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ArticleOnline nowOpen access Affiliations & Notes 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 3Department of Medicine, Harvard Medical School, Boston, MA 02115, USA 4Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA 5Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA 6Department of Immunology,...
Keywords ductal carcinoma in situ immune escape regulatory T cells dendritic cells immuno-oncology progenitor T cells single-cell transcriptomic atlas Introduction Ductal carcinoma in situ (DCIS) is a preinvasive tumor and a non-obligate precursor of invasive breast carcinoma (IBC).1 We previously characterized the DCIS-to-IBC transition as an evolutionary bottleneck marked by immune escape, including reduced cytotoxic CD8+ T cells and enhanced immunosuppression.2,3 Nitroso-N-methylurea...
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