producing devastating and permanent neurological damage.1,2 Perturbation of cerebral blood flow (CBF) during ischemic stroke limits the delivery of oxygen and energy substrate, leading to the dysfunction of mitochondrial oxidative phosphorylation and cellular bioenergetic stress.3 The burden of ischemic stroke continues to rise due to the increased prevalence of risk factors, including hypertension, obesity and...
SARS-CoV-2 Infection and Anemia-A Focus on RBC Deformability and Membrane Proteomics-Integrated Observational Prospective Study
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota - Cell Death & Disease
Abstract Aconitate decarboxylase 1 (ACOD1) is the enzyme synthesizing itaconate, an immuno-regulatory metabolite tuning host-pathogen interactions. Such functions are achieved by affecting metabolic pathways regulating inflammation and microbe survival. However, at the whole-body level, metabolic roles of itaconate remain largely unresolved.
Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance
Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance Abstract Cancer stem cells (CSCs) drive tumor growth, metastasis, and chemoresistance. While emerging evidence suggests that CSCs have a unique dependency on lipid metabolism, the functions and regulation of distinct lipid species in CSCs remain poorly understood.
Modeling Red Blood Cell Metabolism in the Omics Era
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Hemolysis and Metabolic Lesion of G6PD Deficient RBCs in Response to Dapsone Hydroxylamine in a Humanized Mouse Model
Abstract Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans (∼5% of all individuals). G6PD deficiency (G6PDd) is caused by an unstable enzyme and manifests most strongly in red blood cells (RBCs) that cannot synthesize new protein. G6PDd RBCs have decreased ability to mitigate oxidative stress due to lower levels of NADPH, as a result of a defective pentose phosphate pathway.
Quantum reality with negative-mass particles | Proceedings of the National Academy of Sciences
Significance We introduce an intuitive particle-based model of time-symmetric quantum physics that gives a concrete description of what goes on in the time between projective measurements of a quantum system. The time-symmetry in this model means that we treat the results of past measurements on a system on equal footing with the results of future measurements, and use both to determine the physical situation during the intervening time between them.
Red Blood Cell Metabolism In Vivo and In Vitro
Abstract : Red blood cells (RBC) are the most abundant cell in the human body, with a central role in oxygen transport and its delivery to tissues. However, omics technologies recently revealed the unanticipated complexity of the RBC proteome and metabolome, paving the way for a reinterpretation of the mechanisms by which RBC metabolism regulates systems biology beyond oxygen transport.
Dasatinib and Trametinib Promote Anti-Tumor Metabolic Activity
Open AccessBrief Report by Eric L. Bolf 1,†, Thomas C. Beadnell 1,†, Madison M. Rose 1, Angelo D’Alessandro 2, Travis Nemkov 2, Kirk C. Hansen 2 and Rebecca E.
Induction of Drug-Resistance and Production of a Culture Medium Able to Induce Drug-Resistance in Vinblastine Untreated Murine Myeloma Cells
1. Introduction Current pharmaceutical treatments in anticancer therapies use different compounds of synthetic and natural origin. However, despite some positive results, relapses are common, as standard chemotherapy regimens are not fully capable of completely eradicating cancer stem cells [1]. The phenomenon of drug resistance is a process that confers cancer (stem) cells resistance and tolerance to anticancer agents.
The bending rigidity of the red blood cell cytoplasmic membrane
Loading metrics Open Access Peer-reviewed Research Article Abstract An important mechanical property of cells is the membrane bending modulus, κ. In the case of red blood cells (RBCs) there is a composite membrane consisting of a cytoplasmic membrane and an underlying spectrin network. Literature values of κ are puzzling, as they are reported over a wide range, from 5 kBT to 230 kBT.
Longitudinal metabolic study of red blood cells from patients undergoing gender-affirming testosterone therapy
TO THE EDITOR: Transgender and gender diverse (TGD) are umbrella terms that describe people whose gender identities differ from their sex assigned at birth or who are not encompassed by the gender-binary paradigm.
Chaperone-mediated autophagy sustains haematopoietic stem-cell function
Abstract The activation of mostly quiescent haematopoietic stem cells (HSCs) is a prerequisite for life-long production of blood cells1. This process requires major molecular adaptations to allow HSCs to meet the regulatory and metabolic requirements for cell division2,3,4. The mechanisms that govern cellular reprograming upon stem-cell activation, and the subsequent return of stem cells to quiescence, have not been fully characterized.
Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells
Abstract Venetoclax with azacitidine (ven/aza) has emerged as a promising treatment regimen for acute myeloid leukemia (AML), with a high percentage of clinical remissions in newly diagnosed patients. However, approximately 30% of newly diagnosed patients and the majority of patients who have relapsed do not achieve remission with ven/aza.
Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron
Abstract Iron is essential for both microorganisms and their hosts. Although effects of dietary iron on gut microbiota have been described, the effect of systemic iron administration has yet to be explored. Here, we show that dietary iron, intravenous iron administration, and chronic transfusion in mice increase the availability of iron in the gut.
Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II
Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Rachel Culp-Hill, Julie A. Reisz, Shanshan Pei, Annika Gustafson, Nabilah Khan, James DeGregori, Daniel A. Pollyea and Craig T. Jordan Blood 2019 134:389-394; doi: https://doi.org/10.1182/blood.2019898114 Key Points LSCs rely on cysteine for survival. Cysteine metabolism is required for ETC II activity in LSCs. There is a Blood Commentary on this article in this issue.
Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD
Correction to: Nature Communications https://doi.org/10.1038/s41467-018-06929-0; published online 26 October 2018 The original version of this Article omitted from the author list the 7th author Bridget Young, who is from the ‘Department of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora 80045 CO, USA’ and ‘Present address: Department of Pediatrics; Allergy and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642,...
Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5′ Pause Release, Termination, and Transcription Elongation Rate
References Adelman K. Marr M.T. Werner J. Saunders A. Ni Z. Andrulis E.D. Lis J.T. Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS. Mol. Cell. 2005; 17 : 103-112 Anamika K. Gyenis À. Poidevin L. Poch O. Tora L. RNA polymerase II pausing downstream of core histone genes is different from genes producing polyadenylated transcripts. PLoS ONE. 2012; 7 : e38769 Coupling mRNA processing with transcription in time and space. Nat. Rev. Genet.
Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes
To better understand the immunophenotype of MDS stem cells, we employed a high-dimensional analysis of cell surface antigens utilizing mass cytometry and flow cytometry. The unbiased analysis and clustering of mass cytometry data confirmed previous reports17,18 of a CD123 positive population in the primitive compartment of high-risk MDS patient bone marrow specimens. An example of this analysis (Fig.
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
In an effort to determine human erythrocyte response to hypoxia, we recruited 21 young and healthy lowland individuals and brought them to high altitude at 5,260 m for a total of 16 days. Nonbiased metabolomic profiling was performed on the erythrocytes isolated from those 21 human volunteers at sea level (SL), and after 12 h (HA1), 7 days (HA7) and 16 days (HA16) at 5,260 m altitude (for details, see Supplementary Data 1).
Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page.
Fine-Tuning of CD8+ T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
To use the Enhanced view of this article, please enable JavaScript on in your browser and refresh the page.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Angelo
Contact Angelo, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack