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ArticleOnline nowOpen access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 3Department of Medicine, Harvard Medical School, Boston, MA 02115, USA 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA 5Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Department of Immunology,...
ArticleVolume 44, Issue 7p1418-1436.e12Open access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, 02215, United States of America 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA, 02115, United States of America 3Department of Medicine, Harvard Medical School, Boston, MA, 02115, United States of America 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, United States of America 5Department of...
Abstract Spatial transcriptomics provides insights into tissue architecture by linking gene expression with spatial localization. Current deconvolution methods rely heavily on single-cell RNA sequencing (scRNA-seq) references, which are costly and often unavailable, mainly if the tissue under evaluation is limited, such as in a core biopsy specimen.
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